The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Hereditary Cancer Predisposition Syndromes
Abstract
Cancer genetics is increasingly becoming integrated into the practice of modern medical oncology. The ability to distinguish a growing proportion of the 5% to 10% of all cancers that develop in individuals who have inherited a genetic mutation conferring heightened susceptibility to specific cancers may permit targeted efforts in cancer surveillance and prevention. While these individuals comprise a small proportion of the overall burden of cancer, strategies successful in reducing their remarkable cancer risks may be generalizable to the broader population. In this review, we highlight the most common hereditary cancer syndromes, most attributable to genes inherited in an autosomal dominant manner with incomplete penetrance, and a number of rare syndromes in which particular progress has been made. The prevalence, penetrance, tumor spectrum, and underlying genetic defects are discussed and summarized in a large table in which a more comprehensive enumeration of syndromes is provided.
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Cited by
Robson, M. E., Bradbury, A. R., Arun, B., Domchek, S. M., Ford, J. M., Hampel, H. L., Lipkin, S. M., Syngal, S., Wollins, D. S., & Lindor, N. M. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2015.63.0996 · Cited by 934
Ripperger, T., Bielack, S. S., Borkhardt, A., Brecht, I. B., Burkhardt, B., Calaminus, G., Debatin, K., Deubzer, H., Dirksen, U., Eckert, C., et al. (2017) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.38142 · Cited by 283
Iron and thiol redox signaling in cancer: an exquisite balance to escape ferroptosis
Toyokuni, S., Ito, F., Yamashita, K., Okazaki, Y., & Akatsuka, S. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.04.024 · Cited by 252
Cancer in Young Adults 20 to 39 Years of Age: Overview
Bleyer, A., & Barr, R. (2009) · Seminars in Oncology · doi:10.1053/j.seminoncol.2009.03.003 · Cited by 144
Tumor Syndromes Predisposing to Osteosarcoma
Hameed, M., & Mandelker, D. (2018) · Advances in Anatomic Pathology · doi:10.1097/pap.0000000000000190 · Cited by 109
Metadata
- Authors
- Garber, J. E., & Offit, K.
- Venue
- Journal of Clinical Oncology
- Published
- 2005-01-10
- Volume
- 23
- Issue
- 2
- Pages
- 276-292
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2089155477
- Cited by
- 697
- References
- 18
- FWCI
- 17.65
- Type
- journal article
- Language
- en
- Open access
- closed
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