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Symptom Monitoring With Patient-Reported Outcomes During Routine Cancer Treatment: A Randomized Controlled Trial
Open accessAbstract
Purpose: There is growing interest to enhance symptom monitoring during routine cancer care using patient-reported outcomes, but evidence of impact on clinical outcomes is limited. Methods: We randomly assigned patients receiving routine outpatient chemotherapy for advanced solid tumors at Memorial Sloan Kettering Cancer Center to report 12 common symptoms via tablet computers or to receive usual care consisting of symptom monitoring at the discretion of clinicians. Those with home computers received weekly e-mail prompts to report between visits. Treating physicians received symptom printouts at visits, and nurses received e-mail alerts when participants reported severe or worsening symptoms. The primary outcome was change in health-related quality of life (HRQL) at 6 months compared with baseline, measured by the EuroQol EQ-5D Index. Secondary endpoints included emergency room (ER) visits, hospitalizations, and survival. Results: Among 766 patients allocated, HRQL improved among more participants in the intervention group than usual care (34% v 18%) and worsened among fewer (38% v 53%; P < .001). Overall, mean HRQL declined by less in the intervention group than usual care (1.4- v 7.1-point drop; P < .001). Patients receiving intervention were less frequently admitted to the ER (34% v 41%; P = .02) or hospitalized (45% v 49%; P = .08) and remained on chemotherapy longer (mean, 8.2 v 6.3 months; P = .002). Although 75% of the intervention group was alive at 1 year, 69% with usual care survived the year (P = .05), with differences also seen in quality-adjusted survival (mean of 8.7 v. 8.0 months; P = .004). Benefits were greater for participants lacking prior computer experience. Most patients receiving intervention (63%) reported severe symptoms during the study. Nurses frequently initiated clinical actions in response to e-mail alerts. Conclusion: Clinical benefits were associated with symptom self-reporting during cancer care.
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“generate a real-time alert notification sent to the patient's cancer care team, based on prior research.25”
From Implementation of a remote symptom monitoring pathway in oncology care: analysis of real-world experience across 33 cancer centres in France and Belgium (2024) · cites this paper as [25]
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“which have demonstrated improved symptom control, quality of life, and survival when structured symptom reporting is coupled with clinician response [3,4,7]”
From Implementing UK Oncology Nursing Society–Informed Digital Symptom Triage With Episode-Based Review in Routine NHS Acute Oncology: Service Evaluation (2026) · cites this paper as [3]
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“Electronic patient-reported outcome (ePRO) systems have demonstrated that symptom monitoring with clinician response improves symptom control and survival [3,4].”
From Implementing UK Oncology Nursing Society–Informed Digital Symptom Triage With Episode-Based Review in Routine NHS Acute Oncology: Service Evaluation (2026) · cites this paper as [3]
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“The findings of this evaluation are consistent with prior trials of ePRO monitoring”
From Implementing UK Oncology Nursing Society–Informed Digital Symptom Triage With Episode-Based Review in Routine NHS Acute Oncology: Service Evaluation (2026) · cites this paper as [3]
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Cites
EuroQol: a new facility for the measurement of health-related quality of life
(1990) · Health Policy · doi:10.1016/0168-8510(90)90421-9 · Cited by 15,736
A Class of $K$-Sample Tests for Comparing the Cumulative Incidence of a Competing Risk
Gray, R. J. (1988) · The Annals of Statistics · doi:10.1214/aos/1176350951 · Cited by 4,957
Velikova, G., Booth, L., Smith, A. B., Brown, P. M., Lynch, P., Brown, J. M., & Selby, P. J. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.06.078 · Cited by 1,382
Detmar, S. B., Muller, M. J., Schornagel, J. H., Wever, L. D. V., & Aaronson, N. K. (2002) · JAMA · doi:10.1001/jama.288.23.3027 · Cited by 1,011
Kotronoulas, G., Kearney, N., Maguire, R., Harrow, A., Domenico, D. D., Croy, S., & MacGillivray, S. A. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.53.5948 · Cited by 953
Estimation of minimally important differences in EQ-5D utility and VAS scores in cancer
Pickard, A. S., Neary, M. P., & Cella, D. F. (2007) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-5-70 · Cited by 932
Snyder, C., Aaronson, N., Choucair, A., Elliott, T. E., Greenhalgh, J., Halyard, M., Hess, R., Miller, D. M., Reeve, B., & Santana, M. (2012) · Quality of Life Research · doi:10.1007/s11136-011-0054-x · Cited by 808
Chen, J., Ou, L., & Hollis, S. J. (2013) · BMC Health Services Research · doi:10.1186/1472-6963-13-211 · Cited by 796
Valderas, J. M., Kotzeva, A., Espallargues, M., Guyatt, G., Ferrans, C. E., Halyard, M. Y., Revicki, D. A., Symonds, T., Parada, A., & Alonso, J. (2008) · Quality of Life Research · doi:10.1007/s11136-007-9295-0 · Cited by 775
Adverse Symptom Event Reporting by Patients vs Clinicians: Relationships With Clinical Outcomes
Basch, E., Jia, X., Heller, G., Leahy, A. B., Sit, L., Fruscione, M., Appawu, M., Iasonos, A. E., Atkinson, T. M., Goldfarb, S. B., et al. (2009) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djp386 · Cited by 622
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Items 101–200 of 1,001
Under-reporting of harm in clinical trials
Šeruga, B., Templeton, A. J., Badillo, F. E. V., Ocaña, A., Amir, E., & Tannock, I. F. (2016) · The Lancet Oncology · doi:10.1016/s1470-2045(16)00152-2 · Cited by 110
Aiyegbusi, O. L. (2019) · Quality of Life Research · doi:10.1007/s11136-019-02329-z · Cited by 107
Snyder, C. F., Smith, K. C., Bantug, E. T., Tolbert, E. E., Blackford, A. L., Brundage, M., & the PRO Data Presentation Stakeholder Advisory Board (2017) · Cancer · doi:10.1002/cncr.30530 · Cited by 106
Mooney, K. H., Berry, D. L., Whisenant, M., & Sjoberg, D. D. (2017) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_175418 · Cited by 109
Girgis, A., Durcinoska, I., Levesque, J. V., Gerges, M., Sandell, T., Arnold, A., & Delaney, G. P. (2017) · Journal of Medical Internet Research · doi:10.2196/jmir.8360 · Cited by 110
“Recently published research demonstrates improvements in clinical and health service outcomes, including reduced emergency room visits, longer tolerability of chemotherapy, and improved short- and long-term survival [5,6].”
