CoChat
Sign Up
Cited by 183Thyroid Cancer Diagnosis and TreatmentThyroid Disorders and TreatmentsThyroid and Parathyroid Surgery

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Long-Term Cardiovascular Mortality in Patients With Differentiated Thyroid Carcinoma: An Observational Study

Klein Hesselink, Esther N., Klein Hesselink, Mariëlle S., de Bock, Geertruida H., Gansevoort, Ron T., Bakker, Stephan J.L., Vredeveld, Eline J., van der Horst-Schrivers, Anouk N.A., van der Horst, Iwan C.C., Kamphuisen, Pieter W., Plukker, John T.M., Links, Thera P., Lefrandt, Joop D.·2013·Journal of Clinical Oncology
DOI 10.1200/jco.2013.49.1043
Open this paper in CoChat — free account

Abstract

PURPOSE: The primary aim was to study the risk of cardiovascular mortality in patients with differentiated thyroid carcinoma (DTC). Secondary aims were to evaluate all-cause mortality and explore the relation between thyroid-stimulating hormone (TSH; also known as thyrotropin) level and these outcome parameters. PATIENTS AND METHODS: Subjects from two cohorts were retrospectively compared by Cox regression analyses; 524 patients with DTC and 1,572 sex- and age-matched controls from a large population-based study in the same geographic region. RESULTS: Mean age plus or minus standard deviation was 49 ± 14 years. Median follow-up was 8.5 years (interquartile range [IQR], 4.1 to 15.9 years) for patients with DTC and 10.5 years (IQR, 9.9 to 10.9 years) for controls. One hundred patients with DTC (19.1%) died, 22 (4.2%) as a result of cardiovascular disease, 39 (7.4%) as a result of DTC, and 39 (7.4%) as a result of other/unknown causes. Eighty-five controls (5.4%) died, 24 (1.5%) as a result of cardiovascular disease and 61 (3.9%) as a result of other/unknown causes. Patients with DTC had an increased risk of cardiovascular and all-cause mortality (hazard ratios [HRs], 3.35 [95% CI, 1.66 to 6.74] and 4.40 [95% CI, 3.15 to 6.14], respectively, adjusted for age, sex, and cardiovascular risk factors). Within the DTC group, TSH level was predictive for cardiovascular mortality; the adjusted HR was 3.08 (95% CI, 1.32 to 7.21) for each 10-fold decrease in geometric mean TSH level. CONCLUSION: The risk of cardiovascular and all-cause mortality is increased in patients with DTC, independent of age, sex, and cardiovascular risk factors. A lower TSH level is associated with increased cardiovascular mortality, supporting the current European Thyroid Association and the American Thyroid Association guidelines of tempering TSH suppression in patients with low risk of cancer recurrence. Furthermore, patients with DTC may benefit from assessment and treatment of cardiovascular risk factors.

Overview

Integrity signals

Registry

Crossref · 10.1200/jco.2013.49.1043

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 29 references

Research works printed but not linked: 2

  1. Pujol P, 1996, J Clin Endocrinol Metab, 81, 4318
  2. Akslen LA, 1991, Cancer Res, 51, 1234

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Klein Hesselink, E. N., Klein Hesselink, M. S., de Bock, G. H., Gansevoort, R. T., Bakker, S. J. L., Vredeveld, E. J., van der Horst-Schrivers, A. N. A., van der Horst, I. C. C., Kamphuisen, P. W., Plukker, J. T. M., Links, T. P., & Lefrandt, J. D.
Affiliations
  • All authors: University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • University Medical Center Groningen (NL)
ORCID
Venue
Journal of Clinical Oncology
Publisher
American Society of Clinical Oncology (ASCO)
Published
2013-11-10
Volume
31
Issue
32
Pages
4046-4053
ISSN
  • 0732-183X (ISSN-L)
  • 1527-7755
DOI
10.1200/jco.2013.49.1043
OpenAlex
W2142884678
Cited by
183
References
29
Citations by year
2026: 6 · 2025: 20 · 2024: 13 · 2023: 10 · 2022: 16 · 2021: 26 · 2020: 13 · 2019: 11 · 2018: 10 · 2017: 19 · 2016: 12 · 2015: 15 · 2014: 9 · 2013: 3
FWCI
10.23
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Clinical Oncology (publishedVersion)
  • PubMed (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
Keywords
differentiated thyroid cancer, cardiovascular mortality, all-cause mortality, thyroid-stimulating hormone, TSH suppression, cardiovascular risk factors, cancer recurrence risk, cardiovascular risk stratification, American Thyroid Association guidelines, cardiovascular risk
MeSH terms
Cardiovascular Diseases, Female, Follow-Up Studies, Humans, Male, Middle Aged, Retrospective Studies, Risk Factors, Thyroid Neoplasms, Thyrotropin, Proportional Hazards Models, Kaplan-Meier Estimate

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review