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Cited by 285

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Clinical Significance of Tumor-Associated Inflammatory Cells in Metastatic Neuroblastoma

Open access
Asgharzadeh, Shahab, Salo, Jill A., Ji, Lingyun, Oberthuer, André, Fischer, Matthias, Berthold, Frank, Hadjidaniel, Michael, Liu, Cathy Wei-Yao, Metelitsa, Leonid S., Pique-Regi, Roger, Wakamatsu, Peter, Villablanca, Judith G., Kreissman, Susan G., Matthay, Katherine K., Shimada, Hiroyuki, London, Wendy B., Sposto, Richard, Seeger, Robert C.·2012·Journal of Clinical Oncology
DOI 10.1200/jco.2011.40.9169
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Abstract

Purpose: Children diagnosed at age ≥ 18 months with metastatic MYCN-nonamplified neuroblastoma (NBL-NA) are at high risk for disease relapse, whereas those diagnosed at age < 18 months are nearly always cured. In this study, we investigated the hypothesis that expression of genes related to tumor-associated inflammatory cells correlates with the observed differences in survival by age at diagnosis and contributes to a prognostic signature. Methods: Tumor-associated macrophages (TAMs) in localized and metastatic neuroblastomas (n = 71) were assessed by immunohistochemistry. Expression of 44 genes representing tumor and inflammatory cells was quantified in 133 metastatic NBL-NAs to assess age-dependent expression and to develop a logistic regression model to provide low- and high-risk scores for predicting progression-free survival (PFS). Tumors from high-risk patients enrolled onto two additional studies (n = 91) served as independent validation cohorts. Results: Metastatic neuroblastomas had higher infiltration of TAMs than locoregional tumors, and metastatic tumors diagnosed in patients at age ≥ 18 months had higher expression of inflammation-related genes than those in patients diagnosed at age < 18 months. Expression of genes representing TAMs (CD33/CD16/IL6R/IL10/FCGR3) contributed to 25% of the accuracy of a novel 14-gene tumor classification score. PFS at 5 years for children diagnosed at age ≥ 18 months with NBL-NA with a low- versus high-risk score was 47% versus 12%, 57% versus 8%, and 50% versus 20% in three independent clinical trials, respectively. Conclusion: These data suggest that interactions between tumor and inflammatory cells may contribute to the clinical metastatic neuroblastoma phenotype, improve prognostication, and reveal novel therapeutic targets.

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Metadata

Authors
Asgharzadeh, S., Salo, J. A., Ji, L., Oberthuer, A., Fischer, M., Berthold, F., Hadjidaniel, M., Liu, C. W.-Y., Metelitsa, L. S., Pique-Regi, R., Wakamatsu, P., Villablanca, J. G., Kreissman, S. G., Matthay, K. K., Shimada, H., London, W. B., Sposto, R., & Seeger, R. C.
Venue
Journal of Clinical Oncology
Publisher
American Society of Clinical Oncology (ASCO)
Published
2012-10-01
Volume
30
Issue
28
Pages
3525-3532
ISSN
  • 0732-183X (ISSN-L)
  • 1527-7755
DOI
10.1200/jco.2011.40.9169
OpenAlex
W2138983295
Cited by
285
References
49
FWCI
9.16
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Clinical Significance of Tumor-Associated Inflammatory Cells in Metastatic Neuroblastoma. https://app.cochat.ai/papers/10.1200/jco.2011.40.9169
The paper
Asgharzadeh, S., Salo, J. A., Ji, L., Oberthuer, A., Fischer, M., Berthold, F., Hadjidaniel, M., Liu, C. W.-Y., Metelitsa, L. S., Pique-Regi, R., Wakamatsu, P., Villablanca, J. G., Kreissman, S. G., Matthay, K. K., Shimada, H., London, W. B., Sposto, R., & Seeger, R. C. (2012). Clinical Significance of Tumor-Associated Inflammatory Cells in Metastatic Neuroblastoma. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2011.40.9169

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.