BackgroundEaspaig, B. N. G., Tran, Y., Bierbaum, M., Arnolda, G., Delaney, G. P., Liauw, W., Ward, R. L., Olver, I., Currow, D. C., Girgis, A., et al. (2020) · BMC Health Services Research · doi:10.1186/s12913-020-4939-7 · Cited by 115
“The control group received standard care with symptoms monitored by the treating clinician while the intervention group, in addition, electronically reported on 12 common symptoms at set times [1].”
BackgroundMethodHawkins, P. G., Lee, J., Mao, Y., Li, P., Green, M. D., Worden, F. P., Swiecicki, P. L., Mierzwa, M. L., Spector, M. E., Schipper, M. J., et al. (2017) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2017.08.002 · Cited by 101
Provider perspectives on the integration of patient-reported outcomes in an electronic health record
Zhang, R., Burgess, E. R., Reddy, M. C., Rothrock, N. E., Bhatt, S. A., Rasmussen, L. V., Butt, Z. A., & Starren, J. B. (2019) · JAMIA Open · doi:10.1093/jamiaopen/ooz001 · Cited by 99
Pancreatic cancer—A disease in need: Optimizing and integrating supportive care
Moffat, G. T., Epstein, A. S., & O'Reilly, E. M. (2019) · Cancer · doi:10.1002/cncr.32423 · Cited by 100
“In medical oncology, the use of electronic patient-reported outcomes (ePROs) has been demonstrated to improve patient’s QoL, reduce hospitalizations and health care costs, and improve overall survival.(38,39) ePROs provide an efficient, standardized assessment of continuous data collection on the patient and their med…”
BackgroundBasch, E., Rogak, L. J., & Dueck, A. C. (2016) · Clinical Therapeutics · doi:10.1016/j.clinthera.2016.03.011 · Cited by 101
Self-citationImproving quality of life in patients with advanced cancer: Targeting metastatic bone pain
von Moos, R., Costa, L., Ripamonti, C. I., Niepel, D., & Santini, D. (2016) · European Journal of Cancer · doi:10.1016/j.ejca.2016.10.021 · Cited by 100
Effects of web-based interventions on cancer patients’ symptoms: review of randomized trials
Fridriksdóttir, N., Gunnarsdóttir, S., Zoëga, S., Ingadóttir, B., & Hafsteinsdóttir, E. J. G. (2017) · Supportive Care in Cancer · doi:10.1007/s00520-017-3882-6 · Cited by 99
“A recent trial testing the impact of systematic web-based collection of patient-reported symptoms during chemotherapy in advanced cancer with automated alerts to clinicians for severe or worsening symptoms found significant positive intervention effects, resulting in better QOL, fewer ER visits, fewer hospitalizations…”
Backgroundvan der Willik, E. M., Hemmelder, M. H., Bart, H. A. J., van Ittersum, F. J., den Akker, J. M. H.-V., Bos, W. J. W., Dekker, F. W., & Meuleman, Y. (2019) · Clinical Kidney Journal · doi:10.1093/ckj/sfz192 · Cited by 99
“There are some studies suggesting that using PROMs will lead to better outcomes; for example, a randomized controlled trial in routine cancer care showed that web-based symptom monitoring resulted in improved HRQoL after 6 months, fewer hospital admissions and better 1-year survival even though no specific guidance wa…”
BackgroundLi, J., Liu, Y., Jiang, J., Peng, X., & Hu, X. (2021) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2021.103970 · Cited by 98
Home monitoring in interstitial lung diseases
Wijsenbeek, M. S., Moor, C. C., Johannson, K. A., Jackson, P. D., Khor, Y. H., Kondoh, Y., Rajan, S. K., Tabaj, G. C., Varela, B. E., van der Wal, P., et al. (2023) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(22)00228-4 · Cited by 98
“The patient is speaking”: discovering the patient voice in ophthalmology
Dean, S., Mathers, J. M., Calvert, M., Kyte, D. G., Conroy, D. M., Folkard, A., Southworth, S., Murray, P. I., & Denniston, A. K. (2017) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2016-309955 · Cited by 101
Improving Palliative Care and Quality of Life in Pancreatic Cancer Patients
Chung, V. M., Sun, V. C.-Y., Ruel, N. H., Smith, T. J., & FERRELL, B. R. (2021) · Journal of Palliative Medicine · doi:10.1089/jpm.2021.0187 · Cited by 112
“In pancreatic cancer patients, we hypothesize that early palliative care will impact survival.(22,23) To answer that question, we have designed a randomized phase 3 clinical trial of a primary palliative care intervention to improve QOL in metastatic pancreatic cancer patients.”
