Nanomedicine, Volume IIA
Abstract
The safety, effectiveness, and utility of medical nanorobotic devices will critically depend upon their biocompatibility with human organs, tissues, cells, and biochemical systems. In this Volume, we broaden the definition of nanomedical biocompatibility to include all of the mechanical, physiological, immunological, cytological, and biochemical re
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Advanced nanomedicine - specifically, medical nanorobotics - is expected to serve as a dynamic tool toward addressing most human brain disorders.
“The pursuit of ever smaller tools to treat patients is approaching a pivotal juncture in medical history as advanced nanomedicine — specifically, medical nanorobotics — is expected to serve as a dynamic tool toward addressing most human brain disorders.”
From Human Brain/Cloud Interface (2019) · cites this paper as Freitas, 2003
Autonomous nanomedical devices are expected to be biocompatible, primarily due to their structural materials, which would enable extended residency within the human body.
“Furthermore, autonomous nanomedical devices are expected to be biocompatible, primarily due to their structural materials, which would enable extended residency within the human body”
From Human Brain/Cloud Interface (2019) · cites this paper as Freitas, 2003
In cases where there is a complete absence of large BBB junctional gaps, mission-designed strategies, including a combination of cytopenetration, cytolocomotion, and histonatation, would likely permit access to the neuropil.
“However, in cases where there is a complete absence of large BBB junctional gaps, mission-designed strategies, including a combination of cytopenetration, cytolocomotion, and histonatation, would likely permit access to the neuropil (Freitas, 1999b, 2003, 2016).”
From Human Brain/Cloud Interface (2019) · cites this paper as Freitas, 2003
Neural electrodes can be implanted without producing any detectable damage beyond the initial trauma and brief phagocytosis, typically limited to the edges of the electrode insertion pathway.
“Neural electrodes can be implanted without producing any detectable damage beyond the initial trauma and brief phagocytosis, which are typically limited to the edges of the electrode insertion pathway (Babb and Kupfer, 1984) (Freitas, 2003).”
From Human Brain/Cloud Interface (2019) · cites this paper as Freitas, 2003
Total volume displaced by endoneurobots and gliabots would be ∼0.12% of a "typical" ∼14,000 μm3 neuron volume, which is orders of magnitude below the total 1-10% "safe" tissue and organ intrusiveness limit for nanorobots that has been recommended elsewhere.
“Thus, total volume displaced by endoneurobots and gliabots would be ∼0.12% of a “typical” ∼14,000 μm3 neuron volume, which is orders of magnitude below the total 1–10% “safe” tissue and organ intrusiveness limit for nanorobots that has been recommended elsewhere (Freitas, 2003).”
From Human Brain/Cloud Interface (2019) · cites this paper as Freitas, 2003
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Martins, N. R. B., Angelica, A., Chakravarthy, K., Svidinenko, Y., Boehm, F. J., Opris, I., Lebedev, M. A., Swan, M., Garan, S. A., Rosenfeld, J. V., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00112 · Cited by 91 · see citing works
Self-citationKundu, A., Wirenfeldt, M., Harreby, K. R., & Jensen, W. (2014) · The International Journal of Artificial Organs · doi:10.5301/ijao.5000342 · Cited by 15 · see citing works
- Authors
- Freitas, R. A.
- Corresponding author
- Freitas, Robert A.
- ORCID
- Freitas, Robert A.
- Venue
- CRC Press eBooks
- Publisher
- CRC Press
- Published
- 2003-09-26
- OpenAlex
- W4210281108
- Cited by
- 91
- References
- 0
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 7 · 2015: 3 · 2014: 2 · 2013: 5 · 2012: 5
- Type
- reference entry
- Language
- en
- Open access
- closed
- Locations
- CRC Press eBooks (publishedVersion)
- Topics
- Physical Sciences › Physics and Astronomy › Condensed Matter Physics › Micro and Nano Robotics
- Physical Sciences › Engineering › Biomedical Engineering › Nanotechnology research and applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- nanomedicine, biocompatibility, medical nanorobots, immunological safety, machine safety
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