Cited by 1,425Brain Metastases and TreatmentManagement of metastatic bone diseaseCancer survivorship and care

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Summary Report on the Graded Prognostic Assessment: An Accurate and Facile Diagnosis-Specific Tool to Estimate Survival for Patients With Brain Metastases

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Sperduto, Paul W., Kased, Norbert, Roberge, David, Xu, Zhiyuan, Shanley, Ryan, Luo, Xianghua, Sneed, Penny K., Chao, Samuel T., Weil, Robert J., Suh, John, Bhatt, Amit, Jensen, Ashley W., Brown, Paul D., Shih, Helen A., Kirkpatrick, John, Gaspar, Laurie E., Fiveash, John B., Chiang, Veronica, Knisely, Jonathan P.S., Sperduto, Christina Maria, Lin, Nancy, Mehta, Minesh·2012·Journal of Clinical Oncology

DOI 10.1200/jco.2011.38.0527PMC PMC3269967

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Abstract

PURPOSE: Our group has previously published the Graded Prognostic Assessment (GPA), a prognostic index for patients with brain metastases. Updates have been published with refinements to create diagnosis-specific Graded Prognostic Assessment indices. The purpose of this report is to present the updated diagnosis-specific GPA indices in a single, unified, user-friendly report to allow ease of access and use by treating physicians. METHODS: A multi-institutional retrospective (1985 to 2007) database of 3,940 patients with newly diagnosed brain metastases underwent univariate and multivariate analyses of prognostic factors associated with outcomes by primary site and treatment. Significant prognostic factors were used to define the diagnosis-specific GPA prognostic indices. A GPA of 4.0 correlates with the best prognosis, whereas a GPA of 0.0 corresponds with the worst prognosis. RESULTS: Significant prognostic factors varied by diagnosis. For lung cancer, prognostic factors were Karnofsky performance score, age, presence of extracranial metastases, and number of brain metastases, confirming the original Lung-GPA. For melanoma and renal cell cancer, prognostic factors were Karnofsky performance score and the number of brain metastases. For breast cancer, prognostic factors were tumor subtype, Karnofsky performance score, and age. For GI cancer, the only prognostic factor was the Karnofsky performance score. The median survival times by GPA score and diagnosis were determined. CONCLUSION: Prognostic factors for patients with brain metastases vary by diagnosis, and for each diagnosis, a robust separation into different GPA scores was discerned, implying considerable heterogeneity in outcome, even within a single tumor type. In summary, these indices and related worksheet provide an accurate and facile diagnosis-specific tool to estimate survival, potentially select appropriate treatment, and stratify clinical trials for patients with brain metastases.

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Classification and Regression Trees.
Gordon, A. D., Breiman, L., Friedman, J. H., Olshen, R. A., & Stone, C. J. (1984) · Biometrics · doi:10.2307/2530946 · Cited by 23,858
Classification and Regression Trees.
Ryzin, J. V., Breiman, L., Friedman, J. H., Olshen, R. A., & Stone, C. J. (1986) · Journal of the American Statistical Association · doi:10.2307/2288003 · Cited by 21,030
Cancer Statistics, 2008
Jemal, A., Siegel, R. L., Ward, E., Hao, Y., Xu, J., Murray, T., & Thun, M. J. (2008) · CA A Cancer Journal for Clinicians · doi:10.3322/ca.2007.0010 · Cited by 10,184
Recursive partitioning analysis (RPA) of prognostic factors in three radiation therapy oncology group (RTOG) brain metastases trials
Gaspar, L. E., Scott, C., Rotman, M., Asbell, S. O., Phillips, T. L., Wasserman, T. H., McKenna, W. G., & Byhardt, R. W. (1997) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(96)00619-0 · Cited by 2,548
Self-citation
A New Prognostic Index and Comparison to Three Other Indices for Patients With Brain Metastases: An Analysis of 1,960 Patients in the RTOG Database
Sperduto, P. W., Berkey, B. A., Gaspar, L. E., Mehta, M. P., & Curran, W. J. (2007) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2007.06.074 · Cited by 1,031
Self-citation
An Introduction to Recursive Partitioning Using the RPART Routines
Therneau, T. M., & Atkinson, E. J. (2015) · Cited by 1,006
Diagnosis-Specific Prognostic Factors, Indexes, and Treatment Outcomes for Patients With Newly Diagnosed Brain Metastases: A Multi-Institutional Analysis of 4,259 Patients
Sperduto, P. W., Chao, S. T., Sneed, P. K., Luo, X., Suh, J. H., Roberge, D., Bhatt, A. K., Jensen, A. W., Brown, P. D., Shih, H. A., et al. (2009) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2009.08.025 · Cited by 987
Self-citation
Intracerebral metastases in solid-tumor patients: Natural history and results of treatment
Zimm, S., Wampler, G. L., Stablein, D., Hazra, T. A., & Young, H. F. (1981) · Cancer · doi:10.1002/1097-0142(19810715)48:2 · Cited by 597
Validation of the RTOG recursive partitioning analysis (RPA) classification for brain metastases
Gaspar, L. E., Scott, C., Murray, K., & Curran, W. J. (2000) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(00)00547-2 · Cited by 531
Self-citation
Effect of Tumor Subtype on Survival and the Graded Prognostic Assessment for Patients With Breast Cancer and Brain Metastases
Sperduto, P. W., Kased, N., Roberge, D., Xu, Z., Shanley, R., Luo, X., Sneed, P. K., Chao, S. T., Weil, R. J., Suh, J. H., et al. (2011) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2011.02.027 · Cited by 367
Self-citation

