CoChat
Sign Up
Cited by 857Physical Activity and HealthCancer survivorship and careCancer Risks and Factors

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

Physical Activity and Survival After Colorectal Cancer Diagnosis

Meyerhardt, Jeffrey A., Giovannucci, Edward L., Holmes, Michelle D., Chan, Andrew T., Chan, Jennifer A., Colditz, Graham A., Fuchs, Charles S.·2006·Journal of Clinical Oncology
DOI 10.1200/jco.2006.06.0855
Open this paper in CoChat — free account

Abstract

PURPOSE: Physically active individuals have a lower risk of developing colorectal cancer but the influence of exercise on cancer survival is unknown. PATIENTS AND METHODS: By a prospective, observational study of 573 women with stage I to III colorectal cancer, we studied colorectal cancer-specific and overall mortality according to predefined physical activity categories before and after diagnosis and by change in activity after diagnosis. To minimize bias by occult recurrences, we excluded women who died within 6 months of their postdiagnosis physical activity assessment. RESULTS: Increasing levels of exercise after diagnosis of nonmetastatic colorectal cancer reduced cancer-specific mortality (P for trend = .008) and overall mortality (P for trend = .003). Compared with women who engaged in less than 3 metabolic equivalent task [MET] -hours per week of physical activity, those engaging in at least 18 MET-hours per week had an adjusted hazard ratio for colorectal cancer-specific mortality of 0.39 (95% CI, 0.18 to 0.82) and an adjusted hazard ratio for overall mortality of 0.43 (95% CI, 0.25 to 0.74). These results remained unchanged even after excluding women who died within 12 and 24 months of activity assessment. Prediagnosis physical activity was not predictive of mortality. Women who increased their activity (when comparing prediagnosis to postdiagnosis values) had a hazard ratio of 0.48 (95% CI, 0.24 to 0.97) for colorectal cancer deaths and a hazard ratio of 0.51 (95% CI, 0.30 to 0.85) for any-cause death, compared with those with no change in activity. CONCLUSION: Recreational physical activity after the diagnosis of stages I to III colorectal cancer may reduce the risk of colorectal cancer-specific and overall mortality.

Overview

Integrity signals

Registry

Crossref · 10.1200/jco.2006.06.0855

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 55 references

Cited by

Sorted by citations

See all 857

Related

Metadata

Authors
Meyerhardt, J. A., Giovannucci, E. L., Holmes, M. D., Chan, A. T., Chan, J. A., Colditz, G. A., & Fuchs, C. S.
Affiliations
Brigham and Women's Hospital (US)
ORCID
Venue
Journal of Clinical Oncology
Publisher
American Society of Clinical Oncology (ASCO)
Published
2006-08-01
Volume
24
Issue
22
Pages
3527-3534
ISSN
  • 0732-183X (ISSN-L)
  • 1527-7755
DOI
10.1200/jco.2006.06.0855
OpenAlex
W2114841681
Cited by
857
References
55
Citations by year
2026: 13 · 2025: 26 · 2024: 19 · 2023: 24 · 2022: 32 · 2021: 41 · 2020: 43 · 2019: 31 · 2018: 51 · 2017: 62 · 2016: 53 · 2015: 66 · 2014: 36 · 2013: 63 · 2012: 57
FWCI
30.27
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Clinical Oncology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Cancer Institute (P01CA087969, K07CA097992)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
Keywords
physical activity, colorectal cancer, cancer-specific mortality, all-cause mortality, recreational exercise, metabolic equivalent hours, women, non-metastatic colorectal cancer, survival
MeSH terms
Aged, Physical Exertion, Female, Humans, Life Style, Middle Aged, Motor Activity, Neoplasm Staging, Nurses, Prospective Studies, Surveys and Questionnaires, Risk Factors, United States, Colorectal Neoplasms, Exercise, Survival Rate, Multivariate Analysis, Odds Ratio

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review