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Cited by 903

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Pseudoprogression and Immune-Related Response in Solid Tumors

Open access
Chiou, Victoria L., Burotto, Mauricio·2015·Journal of Clinical Oncology

Abstract

Emerging cancer therapeutics target the immune system, stimulating host antitumor response. Tumor cells generate an immunosuppressive milieu with multiple mechanisms to evade immune destruction, including disruption of effective antigen presentation, reduction of effector T-cell function, and upregulation of pathways that promote tolerance and T-cell anergy.1 The programmed death (PD) -1/PD ligand-1 (PD-L1) pathway is a critical component of tumor-mediated immunosuppression. Antibodies to PD-1 and PD-L1 have shown potential clinical benefit in advanced solid tumors.2 The US Food and Drug Administration approved the PD-1 inhibitors pembrolizumab and nivolumab for metastatic melanoma and also recently approved nivolumab for the treatment of metastatic squamous non–small-cell lung cancer. The US Food and Drug Administration has also designated the PD-L1 inhibitor MPDL3280A as a breakthrough therapy for bladder cancer and non–small-cell lung cancer. These drugs and additional immune checkpoint inhibitors are currently under investigation in multiple clinical trials as single-agent therapy and also in combination with other agents.

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Metadata

Authors
Chiou, V. L., & Burotto, M.
Venue
Journal of Clinical Oncology
Published
2015-11-01
Volume
33
Issue
31
Pages
3541-3543
ISSN
  • 0732-183X (ISSN-L)
  • 1527-7755
OpenAlex
W2101571970
Cited by
903
References
10
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Pseudoprogression and Immune-Related Response in Solid Tumors. https://app.cochat.ai/papers/10.1200/jco.2015.61.6870
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Chiou, V. L., & Burotto, M. (2015). Pseudoprogression and Immune-Related Response in Solid Tumors. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2015.61.6870

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.