The time toxicity of cancer treatment

Radiotherapy Plus Concomitant and Adjuvant Temozolomide for Glioblastoma

Stupp, R., Mason, W. P., van den Bent, M. J., Weller, M., Fisher, B., Taphoorn, M. J. B., Belanger, K., Brandes, A. A., Marosi, C., Bogdahn, U., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043330 · Cited by 21,807 · see citing works

<i>MGMT</i> Gene Silencing and Benefit from Temozolomide in Glioblastoma

Hegi, M. E., Diserens, A.-C., Gorlia, T., Hamou, M.-F., de Tribolet, N., Weller, M., Kros, J. M., Hainfellner, J. A., Mason, W., Mariani, L., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043331 · Cited by 7,405 · see citing works

Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness

The ESCAPE Investigators and ESCAPE Study Coordinators* (2005) · JAMA · doi:10.1001/jama.294.13.1625 · Cited by 1,527 · see citing works

Balanced Crystalloids versus Saline in Noncritically Ill Adults

Self, W. H., Semler, M. W., Wanderer, J. P., Wang, L., Byrne, D. W., Collins, S. P., Slovis, C. M., Lindsell, C. J., Ehrenfeld, J. M., Siew, E. D., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1711586 · Cited by 1,156 · see citing works

Prasugrel versus clopidogrel for acute coronary syndromes without revascularization

Roe, M. T., Armstrong, P. W., Fox, K. A. A., White, H. D., Prabhakaran, D., Goodman, S. G., Cornel, J. H., Bhatt, D. L., Clemmensen, P., Martinez, F., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1205512 · Cited by 874 · see citing works

Second-line FOLFOX chemotherapy versus active symptom control for advanced biliary tract cancer (ABC-06): a phase 3, open-label, randomised, controlled trial

Lamarca, Á., Palmer, D. H., Wasan, H. S., Ross, P. J., Ma, Y. T., Arora, A., Falk, S. J., Gillmore, R., Wadsley, J., Patel, K., et al. (2021) · The Lancet Oncology · doi:10.1016/s1470-2045(21)00027-9 · Cited by 781 · see citing works

NXY-059 for Acute Ischemic Stroke

Lees, K. R., Zivin, J. A., Ashwood, T., Davalos, A., Davis, S. M., Diener, H.-C., Grotta, J., Lyden, P., Shuaib, A., Hårdemark, H.-G., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052980 · Cited by 660 · see citing works

Physical rehabilitation for older patients hospitalized for heart failure

Kitzman, D. W., Whellan, D. J., Duncan, P., Pastva, A. M., Mentz, R. J., Reeves, G. R., Nelson, M. B., Chen, H., Upadhya, B., Reed, S. D., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2026141 · Cited by 594 · see citing works

Unintended Consequences of Expensive Cancer Therapeutics—The Pursuit of Marginal Indications and a Me-Too Mentality That Stifles Innovation and Creativity

Fojo, T., Mailankody, S., & Lo, A. W. (2014) · JAMA Otolaryngology–Head & Neck Surgery · doi:10.1001/jamaoto.2014.1570 · Cited by 303 · see citing works

Days Spent at Home — A Patient-Centered Goal and Outcome

Groff, A. C., Colla, C. H., & Lee, T. H.-Y. (2016) · New England Journal of Medicine · doi:10.1056/nejmp1607206 · Cited by 272 · see citing works

Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia

The COVID STEROID 2 Trial Group, Russell, L., Uhre, K. R., Lindgaard, A. L. S., Degn, J. F., Wetterslev, M., Sivapalan, P., Anthon, C. T., Mikkelsen, V. S., la Porta, L. C., et al. (2021) · JAMA · doi:10.1001/jama.2021.18295 · Cited by 253 · see citing works

Days Alive and Out of Hospital

Jerath, A., Austin, P. C., & Wijeysundera, D. N. (2019) · Anesthesiology · doi:10.1097/aln.0000000000002701 · Cited by 225 · see citing works

Evolution of the Randomized Clinical Trial in the Era of Precision Oncology

Paggio, J. C. D., Berry, J. S., Hopman, W. M., Eisenhauer, E. A., Prasad, V. K., Gyawali, B., & Booth, C. M. (2021) · JAMA Oncology · doi:10.1001/jamaoncol.2021.0379 · Cited by 211 · see citing works

Days alive and out of hospital and the patient journey in patients with heart failure: Insights from the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) program

Ariti, C. A., Cleland, J. G. F., Pocock, S., Pfeffer, M. A., Swedberg, K. B., Granger, C. B., McMurray, J. J. V., Michelson, E. L., Östergren, J., & Yusuf, S. (2011) · American Heart Journal · doi:10.1016/j.ahj.2011.08.003 · Cited by 193 · see citing works

Days at Home after Surgery: An Integrated and Efficient Outcome Measure for Clinical Trials and Quality Assurance

Bell, M., Eriksson, L. I., Svensson, T., Hallqvist, L., Granath, F. N., Reilly, J. R., & Myles, P. S. (2019) · EClinicalMedicine · doi:10.1016/j.eclinm.2019.04.011 · Cited by 148 · see citing works

Hospital-Free Days: A Pragmatic and Patient-centered Outcome for Trials among Critically and Seriously Ill Patients

Auriemma, C. L., Taylor, S. P., Harhay, M. O., Courtright, K. R., & Halpern, S. D. (2021) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202104-1063pp · Cited by 130 · see citing works