BackgroundPatient Experience Captured by Quality-of-Life Measurement in Oncology Clinical Trials
Haslam, A., Herrera-Perez, D., Gill, J., & Prasad, V. K. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.0363 · Cited by 99
Collado‐Borrell, R., Escudero‐Vilaplana, V., Villanueva‐Bueno, C., Alonso, A. H., & Sanjurjo‐Sáez, M. (2020) · Journal of Medical Internet Research · doi:10.2196/20334 · Cited by 95
“Recording of symptoms and communication between health care professionals and patients have been shown to improve access to health systems, reduce the use of health care resources, and improve monitoring and control of symptoms [16,19,21].”
BackgroundBenze, G., Nauck, F., Alt‐Epping, B., Gianni, G., Bauknecht, T., Ettl, J., Munte, A., Kretzschmar, L., & Gaertner, J. (2017) · Annals of Palliative Medicine · doi:10.21037/apm.2017.07.05 · Cited by 94
“(6) reported findings from a recently performed randomized, controlled trial (RCT) that showed that if PROs were obtained and recorded routinely, QoL and other clinical outcomes of cancer patients improved substantially compared to those who received standard care.”
BackgroundPROMs for Pain in Adult Cancer Patients: A Systematic Review of Measurement Properties
Abahussin, A. A., West, R. M., Wong, D., & Ziegler, L. E. (2018) · Pain Practice · doi:10.1111/papr.12711 · Cited by 97
Nyrop, K. A., Deal, A. M., Reeder‐Hayes, K. E., Shachar, S. S., Reeve, B. B., Basch, E., Choi, S. K., Lee, J. T., Wood, W. A., Anders, C. K., et al. (2019) · Cancer · doi:10.1002/cncr.32175 · Cited by 95
Self-citationVisual analogies, not graphs, increase patients' comprehension of changes in their health status
Turchioe, M. R., Liu, L. G., Myers, A., Baik, D., Goyal, P., & Creber, R. M. (2019) · Journal of the American Medical Informatics Association · doi:10.1093/jamia/ocz217 · Cited by 95
Barbera, L. C., Sutradhar, R., Seow, H. Y., Earle, C. C., Howell, D., Mittmann, N., Li, Q., & Thiruchelvam, D. (2020) · JCO Oncology Practice · doi:10.1200/jop.19.00660 · Cited by 94
van der Willik, E. M., Terwee, C. B., Bos, W. J. W., Hemmelder, M. H., Jager, K. J., Zoccali, C., Dekker, F. W., & Meuleman, Y. (2020) · Nephrology · doi:10.1111/nep.13843 · Cited by 100
Egbring, M., Far, E., Roos, M., Dietrich, M., Brauchbar, M., Kullak-Ublick, G. A., & Trojan, A. (2016) · Journal of Medical Internet Research · doi:10.2196/jmir.6414 · Cited by 90
Efficace, F., Gaïdano, G., & Lo‐Coco, F. (2017) · Blood · doi:10.1182/blood-2017-03-737403 · Cited by 94
Hong, J. C., Eclov, N. C. W., Dalal, N., Thomas, S. M., Stephens, S. J., Malicki, M., Shields, S., Cobb, A., Mowery, Y. M., Niedzwiecki, D., et al. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.20.01688 · Cited by 93
“Days on treatment 14 (6-35) 32 (14-42) 9 (4-23)”
Fostering Innovation in Symptom Management among Hemodialysis Patients
Flythe, J. E., Hilliard, T. S., Lumby, E., Castillo, G., Orazi, J., Abdel‐Rahman, E. M., Pai, A. B., Rivara, M. B., Peter, W. L. S., Weisbord, S. D., et al. (2018) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.07670618 · Cited by 93
“Data from patients with advanced cancer have shown a link between symptom reporting and better patient-reported and health outcomes (11).”
BackgroundGirgis, A., Durcinoska, I., Arnold, A., Descallar, J., Kaadan, N., Koh, E.-S., Miller, A., Ng, W., Carolan, M., Della-Fiorentina, S. A., et al. (2020) · Journal of Medical Internet Research · doi:10.2196/19685 · Cited by 92
“Finally, there was limited follow-up (one email reminder) if monthly assessments were not completed, in contrast to nurses following up patients in the Basch et al [3] trial to ensure high adherence.”
