Cited by 1,425Brain Metastases and TreatmentManagement of metastatic bone diseaseCancer survivorship and care

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Summary Report on the Graded Prognostic Assessment: An Accurate and Facile Diagnosis-Specific Tool to Estimate Survival for Patients With Brain Metastases

Open access

Sperduto, Paul W., Kased, Norbert, Roberge, David, Xu, Zhiyuan, Shanley, Ryan, Luo, Xianghua, Sneed, Penny K., Chao, Samuel T., Weil, Robert J., Suh, John, Bhatt, Amit, Jensen, Ashley W., Brown, Paul D., Shih, Helen A., Kirkpatrick, John, Gaspar, Laurie E., Fiveash, John B., Chiang, Veronica, Knisely, Jonathan P.S., Sperduto, Christina Maria, Lin, Nancy, Mehta, Minesh·2012·Journal of Clinical Oncology

DOI 10.1200/jco.2011.38.0527PMC PMC3269967

Open this paper in CoChat — free account

Abstract

PURPOSE: Our group has previously published the Graded Prognostic Assessment (GPA), a prognostic index for patients with brain metastases. Updates have been published with refinements to create diagnosis-specific Graded Prognostic Assessment indices. The purpose of this report is to present the updated diagnosis-specific GPA indices in a single, unified, user-friendly report to allow ease of access and use by treating physicians. METHODS: A multi-institutional retrospective (1985 to 2007) database of 3,940 patients with newly diagnosed brain metastases underwent univariate and multivariate analyses of prognostic factors associated with outcomes by primary site and treatment. Significant prognostic factors were used to define the diagnosis-specific GPA prognostic indices. A GPA of 4.0 correlates with the best prognosis, whereas a GPA of 0.0 corresponds with the worst prognosis. RESULTS: Significant prognostic factors varied by diagnosis. For lung cancer, prognostic factors were Karnofsky performance score, age, presence of extracranial metastases, and number of brain metastases, confirming the original Lung-GPA. For melanoma and renal cell cancer, prognostic factors were Karnofsky performance score and the number of brain metastases. For breast cancer, prognostic factors were tumor subtype, Karnofsky performance score, and age. For GI cancer, the only prognostic factor was the Karnofsky performance score. The median survival times by GPA score and diagnosis were determined. CONCLUSION: Prognostic factors for patients with brain metastases vary by diagnosis, and for each diagnosis, a robust separation into different GPA scores was discerned, implying considerable heterogeneity in outcome, even within a single tumor type. In summary, these indices and related worksheet provide an accurate and facile diagnosis-specific tool to estimate survival, potentially select appropriate treatment, and stratify clinical trials for patients with brain metastases.

Integrity signals

Registry

Crossref · 10.1200/jco.2011.38.0527

Cites

21 of 21 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Classification and Regression Trees.
Gordon, A. D., Breiman, L., Friedman, J. H., Olshen, R. A., & Stone, C. J. (1984) · Biometrics · doi:10.2307/2530946 · Cited by 23,858
Classification and Regression Trees.
Ryzin, J. V., Breiman, L., Friedman, J. H., Olshen, R. A., & Stone, C. J. (1986) · Journal of the American Statistical Association · doi:10.2307/2288003 · Cited by 21,030
Cancer Statistics, 2008
Jemal, A., Siegel, R. L., Ward, E., Hao, Y., Xu, J., Murray, T., & Thun, M. J. (2008) · CA A Cancer Journal for Clinicians · doi:10.3322/ca.2007.0010 · Cited by 10,184
Recursive partitioning analysis (RPA) of prognostic factors in three radiation therapy oncology group (RTOG) brain metastases trials
Gaspar, L. E., Scott, C., Rotman, M., Asbell, S. O., Phillips, T. L., Wasserman, T. H., McKenna, W. G., & Byhardt, R. W. (1997) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(96)00619-0 · Cited by 2,548
Self-citation
A New Prognostic Index and Comparison to Three Other Indices for Patients With Brain Metastases: An Analysis of 1,960 Patients in the RTOG Database
Sperduto, P. W., Berkey, B. A., Gaspar, L. E., Mehta, M. P., & Curran, W. J. (2007) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2007.06.074 · Cited by 1,031
Self-citation
An Introduction to Recursive Partitioning Using the RPART Routines
Therneau, T. M., & Atkinson, E. J. (2015) · Cited by 1,006
Diagnosis-Specific Prognostic Factors, Indexes, and Treatment Outcomes for Patients With Newly Diagnosed Brain Metastases: A Multi-Institutional Analysis of 4,259 Patients
Sperduto, P. W., Chao, S. T., Sneed, P. K., Luo, X., Suh, J. H., Roberge, D., Bhatt, A. K., Jensen, A. W., Brown, P. D., Shih, H. A., et al. (2009) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2009.08.025 · Cited by 987
Self-citation
Intracerebral metastases in solid-tumor patients: Natural history and results of treatment
Zimm, S., Wampler, G. L., Stablein, D., Hazra, T. A., & Young, H. F. (1981) · Cancer · doi:10.1002/1097-0142(19810715)48:2 · Cited by 597
Validation of the RTOG recursive partitioning analysis (RPA) classification for brain metastases
Gaspar, L. E., Scott, C., Murray, K., & Curran, W. J. (2000) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(00)00547-2 · Cited by 531
Self-citation
Effect of Tumor Subtype on Survival and the Graded Prognostic Assessment for Patients With Breast Cancer and Brain Metastases
Sperduto, P. W., Kased, N., Roberge, D., Xu, Z., Shanley, R., Luo, X., Sneed, P. K., Chao, S. T., Weil, R. J., Suh, J. H., et al. (2011) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2011.02.027 · Cited by 367
Self-citation