At What Cost to Clinical Trial Enrollment? A Retrospective Study of Patient Travel Burden in Cancer Clinical Trials

Borno, H. T., Zhang, L., Siegel, A. P., Chang, E. G., & Ryan, C. J. (2018) · The Oncologist · doi:10.1634/theoncologist.2017-0628 · Cited by 125 · see citing works

Home-Time After Discharge Among Patients Hospitalized With Heart Failure

Greene, S. J., O'Brien, E. C., Mentz, R. J., Luo, N., Hardy, N. C., Laskey, W. K., Heidenreich, P. A., Chang, C.-L., Turner, S. J., Yancy, C. W., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.03.517 · Cited by 116 · see citing works

Healthy Days at home: A novel population-based outcome measure

Burke, L. G., Orav, E. J., Zheng, J., & Jha, A. K. (2019) · Healthcare · doi:10.1016/j.hjdsi.2019.100378 · Cited by 100 · see citing works

Assessment of Home-Time After Acute Ischemic Stroke in Medicare Beneficiaries

Fonarow, G. C., Liang, L., Thomas, L. E., Xian, Y., Saver, J. L., Smith, E. E., Schwamm, L. H., Peterson, E. D., Hernandez, A. F., Duncan, P. W., et al. (2016) · Stroke · doi:10.1161/strokeaha.115.011599 · Cited by 97 · see citing works

Days Alive and Out of Hospital: Exploring a Patient-Centered, Pragmatic Outcome in a Clinical Trial of Patients With Acute Coronary Syndromes

Fanaroff, A. C., Cyr, D. D., Neely, M. L., Bakal, J. A., White, H. D., Fox, K. A. A., Armstrong, P. W., Lópes, R. D., Ohman, E. M., & Roe, M. T. (2018) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.118.004755 · Cited by 86 · see citing works

Patient-Centered Time-at-Home Outcomes in Older Adults After Surgical Cancer Treatment

Chesney, T. R., Haas, B., Coburn, N. G., Mahar, A. L., Zuk, V., Zhao, H., Wright, F. C., Hsu, A. T., & Hallet, J. I. (2020) · JAMA Surgery · doi:10.1001/jamasurg.2020.3754 · Cited by 73 · see citing works

Opportunity Costs of Receiving Palliative Chemotherapy for Metastatic Pancreatic Ductal Adenocarcinoma

Bange, E. M., Doucette, A. G., Gabriel, P. E., Porterfield, F., Harrigan, J. J., Wang, R., Wojcieszynski, A. P., Boursi, B., Mooney, B., Reiss, K. A., et al. (2020) · JCO Oncology Practice · doi:10.1200/jop.19.00328 · Cited by 69 · see citing works

Evaluation of Oncology Hospital at Home: Unplanned Health Care Utilization and Costs in the Huntsman at Home Real-World Trial

Mooney, K. H., Titchener, K., Haaland, B. A., Coombs, L. A., O'Neil, B. B., Nelson, R. E., McPherson, J. P., Kirchhoff, A. C., Beck, A. C., & Ward, J. H. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.20.03609 · Cited by 64 · see citing works

The Oncology Hospital at Home

Handley, N. R., & Bekelman, J. E. (2019) · Journal of Clinical Oncology · doi:10.1200/jco.18.01167 · Cited by 61 · see citing works

Annual Patient Time Costs Associated With Medical Care Among Cancer Survivors in the United States

Yabroff, K. R., Guy, G. P., Ekwueme, D. U., McNeel, T. S., Rozjabek, H., Dowling, E. C., Li, C., & Virgo, K. S. (2014) · Medical Care · doi:10.1097/mlr.0000000000000151 · Cited by 60 · see citing works

Time-Related Burdens of Cancer Care

Gupta, A., Jensen, E. H., Virnig, B. A., & Beg, M. S. (2021) · JCO Oncology Practice · doi:10.1200/op.21.00662 · Cited by 57 · see citing works

Health care‐related time costs in patients with metastatic breast cancer

Rocque, G. B., Williams, C., Ingram, S. A., Azuero, A., Mennemeyer, S. T., Pierce, J. Y., Nipp, R. D., Reeder-Hayes, K. E., & Kenzik, K. M. (2020) · Cancer Medicine · doi:10.1002/cam4.3461 · Cited by 52 · see citing works

Home Time Is Extended in Patients With Ischemic Stroke Who Receive Thrombolytic Therapy

Mishra, N. K., Shuaib, A. M., Lyden, P. D., Diener, H., Grotta, J. C., Davis, S. M., Dávalos, A., Ashwood, T. J., Wasiewski, W. W., & Lees, K. R. (2011) · Stroke · doi:10.1161/strokeaha.110.601302 · Cited by 50 · see citing works

Hospital Length of Stay in the First 100 Days after Allogeneic Hematopoietic Cell Transplantation for Acute Leukemia in Remission: Comparison among Alternative Graft Sources

Ballen, K. K., Joffe, S., Brazauskas, R., Wang, Z., Aljurf, M. D., Akpek, G., Dandoy, C. E., Frangoul, H., Freytes, C. O., Khera, N., et al. (2014) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2014.07.021 · Cited by 48 · see citing works

Has the Current Oncology Value Paradigm Forgotten Patients’ Time?