BackgroundResultEmbedding patient-reported outcomes at the heart of artificial intelligence health-care technologies
Rivera, S. C., Liu, X., Hughes, S., Dunster, H., Manna, E., Denniston, A. K., & Calvert, M. (2023) · The Lancet Digital Health · doi:10.1016/s2589-7500(22)00252-7 · Cited by 97
Nyrop, K. A., Deal, A. M., Shachar, S. S., Basch, E., Reeve, B. B., Choi, S. K., Lee, J. T., Wood, W. A., Anders, C. K., Carey, L., et al. (2018) · The Oncologist · doi:10.1634/theoncologist.2018-0590 · Cited by 90
“Prior studies have reported how PRO-CTCAE coupled with clinician alerts throughout treatment can trigger early interventions that, in turn, reduce adverse events such as hospitalizations, visits to the emergency room, and early discontinuation [28] and even improve overall survival in patients with metastatic disease…”
BackgroundSelf-citationTreatment‐associated toxicities reported by patients with early‐stage invasive breast cancer
Friese, C. R., Harrison, J. M., Janz, N. K., Jagsi, R., Morrow, M., Li, Y., Hamilton, A. S., Ward, K. C., Kurian, A. W., Katz, S. J., et al. (2017) · Cancer · doi:10.1002/cncr.30547 · Cited by 90
Laetsch, T. W., Myers, G. D., Baruchel, A., Dietz, A. C., Pulsipher, M. A., Bittencourt, H. N. D. S., Buechner, J., Moerloose, B. D., Davis, K. L., Nemecek, E. R., et al. (2019) · The Lancet Oncology · doi:10.1016/s1470-2045(19)30493-0 · Cited by 97
Natural Language Processing to Ascertain Cancer Outcomes from Medical Oncologist Notes
Kehl, K. L., Xu, W., Lepisto, E., Elmarakeby, H., Hassett, M. J., Van Allen, E. M., Johnson, B. E., & Schrag, D. (2020) · JCO Clinical Cancer Informatics · doi:10.1200/cci.20.00020 · Cited by 90
“Some of this information could be gathered by measuring patient-reported outcomes 19 and applying wearable technology, 20 but these data are not yet widely gathered or available in practice across health systems and populations, and they may not capture the integration of clinical status and…”
BackgroundSelf-citationThe HOPE Pilot Study: Harnessing Patient-Reported Outcomes and Biometric Data to Enhance Cancer Care
Wright, A. A., Raman, N., Staples, P. C., Schonholz, S. M., Cronin, A. M., Carlson, K. W., Keating, N. L., & Onnela, J.-P. “. (2018) · JCO Clinical Cancer Informatics · doi:10.1200/cci.17.00149 · Cited by 94
Remote symptom monitoring integrated into electronic health records: A systematic review
Gandrup, J., Ali, S. M., McBeth, J., van der Veer, S. N., & Dixon, W. G. (2020) · Journal of the American Medical Informatics Association · doi:10.1093/jamia/ocaa177 · Cited by 90
“41 Despite not being integrated with the EHR, similar evidence from remote symptom monitoring on patient outcomes are rare across other LTC.”
Basch, E., Schrag, D., Jansen, J., Henson, S. R., Ginos, B., Stover, A. M., Carr, P. M., Spears, P. A., Jönsson, M., Deal, A. M., et al. (2025) · Nature Medicine · doi:10.1038/s41591-025-03507-y · Cited by 94
“…cancers treated in New York found statistically significant benefits associated with electronic PRO symptom monitoring compared to usual care, including 15% fewer patients experiencing health-related quality of life (HRQL) deterioration at 6 months, and a 7% decrease in emergency visits 10 .”
Self-citationSymptom Monitoring in Pediatric Oncology Using Patient-Reported Outcomes: Why, How, and Where Next
Leahy, A. B., Feudtner, C., & Basch, E. (2017) · Patient · doi:10.1007/s40271-017-0279-z · Cited by 87
“In adults, better symptom management has resulted in less emergency room utilization, improved patient engagement, and asignificant survival benefit [4, 11].”
BackgroundSelf-citationSammons, S. L., Topping, D. L., & Blackwell, K. (2017) · Current Cancer Drug Targets · doi:10.2174/1568009617666170330120452 · Cited by 89
Armstrong, T. S., Dirven, L., Arons, D. F., Bates, A., Chang, S. M., Coens, C., Espinasse, C., Gilbert, M. R., Jenkinson, D., Kluetz, P. G., et al. (2020) · The Lancet Oncology · doi:10.1016/s1470-2045(19)30796-x · Cited by 89
Howell, D., Rosberger, Z., Mayer, C., Faria, R., Hamel, M., Snider, A., Bryant‐Lukosius, D., Montgomery, N., Mozuraitis, M., Li, M., et al. (2020) · Journal of Patient-Reported Outcomes · doi:10.1186/s41687-020-00212-x · Cited by 87
Mackler, E. R., Segal, E. M., Muluneh, B., Jeffers, K. D., & Carmichael, J. (2019) · Journal of Oncology Practice · doi:10.1200/jop.18.00581 · Cited by 82
“Patients with metastatic cancer who used the tool while receiving treatment lived a median of 5 months longer than those who did not use the tool.(30) Use of patient-reported outcomes (PROs) in patients who receive oral oncolytic therapy is in the early phases of development, but one can assume that the benefits would…”
BackgroundMultidisciplinary home-based rehabilitation in inoperable lung cancer: a randomised controlled trial
Edbrooke, L., Aranda, S. K., Granger, C. L., McDonald, C. F., Krishnasamy, M., Mileshkin, L., Clark, R. A., Gordon, I., Irving, L., & Denehy, L. (2019) · Thorax · doi:10.1136/thoraxjnl-2018-212996 · Cited by 82
Understanding Treatment Tolerability in Older Adults With Cancer
Flannery, M. A., Culakova, E., Canin, B. E., Peppone, L. J., Ramsdale, E. E., & Mohile, S. G. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.21.00195 · Cited by 81
Lee, K., Kim, S., Kim, S. H., Yoo, S., Sung, J. H., Oh, E. G., Kim, N. W., & Lee, J. (2023) · Journal of Medical Internet Research · doi:10.2196/38333 · Cited by 79
“Promising outcomes have been suggested from digital health intervention trials; for example, Basch et al [6] incorporated electronic patient-reported outcome monitoring of 12 symptoms during routine cancer treatment and demonstrated less decline in health-related quality of life (HRQoL), less…”
Licqurish, S., Cook, O., Pattuwage, L., Saunders, C. M., Jefford, M., Koczwara, B., Johnson, C. E., & Emery, J. D. (2019) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21573 · Cited by 80
Hauth, F., Bizu, V., App, R., Lautenbacher, H., Tenev, A., Bitzer, M., Malek, N. P., Zips, D., & Gani, C. (2019) · JMIR mhealth and uhealth · doi:10.2196/12345 · Cited by 84
“It has been suggested in many studies that self-reporting increases patient contentedness and potentially enables physicians to recognize adverse events at an earlier time point [18,19].”