Show all 21 references

Research works printed but not linked: 1

Therneau TM, 1997, Technical Report 61

Sorted by citations

Items 201–300 of 1,000

Response of brain metastasis from lung cancer patients to an oral nutraceutical product containing silibinin
Bosch‐Barrera, J., Sais, È., Cañete, N., Marruecos, J., Cuyàs, E., Izquierdo, Á., Porta, R., Haro, M., Brunet, J., Pedraza, S., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7900 · Cited by 54
Comparison of up-front radiotherapy and TKI with TKI alone for NSCLC with brain metastases and EGFR mutation: A meta-analysis
Wang, C., Lu, X. J., Lyu, Z., Bi, N., & Wang, L. (2018) · Lung Cancer · doi:10.1016/j.lungcan.2018.05.014 · Cited by 53
A consensus on the role of osimertinib in non-small cell lung cancer from the AME Lung Cancer Collaborative Group
written on behalf of the AME Lung Cancer Collaborative Group, Jiang, T., Su, C., Ren, S., Cappuzzo, F., Rocco, G., Palmer, J. D., van Zandwijk, N., Blackhall, F. H., Le, X., et al. (2018) · Journal of Thoracic Disease · doi:10.21037/jtd.2018.07.61 · Cited by 53
Efficacy and Safety of Combined Brain Radiotherapy and Immunotherapy in Non-Small-Cell Lung Cancer With Brain Metastases: A Systematic Review and Meta-Analysis
Yang, Y., Deng, L., Yang, Y., Zhang, T., Wu, Y., Wang, L., & Bi, N. (2021) · Clinical Lung Cancer · doi:10.1016/j.cllc.2021.06.009 · Cited by 53
The shifting landscape of metastatic breast cancer to the CNS
Quigley, M. R., Fukui, O., Chew, B. G., Bhatia, S., & Karlovits, S. (2012) · Neurosurgical Review · doi:10.1007/s10143-012-0446-6 · Cited by 52
Radiotherapy versus best supportive care in patients with brain metastases and adverse prognostic factors
Nieder, C., Norum, J., Dalhaug, A., Aandahl, G., & Pawinski, A. (2013) · Clinical & Experimental Metastasis · doi:10.1007/s10585-013-9573-x · Cited by 52
Brain metastasis and treatment
Ahluwalia, M. S., Vogelbaum, M. A., Chao, S. T., & Mehta, M. P. (2014) · F1000Prime Reports · doi:10.12703/p6-114 · Cited by 53
Self-citation
BRAF V600E mutation and BRAF kinase inhibitors in conjunction with stereotactic radiosurgery for intracranial melanoma metastases
Xu, Z., Lee, C., Ramesh, A., Mueller, A. C., Schlesinger, D. J., Cohen‐Inbar, O., Shih, H.-H., & Sheehan, J. P. (2016) · Journal of neurosurgery · doi:10.3171/2016.2.jns1633 · Cited by 52
Self-citation
Combining standard clinical blood values for improving survival prediction in patients with newly diagnosed brain metastases—development and validation of the LabBM score
Berghoff, A. S., Wolpert, F., Holland‐Letz, T., Koller, R., Widhalm, G., Gatterbauer, B., Dieckmann, K. U., Birner, P., Bartsch, R., Zielinski, C. C., et al. (2016) · Neuro-Oncology · doi:10.1093/neuonc/now290 · Cited by 52
Pulsatile Erlotinib in EGFR-Positive Non–Small-Cell Lung Cancer Patients With Leptomeningeal and Brain Metastases: Review of the Literature
How, J., Mann, J., Laczniak, A. N., & Baggstrom, M. Q. (2017) · Clinical Lung Cancer · doi:10.1016/j.cllc.2017.01.013 · Cited by 52
Prolonged survival in patients with breast cancer and a history of brain metastases: results of a preplanned subgroup analysis from the randomized phase III BEACON trial
Cortés, J., Rugo, H. S., Awada, A. H., Twelves, C. J., Perez, E. A., Im, S., Gómez-Pardo, P., Schwartzberg, L. S., Dieras, V. C., Yardley, D. A., et al. (2017) · Breast Cancer Research and Treatment · doi:10.1007/s10549-017-4304-7 · Cited by 52
Population-based estimates of survival among elderly patients with brain metastases
Lamba, N., Kearney, R. B., Catalano, P. J., Hassett, M. J., Wen, P. Y., Haas-Kogan, D. A., & Aizer, A. A. (2020) · Neuro-Oncology · doi:10.1093/neuonc/noaa233 · Cited by 52
ASCEND-7: Efficacy and Safety of Ceritinib Treatment in Patients with ALK -Positive Non–Small Cell Lung Cancer Metastatic to the Brain and/or Leptomeninges
Chow, L. Q. M., Barlési, F., Bertino, E. M., van den Bent, M. J., Wakelee, H. A., Wen, P. Y., Chiu, C.-H., Orlov, S., Chiari, R., Majem, M., et al. (2022) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-21-1838 · Cited by 53
Mystery of the brain metastatic disease in breast cancer patients: improved patient stratification, disease prediction and targeted prevention on the horizon?
Polívka, J., Králíčková, M., Polívka, J., Kaiser, C., Kuhn, W. C., & Golubnitschaja, O. (2017) · The EPMA Journal · doi:10.1007/s13167-017-0087-5 · Cited by 51
Patterns of Distant Metastases After Surgical Management of Non–Small-cell Lung Cancer
Torok, J. A., Gu, L., Tandberg, D. J., Wang, X., Harpole, D. H., Kelsey, C. R., & Salama, J. K. (2016) · Clinical Lung Cancer · doi:10.1016/j.cllc.2016.06.011 · Cited by 53
Clinical Value of Upfront Cranial Radiation Therapy in Osimertinib-Treated Epidermal Growth Factor Receptor–Mutant Non-Small Cell Lung Cancer With Brain Metastases