Fundytus, A. M., Prasad, V. K., & Booth, C. M. (2021) · JAMA Oncology · doi:10.1001/jamaoncol.2021.3600 · Cited by 46 · see citing works

Hospital Variation in Home-Time After Acute Ischemic Stroke

O'Brien, E. C., Xian, Y., Xu, H., Wu, J., Saver, J. L., Smith, E. E., Schwamm, L. H., Peterson, E. D., Reeves, M. J., Bhatt, D. L., et al. (2016) · Stroke · doi:10.1161/strokeaha.116.013563 · Cited by 43 · see citing works

Days out of Institution after Tracheostomy and Gastrostomy Placement in Critically Ill Older Adults

Law, A. C., Stevens, J. P., Choi, E., Shen, C., Mehta, A., Yeh, R. W., & Walkey, A. J. (2021) · Annals of the American Thoracic Society · doi:10.1513/annalsats.202106-649oc · Cited by 32 · see citing works

Maximizing Home Time for Persons With Cancer

Banerjee, R. K., George, M., & Gupta, A. (2021) · JCO Oncology Practice · doi:10.1200/op.20.01071 · Cited by 31 · see citing works

Healthcare utilization after liver transplantation is highly variable among both centers and recipients

Bittermann, T., Hubbard, R. A., Serper, M., Lewis, J. D., Hohmann, S., VanWagner, L. B., & Goldberg, D. S. (2017) · American Journal of Transplantation · doi:10.1111/ajt.14539 · Cited by 28 · see citing works

Comparing regression modeling strategies for predicting hometime

Holodinsky, J. K., Yu, A., Kapral, M. K., & Austin, P. C. (2021) · BMC Medical Research Methodology · doi:10.1186/s12874-021-01331-9 · Cited by 25 · see citing works

Alirocumab Reduces Total Hospitalizations and Increases Days Alive and Out of Hospital in the ODYSSEY OUTCOMES Trial

Szarek, M. J., Steg, P. G., DiCenso, D., Bhatt, D. L., Bittner, V., Budaj, A., Díaz, R., Goodman, S. G., Gotcheva, N. N., Jukema, J. W., et al. (2019) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.119.005858 · Cited by 23 · see citing works

Opportunity Costs of Surgical Resection and Perioperative Chemotherapy for Locoregional Pancreatic Adenocarcinoma

Lim, S.-A., Hao, S. B., Boyd, B. A., Mitsakos, A. T., Irish, W. D., Burke, A. M., Parikh, A. A., & Snyder, R. A. (2021) · JCO Oncology Practice · doi:10.1200/op.21.00311 · Cited by 23 · see citing works

The Toxicity of Time

Daily, K. C. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2017.74.7907 · Cited by 19 · see citing works

Evaluation of Risk-Adjusted Home Time After Acute Myocardial Infarction as a Novel Hospital-Level Performance Metric for Medicare Beneficiaries

Pandey, A., Keshvani, N., Vaughan‐Sarrazin, M., Gao, Y., & Girotra, S. R. (2020) · Circulation · doi:10.1161/circulationaha.119.044765 · Cited by 19 · see citing works

Comparison of Days Alive Out of Hospital With Initial Invasive vs Conservative Management

White, H. D., O’Brien, S. M., Alexander, K. P., Boden, W. E., Bangalore, S., Li, J., Manjunath, C. N., Lopez-Sendon, J. L., Peteiro, J., Gosselin, G., et al. (2021) · JAMA Cardiology · doi:10.1001/jamacardio.2021.1651 · Cited by 18 · see citing works

Reducing Wait Time Between Admission and Chemotherapy Initiation

Gupta, A., Li, J., Tawfik, B., Pham, T. N., Pathak, S., Singh, P., Porsa, E., Sadeghi, N., & Li, H. C. (2018) · Journal of Oncology Practice · doi:10.1200/jop.17.00028 · Cited by 14 · see citing works

Time Spent Away from Home in the Year Following High‐Risk Cancer Surgery in Older Adults

Suskind, A. M., Zhao, S., Boscardin, W. J., Smith, A. K., & Finlayson, E. V. A. (2020) · Journal of the American Geriatrics Society · doi:10.1111/jgs.16344 · Cited by 14 · see citing works

Caregiver Burden #419

Sedhom, R., Samaan, A., & Gupta, A. (2021) · Journal of Palliative Medicine · doi:10.1089/jpm.2021.0244 · Cited by 10 · see citing works

Risk-Standardized Home Time as a Novel Hospital Performance Metric for Pneumonia Hospitalization Among Medicare Beneficiaries: a Retrospective Cohort Study

Nair, R., Gao, Y., Vaughan‐Sarrazin, M., Perencevich, E. N., Girotra, S. R., & Pandey, A. (2021) · Journal of General Internal Medicine · doi:10.1007/s11606-021-06712-w · Cited by 9 · see citing works

Development of the Oncology Opportunity Cost Assessment Tool: Item Generation and Content Validity Testing

Handley, N. R., Binder, A. F., Heyer, A., Granberg, R. E., Davis, G., Nord, G., Gentsch, A. T., & Rising, K. L. (2021) · JCO Oncology Practice · doi:10.1200/op.21.00288 · Cited by 9 · see citing works

Seeking patient-centered trial outcomes: The case for days alive out of hospital

Faggioni, M., & Fanaroff, A. C. (2021) · American Heart Journal · doi:10.1016/j.ahj.2021.04.016 · Cited by 8 · see citing works