Osborn, J., Ajakaiye, A., Cooksley, T., & Subbe, C. P. (2019) · Supportive Care in Cancer · doi:10.1007/s00520-019-04945-4 · Cited by 75
Models of Integration of Specialized Palliative Care with Oncology
Mathews, J. J., Hannon, B. L., & Zimmermann, C. (2021) · Current Treatment Options in Oncology · doi:10.1007/s11864-021-00836-1 · Cited by 79
Lage, D. E., El-Jawahri, A. R., Fuh, C., Newcomb, R. A., Jackson, V. A., Ryan, D. P., Greer, J. A., Temel, J. S., & Nipp, R. D. (2020) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2019.7385 · Cited by 77
Avutu, V., Lynch, K. A., Barnett, M. E., Vera, J. A., Bender, J. G., Tap, W. D., & Atkinson, T. M. (2022) · Cancers · doi:10.3390/cancers14030710 · Cited by 82
Self-citationDigital Health Applications in Oncology: An Opportunity to Seize
Parikh, R. B., Basen-Enquist, K. M., Bradley, C. J., Estrin, D. L., Levy, M. A., Lichtenfeld, J. L., Malin, B., McGraw, D., Meropol, N. J., Oyer, R. A., et al. (2022) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djac108 · Cited by 81
“Recent randomized trials show that routine collection of PROs during cancer treatment leads to improved physical function, symptom control, and quality of life (81) while reducing acute care utilization (82).”
BackgroundLizán, L., Pérez–Carbonell, L., & Comellas, M. (2021) · Cancers · doi:10.3390/cancers13184615 · Cited by 76
“[20] trial in metastatic patients, demonstrated that the electronic patient-reported symptom monitoring strategy was a cost-effective alternative (incremental cost-effectiveness ratio of €10,500.”
BackgroundMethodInfluentialHassett, M. J., Cronin, C., Tsou, T. C., Wedge, J., Bian, J., Dizon, D. S., Hazard-Jenkins, H. W., Osarogiagbon, R. U., Wong, S., Basch, E., et al. (2022) · JCO Clinical Cancer Informatics · doi:10.1200/cci.21.00137 · Cited by 81
“Recent studies suggest that patientreported outcomes (PROs) help address these shortcomings by enhancing symptom detection and improving symptom control.(9,13) Studies have found that using telehealth and web-based services to collect electronic PROs (ePROs) from patients with cancer is ASSOCIATED CONTENT”
BackgroundMethodInfluentialSelf-citationLoh, K. P., Ramsdale, E. E., Culakova, E., Mendler, J. H., Liesveld, J. L., O’Dwyer, K. M., McHugh, C. M., Gilles, M., Lloyd, T., Goodman, M., et al. (2018) · JMIR Cancer · doi:10.2196/10296 · Cited by 75
“In the cancer setting, mHealth apps have been designed for various uses which include providing education and support [16], monitoring symptoms and facilitating symptom reporting [17-20], monitoring medication adherence [21], promoting physical activity [22,23], and monitoring nutritional status and surgical care [24].”
