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Cited by 417

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Doxorubicin With Cyclophosphamide Followed by Docetaxel Every 21 Days Compared With Doxorubicin and Docetaxel Every 14 Days As Preoperative Treatment in Operable Breast Cancer: The GEPARDUO Study of the German Breast Group

Open access
von Minckwitz, Gunter, Raab, Günter, Caputo, Angelika, Schütte, Martin, Hilfrich, Jörn, Blohmer, Jens U., Gerber, Bernd, Costa, Serban D., Merkle, Elisabeth, Eidtmann, Holger, Lampe, Dieter, Jackisch, Christian, du Bois, Andreas, Kaufmann, Manfred·2005·Journal of Clinical Oncology
DOI 10.1200/jco.2005.05.078
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Abstract

Purpose: Dose-dense and sequential administration of cytotoxic drugs are current approaches to improve outcomes in patients with early-stage breast cancer. Methods: This phase III study investigated 913 women with untreated operable breast cancer (T2-3, N0-2, M0) randomly assigned to receive either doxorubicin 50 mg/m 2 plus docetaxel 75 mg/m 2 every 14 days for four cycles with filgrastim support (ADOC), or doxorubicin 60 mg/m 2 plus cyclophosphamide 600 mg/m 2 every 21 days followed by docetaxel 100 mg/m 2 every 21 days for four cycles each (AC-DOC). The primary end point was the incidence of pathologic complete (invasive and noninvasive) response (pCR) in the breast and axillary nodes. Secondary end points were predictors for pCR, clinical response, rate of breast conservation, and safety. Results: A pCR was achieved in 94 patients (10.6%), but the likelihood was significantly greater with AC-DOC (14.3%; n = 63) than with ADOC (7.0%; n = 31) (odds ratio, 2.22; 90% CI, 1.52 to 3.24; P < .001). Independent predictors of attaining a pCR included the use of sequential therapy, high tumor grade, and negative hormone receptor status. The response rates detected by palpation and by imaging were significantly higher with AC-DOC (85.0% and 78.6%, respectively) than with ADOC (75.2% and 68.6%, respectively; both P values < .001). The rate of breast-conserving surgery was 63.4% for AC-DOC and 58.1% for ADOC (P = .05). Predominant grade 3/4 toxicities were leucopenia (AC-DOC, 74.2%; ADOC, 53.7%) and neutropenia (AC-DOC, 66.4%; ADOC, 44.7%) but were infrequently associated with fever (AC-DOC, 4.6%; ADOC, 3.1%). Conclusion: Sequential AC-DOC is more effective at inducing pCR than dose-dense ADOC as preoperative treatment for patients with operable breast cancer.

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Metadata

Authors
von Minckwitz, G., Raab, G., Caputo, A., Schütte, M., Hilfrich, J., Blohmer, J. U., Gerber, B., Costa, S. D., Merkle, E., Eidtmann, H., Lampe, D., Jackisch, C., du Bois, A., & Kaufmann, M.
Venue
Journal of Clinical Oncology
Publisher
American Society of Clinical Oncology (ASCO)
Published
2005-04-20
Volume
23
Issue
12
Pages
2676-2685
ISSN
  • 0732-183X (ISSN-L)
  • 1527-7755
DOI
10.1200/jco.2005.05.078
OpenAlex
W2140654333
Cited by
417
References
12
FWCI
10.56
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Doxorubicin With Cyclophosphamide Followed by Docetaxel Every 21 Days Compared With Doxorubicin and Docetaxel Every 14 Days As Preoperative Treatment in Operable Breast Cancer: The GEPARDUO Study of the German Breast Group. https://app.cochat.ai/papers/10.1200/jco.2005.05.078
The paper
von Minckwitz, G., Raab, G., Caputo, A., Schütte, M., Hilfrich, J., Blohmer, J. U., Gerber, B., Costa, S. D., Merkle, E., Eidtmann, H., Lampe, D., Jackisch, C., du Bois, A., & Kaufmann, M. (2005). Doxorubicin With Cyclophosphamide Followed by Docetaxel Every 21 Days Compared With Doxorubicin and Docetaxel Every 14 Days As Preoperative Treatment in Operable Breast Cancer: The GEPARDUO Study of the German Breast Group. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2005.05.078

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.