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Brastianos, P. K., Kim, A. E., Giobbie‐Hurder, A., Lee, E. Q., Lin, N., Overmoyer, B. A., Wen, P. Y., Nayak, L., Cohen, J. V., Dietrich, J., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02392-7 · Cited by 67
Self-citation
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Lin, N., Freedman, R. A., Ramakrishna, N. R., Younger, J., Storniolo, A. M., Bellon, J. R., Come, S. E., Gelman, R. S., Harris, G. J., Henderson, M. A., et al. (2013) · Breast Cancer Research and Treatment · doi:10.1007/s10549-013-2754-0 · Cited by 64
Self-citation
Melanoma Brain Metastasis: Mechanisms, Models, and Medicine
Kircher, D. A., Silvis, M. R., Cho, J., & Holmen, S. L. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17091468 · Cited by 66
Liposomal Irinotecan Accumulates in Metastatic Lesions, Crosses the Blood-Tumor Barrier (BTB), and Prolongs Survival in an Experimental Model of Brain Metastases of Triple Negative Breast Cancer
Mohammad, A. S., Griffith, J. I. G., Adkins, C. E., Shah, N., Sechrest, E. R., Dolan, E. L., Terrell-Hall, T. B., Hendriks, B. S., Lee, H., & Lockman, P. R. (2018) · Pharmaceutical Research · doi:10.1007/s11095-017-2278-0 · Cited by 64
Immune Microenvironment of Brain Metastases—Are Microglia and Other Brain Macrophages Little Helpers?
You, H., Baluszek, S., & Kaminska, B. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01941 · Cited by 68
Neurological symptom burden impacts survival prognosis in patients with newly diagnosed non–small cell lung cancer brain metastases
Steindl, A., Yadavalli, S., Gruber, K., Seiwald, M., Gatterbauer, B., Dieckmann, K. U., Frischer, J. M., Klikovits, T., Zöchbauer‐Müller, S., Grisold, A., et al. (2020) · Cancer · doi:10.1002/cncr.33085 · Cited by 64
Impact of systemic targeted agents on the clinical outcomes of patients with brain metastases
Johnson, A. G., Ruiz, J., Hughes, R. T., Page, B. R., Isom, S. P., Lucas, J. T., McTyre, E., Houseknecht, K. W., Ayala-Peacock, D. N., Bourland, D. J., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4153 · Cited by 63
Stereotactic Radiosurgery and Immune Checkpoint Inhibitors in the Management of Brain Metastases
Lehrer, E. J., McGee, H. M., Peterson, J., Vallow, L. A., Ruiz-Garcia, H. J., Zaorsky, N. G., Sharma, S., & Trifiletti, D. M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103054 · Cited by 63
Late effects of cancer treatment: consequences for long-term brain cancer survivors
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Nardin, C., Mateus, C., Texier, M., Lanoy, É., Hibat-Allah, S., Ammari, S., Robert, C., & Dhermain, F. G. (2018) · Melanoma Research · doi:10.1097/cmr.0000000000000413 · Cited by 61
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Self-citation
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Niikura, N., Saji, S., Tokuda, Y., & Iwata, H. (2014) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyu156 · Cited by 60
SBRT for oligoprogressive oncogene addicted NSCLC
Basler, L., Kroeze, S. G. C., & Gückenberger, M. (2017) · Lung Cancer · doi:10.1016/j.lungcan.2017.02.007 · Cited by 59
Clinical trial design for local therapies for brain metastases: a guideline by the Response Assessment in Neuro-Oncology Brain Metastases working group
Alexander, B. M., Brown, P. D., Ahluwalia, M. S., Aoyama, H., Baumert, B. G., Chang, S. M., Gaspar, L. E., Kalkanis, S. N., Macdonald, D. R., Mehta, M. P., et al. (2017) · The Lancet Oncology · doi:10.1016/s1470-2045(17)30692-7 · Cited by 59
Self-citation
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Serizawa, T., Higuchi, Y., Yamamoto, M., Matsunaga, S., Nagano, O., Sato, Y., Aoyagi, K., Yomo, S., Koiso, T., Hasegawa, T., et al. (2018) · Journal of neurosurgery · doi:10.3171/2018.4.jns172596 · Cited by 59
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Petrelli, F., Stefani, A. D., Trevisan, F., Parati, M. C., Inno, A., Merelli, B., Ghidini, M., Bruschieri, L., Vitali, E., Cabiddu, M., et al. (2019) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2019.102830 · Cited by 59
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Berghoff, A. S., & Preusser, M. (2015) · PubMed · doi:10.3978/j.issn.2304-3865.2015.06.03 · Cited by 59
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Cao, K. I., Lebas, N., Gerber, S., Lévy, C., Scodan, R. L., Bourgier, C., Pierga, J., Gobillion, A., Savignoni, A., & Kirova, Y. (2014) · Annals of Oncology · doi:10.1093/annonc/mdu488 · Cited by 57
