Cited by 71Frailty in Older AdultsCancer survivorship and careAging, Health, and Disability

Geriatric assessment findings independently associated with clinical depression in 1092 older patients with cancer: the ELCAPA Cohort Study

Canoui‐Poitrine, Florence, Reinald, Nicoleta, Laurent, Marie, Guery, Esther, Caillet, Philippe, David, Jean‐Philippe, Tournigand, Christophe, Lagrange, Jean‐Leon +4 more·2016·Psycho-Oncology

Abstract

Objective: We aim to assess the prevalence and associated factors of clinical depression in older patients with cancer. Methods: We studied a prospective cohort of cancer patients aged ≥70 years and referred to geriatric oncology clinics between 2007 and 2012. A multidimensional geriatric assessment was performed before choosing the cancer‐treatment strategy. Clinical depression was diagnosed by senior geriatricians by a semi‐structured interview. It encompassed criteria of the Diagnostic and Statistical Manual of Mental Disorders (fourth edition) and of the International Classification of Diseases (10th edition). Multivariate logistic regression was performed. Results: Of 1121 consecutive patients, 1092 had available data (mean age, 80.4 years; women, 48.8%; metastases, 51.3%; cancer location: colorectal 21.1%, breast 16.8%, kidney, bladder or urinary tract 14.0%, and prostate 11.4%). The overall prevalence of clinical depression was 28.4% (95% confidence interval, 25.7–31.2). Factors independently associated with clinical depression by multivariate analysis adjusting for all following factors plus gender, and metastasis were impaired mobility (adjusted odds ratio [aOR], 2.35; 1.59–3.46), impaired functional status defined as Eastern Cooperative Oncology Group Performance Status ≥ 2 (aOR, 2.39; 1.66–3.43) or as activities of daily living < 6 (aOR, 2.43; 1.73–3.41), inpatient status (aOR, 1.68; 1.20–2.37), inadequate social support (aOR, 1.66; 1.16–2.37), cognitive impairment (aOR, 1.76; 1.24–2.49), polypharmacy defined as five or more non‐antidepressant drugs (aOR, 1.65; 1.14–2.38), multimorbidity (aOR additional CIRS‐G point, 1.08; 1.04–1.12), and cancer‐related pain (aOR, 1.76; 1.26–2.46). Conclusion: In older patients with as‐yet untreated cancer at various sites and stages, clinical depression was highly prevalent. Clinical depression was independently associated with several geriatric assessment findings (impaired mobility and function, inadequate social support, cognitive impairment, polypharmacy, and multimorbidity) independently from gender, tumor site, and metastatic status. Copyright © 2015 John Wiley & Sons, Ltd.

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Crossref · 10.1002/pon.3886

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Authors
Canoui‐Poitrine, F., Reinald, N., Laurent, M., Guery, E., Caillet, P., David, J., Tournigand, C., Lagrange, J., Bastuji‐Garin, S., Lemogne, C., Paillaud, E., & on behalf of the ELCAPA Study Group
Affiliations
  • APHP Hôpital Henri‐Mondor, Service de Santé Publique F‐94000 Créteil France
  • Université Paris-Est Créteil (FR)
  • APHP Hôpital Henri‐Mondor, Service de Radiothérapie F‐94000 Créteil France
  • Université Paris Descartes, Sorbonne Paris Cité Faculté de Médecine Paris France
  • Université Paris‐Est, UPEC, DHU A‐TVB, IMRB, EA493 CEpiA (Clinical Epidemiology And Ageing) F‐94000 Créteil France
Venue
Psycho-Oncology
Publisher
Wiley
Published
2015-06-30
Volume
25
Issue
1
Pages
104-111
ISSN
  • 1057-9249 (ISSN-L)
  • 1099-1611
OpenAlex
W1613566575
Cited by
71
References
47
Citations by year
2026: 2 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 10 · 2021: 6 · 2020: 9 · 2019: 8 · 2018: 9 · 2017: 6 · 2016: 6
FWCI
3.49
Type
journal article
Language
en
Open access
closed
Locations
  • Psycho-Oncology (publishedVersion)
  • PubMed (publishedVersion)
Funders
French National Cancer Institute (INCa)
Topics
  • Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
Keywords
major depressive disorder, elderly cancer patients, geriatric assessment, geriatric oncology, depression prevalence, mobility impairment, functional status, activities of daily living, social support, cognitive impairment, polypharmacy, multimorbidity, cancer pain, geriatric comorbidities, treatment decision-making, metastatic cancer, treatment-related adverse events, quality of life
MeSH terms
Activities of Daily Living, Aged, Aged, 80 and over, Cognition Disorders, Depression, Female, Humans, Male, Neoplasms, Prospective Studies, Risk Factors, Social Support, Geriatric Assessment, Comorbidity, Prevalence, Polypharmacy

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