Digital health and telehealth in cancer care: A scoping review of reviews

Shaffer, K. M., Turner, K. L., Siwik, C., Gonzalez, B. D., Upasani, R., Glazer, J. V., Ferguson, R. J., Joshua, C., & Low, C. A. (2023) · The Lancet Digital Health · doi:10.1016/s2589-7500(23)00049-3 · Cited by 263 · see citing works

Patient-Reported Outcome Measures in Cancer Care

Balitsky, A. K., Rayner, D. G., Britto, J., Lionel, A. C., Ginsberg, L., Cho, W., Wilfred, A. M., Sardar, H., Cantor, N., Mian, H. S., et al. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.24793 · Cited by 134 · see citing works

Addressing Transportation Insecurity Among Patients With Cancer

Graboyes, E. M., Chaiyachati, K. H., Gall, J. S., Johnson, W., Krishnan, J. A., McManus, S. S., Thompson, L., Shulman, L. N., & Yabroff, K. R. (2022) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djac134 · Cited by 97 · see citing works

Oral decitabine–cedazuridine versus intravenous decitabine for myelodysplastic syndromes and chronic myelomonocytic leukaemia (ASCERTAIN): a registrational, randomised, crossover, pharmacokinetics, phase 3 study

Garcia‐Manero, G., McCloskey, J. K., Griffiths, E. A., Yee, K. W. L., Zeidan, A. M., Al‐Kali, A., Deeg, H. J., Patel, P. A., Sabloff, M., Keating, M., et al. (2023) · The Lancet Haematology · doi:10.1016/s2352-3026(23)00338-1 · Cited by 94 · see citing works

Evaluating the Time Toxicity of Cancer Treatment in the CCTG CO.17 Trial

Gupta, A., O'Callaghan, C. J., Zhu, L., Jonker, D. J., Wong, R. P. W., Colwell, B., Moore, M. J., Karapetis, C. S., Tebbutt, N. C., Shapiro, J. D., et al. (2023) · JCO Oncology Practice · doi:10.1200/op.22.00737 · Cited by 79 · see citing works

Patient, Caregiver, and Clinician Perspectives on the Time Burdens of Cancer Care

Gupta, A., Johnson, W. V., Henderson, N. L., Ogunleye, O. O., Sekar, P., George, M., Breininger, A., Kyle, M. A., Booth, C. M., Hanna, T. P., et al. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.47649 · Cited by 72 · see citing works

The unequal burden of time toxicity

Johnson, W. V., Blaes, A. H., Booth, C. M., Ganguli, I., & Gupta, A. (2023) · Trends in cancer · doi:10.1016/j.trecan.2023.01.006 · Cited by 61 · see citing works

Progression-free survival and quality of life in metastatic breast cancer: The patient perspective

Mertz, S. A., Benjamin, C., Girvalaki, C., Cardone, A., Gono, P., May, S. G., Comerford, E., Than, K., Birch, K., Roach, M., et al. (2022) · The Breast · doi:10.1016/j.breast.2022.07.006 · Cited by 56 · see citing works

The human crisis in cancer: a Lancet Oncology Commission

Rodin, G., Feldman, A., Trapani, D., Skelton, M., Unger‐Saldaña, K., Essue, B. M., Pihlak, R., Walshe, C., Rosa, W. E., Banegas, M. P., et al. (2025) · The Lancet Oncology · doi:10.1016/s1470-2045(25)00530-3 · Cited by 67 · see citing works

Treatment burden in individuals living with and beyond cancer: A systematic review of qualitative literature

Adam, R., Nair, R., Duncan, L., Yeoh, E., Chan, J., Vilenskaya, V., & Gallacher, K. (2023) · PLoS ONE · doi:10.1371/journal.pone.0286308 · Cited by 56 · see citing works

Consuming Patients’ Days: Time Spent on Ambulatory Appointments by People With Cancer

Kagalwalla, S., Tsai, A. K., George, M., Waldock, A., Davis, S., Jewett, P. I., Vogel, R. I., Ganguli, I., Booth, C. M., Dusetzina, S. B., et al. (2024) · The Oncologist · doi:10.1093/oncolo/oyae016 · Cited by 49 · see citing works

Common Sense Oncology principles for the design, analysis, and reporting of phase 3 randomised clinical trials

Gyawali, B., Eisenhauer, E. A., van der Graaf, W., Booth, C. M., Cherny, N. I., Goodman, A. M., Koven, R., Pe, M. L., Marini, B. L., Mohyuddin, G. R., et al. (2025) · The Lancet Oncology · doi:10.1016/s1470-2045(24)00451-0 · Cited by 50 · see citing works

Changes in Health Care Costs, Survival, and Time Toxicity in the Era of Immunotherapy and Targeted Systemic Therapy for Melanoma

Bateni, S. B., Nguyen, P., Eskander, A. E., Seung, S. J., Mittmann, N., Jalink, M., Gupta, A., Chan, K., Hong, N. J. L., & Hanna, T. P. (2023) · JAMA Dermatology · doi:10.1001/jamadermatol.2023.3179 · Cited by 46 · see citing works

Outcome prioritization and preferences among older adults with cancer starting chemotherapy in a randomized clinical trial