Yu, F., Ni, J., Zeng, W., Zhou, Y., Guo, T., Zeng, Y., Zhao, Y., Li, S., Li, Y., Yang, X., et al. (2021) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2021.05.125 · Cited by 52
ecancermedicalscience
Lin, N. (2016) · ecancermedicalscience · doi:10.3332/ecancer.2013.307 · Cited by 51
Self-citation
Palbociclib demonstrates intracranial activity in progressive brain metastases harboring cyclin-dependent kinase pathway alterations
Brastianos, P. K., Kim, A. E., Wang, N., Lee, E. Q., Ligibel, J. A., Cohen, J. V., Chukwueke, U. N., Mahar, M. K., Oh, K. S., White, M. D., et al. (2021) · Nature Cancer · doi:10.1038/s43018-021-00198-5 · Cited by 50
Self-citation
Management of brain metastases in lung cancer: evolving roles for radiation and systemic treatment in the era of targeted and immune therapies
Myall, N. J., Yu, H. A., Soltys, S. G., Wakelee, H. A., & Pollom, E. L. (2021) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdab106 · Cited by 54
The economic burden of brain metastasis among lung cancer patients in the United States
Guérin, A., Sasané, M., Dea, K., Zhang, J., Culver, K. W., Nitulescu, R., Wu, E. Q., & Macalalad, A. R. (2016) · Journal of Medical Economics · doi:10.3111/13696998.2016.1138962 · Cited by 50
Treatment of brain metastases in the modern genomic era
Dagogo‐Jack, I., Gill, C. M., Cahill, D. P., Santagata, S., & Brastianos, P. K. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.10.011 · Cited by 50
Information criteria for Firth's penalized partial likelihood approach in Cox regression models
Nagashima, K., & Sato, Y. (2017) · Statistics in Medicine · doi:10.1002/sim.7368 · Cited by 50
Interventions for cognitive problems in adults with brain cancer: A narrative review
van Lonkhuizen, P. J. C., Klaver, K. M., Wefel, J. S., Sitskoorn, M. M., Schagen, S. B., & Gehring, K. (2019) · European Journal of Cancer Care · doi:10.1111/ecc.13088 · Cited by 52
Palliative radiotherapy for advanced malignancies in a changing oncologic landscape: guiding principles and practice implementation.
Jones, J., & Simone, C. B. (2014) · PubMed · doi:10.3978/j.issn.2224-5820.2014.07.06 · Cited by 50
Targeted Therapies in Brain Metastases
Lin, N. (2013) · Current Treatment Options in Neurology · doi:10.1007/s11940-013-0276-z · Cited by 49
Self-citation
Breast Cancer in the Central Nervous System: Multidisciplinary Considerations and Management
Lin, N., Gaspar, L. E., & Soffietti, R. (2017) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_175338 · Cited by 48
Self-citation
Estimating survival in patients with gastrointestinal cancers and brain metastases: An update of the graded prognostic assessment for gastrointestinal cancers (GI-GPA)
Sperduto, P. W., Fang, P., Li, J., Breen, W. G., Brown, P. D., Cagney, D. N., Aizer, A. A., Yu, J. B., Chiang, V., Jain, S. K., et al. (2019) · Clinical and Translational Radiation Oncology · doi:10.1016/j.ctro.2019.06.007 · Cited by 48
Self-citation
Prognostic significance of Ki67 proliferation index, HIF1 alpha index and microvascular density in patients with non-small cell lung cancer brain metastases
Berghoff, A. S., Ilhan‐Mutlu, A., Wöehrer, A., Hackl, M., Widhalm, G., Hainfellner, J. A., Dieckmann, K. U., Melchardt, T., Döme, B., Heinzl, H., et al. (2014) · Strahlentherapie und Onkologie · doi:10.1007/s00066-014-0639-8 · Cited by 49
EGFR-TKI plus brain radiotherapy versus EGFR-TKI alone in the management of EGFR-mutated NSCLC patients with brain metastases
Dong, K., Liang, W., Zhao, S., Guo, M., He, Q., Li, C., Song, H., He, J., & Xia, X. (2019) · Translational Lung Cancer Research · doi:10.21037/tlcr.2019.06.12 · Cited by 47
Modern Radiation Therapy for the Management of Brain Metastases From Non-Small Cell Lung Cancer: Current Approaches and Future Directions
Mantovani, C., Gastino, A., Cerrato, M., Badellino, S., Ricardi, U., & Levis, M. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.772789 · Cited by 47
Local control after fractionated stereotactic radiation therapy for brain metastases
Rajakesari, S., Arvold, N. D., Jimenez, R., Christianson, L. W., Horvath, M. C., Claus, E. B., Golby, A. J., Johnson, M. D., Dunn, I. F., Lee, E. Q., et al. (2014) · Journal of Neuro-Oncology · doi:10.1007/s11060-014-1556-5 · Cited by 46
Self-citation
Molecular Pathways Mediating Metastases to the Brain via Epithelial-to-Mesenchymal Transition: Genes, Proteins, and Functional Analysis.
Jeevan, D. S., Cooper, J., Braun, A., Murali, R., & Jhanwar‐Uniyal, M. (2016) · PubMed · Cited by 46
Brain Metastases at Presentation in Patients With Non–Small Cell Lung Cancer
Waqar, S. N., Waqar, S. H., Trinkaus, K. M., Gadea, C. A., Robinson, C. G., Bradley, J. D., Watson, M. A., Puri, V., Govindan, R., & Morgensztern, D. (2015) · American Journal of Clinical Oncology · doi:10.1097/coc.0000000000000230 · Cited by 46
Metabolic advantages and vulnerabilities in brain metastases
