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Cited by 486

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Cerebral White Matter: Neuroanatomy, Clinical Neurology, and Neurobehavioral Correlates

Open access
Schmahmann, Jeremy D., Smith, Eric E., Eichler, Florian S., Filley, Christopher M.·2008·Annals of the New York Academy of Sciences
DOI 10.1196/annals.1444.017
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Abstract

Lesions of the cerebral white matter (WM) result in focal neurobehavioral syndromes, neuropsychiatric phenomena, and dementia. The cerebral WM contains fiber pathways that convey axons linking cerebral cortical areas with each other and with subcortical structures, facilitating the distributed neural circuits that subserve sensorimotor function, intellect, and emotion. Recent neuroanatomical investigations reveal that these neural circuits are topographically linked by five groupings of fiber tracts emanating from every neocortical area: (1) cortico‐cortical association fibers; (2) corticostriatal fibers; (3) commissural fibers; and cortico‐subcortical pathways to (4) thalamus and (5) pontocerebellar system, brain stem, and/or spinal cord. Lesions of association fibers prevent communication between cortical areas engaged in different domains of behavior. Lesions of subcortical structures or projection/striatal fibers disrupt the contribution of subcortical nodes to behavior. Disconnection syndromes thus result from lesions of the cerebral cortex, subcortical structures, and WM tracts that link the nodes that make up the distributed circuits. The nature and the severity of the clinical manifestations of WM lesions are determined, in large part, by the location of the pathology: discrete neurological and neuropsychiatric symptoms result from focal WM lesions, whereas cognitive impairment across multiple domains—WM dementia—occurs in the setting of diffuse WM disease. We present a detailed review of the conditions affecting WM that produce these neurobehavioral syndromes, and consider the pathophysiology, clinical effects, and broad significance of the effects of aging and vascular compromise on cerebral WM, in an attempt to help further the understanding, diagnosis, and treatment of these disorders.

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Metadata

Authors
Schmahmann, J. D., Smith, E. E., Eichler, F. S., & Filley, C. M.
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2008-10
Volume
1142
Issue
1
Pages
266-309
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
DOI
10.1196/annals.1444.017
OpenAlex
W1529598366
Cited by
486
References
34
FWCI
13.38
Type
journal article
Language
en
Open access
green

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