The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Macrophage Markers in Serum and Tumor Have Prognostic Impact in American Joint Committee on Cancer Stage I/II Melanoma
Abstract
Purpose: To evaluate the prognostic role of soluble CD163 (sCD163) in serum and macrophage infiltration in primary melanomas from patients with American Joint Committee on Cancer (AJCC) stage I/II melanoma. The scavenger receptor CD163 is associated with anti-inflammatory macrophages, and it is shed from their surface. Patients and Methods: Serum samples from 227 patients with stage I/II melanoma obtained before definitive surgery (baseline) and during 5 years of follow-up were analyzed for sCD163 by enzyme-linked immunosorbent assay. Excised formalin-fixed, paraffin-embedded primary melanomas from 190 patients were available for immunohistochemical analyzes of CD163+ and CD68+ macrophage infiltration. They were estimated semiquantitatively in three different tumor compartments: tumor nests, tumor stroma, and at the invasive front of the tumor. Results: Serum sCD163 treated as an updated continuous covariate as well as the baseline value were analyzed together with the covariate's ulceration and thickness in a Cox proportional hazards model. sCD163 was an independent prognostic factor for overall survival (baseline, hazard ratio [HR] = 1.4; 95% CI, 1.1 to 1.7; P = .01; and updated, HR = 1.4; 95% CI, 1.1 to 1.8; P = .003). Melanomas with dense CD163+ macrophage infiltration in tumor stroma and CD68+ macrophage infiltration at the invasive front were associated with poor overall survival (CD163, HR = 2.7; 95% CI, 0.8 to 9.3; P = .11; and CD68, HR = 2.8; 95% CI, 1.2 to 6.8; P = .02) independent (borderline for CD163) of thickness and ulceration. Conclusion: Both serum levels of sCD163 and the presence of CD68+ macrophage infiltration at the tumor invasive front are independent predictors of survival in AJCC stage I/II melanoma. CD163+ cell infiltration in tumor stroma may be predictive of survival.
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Cancer and the chemokine network
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Association of Microvessel Density with Infiltrating Cells in Human Cutaneous Malignant Melanoma
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Circulating and Tumor-Infiltrating Myeloid Cells Predict Survival in Human Pleural Mesothelioma
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ATF 2 alters melanocyte response and macrophage recruitment in UV‐irradiated neonatal mouse skin
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Metadata
- Authors
- Jensen, T. O., Schmidt, H., Møller, H. J., Høyer, M., Maniecki, M. B., Sjoegren, P., Christensen, I. J., & Steiniche, T.
- Venue
- Journal of Clinical Oncology
- Published
- 2009-07-10
- Volume
- 27
- Issue
- 20
- Pages
- 3330-3337
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2104839914
- Cited by
- 299
- References
- 5
- FWCI
- 5.86
- Type
- journal article
- Language
- en
- Open access
- closed
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