Ciminera, A. K., Jandial, R., & Termini, J. S. (2017) · Clinical & Experimental Metastasis · doi:10.1007/s10585-017-9864-8 · Cited by 46
Comparison of radiomic feature aggregation methods for patients with multiple tumors
Chang, E., Joel, M. Z., Chang, H., Du, J., Khanna, O., Omuro, A. M. P., Chiang, V., & Aneja, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-89114-6 · Cited by 46
Self-citation
Brain Metastases in Non–Small-Cell Lung Cancer
Dawe, D. E., Greenspoon, J. N., & Ellis, P. M. (2014) · Clinical Lung Cancer · doi:10.1016/j.cllc.2014.04.008 · Cited by 45
Outcomes of postoperative stereotactic radiosurgery to the resection cavity versus stereotactic radiosurgery alone for melanoma brain metastases
Minniti, G. C., Paolini, S., D’Andrea, G., Lanzetta, G., Cicone, F., Confaloni, V., Bozzao, A., Esposito, V., & Osti, M. F. (2017) · Journal of Neuro-Oncology · doi:10.1007/s11060-017-2394-z · Cited by 45
Concurrent versus non-concurrent immune checkpoint inhibition with stereotactic radiosurgery for metastatic brain disease: a systematic review and meta-analysis
Lu, V. M., Goyal, A., Rovin, R., Lee, A. V., & McDonald, K. L. (2018) · Journal of Neuro-Oncology · doi:10.1007/s11060-018-03020-y · Cited by 45
Brain metastases treated with hypofractionated stereotactic radiotherapy: 8 years experience after Cyberknife installation
Mengue, L., Bertaut, A., Mbus, L. N., Dore, M., Ayadi, M., Clément-Colmou, K., Claude, L., Carrié, C., Laude, C., Tanguy, R., et al. (2020) · Radiation Oncology · doi:10.1186/s13014-020-01517-3 · Cited by 45
Outcome and prognostic factors in patients with brain metastases from small-cell lung cancer treated with whole brain radiotherapy
Bernhardt, D., Adeberg, S., Bozorgmehr, F., Opfermann, N., Hoerner‐Rieber, J., König, L., Kappes, J., Thomas, M., Herth, F. J. F., Heußel, C. P., et al. (2017) · Journal of Neuro-Oncology · doi:10.1007/s11060-017-2510-0 · Cited by 45
Long-term follow-up of unruptured intracranial aneurysms repaired in California
Gonda, D. D., Khalessi, A. A., McCutcheon, B. A., Marcus, L. P., Noorbakhsh, A., Chen, C. C., Chang, D. C., & Carter, B. S. (2014) · Journal of neurosurgery · doi:10.3171/2014.3.jns131159 · Cited by 44
Genomic analysis of exceptional responders to radiotherapy reveals somatic mutations in ATM
Ma, J., Setton, J. S., Morris, L. G. T., Blecua, P., Barker, C. A., Lok, B. H., Sherman, E. J., Katabi, N., Beal, K. P., Ganly, I., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.14400 · Cited by 44
T-Cell Densities in Brain Metastases Are Associated with Patient Survival Times and Diffusion Tensor MRI Changes
Zakaria, R., Platt-Higgins, A. M., Rathi, N., Radon, M. R., Das, S. K., Das, K., Bhojak, M., Brodbelt, A. R., Chavredakis, E., Jenkinson, M. D., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-1720 · Cited by 44
Immune checkpoint inhibitors in non-small cell lung cancer (NSCLC): Approaches on special subgroups and unresolved burning questions
Remón, J., Vilariño, N., & Reguart, N. (2018) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2018.02.002 · Cited by 45
MiR-423-5p in brain metastasis: potential role in diagnostics and molecular biology
Sun, G., Ding, X., Bi, N., Wu, L., Wang, J., Zhang, W., Dong, X., Lv, N., Song, Y., Zhan, Q., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0955-5 · Cited by 44
Impact of time of day on outcomes after stereotactic radiosurgery for non–small cell lung cancer brain metastases
Badiyan, S. N., Ferraro, D. J., Yaddanapudi, S., Drzymala, R. E., Lee, A. Y., Silver, S. A., Dyk, P. T., DeWees, T. A., Simpson, J. R., Rich, K. M., et al. (2013) · Cancer · doi:10.1002/cncr.28237 · Cited by 43
Multidisciplinary Approach to Brain Metastasis from Melanoma; Local Therapies for Central Nervous System Metastases
Ramakrishna, N. R., & Margolin, K. A. (2013) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbook_am.2013.33.399 · Cited by 45
Management of Brain Metastases in Patients With Melanoma
Chukwueke, U. N., Batchelor, T. T., & Brastianos, P. K. (2016) · Journal of Oncology Practice · doi:10.1200/jop.2016.011882 · Cited by 43
Validation of the graded prognostic assessment for lung cancer with brain metastases using molecular markers (lung-molGPA)
Nieder, C., Hintz, M., Oehlke, O., Bilger, A., & Grosu, A. (2017) · Radiation Oncology · doi:10.1186/s13014-017-0844-6 · Cited by 43
Continued Endocrine Therapy Is Associated with Improved Survival in Patients with Breast Cancer Brain Metastases
Bergen, E. S., Berghoff, A. S., Medjedovic, M., Rudas, M., Fitzal, F., Bagó-Horváth, Z., Dieckmann, K. U., Mader, R. M., Exner, R., Gnant, M., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-1968 · Cited by 43
Does Stereotactic Radiosurgery Have a Role in the Management of Patients Presenting With 4 or More Brain Metastases?