BackgroundWasson, J. H., Ho, L., Soloway, L. E., & Moore, L. G. (2018) · PLoS ONE · doi:10.1371/journal.pone.0192475 · Cited by 72
Reck, M., Brahmer, J. R., Bennett, B., Taylor, F. C., Penrod, J. R., DeRosa, M., Dastani, H. B., Spigel, D. R., & Gralla, R. J. (2018) · European Journal of Cancer · doi:10.1016/j.ejca.2018.05.005 · Cited by 71
Turner, G., Litchfield, I. J., Finnikin, S., Aiyegbusi, O. L., & Calvert, M. (2020) · BMC Family Practice · doi:10.1186/s12875-019-1077-6 · Cited by 71
Zimmermann, C., Pope, A. J., Hannon, B. L., Krzyzanowska, M. K., Rodin, G., Li, M., Howell, D., Knox, J. J., Leighl, N. B., Sridhar, S. S., et al. (2021) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2020.7803 · Cited by 72
Innominato, P. F., Komarzynski, S., Palesh, O. G., Dallmann, R., Bjarnason, G. A., Giacchetti, S., Ulusakarya, A., Bouchahda, M., Haydar, M., Ballesta, A., et al. (2018) · Cancer Medicine · doi:10.1002/cam4.1711 · Cited by 71
Atkinson, T. M., Schwartz, C. E., Goldstein, L. A., Garcia, I., Storfer, D. F., Li, Y., Zhang, J., Bochner, B. H., & Rapkin, B. D. (2018) · Value in Health · doi:10.1016/j.jval.2018.07.875 · Cited by 72
“Despite the potential response burden associated with the completion of PRO measures in routine care and clinical trials, a growing number of patients with cancer are willing to selfreport their experiences to not only to inform the care that they personally receive, but also to assist others who may share similar dis…”
BackgroundSelf-citationSmith, T. G., Troeschel, A. N., Castro, K. M., Arora, N., Stein, K., Lipscomb, J., Brawley, O. W., McCabe, R. M., Clauser, S. B., & Ward, E. (2019) · Journal of Clinical Oncology · doi:10.1200/jco.18.01579 · Cited by 71
“With proper implementation, clinical use of PROs can improve symptom care and other outcomes.(45,46) This work highlights patient perceptions of symptom management, which are different from measures of symptom intensity.”
MethodMertz, B. G., Duun‐Henriksen, A. K., Kroman, N. T., Johansen, C., Andersen, K. G., Andersson, M., Mathiesen, U. B., Vibe-Petersen, J., Dalton, S. O., & Bidstrup, P. E. (2017) · Acta Oncologica · doi:10.1080/0284186x.2017.1358462 · Cited by 70
“studies have shown promising clinical benefits [8] and reduced symptoms [9].”
BackgroundNipp, R. D., El-Jawahri, A. R., Ruddy, M., Fuh, C., Temel, B., D’Arpino, S., Cashavelly, B. J., Jackson, V. A., Ryan, D. P., Hochberg, E. P., et al. (2018) · Annals of Oncology · doi:10.1093/annonc/mdy488 · Cited by 71
Aresi, G., Rayner, H. C., Hassan, L., Burton, J. O., Mitra, S., Sanders, C., & van der Veer, S. N. (2019) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2019.06.010 · Cited by 70
Patient-Reported Outcomes and Evidence-Based Practice in Speech-Language Pathology
Cohen, M. L., & Hula, W. D. (2020) · American Journal of Speech-Language Pathology · doi:10.1044/2019_ajslp-19-00076 · Cited by 77
Wei, X., Yu, H., Dai, W., Mu, Y., Wang, Y., Liao, J. X., Peng, L., Han, Y., Li, Q., & Shi, Q. (2021) · Annals of Surgical Oncology · doi:10.1245/s10434-021-09981-1 · Cited by 70
“A severe postoperative symptom burden and interference with daily functioning also may result in delayed postoperative chemotherapy.(17) Some studies have confirmed that the timing of postoperative treatment significantly affects overall prognosis and the long-term survival of patients.”
BackgroundDaly, B., Nicholas, K. J., Flynn, J. R., Silva, N., Panageas, K. S., Mao, J. J. J., Gazit, L., Gorenshteyn, D., Sokolowski, S. S., Newman, T., et al. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.1078 · Cited by 69
Rotenstein, L. S., Agarwal, A., O’Neil, K. A., Kelly, A. T., Keaty, M., Whitehouse, C., Kalinowski, B., Orio, P. F., Wagle, N. W., & Martin, N. E. (2017) · Journal of the American Medical Informatics Association · doi:10.1093/jamia/ocx009 · Cited by 68
Aapro, M., Scotté, F., Escobar, Y., Celio, L., Berman, R. B., Franceschetti, A., Bell, D., & Jordan, K. (2021) · The Oncologist · doi:10.1002/onco.13716 · Cited by 66
“Monitoring of common chemotherapy-related symptoms, such as nausea and vomiting, among others, through electronic patientreported outcomes, and their management has been shown to increase overall survival [5, 6].”
BackgroundCheung, Y. T., Chan, A., Charalambous, A., Darling, H., Eng, L., Grech, L., van den Hurk, C. J. G., Kirk, D., Mitchell, S. A., Poprawski, D. M., et al. (2021) · Supportive Care in Cancer · doi:10.1007/s00520-021-06545-7 · Cited by 72
Role of Kindness in Cancer Care
Berry, L. L., Danaher, T. S., Chapman, R., & Awdish, R. (2017) · Journal of Oncology Practice · doi:10.1200/jop.2017.026195 · Cited by 68
Patient-reported symptoms after breast cancer diagnosis and treatment: A retrospective cohort study
Davis, L., Bubis, L. D., Mahar, A. L., Li, Q., SUSSMAN, J. S., Moody, L., Barbera, L. C., Holloway, C. M. B., & Coburn, N. G. (2018) · European Journal of Cancer · doi:10.1016/j.ejca.2018.06.006 · Cited by 67
Evidence on the Use of Mobile Apps During the Treatment of Breast Cancer: Systematic Review
Cruz, F. O. A. M., Vilela, R. A., Ferreira, E. B., Melo, N. S., & Reis, P. E. D. D. (2019) · JMIR mHealth and uHealth · doi:10.2196/13245 · Cited by 66
“The use of tablet computers to self-report symptoms during cancer treatment was associated with significant clinical benefits, decreased emergency room admissions, and reduced hospitalizations [27].”
