The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
New Malignancies After Blood or Marrow Stem-Cell Transplantation in Children and Adults: Incidence and Risk Factors
Abstract
Purpose: To determine the incidence and risk factors for the development of new malignancies occurring after stem-cell transplantation (SCT). Patients: Between January 1, 1974, and March 31, 2001, 3,372 patients underwent SCT at the University of Minnesota. From these transplants, 147 posttransplant malignancies (PTMs) were identified in 137 patients. Results: Excluding nonmelanoma skin cancers (n = 19) and carcinoma-in-situ (n = 5), the remaining 123 cases represented an 8.1-fold (95% confidence interval [CI], 6.7 to 9.6) increased risk of a PTM, an excess risk of 102.7 cases/10,000 persons/yr (age and sex adjusted). This includes a significantly elevated risk for developing myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML; standardized incidence ratio [SIR] = 300; 95% CI, 210 to 406), non-Hodgkin’s lymphoma including posttransplant lymphoproliferative disorder (PTLD; SIR = 54.3; 95% CI, 39.5 to 41.1), Hodgkin’s disease (SIR = 14.8; 95% CI, 3.9 to 32.9), or solid tumors overall (SIR = 2.8; CI, 2.0 to 3.7) and in specific for melanoma, brain, and oral cavity tumors. The cumulative incidence for the development of any PTM was 6.9% (95% CI, 5.2 to 8.6) at 20 years post-SCT. For PTLD (n = 43), the cumulative incidence plateaued at 1.4% (95% CI, 1.0 to 1.8) by 10 years post-SCT. For MDS or AML, the cumulative incidence plateaued at 1.4% (95% CI, 0.9 to 1.9) by 10 years post-SCT. The cumulative incidence of developing a solid tumor did not plateau and was 3.8% (95% CI, 2.2 to 5.4) at 20 years post-SCT. Conclusion: These data reveal that the risk of PTMs, especially solid tumors, continues to increase even 20 years after transplant, necessitating long-term close follow-up for these patients.
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Citations
Cites
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1992) · Springer Series in Statistics · doi:10.1007/978-1-4612-4380-9_25 · Cited by 45,181
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Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158
Regression Models and Life-Tables
Cox, D. R. (1992) · Springer Series in Statistics · doi:10.1007/978-1-4612-4380-9_37 · Cited by 26,297
Solid Cancers after Bone Marrow Transplantation
Curtis, R. E., Rowlings, P. A., Deeg, H. J., Shriner, D. A., Socié, G., Travis, L. B., Horowitz, M. M., Witherspoon, R. P., Hoover, R. N., Sobocinski, K. A., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199703273361301 · Cited by 965
Bone Sarcomas Linked to Radiotherapy and Chemotherapy in Children
Tucker, M. A., D'Angio, G. J., Boice, J. D., Strong, L. C., Li, F. P., Stovall, M., Stone, B. J., Green, D. M., Lombardi, F., Newton, W., et al. (1987) · New England Journal of Medicine · doi:10.1056/nejm198709033171002 · Cited by 765
Second Neoplasms after Acute Lymphoblastic Leukemia in Childhood
Neglia, J. P., Meadows, A. T., Robison, L. L., Kim, T. H., Newton, W. A., Ruymann, F. B., Sather, H. N., & Hammond, G. D. (1991) · New England Journal of Medicine · doi:10.1056/nejm199111073251902 · Cited by 549
Self-citationNON-PARAMETRIC INFERENCE FOR CUMULATIVE INCIDENCE FUNCTIONS IN COMPETING RISKS STUDIES
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Malignant neoplasms following bone marrow transplantation
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Self-citationNew Malignant Diseases After Allogeneic Marrow Transplantation for Childhood Acute Leukemia
Socié, G., Curtis, R. E., Deeg, H. J., Sobocinski, K. A., Filipovich, A. H., Travis, L. B., Sullivan, K. M., Rowlings, P. A., Kingma, D. W., Banks, P. M., et al. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.2.348 · Cited by 337
Cited by
Solid cancers after allogeneic hematopoietic cell transplantation
Rizzo, J. D., Curtis, R. E., Socié, G., Sobocinski, K. A., Gilbert, E., Landgren, O., Travis, L. B., Travis, W. D., Flowers, M. E. D., Friedman, D. L., et al. (2009) · Blood · doi:10.1182/blood-2008-05-158782 · Cited by 439
Secondary Neoplasms After Hematopoietic Cell Transplant for Sickle Cell Disease
Eapen, M., Brazauskas, R., Williams, D. A., Walters, M. C., St Martin, A., Jacobs, B. L., Antin, J. H., Bona, K., Chaudhury, S., Coleman-Cowger, V. H., et al. (2023) · Journal of Clinical Oncology · doi:10.1200/jco.22.01203 · Cited by 60
Adhikari, J., Sharma, P., & Bhatt, V. R. (2015) · Future Oncology · doi:10.2217/fon.15.252 · Cited by 31
Metadata
- Authors
- Baker, K. S., DeFor, T. E., Burns, L. J., Ramsay, N. K. C., Neglia, J. P., & Robison, L. L.
- Venue
- Journal of Clinical Oncology
- Published
- 2003-04-01
- Volume
- 21
- Issue
- 7
- Pages
- 1352-1358
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2044507524
- Cited by
- 317
- References
- 27
- FWCI
- 7.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- Baker, K. S., DeFor, T. E., Burns, L. J., Ramsay, N. K. C., Neglia, J. P., & Robison, L. L. (2003). New Malignancies After Blood or Marrow Stem-Cell Transplantation in Children and Adults: Incidence and Risk Factors. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2003.05.108
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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