Soto‐Pérez‐de‐Celis, E., Dale, W., Katheria, V., Kim, H., Fakih, M., Chung, V. M., Lim, D. W., Mortimer, J. E., Chien, L. C., Charles, K., et al. (2024) · Cancer · doi:10.1002/cncr.35333 · Cited by 46 · see citing works

Health Care Contact Days Among Older Adults in Traditional Medicare

Ganguli, I., Chant, E. D., Orav, E. J., Mehrotra, A., & Ritchie, C. S. (2024) · Annals of Internal Medicine · doi:10.7326/m23-2331 · Cited by 44 · see citing works

Patients’ considerations of time toxicity when assessing cancer treatments with marginal benefit

Gupta, A., Brundage, M., Galica, J., Karim, S., Koven, R., Ng, T. L., O’Donnell, J., tenHove, J., Robinson, A. G., & Booth, C. M. (2024) · The Oncologist · doi:10.1093/oncolo/oyae187 · Cited by 46 · see citing works

The intersecting time, administrative, and financial burdens of a cancer diagnosis

Parsons, H. M., Gupta, A., Jewett, P. I., & Vogel, R. I. (2024) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djae252 · Cited by 46 · see citing works

Health Care Contact Days Experienced by Decedents With Advanced GI Cancer

Patel, V. R., Ramesh, V., Tsai, A. K., Sedhom, R., Westanmo, A. D., Blaes, A. H., Vogel, R. I., Parsons, H. M., Hanna, T. P., Ganguli, I., et al. (2023) · JCO Oncology Practice · doi:10.1200/op.23.00232 · Cited by 42 · see citing works

10-day decitabine versus 3 + 7 chemotherapy followed by allografting in older patients with acute myeloid leukaemia: an open-label, randomised, controlled, phase 3 trial

Lübbert, M., Wijermans, P., Kiciński, M., Chantepie, S., van der Velden, W. J. F. M., Noppeney, R., Griškevičius, L., Neubauer, A., Crysandt, M. M., Vrḫovac, R., et al. (2023) · The Lancet Haematology · doi:10.1016/s2352-3026(23)00273-9 · Cited by 40 · see citing works

Time toxicity associated with early phase clinical trial participation

Nindra, U., Shivasabesan, G., Childs, S., Yoon, R., Haider, S., Hong, M., Cooper, A. J., Roohullah, A., Wilkinson, K., Pal, A., et al. (2023) · ESMO Open · doi:10.1016/j.esmoop.2023.102046 · Cited by 39 · see citing works

Unmet Needs, Quality of Life, and Financial Toxicity Among Survivors of Lung Cancer

Hsu, M. L., Boulanger, M. C., Olson, S., Eaton, C. K., Prichett, L. M., Guo, M. Z., Miller, M. E., Brahmer, J. R., Forde, P. M., Marrone, K. A., et al. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.6872 · Cited by 39 · see citing works

Contact Days Associated With Cancer Treatments in the CCTG LY.12 Trial

Gupta, A., Hay, A. E., Crump, M., Djurfeldt, M., Zhu, L., Cheung, M. C., Shepherd, L. E., Chen, B. E., & Booth, C. M. (2023) · The Oncologist · doi:10.1093/oncolo/oyad128 · Cited by 37 · see citing works

Rapid Advances in Resectable Non–Small Cell Lung Cancer

West, H., & Kim, J. Y. (2023) · JAMA Oncology · doi:10.1001/jamaoncol.2023.5276 · Cited by 37 · see citing works

Financial Toxicity, Time Toxicity, and Quality of Life in Multiple Myeloma

Banerjee, R. K., Cowan, A. J., Chavez-Ortega, M., Missimer, C., Carpenter, P. A., Ueda, M., Salit, R. B., Vo, P., Lee, C. J., Mehta, R. S., et al. (2024) · Clinical Lymphoma Myeloma & Leukemia · doi:10.1016/j.clml.2024.02.013 · Cited by 37 · see citing works

Arf1 Ablation in Colorectal Cancer Cells Activates a Super Signal Complex in DC to Enhance Anti‐Tumor Immunity

Ma, H., Fang, W., Li, Q., Wang, Y., & Hou, X. S. (2023) · Advanced Science · doi:10.1002/advs.202305089 · Cited by 36 · see citing works

Impact of Performance Status on Survival Outcomes and Health Care Utilization in Patients With Advanced NSCLC Treated With Immune Checkpoint Inhibitors

Meyers, D. E., Pasternak, M., Dolter, S., Grosjean, H. A. I., Lim, C. A.-R., Stukalin, I., Goutam, S., Navani, V., Heng, D. Y. C., Cheung, W. Y., et al. (2023) · JTO Clinical and Research Reports · doi:10.1016/j.jtocrr.2023.100482 · Cited by 35 · see citing works

Tackling Non–Small Cell Lung Cancer in Young Adults: From Risk Factors and Genetic Susceptibility to Lung Cancer Profile and Outcomes

Laguna, J. C., Tagliamento, M., Lambertini, M., Hiznay, J. M., & Mezquita, L. (2024) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_432488 · Cited by 37 · see citing works

Liver Transplantation for Hepatic Metastases from Colorectal Cancer: Current Knowledge and Open Issues

Maspero, M., Sposito, C., Virdis, M., Citterio, D., Pietrantonio, F., Bhoori, S., Belli, F., & Mazzaferro, V. (2023) · Cancers · doi:10.3390/cancers15020345 · Cited by 35 · see citing works

Cancer diagnosis and treatment in working‐age adults: Implications for employment, health insurance coverage, and financial hardship in the United States

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Logistic burdens of cancer care: A qualitative study

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Trajectories of Health Care Contact Days for Patients With Stage IV Non–Small Cell Lung Cancer

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Exercise as cancer treatment: A clinical oncology framework for exercise oncology research

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Health Care Contact Days Among Older Cancer Survivors

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Trajectory of Healthcare Contact Days for Veterans With Advanced Gastrointestinal Malignancy

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Time Toxicity Experienced by Early-Phase Cancer Clinical Trial Participants

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A taxonomy of the factors contributing to the overtreatment of cancer patients at the end of life. What is the problem? Why does it happen? How can it be addressed?

