The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Hypoxic Radiosensitization: Adored and Ignored
Abstract
Since observations from the beginning of the last century, it has become well established that solid tumors may contain oxygen-deficient hypoxic areas and that cells in such areas may cause tumors to become radioresistant. Identifying hypoxic cells in human tumors has improved by the help of new imaging and physiologic techniques, and a substantial amount of data indicates the presence of hypoxia in many types of human tumors, although with a considerable heterogeneity among individual tumors. Controlled clinical trials during the last 40 years have indicated that this source of radiation resistance can be eliminated or modified by normobaric or hyperbaric oxygen or by the use of nitroimidazoles as hypoxic radiation sensitizers. More recently, attention has been given to hypoxic cytotoxins, a group of drugs that selectively or preferably destroys cells in a hypoxic environment. An updated systematic review identified 10,108 patients in 86 randomized trials designed to modify tumor hypoxia in patients treated with curative attempted primary radiation therapy alone. Overall modification of tumor hypoxia significantly improved the effect of radiotherapy, with an odds ratio of 0.77 (95% CI, 0.71 to 0.86) for the outcome of locoregional control and with an associated significant overall survival benefit (odds ratio = 0.87; 95% CI, 0.80 to 0.95). No significant influence was found on the incidence of distant metastases or on the risk of radiation-related complications. Ample data exist to support a high level of evidence for the benefit of hypoxic modification. However, hypoxic modification still has no impact on general clinical practice.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In 1909, Schwarz demonstrated in a simple experiment that if the skin was clamped to reduce blood flow to the arm, the skin's response to radiation was significantly reduced.”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [332]
Citations
Cites
1 retracted
Lysyl oxidase is essential for hypoxia-induced metastasis
Erler, J. T., Bennewith, K. L., Nicolau, M., Dornhöfer, N., Kong, C., Le, Q.-T., Chi, J.-T. A., Jeffrey, S. S., & Giaccia, A. J. (2006) · Nature · doi:10.1038/nature04695 · Cited by 1,309
RetractedHypoxia — a key regulatory factor in tumour growth
Harris, A. L. (2002) · Nature Reviews Cancer · doi:10.1038/nrc704 · Cited by 5,177
Parmar, M. K. B., Torri, V., & Stewart, L. (1998) · Statistics in Medicine · doi:10.1002/(sici)1097-0258(19981230)17:24 · Cited by 4,519
Exploiting tumour hypoxia in cancer treatment
Brown, J. M., & Wilson, W. R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1367 · Cited by 2,828
Hypoxia in cancer: significance and impact on clinical outcome
Vaupel, P., & Mayer, A. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9055-1 · Cited by 2,240
The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy
Thomlinson, R. H., & Gray, L. H. (1955) · British Journal of Cancer · doi:10.1038/bjc.1955.55 · Cited by 2,228
Gray, L. H., Conger, A. D., Ebert, M., Hornsey, S., & Scott, O. C. A. (1953) · The British Journal of Radiology · doi:10.1259/0007-1285-26-312-638 · Cited by 2,158
Nordsmark, M., Bentzen, S. M., Rudat, V., Brizel, D., Lartigau, E., Stadler, P., Becker, A., Adam, M., Molls, M., Dunst, J., et al. (2005) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2005.06.038 · Cited by 953
Self-citationNordsmark, M., Overgaard, M., & Overgaard, J. (1996) · Radiotherapy and Oncology · doi:10.1016/s0167-8140(96)91811-3 · Cited by 942
Self-citationTatum, J. L. (2006) · International Journal of Radiation Biology · doi:10.1080/09553000601002324 · Cited by 626
Flagged first, then by citations
Research works printed but not linked: 1