BackgroundRichards, H. S., Blazeby, J. M., Portal, A., Harding, R., Reed, T., Lander, T., Chalmers, K. A., Carter, R., Singhal, R., Absolom, K., et al. (2020) · BMC Cancer · doi:10.1186/s12885-020-07027-5 · Cited by 68
Next-Generation Cancer Rehabilitation: A Giant Step Forward for Patient Care
Alfano, C. M., & Pergolotti, M. (2018) · Rehabilitation Nursing · doi:10.1097/rnj.0000000000000174 · Cited by 69
Zhang, L., Zhang, X., Shen, L., Zhu, D., Ma, S., & Cong, L. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.4427 · Cited by 67
Treatment decisions and employment of breast cancer patients: Results of a population‐based survey
Jagsi, R., Abrahamse, P. H., Lee, K. L., Wallner, L. P., Janz, N. K., Hamilton, A. S., Ward, K. C., Morrow, M., Kurian, A. W., Friese, C. R., et al. (2017) · Cancer · doi:10.1002/cncr.30959 · Cited by 66
Estimation of Symptom Severity During Chemotherapy From Passively Sensed Data: Exploratory Study
Low, C. A., Dey, A. K., Ferreira, D., Kamarck, T. W., Sun, W., Bae, S. W., & Doryab, A. (2017) · Journal of Medical Internet Research · doi:10.2196/jmir.9046 · Cited by 66
“During outpatient treatment, such as chemotherapy, remote real-time monitoring of symptoms can enhance patient-provider communication and prevent potentially life-threatening adverse effects [3,4].”
BackgroundKirkhus, L., Harneshaug, M., Benth, J. Š., Grønberg, B. H., Rostoft, S., Bergh, S., Hjermstad, M. J., Selbæk, G., Wyller, T. B., Kirkevold, Ø., et al. (2019) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2019.08.001 · Cited by 66
Aiyegbusi, O. L., Nair, D., Peipert, J. D., Schick‐Makaroff, K., & Mucsi, I. (2021) · Therapeutic Advances in Chronic Disease · doi:10.1177/20406223211015958 · Cited by 66
“28 This effect was more pronounced when the computer-inexperienced subgroups of the two study arms were compared directly (34% versus 56%).”
BackgroundMethodInfluentialPatient-Reported Outcomes, Digital Health, and the Quest to Improve Health Equity
Pritchett, J. C., Patt, D., Thanarajasingam, G., Schuster, A., & Snyder, C. (2023) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_390678 · Cited by 65
Huang, I., Hudson, M. M., Robison, L. L., & Krull, K. R. (2017) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-16-1007 · Cited by 65
on behalf of the eRAPID systemic treatment work group, Absolom, K. L., Holch, P., Warrington, L., Samy, F., Hulme, C. T., Hewison, J., Morris, C., Bamforth, L., Conner, M. T., et al. (2017) · BMC Cancer · doi:10.1186/s12885-017-3303-8 · Cited by 65
Efficace, F., & Cannella, L. (2016) · Hematology · doi:10.1182/asheducation-2016.1.170 · Cited by 64
Health-Related Quality of Life after Autologous Stem Cell Transplantation for Multiple Myeloma
Chakraborty, R., Hamilton, B. K., Hashmi, S. K., Kumar, S. K., & Majhail, N. S. (2018) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2018.03.027 · Cited by 65
Perspectives on symptom experiences and symptom reporting among individuals on hemodialysis
Flythe, J. E., Dorough, A., Narendra, J. H., Forfang, D. L., Hartwell, L., & Abdel‐Rahman, E. M. (2018) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfy069 · Cited by 64
A step-by-step approach for selecting an optimal minimal important difference
Wang, Y., Devji, T., Carrasco‐Labra, A., King, M. T., Terluin, B., Terwee, C. B., Walsh, M. W., Furukawa, T. A., & Guyatt, G. H. (2023) · BMJ · doi:10.1136/bmj-2022-073822 · Cited by 63
Rocque, G. B., Dent, D. N., Ingram, S. A., Caston, N. E., Thigpen, H. B., Lalor, F. R., Jamy, O. H., Giri, S., Azuero, A., Young Pierce, J., et al. (2022) · JCO Oncology Practice · doi:10.1200/op.22.00360 · Cited by 62
“The remote symptom monitoring intervention implemented at UAB and MCI is consistent with the evidence-based intervention shown to be effective by Basch et al 1,2 and consistent with the European Society of Medical Oncology clinical practice guidelines.”
