Cited by 594Frailty in Older AdultsHeart Failure Treatment and ManagementCardiac Health and Mental Health

Physical rehabilitation for older patients hospitalized for heart failure

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Kitzman, Dalane W., Whellan, David J., Duncan, Pamela, Pastva, Amy M., Mentz, Robert J., Reeves, Gordon R., Nelson, M. Benjamin, Chen, Haiying +5 more·2021·New England Journal of Medicine

Abstract

BACKGROUND: Older patients who are hospitalized for acute decompensated heart failure have high rates of physical frailty, poor quality of life, delayed recovery, and frequent rehospitalizations. Interventions to address physical frailty in this population are not well established. METHODS: We conducted a multicenter, randomized, controlled trial to evaluate a transitional, tailored, progressive rehabilitation intervention that included four physical-function domains (strength, balance, mobility, and endurance). The intervention was initiated during, or early after, hospitalization for heart failure and was continued after discharge for 36 outpatient sessions. The primary outcome was the score on the Short Physical Performance Battery (total scores range from 0 to 12, with lower scores indicating more severe physical dysfunction) at 3 months. The secondary outcome was the 6-month rate of rehospitalization for any cause. RESULTS: A total of 349 patients underwent randomization; 175 were assigned to the rehabilitation intervention and 174 to usual care (control). At baseline, patients in each group had markedly impaired physical function, and 97% were frail or prefrail; the mean number of coexisting conditions was five in each group. Patient retention in the intervention group was 82%, and adherence to the intervention sessions was 67%. After adjustment for baseline Short Physical Performance Battery score and other baseline characteristics, the least-squares mean (±SE) score on the Short Physical Performance Battery at 3 months was 8.3±0.2 in the intervention group and 6.9±0.2 in the control group (mean between-group difference, 1.5; 95% confidence interval [CI], 0.9 to 2.0; P<0.001). At 6 months, the rates of rehospitalization for any cause were 1.18 in the intervention group and 1.28 in the control group (rate ratio, 0.93; 95% CI, 0.66 to 1.19). There were 21 deaths (15 from cardiovascular causes) in the intervention group and 16 deaths (8 from cardiovascular causes) in the control group. The rates of death from any cause were 0.13 and 0.10, respectively (rate ratio, 1.17; 95% CI, 0.61 to 2.27). CONCLUSIONS: In a diverse population of older patients who were hospitalized for acute decompensated heart failure, an early, transitional, tailored, progressive rehabilitation intervention that included multiple physical-function domains resulted in greater improvement in physical function than usual care. (Funded by the National Institutes of Health and others; REHAB-HF ClinicalTrials.gov number, NCT02196038.).

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Authors
Kitzman, D. W., Whellan, D. J., Duncan, P., Pastva, A. M., Mentz, R. J., Reeves, G. R., Nelson, M. B., Chen, H., Upadhya, B., Reed, S. D., Espeland, M. A., Hewston, L., & O’Connor, C. M.
Affiliations
  • Duke University (US)
  • Thomas Jefferson University (US)
  • From the Department of Internal Medicine, Sections of Cardiovascular Medicine (D.W.K., M.B.N., B.U.) and Gerontology and Geriatric Medicine (D.W.K., M.A.E.), and the Departments of Neurology (P.D.) and Biostatistics and Data Science (H.C., M.A.E.), Wake Forest School of Medicine, Winston-Salem, the Department of Orthopedic Surgery, Doctor of Physical Therapy Division (A.M.P.), the Department of Medicine, Division of Cardiology (R.J.M.), and the Department of Population Health Sciences (S.D.R.), Duke University School of Medicine, Durham, and Novant Health Heart and Vascular Institute, Charlotte (G.R.R.) — all in North Carolina; the Department of Medicine, Sidney Kimmel Medical College at Thomas Jefferson University (D.J.W.), and the Department of Physical Therapy, Jefferson College of Rehabilitation Sciences at Thomas Jefferson University (L.A.H.) — both in Philadelphia; and Inova Heart and Vascular Institute, Fairfax, VA (C.M.O.).
Venue
New England Journal of Medicine
Published
2021-07-15
Volume
385
Issue
3
Pages
203-216
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W3161724438
Cited by
594
References
42
Citations by year
2026: 101 · 2025: 124 · 2024: 109 · 2023: 102 · 2022: 105 · 2021: 53
FWCI
50.56
Type
journal article
Language
en
Open access
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Oristano Family Fund at Wake Forest School of Medicine
  • Kermit Glenn Phillips II Chair in Cardiovascular Medicine at Wake Forest School of Medicine
  • National Institutes of Health (P30AG021332, P30AG028716, R01AG045551, R01AG18915, U24AG059624)
Topics
  • Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Keywords
heart failure, older adults, physical rehabilitation, frailty, acute decompensated heart failure, Short Physical Performance Battery, physical function, hospital readmission, mortality, resistance training, balance training, mobility (physical function), endurance, outpatient rehabilitation, multimorbidity, quality of life, post-discharge recovery, cardiac rehabilitation, mortality risk stratification
MeSH terms
Cardiac Rehabilitation, Physical Functional Performance, Acute Disease, Aged, Aged, 80 and over, Exercise Therapy, Female, Follow-Up Studies, Heart Failure, Hospitalization, Humans, Male, Middle Aged, Patient Readmission, Frail Elderly, Recovery of Function

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