The DOI matches its Crossref record; 114 of the 115 references it cites were found in a registry or an index.
Stem Cells and the Pathogenesis of Endometriosis
Open accessAbstract
Endometriosis is a common gynecological disorder that is defined by the presence of endometrial tissue outside the uterine cavity. This disease often results in extensive morbidity, including chronic pelvic pain and infertility. The pathogenesis of endometriosis is likely multifactorial, and extensive investigation has explored the role of genetics, environmental factors, and the immune system in predisposing patients to developing endometriosis. A series of recent publications have described the identification of endometrial stem/progenitor cells. Such cells have long been speculated to function in the cyclic regeneration of the endometrium during the menstrual cycle and in the pathogenesis of several gynecological disorders. This narrative review will (i) examine the evidence for endometrial stem cells, (ii) examine their potential role in the pathogenesis of endometriosis, and (iii) identify important unanswered questions with suggestions for future investigation.
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“Currently, there are no definitive markers to allow isolation and characterization of endometrial progenitor or stem cells, and it is unknown what drives the recruitment and homing of these cells to eutopic endometrium or ectopic sites.107,108”
From Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France (2013) · cites this paper as [108]
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Cites
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1 of the 115 references couldn’t be matched to a known paper.
Research works printed but not linked: 5
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Metadata
- Authors
- Sasson, I. E., & Taylor, H. S.
- Affiliations
- Yale University (US)
- Corresponding author
- Taylor, Hugh S.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2008-04
- Volume
- 1127
- Issue
- 1
- Pages
- 106-115
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- PMC
- PMC3107843
- OpenAlex
- W2079224311
- Cited by
- 371
- References
- 115
- Citations by year
- 2026: 11 · 2025: 16 · 2024: 19 · 2023: 18 · 2022: 17 · 2021: 26 · 2020: 20 · 2019: 23 · 2018: 20 · 2017: 29 · 2016: 20 · 2015: 26 · 2014: 29 · 2013: 29 · 2012: 21
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD052668)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Obstetrics and Gynecology › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, endometrial stem cells, stem/progenitor cells, endometriosis pathogenesis, endometrial regeneration, menstrual cycle, infertility, chronic pelvic pain, immune system, genetic susceptibility, environmental factors
- MeSH terms
- Bone Marrow Cells, Endometriosis, Endometrium, Female, Humans, Infertility, Female, Lymphatic Metastasis, Neoplasm Metastasis, Stem Cells, Uterine Diseases, Uterus
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