Soike, M. H., Hughes, R. T., Farris, M. K., McTyre, E., Cramer, C. K., Bourland, J. D., & Chan, M. D. (2018) · Neurosurgery · doi:10.1093/neuros/nyy216 · Cited by 44
Long-Term Outcomes in BRAF-Mutated Melanoma Treated with Combined Targeted Therapy or Immune Checkpoint Blockade: Are We Approaching a True Cure?
Schummer, P., Schilling, B., & Gesierich, A. (2020) · American Journal of Clinical Dermatology · doi:10.1007/s40257-020-00509-z · Cited by 44
Current Treatment of Melanoma Brain Metastasis
Rishi, A., & Yu, H.-H. M. (2020) · Current Treatment Options in Oncology · doi:10.1007/s11864-020-00733-z · Cited by 44
In vitro study of combined cilengitide and radiation treatment in breast cancer cell lines
Lautenschlaeger, T., Perry, J., Peereboom, D. M., Li, B., Ibrahim, A., Hüebner, A., Meng, W., White, J. R., & Chakravarti, A. (2013) · Radiation Oncology · doi:10.1186/1748-717x-8-246 · Cited by 43
Trial design on prophylaxis and treatment of brain metastases: Lessons learned from the EORTC Brain Metastases Strategic Meeting 2012
Preusser, M., Winkler, F., Collette, L., Haller, S., Marreaud, S. I., Soffietti, R., Klein, M., Reijneveld, J. C., Tonn, J., Baumert, B. G., et al. (2012) · European Journal of Cancer · doi:10.1016/j.ejca.2012.07.002 · Cited by 42
Self-citation
HFSRT of the resection cavity in patients with brain metastases
Specht, H. M., Kessel, K. A., Oechsner, M., Meyer, B., Zimmer, C., & Combs, S. E. (2016) · Strahlentherapie und Onkologie · doi:10.1007/s00066-016-0955-2 · Cited by 42
Emergencies in Hematology and Oncology
Halfdanarson, T. R., Hogan, W. J., & Madsen, B. E. (2017) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2017.02.008 · Cited by 42
Role of Radiosurgery/Stereotactic Radiotherapy in Oligometastatic Disease: Brain Oligometastases
Mazzola, R., Corradini, S., Gregucci, F., Figlia, V., Fiorentino, A., & Alongi, F. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00206 · Cited by 43
Survival and prognostic factors in surgically treated brain metastases
Kavouridis, V. K., Harary, M., Hulsbergen, A. F. C., Lo, Y. T., Reardon, D. A., Aizer, A. A., Iorgulescu, J. B., & Smith, T. R. (2019) · Journal of Neuro-Oncology · doi:10.1007/s11060-019-03171-6 · Cited by 42
Physiologically Based Pharmacokinetic Modeling of Central Nervous System Pharmacokinetics of CDK4/6 Inhibitors to Guide Selection of Drug and Dosing Regimen for Brain Cancer Treatment
Li, J., Jiang, J., Wu, J., Bao, X., & Sanai, N. (2020) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.2021 · Cited by 42
Predicting the outcome of radiotherapy in brain metastasis by integrating the clinical and MRI‐based deep learning features
Jalalifar, S. A., Soliman, H., Sahgal, A., & Naini, A. S. (2022) · Medical Physics · doi:10.1002/mp.15814 · Cited by 45
Netrin-1 Expression Is an Independent Prognostic Factor for Poor Patient Survival in Brain Metastases
Harter, P. N., Zinke, J., Scholz, A., Tichy, J., Zachskorn, C., Kvasnicka, H. M., Goeppert, B., Delloye-Bourgeois, C., Hattingen, E., Senft, C., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092311 · Cited by 41
Comparable outcomes of nivolumab in patients with advanced NSCLC presenting with or without brain metastases: a retrospective cohort study
Zhang, G., Cheng, R., Wang, H., Zhang, Y., Yan, X., Li, P., Zhang, M., Zhang, X., Yang, J., Niu, Y., et al. (2020) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-019-02462-1 · Cited by 41
Brain metastases from hepatocellular carcinoma: recent advances and future avenues
Wang, S., Wang, A., Lin, J., Xie, Y., Wu, L., Huang, H., Bian, J., Yang, X., Wan, X., Zhao, H., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.15730 · Cited by 42
Overview of metastatic disease of the central nervous system
Nolan, C. P., & DeAngelis, L. M. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-12-811161-1.00001-3 · Cited by 42
Prognostic factors of brain metastases from colorectal cancer
Imaizumi, J., Shida, D., Narita, Y., Miyakita, Y., Tanabe, T., Takashima, A., Boku, N., Igaki, H., Itami, J., & Kanemitsu, Y. (2019) · BMC Cancer · doi:10.1186/s12885-019-5973-x · Cited by 41
Prognostic value of lymphocyte-to-monocyte ratio and systemic immune-inflammation index in non-small-cell lung cancer patients with brain metastases
Li, A., Mu, X., He, K., Wang, P., Wang, D., Liu, C., & Yu, J. (2020) · Future Oncology · doi:10.2217/fon-2020-0423 · Cited by 41
Automated Detection and Segmentation of Brain Metastases in Malignant Melanoma: Evaluation of a Dedicated Deep Learning Model
Pennig, L., Shahzad, R., Caldeira, L., Lennartz, S., Thiele, F. O., Goertz, L., Zopfs, D., Meißner, A.-K., Fürtjes, G., Perkuhn, M., et al. (2021) · American Journal of Neuroradiology · doi:10.3174/ajnr.a6982 · Cited by 42
Risk factors and survival outcomes in patients with brain metastases from breast cancer
