The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Mastectomy versus breast-conserving therapy in the treatment of stage I and II carcinoma of the breast: a randomized trial at the National Cancer Institute.
Abstract
PURPOSE: Mastectomy versus excisional biopsy (lumpectomy) plus radiation for the treatment of stage I and II breast cancer was compared in a prospective randomized study. PATIENTS AND METHODS: From 1979 to 1987, 247 women were randomized and 237 were treated on this study. All patients received a full axillary dissection and all node-positive patients received adjuvant chemotherapy with cyclophosphamide and doxorubicin. Radiation consisted of external-beam therapy to the whole breast with or without supraclavicular nodal irradiation followed by a boost to the tumor bed. RESULTS: The minimum time on the study was 18 months and the median time on the study was 68 months. No differences in overall survival or disease-free survival were observed. Actuarial estimates at 5 years showed that 85% of mastectomy-treated patients were alive compared with 89% of the lumpectomy/radiation patients (P2 = .49; 95% two-sided confidence interval [CI] about this difference, 0% to 9% favoring lumpectomy plus radiation). The probability of failure in the irradiated breast was 12% by 5 years and 20% by 8 years according to actuarial estimates. Of 15 local breast failures, 14 were treated with and 12 were controlled by mastectomy; the ultimate local-regional control was similar in both arms of the trial. CONCLUSION: These data add further weight to the conclusion that breast conservation using lumpectomy and breast irradiation is equivalent to mastectomy in terms of survival and ultimate local control for stage I and II breast cancer patients.
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Cites
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Cited by
Hughes, K. S., Schnaper, L. A., Berry, D., Cirrincione, C., McCormick, B., Shank, B., Wheeler, J., Champion, L. A., Smith, T. J., Smith, B. L., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040587 · Cited by 1,078
Jacobson, J. A., Danforth, D. N., Cowan, K. H., d'Angelo, T., Steinberg, S. M., Pierce, L., Lippman, M. E., Lichter, A. S., Glatstein, E., & Okunieff, P. (1995) · New England Journal of Medicine · doi:10.1056/nejm199504063321402 · Cited by 892
Self-citationPoggi, M. M., Danforth, D. N., Sciuto, L. C., Smith, S. L., Steinberg, S. M., Liewehr, D. J., Menard, C., Lippman, M. E., Lichter, A. S., & Altemus, R. M. (2003) · Cancer · doi:10.1002/cncr.11580 · Cited by 569
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Agarwal, S., Pappas, L., Neumayer, L., Kokeny, K., & Agarwal, J. (2014) · JAMA Surgery · doi:10.1001/jamasurg.2013.3049 · Cited by 391
Metadata
- Authors
- Lichter, A. S., Lippman, M. E., Danforth, D. N., d'Angelo, T., Steinberg, S. M., deMoss, E., MacDonald, H. D., Reichert, C. M., Merino, M., & Swain, S. M.
- Venue
- Journal of Clinical Oncology
- Published
- 1992-06
- Volume
- 10
- Issue
- 6
- Pages
- 976-983
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W1888411879
- Cited by
- 347
- References
- 21
- FWCI
- 7.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Mastectomy versus breast-conserving therapy in the treatment of stage I and II carcinoma of the breast: a randomized trial at the National Cancer Institute. https://app.cochat.ai/papers/10.1200/jco.1992.10.6.976
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- Lichter, A. S., Lippman, M. E., Danforth, D. N., d'Angelo, T., Steinberg, S. M., deMoss, E., MacDonald, H. D., Reichert, C. M., Merino, M., & Swain, S. M. (1992). Mastectomy versus breast-conserving therapy in the treatment of stage I and II carcinoma of the breast: a randomized trial at the National Cancer Institute. Journal of Clinical Oncology. https://doi.org/10.1200/jco.1992.10.6.976
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