- Okkan S, Uzel R, Yazici A, et al: Effect of ornisazole on fractionated irradiation in carcinoma of the cervix and larynx, in: Radiotherapy in Developing Countries. Proceedings Series. Vienna, Austria, International Atomic Energy Agency, pp 271,1987-280
Cited by
Sorted by citations
Items 601–617 of 617
Mittal, S., Jain, A., Babu, A., Kumar, C., & Mallia, M. B. (2026) · Drug Development Research · doi:10.1002/ddr.70228
Between hope and uncertainty: the elusive evidence on hyperbaric oxygen therapy and radiotherapy
Cuccia, F., Cracchiolo, A. N., Piras, A., D’Alessandro, S., Carruba, G., Mercadante, S., & Ferrera, G. (2026) · Supportive Care in Cancer · doi:10.1007/s00520-026-10323-8
Influence of hypoxia on tumour cell susceptibility to cytotoxic T lymphocyte mediated lysis
Noman, M. Z. (2012) · theses.fr (ABES) · doi:10.70675/306da2eez5bc3z478ez83c5zdc39407a896e
Hypoxia Induces a Mitotic Survival Advantage After Radiotherapy in Head and Neck Cancer Cells
Wegge, M., Dok, R., Dubois, L. J., & Nuyts, S. (2026) · International Journal of Cancer · doi:10.1002/ijc.70479
Holt‐Martyn, J. P., Machado, N., Coates, J. T. T., Puliyadi, R., Ashton, T., Traynor, E., Aslam, S., Wise, T. K., Rodríguez‐Berriguete, G., Schofield, C. J., et al. (2026) · RSC Medicinal Chemistry · doi:10.1039/d5md00742a
Shih, H.-Y., & Chen, C.-C. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48050525
Personalized Treatment of Head and Neck Cancers: Role of Functional Imaging and AI
Tanghe, J., Dok, R., & Nuyts, S. (2026) · Cancers · doi:10.3390/cancers18121954
Datta, A., Dubec, M. J., Berks, M., Little, R. A., Barraclough, L., Haslett, K., Porta, N., Manoharan, P., Buckley, D. L., West, C., et al. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1859532
Siah, N., Qi, P., Hu, B., Chen, M. I., Cao, T., Li, X. A., & Han, J. (2026) · Journal of Applied Clinical Medical Physics · doi:10.1002/acm2.70713
Joseph, N., Ajanthan, S., Jeyakumaran, N., Rathnayake, W., Jayawickrema, P., Fernandopulle, P., Iqbal, A., Malinda, Y., Bandusena, M., Gamage, A., et al. (2026) · Clinical Oncology · doi:10.1016/j.clon.2026.104327
Brownstein, J. M., Williams, T., Xu-Welliver, M., Sebastian, N., Ma, S. J., Haglund, K. E., Sim, A. J., Benej, M., Papandreou, I., Qing, K., et al. (2026) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2026.10.012
Joshi, G. S. (2014) · Human Biology
Stegeman, H. (2013) · Radboud Repository (Radboud University)
Identifying response to therapy in longitudinal PET imaging studies
Phillips, M. R. (2014) · UPT. Syiah Kuala University Library (Syiah Kuala University)
Studies on regulation of versican gene expression by hypoxia in primary human macrophages
Sotoodehnejadnematalahi, F. (2011) · Leicester Research Archive (University of Leicester)
Metadata
- Authors
- Overgaard, J.
- Affiliations
- Aarhus University Hospital (DK)
- Corresponding author
- Overgaard, Jens
- ORCID
- Overgaard, Jens
- Venue
- Journal of Clinical Oncology
- Published
- 2007-09-10
- Volume
- 25
- Issue
- 26
- Pages
- 4066-4074
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2123838717
- Cited by
- 619
- References
- 73
- Citations by year
- 2026: 16 · 2025: 12 · 2024: 25 · 2023: 35 · 2022: 34 · 2021: 41 · 2020: 26 · 2019: 39 · 2018: 38 · 2017: 31 · 2016: 40 · 2015: 37 · 2014: 47 · 2013: 42 · 2012: 40
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Oncology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Physical Sciences › Physics and Astronomy › Radiation › Radiation Therapy and Dosimetry
- Physical Sciences › Physics and Astronomy › Radiation › Advanced Radiotherapy Techniques
- Keywords
- tumor hypoxia, radiosensitization, radioresistance (biology), hyperbaric oxygen therapy, normobaric oxygen, nitroimidazoles, radiotherapy, locoregional control, overall survival, metastasis
- MeSH terms
- Combined Modality Therapy, Humans, Neoplasms, Radiation-Sensitizing Agents, Cell Hypoxia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