Minisini, A. M., Moroso, S., Gerratana, L., Giangreco, M., Iacono, D., Poletto, E., Guardascione, M., Fontanella, C., Fasola, G., & Puglisi, F. (2013) · Clinical & Experimental Metastasis · doi:10.1007/s10585-013-9594-5 · Cited by 41
Multi-Omics Analysis of Brain Metastasis Outcomes Following Craniotomy
Su, J., Song, Q., Qasem, S. A., O’Neill, S. S., Lee, J., Furdui, C. M., Pasche, B., Metheny‐Barlow, L. J., Masters, A. H., Lo, H., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.615472 · Cited by 40
Validity of two recently-proposed prognostic grading indices for lung, gastro-intestinal, breast and renal cell cancer patients with radiosurgically-treated brain metastases
Yamamoto, M., Serizawa, T., Sato, Y., Kawabe, T., Higuchi, Y., Nagano, O., Barfod, B. E., Ono, J., Kasuya, H., & Urakawa, Y. (2012) · Journal of Neuro-Oncology · doi:10.1007/s11060-012-1019-9 · Cited by 40
Effects of icotinib with and without radiation therapy on patients with EGFR mutant non-small cell lung cancer and brain metastases
Fan, Y., Xu, Y., Gong, L., Fang, L., Lu, H., Qin, J., Han, N., Xie, F., Qiu, G., & Huang, Z. (2017) · Scientific Reports · doi:10.1038/srep45193 · Cited by 40
AXL–GAS6 expression can predict for adverse prognosis in non-small cell lung cancer with brain metastases
Wu, X., Ma, W., Zhou, Q., Yan, H., Lim, Z.-F., Huang, M., Deng, C., Yu, X., Su, H., Komo, S., et al. (2017) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-017-2408-4 · Cited by 41
Systematic review and meta-analysis of breast cancer brain metastasis and primary tumor receptor expression discordance
Kotecha, R. R., Tonse, R., Rubens, M., McDermott, M. W., Odia, Y., Appel, H. R., & Mehta, M. P. (2021) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdab010 · Cited by 40
Self-citation
Significant correlation between gross tumor volume (GTV) D98% and local control in multifraction stereotactic radiotherapy (MF-SRT) for unresected brain metastases
Dupic, G., Brun, L., Molnar, I., Leyrat, B., Chassin, V., Moreau, J., Dedieu, V., Khalil, T., Verrelle, P., Lapeyre, M., et al. (2020) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2020.11.021 · Cited by 40
Brain metastases: advances over the decades.
Tsao, M. N. (2015) · PubMed · doi:10.3978/j.issn.2224-5820.2015.09.01 · Cited by 39
Three or More Courses of Stereotactic Radiosurgery for Patients with Multiply Recurrent Brain Metastases
Kotecha, R. R., Damico, N., Miller, J. A., Suh, J. H., Murphy, E. S., Reddy, C. A., Barnett, G. H., Vogelbaum, M. A., Angelov, L., Mohammadi, A. M., et al. (2017) · Neurosurgery · doi:10.1093/neuros/nyw147 · Cited by 39
Self-citation
External validation of Modified Breast Graded Prognostic Assessment for breast cancer patients with brain metastases: A multicentric European experience
Griguolo, G., Jacot, W., Kantelhardt, E. J., Dieci, M. V., Bourgier, C., Thomssen, C., Bailleux, C., Miglietta, F., Braccini, A.-L., Conte, P., et al. (2017) · The Breast · doi:10.1016/j.breast.2017.10.006 · Cited by 39
Deep learning‐based survival analysis for brain metastasis patients with the national cancer database
Bice, N., Kirby, N., Bahr, T. A., Rasmussen, K., Saenz, D. B., Wagner, T. D., Papanikolaou, N., & Fakhreddine, M. (2020) · Journal of Applied Clinical Medical Physics · doi:10.1002/acm2.12995 · Cited by 41
Survival after whole brain radiotherapy for brain metastases from lung cancer and breast cancer is poor in 6325 Dutch patients treated between 2000 and 2014
Jeene, P. M., de Vries, K. C., van Nes, J. G. H., Kwakman, J. J. M., Wester, G., Rozema, T., Braam, P. M., Zindler, J. D., Koper, P. C. M., Nuyttens, J. J. M. E., et al. (2017) · Acta Oncologica · doi:10.1080/0284186x.2017.1418534 · Cited by 39
Advances in the Molecular Landscape of Lung Cancer Brain Metastasis
Souza, V. G. P., de Araújo, R. P., Santesso, M. R., Seneda, A. L., Minutentag, I. W., Felix, T. F., Filho, P. T. H., Pewarchuk, M. E., Brockley, L. J., Marchi, F. A., et al. (2023) · Cancers · doi:10.3390/cancers15030722 · Cited by 42
The impact of radiosurgery fractionation and tumor radiobiology on the local control of brain metastases
Oermann, E. K., Kress, M.-A. S., Todd, J., Collins, B. T., Hoffman, R., Chaudhry, H., Collins, S. P., Morris, D., & Ewend, M. G. (2013) · Journal of neurosurgery · doi:10.3171/2013.8.jns122177 · Cited by 38
Neurocognitive Effects Following Cranial Irradiation for Brain Metastases
Pinkham, M. B., Sanghera, P., Wall, G., Dawson, B., & Whitfield, G. A. (2015) · Clinical Oncology · doi:10.1016/j.clon.2015.06.005 · Cited by 39
Initial experience with combined BRAF and MEK inhibition with stereotactic radiosurgery for BRAF mutant melanoma brain metastases
Patel, B. G., Ahmed, K. A., Johnstone, P. A. S., Yu, H.-H. M., & Etame, A. B. (2016) · Melanoma Research · doi:10.1097/cmr.0000000000000250 · Cited by 38