Cherny, N. I., Nortjé, N., Kelly, R., Zimmermann, C., Jordan, K., Kreye, G., Le, N., & Adelson, K. B. (2025) · ESMO Open · doi:10.1016/j.esmoop.2024.104099 · Cited by 28 · see citing works

Time toxicity in cancer care: A concept analysis using Walker and Avant's method

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Promising Therapeutic Strategies for Hematologic Malignancies: Innovations and Potential

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Efficacy‐effectiveness gaps in oncology: Looking beyond survival

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Same-day post-therapy imaging with a new generation whole-body digital SPECT/CT in assessing treatment response to [177Lu]Lu-PSMA-617 in metastatic castration-resistant prostate cancer

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Real-World Implementation of Simulation-Free Radiation Therapy (SFRT-1000): A Propensity Score-Matched Analysis of 1000 Consecutive Palliative Courses Delivered in Routine Care

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Cost and value of cancer medicines in a single-payer public health system in Ontario, Canada: a cross-sectional study

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“It is not the fault of the health care team - it is the way the system works”: a mixed-methods quality improvement study of patients with advanced cancer and family members reveals challenges navigating a fragmented healthcare system and the administrative and financial burdens of care

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Oral decitabine/cedazuridine versus intravenous decitabine for acute myeloid leukaemia: A randomised, crossover, registration, pharmacokinetics study

Geissler, K. H., Kořı́stek, Z., Bernal, T., Novák, J., Rodríguez‐Macías, G., Metzelder, S., Illés, Á., Mayer, J., Arnán, M., Keating, M., et al. (2024) · British Journal of Haematology · doi:10.1111/bjh.19741 · Cited by 23 · see citing works

Time Toxicity of Systemic Anticancer Therapy for Metastatic Lung Cancer in Routine Clinical Practice: A Nationwide Cohort Study

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Systemic treatment in patients with hepatocellular carcinoma and advanced liver dysfunction

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Climate toxicity: An increasingly relevant clinical issue in Cancer Care

Weadick, C. S., Keogh, R. J., Carroll, H. K., Boldrin, S., Mulroe, E., Murphy, L., Sheils, B., Barry, A. S., & O’Reilly, S. (2023) · Journal of Cancer Policy · doi:10.1016/j.jcpo.2023.100410 · Cited by 20 · see citing works

Improving Access to Patient-Focused, Decentralized Clinical Trials Requires Streamlined Regulatory Requirements: An ASCO Research Statement

Thota, R., Hurley, P. A., Miller, T. M., Bruinooge, S. S., Lipset, C. H., Harvey, R. D., Black, L. J., Dinsdale, A., Merrill, J. K., Pollastro, T., et al. (2024) · Journal of Clinical Oncology · doi:10.1200/jco.24.00961 · Cited by 20 · see citing works

Common Sense Oncology: Equity, Value, and Outcomes That Matter

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A Life-Affirming Palliative Care Model for Severe and Enduring Anorexia Nervosa

Treem, J., Yager, J., & Gaudiani, J. L. (2023) · The AMA Journal of Ethic · doi:10.1001/amajethics.2023.703 · Cited by 18 · see citing works

Mitigating time toxicity in lymphoma and multiple myeloma

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Subcutaneous vs Intravenous Trastuzumab/Pertuzumab: A Time and Motion Substudy of a Phase II Trial of Adjuvant Trastuzumab/Pertuzumab for Stage I HER2+ Breast Cancer (ADEPT trial)

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Time toxicity among older patients with cancer treated with palliative systemic therapy

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All-Oral Treatment of Newly Diagnosed Acute Myeloid Leukemia

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Estimation of time cost of anti-cancer drugs approved based on comparisons to best supportive care: A cross sectional analysis

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Estimating the Time Toxicity of Contemporary Systemic Treatment Regimens for Advanced Esophageal and Gastric Cancers

Agrawal, N. Y., Thawani, R., Edmondson, C. P., & Chen, E. Y.-S. (2023) · Cancers · doi:10.3390/cancers15235677 · Cited by 17 · see citing works

Real world efficacy and toxicity of consolidation durvalumab following chemoradiotherapy in older Australian patients with unresectable stage III non-small cell lung cancer

Stevens, S. X., Nindra, U., Shahnam, A., Wei, J., Bray, V., Pal, A., Yip, P. Y., Linton, A., Blinman, P. L., Nagrial, A. M., et al. (2024) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2024.101705 · Cited by 16 · see citing works

Reporting time toxicity in prospective cancer clinical trials: A scoping review

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The association of health-care contact days with physical function and survival in CCTG/AGITG CO.17

