Cited by 1,425Brain Metastases and TreatmentManagement of metastatic bone diseaseCancer survivorship and care

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Summary Report on the Graded Prognostic Assessment: An Accurate and Facile Diagnosis-Specific Tool to Estimate Survival for Patients With Brain Metastases

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Sperduto, Paul W., Kased, Norbert, Roberge, David, Xu, Zhiyuan, Shanley, Ryan, Luo, Xianghua, Sneed, Penny K., Chao, Samuel T., Weil, Robert J., Suh, John, Bhatt, Amit, Jensen, Ashley W., Brown, Paul D., Shih, Helen A., Kirkpatrick, John, Gaspar, Laurie E., Fiveash, John B., Chiang, Veronica, Knisely, Jonathan P.S., Sperduto, Christina Maria, Lin, Nancy, Mehta, Minesh·2012·Journal of Clinical Oncology

DOI 10.1200/jco.2011.38.0527PMC PMC3269967

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Abstract

PURPOSE: Our group has previously published the Graded Prognostic Assessment (GPA), a prognostic index for patients with brain metastases. Updates have been published with refinements to create diagnosis-specific Graded Prognostic Assessment indices. The purpose of this report is to present the updated diagnosis-specific GPA indices in a single, unified, user-friendly report to allow ease of access and use by treating physicians. METHODS: A multi-institutional retrospective (1985 to 2007) database of 3,940 patients with newly diagnosed brain metastases underwent univariate and multivariate analyses of prognostic factors associated with outcomes by primary site and treatment. Significant prognostic factors were used to define the diagnosis-specific GPA prognostic indices. A GPA of 4.0 correlates with the best prognosis, whereas a GPA of 0.0 corresponds with the worst prognosis. RESULTS: Significant prognostic factors varied by diagnosis. For lung cancer, prognostic factors were Karnofsky performance score, age, presence of extracranial metastases, and number of brain metastases, confirming the original Lung-GPA. For melanoma and renal cell cancer, prognostic factors were Karnofsky performance score and the number of brain metastases. For breast cancer, prognostic factors were tumor subtype, Karnofsky performance score, and age. For GI cancer, the only prognostic factor was the Karnofsky performance score. The median survival times by GPA score and diagnosis were determined. CONCLUSION: Prognostic factors for patients with brain metastases vary by diagnosis, and for each diagnosis, a robust separation into different GPA scores was discerned, implying considerable heterogeneity in outcome, even within a single tumor type. In summary, these indices and related worksheet provide an accurate and facile diagnosis-specific tool to estimate survival, potentially select appropriate treatment, and stratify clinical trials for patients with brain metastases.

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Authors: Sperduto, P. W., Kased, N., Roberge, D., Xu, Z., Shanley, R., Luo, X., Sneed, P. K., Chao, S. T., Weil, R. J., Suh, J., Bhatt, A., Jensen, A. W., Brown, P. D., Shih, H. A., Kirkpatrick, J., Gaspar, L. E., Fiveash, J. B., Chiang, V., Knisely, J. P. S., Sperduto, C. M., Lin, N., & Mehta, M.
Affiliations: University of Minnesota (US)
University of California, San Francisco (US)
McGill University (CA)
Cleveland Clinic (US)
Author affiliations appear at the end of this article.
Mayo Clinic (US)
Harvard University (US)
Duke University (US)
University of Colorado Denver (US)
University of Alabama at Birmingham (US)
Yale University (US)
Hofstra University (US)
Dartmouth College (US)
Northwestern University (US)
ORCID: Sperduto, Paul W.
Kased, Norbert
Roberge, David
Xu, Zhiyuan
Shanley, Ryan
Luo, Xianghua
Sneed, Penny K.
Chao, Samuel T.
Weil, Robert J.
Suh, John
Bhatt, Amit
Brown, Paul D.
Shih, Helen A.
Kirkpatrick, John
Fiveash, John B.
Chiang, Veronica
Knisely, Jonathan P.S.
Mehta, Minesh
Venue: Journal of Clinical Oncology
Publisher: American Society of Clinical Oncology (ASCO)
Published: 2012-02-01
Volume: 30
Issue: 4
Pages: 419-425
ISSN: 0732-183X (ISSN-L)
1527-7755
DOI: 10.1200/jco.2011.38.0527
PMC: PMC3269967
OpenAlex: W1974820090
Cited by: 1,425
References: 21
Citations by year: 2026: 41 · 2025: 57 · 2024: 88 · 2023: 112 · 2022: 103 · 2021: 113 · 2020: 146 · 2019: 117 · 2018: 131 · 2017: 134 · 2016: 115 · 2015: 94 · 2014: 68 · 2013: 62 · 2012: 38
FWCI: 45.80
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Journal of Clinical Oncology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (P30CA-77598, P30CA077598)
Topics: Health Sciences › Medicine › Oncology › Brain Metastases and Treatment
Health Sciences › Medicine › Surgery › Management of metastatic bone disease
Health Sciences › Medicine › Oncology › Cancer survivorship and care
Keywords: brain metastases, Graded Prognostic Assessment, prognosis, survival estimation, prognostic factors, lung cancer, melanoma, renal cell carcinoma, breast cancer, gastrointestinal cancer, Karnofsky performance status, extracranial metastases, number of brain metastases, clinical trial stratification
MeSH terms: Brain Neoplasms, Breast Neoplasms, Carcinoma, Renal Cell, Female, Humans, Kidney Neoplasms, Lung Neoplasms, Male, Melanoma, Neoplasm Metastasis, Prognosis, Retrospective Studies, Survival Analysis, Neoplasm Grading

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Summary Report on the Graded Prognostic Assessment: An Accurate and Facile Diagnosis-Specific Tool to Estimate Survival for Patients With Brain Metastases

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