The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Functional Decline in Older Patients With Cancer Receiving First-Line Chemotherapy
Abstract
Purpose: To determine factors associated with early functional decline during first-line chemotherapy in older patients. Patients and Methods: Patients age ≥ 70 years receiving first-line chemotherapy for cancer were prospectively considered for inclusion across 12 centers in France. Functional decline was defined as a decrease of ≥ 0.5 points on the Activities of Daily Living (ADL) scale between the beginning of chemotherapy and the second cycle. Factors associated with functional decline were sought from pretreatment abbreviated comprehensive geriatric assessment, including ADL, Instrumental ADL (IADL), Mini-Nutritional Assessment (MNA), Mini–Mental State Examination (MMSE), Geriatric Depression Scale (GDS15), and Timed Get Up and Go (GUG) test, and from comorbidities (Cumulative Illness Rating Scale–Geriatrics), MAX2 index, and baseline biologic and clinical information. Results: Of 364 included patients, 50 experienced functional decline (16.7%; median, 0.5 points). Abnormal preadmission performance status, IADL, GDS15, MMSE, GUG, and MNA were associated with increased likelihood of functional decline (univariate analysis). In the multivariate model adjusted for baseline ADL and MAX2 index, high baseline GDS (odds ratio [OR], 2.16; 95% CI, 1.09 to 4.30; P = .03) and low IADL scores (OR, 2.87; 95% CI, 1.06 to 7.79; P = .04) were independently associated with increased risk of functional decline. Conclusion: Our results outline associations between baseline depression, instrumental dependencies, and early functional decline during chemotherapy for older patients. ADL should be sequentially evaluated early during treatment. Baseline evaluation of GDS15 and IADL may be proposed to anticipate this event.
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Cites
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The Timed “Up & Go”: A Test of Basic Functional Mobility for Frail Elderly Persons
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Comprehensive geriatric assessment: a meta-analysis of controlled trials
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Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study
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Use of comprehensive geriatric assessment in older cancer patients:
Extermann, M., Aapro, M., Bernabei, R., Cohen, H. J., Droz, J.-P., Lichtman, S., Mor, V., Monfardini, S., Repetto, L., Sørbye, L., et al. (2005) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2005.06.003 · Cited by 1,098
Functional Outcomes of Acute Medical Illness and Hospitalization in Older Persons
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Cited by
Mohile, S. G., Dale, W., Somerfield, M. R., Schonberg, M. A., Boyd, C. M., Burhenn, P. S., Canin, B., Cohen, H. J., Holmes, H. M., Hopkins, J. O., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2018.78.8687 · Cited by 1,479
Soubeyran, P., Bellera, C., Goyard, J., Heitz, D., Curé, H., Rousselot, H., Albrand, G., Servent, V., Jean, O. S., van Praagh, I., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115060 · Cited by 601
Self-citationEstimated global cancer incidence in the oldest adults in 2018 and projections to 2050
Pilleron, S., Soto‐Perez‐de‐Celis, E., Vignat, J., Ferlay, J., Soerjomataram, I., Bray, F., & Sarfati, D. (2021) · International Journal of Cancer · doi:10.1002/ijc.33232 · Cited by 357
Canoui‐Poitrine, F., Reinald, N., Laurent, M., Guery, E., Caillet, P., David, J., Tournigand, C., Lagrange, J., Bastuji‐Garin, S., Lemogne, C., et al. (2016) · Psycho-Oncology · doi:10.1002/pon.3886 · Cited by 71
The Role of Family Caregivers in the Care of Older Adults with Cancer
Sun, V., Puts, M., Haase, K., Pilleron, S., Hannan, M., Sattar, S., & Strohschein, F. J. (2021) · Seminars in Oncology Nursing · doi:10.1016/j.soncn.2021.151232 · Cited by 32
Metadata
- Authors
- Hoppe, S., Rainfray, M., Fonck, M., Hoppenreys, L., Blanc, J.-F., Ceccaldi, J., Mertens, C., Blanc-Bisson, C., Imbert, Y., Cany, L., Vogt, L., Dauba, J., Houédé, N., Bellera, C. A., Floquet, A., Fabry, M.-N., Ravaud, A., Chakiba, C., Mathoulin-Pélissier, S., & Soubeyran, P.
- Venue
- Journal of Clinical Oncology
- Published
- 2013-11-01
- Volume
- 31
- Issue
- 31
- Pages
- 3877-3882
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2167568167
- Cited by
- 236
- References
- 9
- FWCI
- 6.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hoppe, S., Rainfray, M., Fonck, M., Hoppenreys, L., Blanc, J.-F., Ceccaldi, J., Mertens, C., Blanc-Bisson, C., Imbert, Y., Cany, L., Vogt, L., Dauba, J., Houédé, N., Bellera, C. A., Floquet, A., Fabry, M.-N., Ravaud, A., Chakiba, C., Mathoulin-Pélissier, S., & Soubeyran, P. (2013). Functional Decline in Older Patients With Cancer Receiving First-Line Chemotherapy. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2012.47.7430
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