Gupta, A., O'Callaghan, C. J., Zhu, L., Jonker, D. J., Wong, R. P. W., Colwell, B., Moore, M. J., Karapetis, C. S., Tebbutt, N. C., Shapiro, J. D., et al. (2024) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djae077 · Cited by 16 · see citing works

Treatment burden in survivors of prostate and colorectal cancers: a qualitative interview study

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Treatment Selection for Patients with HER2-Negative Metastatic Gastric Cancer Expressing Claudin 18.2 and PD-L1

Miyajima, Y., & Kawakami, T. (2025) · Cancers · doi:10.3390/cancers17071120 · Cited by 14 · see citing works

Novel patient-centred outcome in cancer care, days at home: a scoping review protocol

Ribeiro, T., Mahar, A. L., Jerath, A., Bondzi‐Simpson, A., Barabash, V., Barr, A. A., Wright, F. C., Kosyachkova, E., Deleemans, J. M., Coburn, N. G., et al. (2023) · BMJ Open · doi:10.1136/bmjopen-2022-071201 · Cited by 14 · see citing works

Patient-centered, self-funding dose optimization trials as a route to reduce toxicity, lower cost, and improve access to cancer therapy

Tannock, I. F., Bouche, G., Goldstein, D. A., Goto, Y., Lichter, A. S., Prabhash, K., Ranganathan, P., Saltz, L. B., Sonke, G. S., Strohbehn, G. W., et al. (2023) · Annals of Oncology · doi:10.1016/j.annonc.2023.05.006 · Cited by 14 · see citing works

Elucidating the Benefit of Radiation Therapy in GI Cancers: Rethinking Trial End Points and Patient Selection

Sanford, N. N., Hong, T. S., & Hall, W. A. (2023) · Journal of Clinical Oncology · doi:10.1200/jco.23.01402 · Cited by 14 · see citing works

Are We Ready for Life in the Fast Lane? A Critical Review of Preoperative Hypofractionated Radiotherapy for Localized Soft Tissue Sarcoma

Guadagnolo, B. A., & Baldini, E. H. (2024) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2023.12.003 · Cited by 14 · see citing works

Home Time Among Older Adults With Acute Myeloid Leukemia Following Chemotherapy

Richardson, D. R., Zhou, X., Reeder-Hayes, K. E., Jensen, C. E., Islam, J. Y., Loh, K. P., Gupta, A., Basch, E., Bennett, A. V., Bridges, J. F. P., et al. (2024) · JAMA Oncology · doi:10.1001/jamaoncol.2024.1823 · Cited by 14 · see citing works

Time Burdens for Participants With Advanced Cancer in Phase I Trials: A Cross-Sectional Study

Iskander, R., Robart, A. M., Moyer, H., Nipp, R. D., Gupta, A., & Kimmelman, J. (2024) · JCO Oncology Practice · doi:10.1200/op.24.00334 · Cited by 14 · see citing works

A Fifth of Their Days: The Time Commitments of Advanced Cancer and Its Care

Johnson, W. V., Hsu, M. L., & Gupta, A. (2025) · JCO Oncology Practice · doi:10.1200/op-24-01085 · Cited by 14 · see citing works

Practical Management of Zolbetuximab Administration: The Project VYLOY Initiative

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Health Care Contact Days and Outcomes in Clinical Trials vs Routine Care Among Patients With Non–Small Cell Lung Cancer

Gupta, A., Nguyen, P. L., Wilson, B. E., Booth, C. M., & Hanna, T. P. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.5033 · Cited by 13 · see citing works

T-cell redirecting therapies for B-cell non-Hodgkin lymphoma: recent progress and future directions

Russler‐Germain, D. A., & Ghobadi, A. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1168622 · Cited by 12 · see citing works

Metronomic chemotherapy in ovarian cancer

Garg, V., & Kumar, L. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216469 · Cited by 12 · see citing works

Patients’ perspectives on oral decitabine/cedazuridine for the treatment of myelodysplastic syndromes/neoplasms

Zeidan, A. M., Perepezko, K. M., Salimi, T., Washington, T. L., & Epstein, R. S. (2024) · Therapeutic Advances in Hematology · doi:10.1177/20406207241257313 · Cited by 12 · see citing works

Health Care Contact Days for Older Adults Enrolled in Cancer Clinical Trials

Gupta, A., Till, C., Vaidya, R., Hershman, D. L., & Unger, J. M. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.0778 · Cited by 12 · see citing works

New treatment opportunities for older patients with acute myeloid leukemia and the increasing importance of frailty assessment – An oncogeriatric perspective

Diekmann, B., Timmerman, M., Hempenius, L., van Roon, E., Franken, B., & Hoogendoorn, M. (2023) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2023.101631 · Cited by 12 · see citing works

Finding the Lowest-Cost Pharmacy for Cancer Supportive Care Medications: Not So Easy

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Antibiotic prophylaxis in immunosuppressed patients – Missed opportunities from trimethoprim-sulfamethoxazole allergy label

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“The biggest challenge is there’s never a routine”: a qualitative study of the time burdens of cancer care at home

Sekar, P., Johnson, W. V., George, M., Breininger, A., Parsons, H. M., Vogel, R. I., Blaes, A. H., & Gupta, A. (2025) · Supportive Care in Cancer · doi:10.1007/s00520-024-09132-8 · Cited by 11 · see citing works

Long-Term Toxicity of Immune Checkpoint Inhibitors—Time to Widen the Lens

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Perceived Appropriateness of Assessing for Health-related Socioeconomic Risks Among Adult Patients with Cancer

