Cited by 619Cancer, Hypoxia, and MetabolismRadiation Therapy and DosimetryAdvanced Radiotherapy Techniques

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Hypoxic Radiosensitization: Adored and Ignored

Overgaard, Jens·2007·Journal of Clinical Oncology

DOI 10.1200/jco.2007.12.7878

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Abstract

Since observations from the beginning of the last century, it has become well established that solid tumors may contain oxygen-deficient hypoxic areas and that cells in such areas may cause tumors to become radioresistant. Identifying hypoxic cells in human tumors has improved by the help of new imaging and physiologic techniques, and a substantial amount of data indicates the presence of hypoxia in many types of human tumors, although with a considerable heterogeneity among individual tumors. Controlled clinical trials during the last 40 years have indicated that this source of radiation resistance can be eliminated or modified by normobaric or hyperbaric oxygen or by the use of nitroimidazoles as hypoxic radiation sensitizers. More recently, attention has been given to hypoxic cytotoxins, a group of drugs that selectively or preferably destroys cells in a hypoxic environment. An updated systematic review identified 10,108 patients in 86 randomized trials designed to modify tumor hypoxia in patients treated with curative attempted primary radiation therapy alone. Overall modification of tumor hypoxia significantly improved the effect of radiotherapy, with an odds ratio of 0.77 (95% CI, 0.71 to 0.86) for the outcome of locoregional control and with an associated significant overall survival benefit (odds ratio = 0.87; 95% CI, 0.80 to 0.95). No significant influence was found on the incidence of distant metastases or on the risk of radiation-related complications. Ample data exist to support a high level of evidence for the benefit of hypoxic modification. However, hypoxic modification still has no impact on general clinical practice.

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Lysyl oxidase is essential for hypoxia-induced metastasis
Erler, J. T., Bennewith, K. L., Nicolau, M., Dornhöfer, N., Kong, C., Le, Q.-T., Chi, J.-T. A., Jeffrey, S. S., & Giaccia, A. J. (2006) · Nature · doi:10.1038/nature04695 · Cited by 1,309
Retracted
Hypoxia — a key regulatory factor in tumour growth
Harris, A. L. (2002) · Nature Reviews Cancer · doi:10.1038/nrc704 · Cited by 5,177
Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints.
Parmar, M. K. B., Torri, V., & Stewart, L. (1998) · Statistics in Medicine · doi:10.1002/(sici)1097-0258(19981230)17:24 · Cited by 4,519
Exploiting tumour hypoxia in cancer treatment
Brown, J. M., & Wilson, W. R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1367 · Cited by 2,828
Hypoxia in cancer: significance and impact on clinical outcome
Vaupel, P., & Mayer, A. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9055-1 · Cited by 2,240
The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy
Thomlinson, R. H., & Gray, L. H. (1955) · British Journal of Cancer · doi:10.1038/bjc.1955.55 · Cited by 2,228
The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy
Gray, L. H., Conger, A. D., Ebert, M., Hornsey, S., & Scott, O. C. A. (1953) · The British Journal of Radiology · doi:10.1259/0007-1285-26-312-638 · Cited by 2,158
Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study
Nordsmark, M., Bentzen, S. M., Rudat, V., Brizel, D., Lartigau, E., Stadler, P., Becker, A., Adam, M., Molls, M., Dunst, J., et al. (2005) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2005.06.038 · Cited by 953
Self-citation
Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck
Nordsmark, M., Overgaard, M., & Overgaard, J. (1996) · Radiotherapy and Oncology · doi:10.1016/s0167-8140(96)91811-3 · Cited by 942
Self-citation
Hypoxia: Importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy
Tatum, J. L. (2006) · International Journal of Radiation Biology · doi:10.1080/09553000601002324 · Cited by 626

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Show all 73 references

Research works printed but not linked: 1

Okkan S, Uzel R, Yazici A, et al: Effect of ornisazole on fractionated irradiation in carcinoma of the cervix and larynx, in: Radiotherapy in Developing Countries. Proceedings Series. Vienna, Austria, International Atomic Energy Agency, pp 271,1987-280

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Xie, G., Liu, Y., Yao, Q., Zheng, R., Zhang, L., Lin, J., Guo, Z., Du, S., Ren, C., Yuan, Q., et al. (2017) · Scientific Reports · doi:10.1038/srep42396 · Cited by 41
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Duan, Q., Liu, Y., & Rockwell, S. (2013) · PubMed · Cited by 37
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Liu, H., Cai, Y., Zhang, Y., Xie, Y., Qiu, H., Hua, L., Liu, X., Li, Y., Lu, J. L., Zhang, L., et al. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201601377 · Cited by 32
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Chia, K., Fleming, I. N., & Blower, P. J. (2011) · Nuclear Medicine Communications · doi:10.1097/mnm.0b013e32834eacb7 · Cited by 27
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Authors: Overgaard, J.
Affiliations: Aarhus University Hospital (DK)
Corresponding author: Overgaard, Jens
ORCID: Overgaard, Jens
Venue: Journal of Clinical Oncology
Publisher: American Society of Clinical Oncology (ASCO)
Published: 2007-09-10
Volume: 25
Issue: 26
Pages: 4066-4074
ISSN: 0732-183X (ISSN-L)
1527-7755
DOI: 10.1200/jco.2007.12.7878
OpenAlex: W2123838717
Cited by: 619
References: 73
Citations by year: 2026: 16 · 2025: 12 · 2024: 25 · 2023: 35 · 2022: 34 · 2021: 41 · 2020: 26 · 2019: 39 · 2018: 38 · 2017: 31 · 2016: 40 · 2015: 37 · 2014: 47 · 2013: 42 · 2012: 40
FWCI: 2.08
Type: journal article
Language: en
Open access: closed
Locations: Journal of Clinical Oncology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Physical Sciences › Physics and Astronomy › Radiation › Radiation Therapy and Dosimetry
Physical Sciences › Physics and Astronomy › Radiation › Advanced Radiotherapy Techniques
Keywords: tumor hypoxia, radiosensitization, radioresistance (biology), hyperbaric oxygen therapy, normobaric oxygen, nitroimidazoles, radiotherapy, locoregional control, overall survival, metastasis
MeSH terms: Combined Modality Therapy, Humans, Neoplasms, Radiation-Sensitizing Agents, Cell Hypoxia

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Hypoxic Radiosensitization: Adored and Ignored

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