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Multi-institutional validation of brain metastasis velocity, a recently defined predictor of outcomes following stereotactic radiosurgery
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Seicean, A., Seicean, S., Schiltz, N. K., Alan, N., Jones, P. K., Neuhauser, D. B., & Weil, R. J. (2012) · Cancer · doi:10.1002/cncr.27851 · Cited by 55
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Zhang, D., Wang, Z., Shang, D., Yu, J., & Yuan, S. (2018) · Melanoma Research · doi:10.1097/cmr.0000000000000538 · Cited by 55
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Patel, T. R., Knisely, J. P. S., & Chiang, V. (2012) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2012.04.008 · Cited by 55
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Neal, M. T., Chan, M. D., Lucas, J. T., Loganathan, A. G., Dillingham, C., Pan, E., Stewart, J. H., Bourland, J. D., Shaw, E. G., Tatter, S. B., et al. (2013) · World Neurosurgery · doi:10.1016/j.wneu.2013.02.025 · Cited by 55
Epidermal growth factor receptor mutation and pattern of brain metastasis in patients with non-small cell lung cancer
Baek, M. Y., Ahn, H. K., Park, K. R., Park, H.-S., Kang, S. M., Park, I., Kim, Y. S., Hong, J., Sym, S. J., Park, J., et al. (2016) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2015.158 · Cited by 54
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Weil, R. J., Mavinkurve, G. G., Chao, S. T., Vogelbaum, M. A., Suh, J. H., Kolar, M. D., & Toms, S. A. (2015) · Journal of neurosurgery · doi:10.3171/2014.11.jns1449 · Cited by 53
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Authors: Sperduto, P. W., Kased, N., Roberge, D., Xu, Z., Shanley, R., Luo, X., Sneed, P. K., Chao, S. T., Weil, R. J., Suh, J., Bhatt, A., Jensen, A. W., Brown, P. D., Shih, H. A., Kirkpatrick, J., Gaspar, L. E., Fiveash, J. B., Chiang, V., Knisely, J. P. S., Sperduto, C. M., Lin, N., & Mehta, M.
Affiliations: University of Minnesota (US)
University of California, San Francisco (US)
McGill University (CA)
Cleveland Clinic (US)
Author affiliations appear at the end of this article.
Mayo Clinic (US)
Harvard University (US)
Duke University (US)
University of Colorado Denver (US)
University of Alabama at Birmingham (US)
Yale University (US)
Hofstra University (US)
Dartmouth College (US)
Northwestern University (US)
ORCID: Sperduto, Paul W.
Kased, Norbert
Roberge, David
Xu, Zhiyuan
Shanley, Ryan
Luo, Xianghua
Sneed, Penny K.
Chao, Samuel T.
Weil, Robert J.
Suh, John
Bhatt, Amit
Brown, Paul D.
Shih, Helen A.
Kirkpatrick, John
Fiveash, John B.
Chiang, Veronica
Knisely, Jonathan P.S.
Mehta, Minesh
Venue: Journal of Clinical Oncology
Publisher: American Society of Clinical Oncology (ASCO)
Published: 2012-02-01
Volume: 30
Issue: 4
Pages: 419-425
ISSN: 0732-183X (ISSN-L)
1527-7755
DOI: 10.1200/jco.2011.38.0527
PMC: PMC3269967
OpenAlex: W1974820090
Cited by: 1,425
References: 21
Citations by year: 2026: 41 · 2025: 57 · 2024: 88 · 2023: 112 · 2022: 103 · 2021: 113 · 2020: 146 · 2019: 117 · 2018: 131 · 2017: 134 · 2016: 115 · 2015: 94 · 2014: 68 · 2013: 62 · 2012: 38
FWCI: 45.80
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Journal of Clinical Oncology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (P30CA-77598, P30CA077598)
Topics: Health Sciences › Medicine › Oncology › Brain Metastases and Treatment
Health Sciences › Medicine › Surgery › Management of metastatic bone disease
Health Sciences › Medicine › Oncology › Cancer survivorship and care
Keywords: brain metastases, Graded Prognostic Assessment, prognosis, survival estimation, prognostic factors, lung cancer, melanoma, renal cell carcinoma, breast cancer, gastrointestinal cancer, Karnofsky performance status, extracranial metastases, number of brain metastases, clinical trial stratification
MeSH terms: Brain Neoplasms, Breast Neoplasms, Carcinoma, Renal Cell, Female, Humans, Kidney Neoplasms, Lung Neoplasms, Male, Melanoma, Neoplasm Metastasis, Prognosis, Retrospective Studies, Survival Analysis, Neoplasm Grading

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Summary Report on the Graded Prognostic Assessment: An Accurate and Facile Diagnosis-Specific Tool to Estimate Survival for Patients With Brain Metastases

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