Vu, M., Boyd, K., Marchis, E. H. D., Garnache, B. G., Gottlieb, L. M., Gross, C. P., Lee, N. K., Lindau, S. T., Mun, S., Winslow, V. A., et al. (2023) · Cancer Research Communications · doi:10.1158/2767-9764.crc-22-0283 · Cited by 11 · see citing works

Patient-reported outcomes and tolerability in patients receiving ripretinib versus sunitinib after treatment with imatinib in INTRIGUE, a phase 3, open-label study

Gelderblom, H. A. J., Jones, R. L., Blay, J., George, S., von Mehren, M., Zalcberg, J. R., Kang, Y., Razak, A. A., Trent, J. C., Attia, S., et al. (2023) · European Journal of Cancer · doi:10.1016/j.ejca.2023.113245 · Cited by 11 · see citing works

The least costly pharmacy for cancer supportive care medications over time: the logistic toxicity of playing catch up

Etteldorf, A., Sedhom, R., Rotolo, S. M., Vogel, R. I., Booth, C. M., Blaes, A. H., Virnig, B. A., Dusetzina, S. B., & Gupta, A. (2022) · Supportive Care in Cancer · doi:10.1007/s00520-022-07472-x · Cited by 11 · see citing works

Characterization of time toxicity in older patients with metastatic breast cancer

Atre, S. Y., Soulos, P. R., Kuderer, N. M., Gross, C. P., Baum, L. V. M., Dinan, M. A., & Lustberg, M. B. (2024) · Breast Cancer Research and Treatment · doi:10.1007/s10549-024-07379-7 · Cited by 10 · see citing works

Telehealth and Health Care Contact Days Among Patients With Advanced Cancer After COVID-19

Duffens, A. M., Zhu, S., Shirazi, A., Gupta, A., & Liu, R. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.16762 · Cited by 10 · see citing works

The impact of travel time to cancer treatment centre on post-diagnosis care and mortality among cancer patients in Scotland

Turner, M. E., Carriere, R., Fielding, S., Ramsay, G., Samuel, L. M., Maclaren, A. S., & Murchie, P. (2023) · Health & Place · doi:10.1016/j.healthplace.2023.103139 · Cited by 10 · see citing works

Is aggressive treatment of smoldering myeloma the path to curing myeloma?

Chakraborty, R., Hadidi, S. A., Cliff, E. R. S., & Mohyuddin, G. R. (2023) · Blood Advances · doi:10.1182/bloodadvances.2023009658 · Cited by 10 · see citing works

Dosimetric evaluation and treatment planning considerations for GammaTile permanent brain implants – a pilot, institutional experience

Zhang, S., Patel, K. R., Dusenbery, K., Alshreef, A., Sterling, D., Sloan, L., Reynolds, M. A., Chen, C. C., & Ferreira, C. (2024) · Journal of Neuro-Oncology · doi:10.1007/s11060-024-04631-4 · Cited by 9 · see citing works

Transforming patient-centered cancer care using telehealth: the MATCHES Center

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A digital, decentralized trial of exercise therapy in patients with cancer

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Health Care Contact Days in Older Adults With Metastatic Cancer

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Diversity in Cancer Care

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Telemedicine and Cancer Clinical Research

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Diet and physical activity interventions in Black and Latina women with breast cancer: A scoping review

Pichardo, M. S., Sanft, T. B., Ferrucci, L. M., Romero-Ramos, Y. M., Cartmel, B., Harrigan, M., Velázquez, A. I., Fayanju, O. M., Winer, E. P., & Irwin, M. L. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1079293 · Cited by 9 · see citing works

Management of malignant bowel obstruction

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The Patient's perspective: A review of the results from a radiotherapy patient experience survey in the North-West of England.

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Racial differences in treatment adherence and response to acupuncture and cognitive behavioral therapy for insomnia among Black and White cancer survivors

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Feasibility, acceptability, and preliminary efficacy of a self-directed online psychosocial intervention for women with metastatic breast cancer: Finding My Way-Advanced

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“The Cancer is My Life”: patient and caregiver perceptions of the time toxicity of palliative systemic cancer treatments for advanced gastrointestinal cancers

Stevens, S. X., El-Katateny, E., Lourenço, R. D. A., Booth, C. M., Shaw, J., & Vardy, J. L. (2025) · Supportive Care in Cancer · doi:10.1007/s00520-025-09621-4 · Cited by 8 · see citing works

Subcutaneous versus intravenous amivantamab, both in combination with lazertinib, in refractory EGFR-mutated non-small cell lung cancer: Patient satisfaction and resource utilization results from the PALOMA-3 study

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Oral decitabine and cedazuridine for the treatment of myelodysplastic syndromes: an integrated review of clinical, economic and patient-centered evidence

Zeidan, A. M., Zhao, R., Epstein, R. S., & Salimi, T. (2025) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2025.2544859 · Cited by 8 · see citing works

The Toxicity of Time

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Time Toxicity of Cancer Care—A Call to Action

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Time Is Money, but for Whom? The Commodification of Time Toxicity in Oncology

Gupta, A., Patel, V. R., Sedhom, R., & Booth, C. M. (2026) · Journal of Clinical Oncology · doi:10.1200/jco-26-01458

‘Time Toxicity’ in the Metastatic Setting

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Love in the Time of Cancer

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