Oligo-recurrence predicts favorable prognosis of brain-only oligometastases in patients with non-small cell lung cancer treated with stereotactic radiosurgery or stereotactic radiotherapy: a multi-institutional study of 61 subjects
Niibe, Y., Nishimura, T., Inoue, T., Karasawa, K., Shioyama, Y., Jingu, K., & Shirato, H. (2016) · BMC Cancer · doi:10.1186/s12885-016-2680-8 · Cited by 38
Predictors of quality of life and survival following Gamma Knife surgery for lung cancer brain metastases: a prospective study
Bragstad, S., Flatebø, M., Natvig, G. K., Eide, G. E., SKEIE, G. O., Behbahani, M., Pedersen, P., Enger, P. Ø., & Skeie, B. S. (2017) · Journal of neurosurgery · doi:10.3171/2017.2.jns161659 · Cited by 38
BRAF V600 Mutation and BRAF Kinase Inhibitors in Conjunction With Stereotactic Radiosurgery for Intracranial Melanoma Metastases: A Multicenter Retrospective Study
Mastorakos, P., Xu, Z., Yu, J. B., Hess, J. A., Qian, J. M., Chatrath, A., Taylor, D. G., Kondziolka, D. S., Warnick, R. E., Chiang, V., et al. (2018) · Neurosurgery · doi:10.1093/neuros/nyy203 · Cited by 38
Self-citation
Real-world evidence and clinical observations of the treatment of advanced non-small cell lung cancer with PD-1/PD-L1 inhibitors
Song, P., Zhang, J., Shang, C., & Zhang, L. (2019) · Scientific Reports · doi:10.1038/s41598-019-40748-7 · Cited by 38
Executive summary from American Radium Society’s appropriate use criteria on neurocognition after stereotactic radiosurgery for multiple brain metastases
Milano, M. T., Chiang, V., Soltys, S. G., Wang, T. J. C., Lo, S. S.-M., Brackett, A. L., Nagpal, S., Chao, S. T., Garg, A. K., Jabbari, S., et al. (2020) · Neuro-Oncology · doi:10.1093/neuonc/noaa192 · Cited by 38
Self-citation
Long-term survival of breast cancer patients with brain metastases: subanalysis of the BMBC registry
Riecke, K., Müller, V., Neunhöffer, T., Park-Simon, T., Weide, R., Polasik, A., Schmidt, M., Puppe, J., Mundhenke, C., Lübbe, K., et al. (2023) · ESMO Open · doi:10.1016/j.esmoop.2023.101213 · Cited by 38
Non-small cell lung cancer (NSCLC) and central nervous system (CNS) metastases: role of tyrosine kinase inhibitors (TKIs) and evidence in favor or against their use with concurrent cranial radiotherapy
Economopoulou, P., & Mountzios, G. (2016) · Translational Lung Cancer Research · doi:10.21037/tlcr.2016.12.06 · Cited by 40
Erlotinib for the treatment of brain metastases in non-small cell lung cancer
Brower, J. V., & Robins, H. I. (2016) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2016.1165206 · Cited by 37
Impact of immunotherapy among patients with melanoma brain metastases managed with radiotherapy
Stokes, W. A., Binder, D. C., Jones, B. L., Oweida, A., Liu, A. K., Rusthoven, C. G., & Karam, S. D. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2017.10.006 · Cited by 38
Stereotactic Radiation Therapy for Renal Cell Carcinoma Brain Metastases in the Tyrosine Kinase Inhibitors Era: Outcomes of 120 Patients
Klausner, G., Troussier, I., Biau, J., Jacob, J., Schernberg, A., Canova, C.-H., Simon, J.-M., Borius, P.-Y., Malouf, G. G., Spano, J., et al. (2019) · Clinical Genitourinary Cancer · doi:10.1016/j.clgc.2019.02.007 · Cited by 37
Karnofsky Performance Status Following Liver Transplantation in Patients With Multiple Organ Failures and Probable Acute-on-Chronic Liver Failure
Thuluvath, P. J., Thuluvath, A. J., Savva, Y., & Zhang, T. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2019.03.016 · Cited by 37
Supportive roles of brain macrophages in CNS metastases and assessment of new approaches targeting their functions
You, H., Baluszek, S., & Kaminska, B. (2020) · Theranostics · doi:10.7150/thno.40783 · Cited by 40
The role of brachytherapy in the management of brain metastases: a systematic review
Chitti, B., Goyal, S., Sherman, J. H., Caputy, A. J., Sarfaraz, M., Cifter, G., Aghdam, H., & Rao, Y. J. (2020) · Journal of Contemporary Brachytherapy · doi:10.5114/jcb.2020.93543 · Cited by 37
Durable 5-year local control for resected brain metastases with early adjuvant SRS: the effect of timing on intended-field control
Bander, E. D., Yuan, M., Reiner, A. S., Panageas, K. S., Ballangrud, Å., Brennan, C., Beal, K. P., Tabar, V. S., & Moss, N. S. (2021) · Neuro-Oncology Practice · doi:10.1093/nop/npab005 · Cited by 37
Nomogram-Predicted Survival of Breast Cancer Brain Metastasis: a SEER-Based Population Study
Xiong, Y., Cao, H., Zhang, Y., Zou, P., Dong, S., Wang, G., Wang, F., & Li, X. (2019) · World Neurosurgery · doi:10.1016/j.wneu.2019.04.262 · Cited by 37
Estimating the risk of brain metastasis for patients newly diagnosed with cancer
Miccio, J. A., Tian, Z., Mahase, S. S., Lin, C. S., Choi, S., Zacharia, B. E., Sheehan, J. P., Brown, P. D., Trifiletti, D. M., Palmer, J. D., et al. (2024) · Communications Medicine · doi:10.1038/s43856-024-00445-7 · Cited by 36
Self-citation