MethodSelf-citationSkovlund, P. C., Ravn, S., Seibæk, L., Thaysen, H. V., Lomborg, K. E., & Nielsen, B. K. (2020) · Journal of Patient-Reported Outcomes · doi:10.1186/s41687-020-0174-6 · Cited by 62
Mitchell, K. R., Brassil, K. J., Rodriguez, S. A., Tsai, E., Fujimoto, K., Krause, K. J., Shay, L. A., & Springer, A. E. (2020) · Psycho-Oncology · doi:10.1002/pon.5500 · Cited by 62
Hueniken, K., Douglas, C. M., Jethwa, A. R., Mirshams, M., Eng, L., Hope, A. J., Chepeha, D. B., Goldstein, D. P., Ringash, J. G., Hansen, A. R., et al. (2020) · Cancer · doi:10.1002/cncr.33032 · Cited by 63
Withers, K. L., Palmer, R. I., Lewis, S., & Carolan‐Rees, G. (2020) · Quality of Life Research · doi:10.1007/s11136-020-02711-2 · Cited by 72
van den Hurk, C. J. G., Mols, F., Eicher, M., Chan, R. J., Becker‐Commissaris, A., Geleijnse, G., Walraven, I., Coolbrandt, A., Lustberg, M. B., Velikova, G., et al. (2022) · Current Oncology · doi:10.3390/curroncol29060349 · Cited by 64
“, moderate or severe symptoms) and/or worsening of a symptom(s) are common in cancer symptom monitoring [37,56,57].”
BackgroundSelf-citationDronkers, E. A. C., de Jong, R. J. B., van der Poel, E. F., Sewnaik, A., & Offerman, M. P. J. (2020) · Head & Neck · doi:10.1002/hed.26425 · Cited by 61
“There is evidence from general cancer care that clinical interventions following the routine use of ePROs in clinical practice may improve patients' HRQoL, enhance doctor-patient communication, and may even lengthen survival, for example, among patients with advanced cancers.(1,12) ePROs can also play a role in shared…”
BackgroundInfluentialAttia, S., Bolejack, V., Ganjoo, K. N., George, S., Agulnik, M., Rushing, D. A., Loggers, E. T., Livingston, M. B., Wright, J. A., Chawla, S. P., et al. (2022) · Cancer Medicine · doi:10.1002/cam4.5044 · Cited by 60
Bæksted, C., Pappot, H., Nissen, A., Hjøllund, N. H., Mitchell, S. A., Basch, E., Bidstrup, P. E., Dalton, S. O., & Johansen, C. (2017) · Journal of Patient-Reported Outcomes · doi:10.1186/s41687-017-0005-6 · Cited by 60
“Prior studies have used hardcopy feedback reports to clinicians or a limited number of symptom questions, as well as a variety of software systems for patient reporting [9 – 14].”
MethodSelf-citationPatient-Reported Outcomes in Patients with Chronic Kidney Disease and Kidney Transplant—Part 1
Tang, E., Bansal, A., Novak, M., & Mucsi, I. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2017.00254 · Cited by 51
“These findings support the use and potential implications of using PROs in CKD management (39, 47).”
BackgroundResultAiyegbusi, O. L., Kyte, D. G., Cockwell, P., Marshall, T. P., Dutton, M., Walmsley-Allen, N., Slade, A. L., McMullan, C., & Calvert, M. (2019) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2019.02.011 · Cited by 60
Metadata
- Authors
- Basch, E., Deal, A. M., Kris, M. G., Scher, H. I., Hudis, C. A., Sabbatini, P., Rogak, L., Bennett, A. V., Dueck, A. C., Atkinson, T. M., Chou, J. F., Dulko, D., Sit, L., Barz, A., Novotny, P., Fruscione, M., Sloan, J. A., & Schrag, D.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Ethan Basch, Mark G. Kris, Howard I. Scher, Clifford A. Hudis, Paul Sabbatini, Lauren Rogak, Thomas M. Atkinson, Joanne F. Chou, Dorothy Dulko, Laura Sit, Michael Fruscione, and Deborah Schrag, Memorial Sloan Kettering Cancer Center, New York, NY; Ethan Basch, Allison M. Deal, and Antonia V. Bennett, University of North Carolina, Chapel Hill, NC; Amylou C. Dueck, Mayo Clinic, Scottsdale, AZ; Allison Barz, Children’s Hospital of Philadelphia, Philadelphia, PA; Paul Novotny and Jeff A. Sloan, Mayo Clinic,...
- ORCID
- Venue
- Journal of Clinical Oncology
- Published
- 2016-02-20
- Volume
- 34
- Issue
- 6
- Pages
- 557-565
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- PMC
- PMC4872028
- OpenAlex
- W2195040438
- Cited by
- 2,593
- References
- 36
- Citations by year
- 2026: 252 · 2025: 263 · 2024: 321 · 2023: 288 · 2022: 316 · 2021: 299 · 2020: 292 · 2019: 191 · 2018: 180 · 2017: 143 · 2016: 44
- FWCI
- 53.87
- Type
- journal article
- Language
- en
- Update notices
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Oncology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Memorial Sloan-Kettering Cancer Center
- Society of Memorial Sloan Kettering
- National Cancer Institute (P30CA008748, P30CA015083, P30CA016086)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Keywords
- patient-reported outcomes, symptom monitoring, cancer chemotherapy, health-related quality of life, advanced solid tumors, e-mail alerts, emergency department visits, hospitalization, survival, quality-adjusted survival, computer literacy, outpatient oncology
- MeSH terms
- Adult, Aged, Aged, 80 and over, Ambulatory Care, Antineoplastic Agents, Emergency Service, Hospital, Female, Hospitalization, Humans, Male, Middle Aged, Neoplasms, Quality of Life, Survival Rate, Internet, Nurse's Role, Electronic Mail, Self Report, Symptom Assessment
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