Authors: Sperduto, P. W., Kased, N., Roberge, D., Xu, Z., Shanley, R., Luo, X., Sneed, P. K., Chao, S. T., Weil, R. J., Suh, J., Bhatt, A., Jensen, A. W., Brown, P. D., Shih, H. A., Kirkpatrick, J., Gaspar, L. E., Fiveash, J. B., Chiang, V., Knisely, J. P. S., Sperduto, C. M., Lin, N., & Mehta, M.
Affiliations: University of Minnesota (US)
University of California, San Francisco (US)
McGill University (CA)
Cleveland Clinic (US)
Author affiliations appear at the end of this article.
Mayo Clinic (US)
Harvard University (US)
Duke University (US)
University of Colorado Denver (US)
University of Alabama at Birmingham (US)
Yale University (US)
Hofstra University (US)
Dartmouth College (US)
Northwestern University (US)
ORCID: Sperduto, Paul W.
Kased, Norbert
Roberge, David
Xu, Zhiyuan
Shanley, Ryan
Luo, Xianghua
Sneed, Penny K.
Chao, Samuel T.
Weil, Robert J.
Suh, John
Bhatt, Amit
Brown, Paul D.
Shih, Helen A.
Kirkpatrick, John
Fiveash, John B.
Chiang, Veronica
Knisely, Jonathan P.S.
Mehta, Minesh
Venue: Journal of Clinical Oncology
Publisher: American Society of Clinical Oncology (ASCO)
Published: 2012-02-01
Volume: 30
Issue: 4
Pages: 419-425
ISSN: 0732-183X (ISSN-L)
1527-7755
DOI: 10.1200/jco.2011.38.0527
PMC: PMC3269967
OpenAlex: W1974820090
Cited by: 1,425
References: 21
Citations by year: 2026: 41 · 2025: 57 · 2024: 88 · 2023: 112 · 2022: 103 · 2021: 113 · 2020: 146 · 2019: 117 · 2018: 131 · 2017: 134 · 2016: 115 · 2015: 94 · 2014: 68 · 2013: 62 · 2012: 38
FWCI: 45.80
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Journal of Clinical Oncology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (P30CA-77598, P30CA077598)
Topics: Health Sciences › Medicine › Oncology › Brain Metastases and Treatment
Health Sciences › Medicine › Surgery › Management of metastatic bone disease
Health Sciences › Medicine › Oncology › Cancer survivorship and care
Keywords: brain metastases, Graded Prognostic Assessment, prognosis, survival estimation, prognostic factors, lung cancer, melanoma, renal cell carcinoma, breast cancer, gastrointestinal cancer, Karnofsky performance status, extracranial metastases, number of brain metastases, clinical trial stratification
MeSH terms: Brain Neoplasms, Breast Neoplasms, Carcinoma, Renal Cell, Female, Humans, Kidney Neoplasms, Lung Neoplasms, Male, Melanoma, Neoplasm Metastasis, Prognosis, Retrospective Studies, Survival Analysis, Neoplasm Grading

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Summary Report on the Graded Prognostic Assessment: An Accurate and Facile Diagnosis-Specific Tool to Estimate Survival for Patients With Brain Metastases

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks