Cited by 353Growth Hormone and Insulin-like Growth FactorsDiabetes, Cardiovascular Risks, and LipoproteinsPancreatic function and diabetes

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Longitudinal Study of Physiologic Insulin Resistance and Metabolic Changes of Puberty

Hannon, Tamara S, Janosky, Janine, Arslanian, Silva A·2006·Pediatric Research

DOI 10.1203/01.pdr.0000246097.73031.27

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Abstract

Cross-sectional studies have shown that 1) adolescents are insulin resistant compared with prepubertal children and adults, 2) pubertal insulin resistance is likely mediated by growth hormone (GH), and 3) pubertal insulin resistance is associated with increased fat oxidation and decreased glucose oxidation. The aim of this study was to assess the validity of these cross-sectional observations by performing a longitudinal study in normal children during the prepubertal and pubertal periods. Nine healthy, normal weight, prepubertal children underwent hyperinsulinemic-euglycemic and hyperglycemic clamp studies for evaluation of insulin sensitivity and insulin secretion. Children had repeat evaluations during puberty. Consistent with cross-sectional observations, this longitudinal study demonstrated that during puberty: 1) insulin sensitivity decreased by approximately 50%, 2) the decrease in insulin sensitivity was compensated by a doubling in insulin secretion, and 3) the decrease in insulin sensitivity was independent of changes in percentage of body fat. Puberty was associated with increased total body lipolysis and decreased glucose oxidation. A novel observation is the demonstration of approximately 50% decrease in adiponectin levels at the pubertal time point. These metabolic changes are proposed to be partially mediated by increased GH secretion and are consistent with the Randle cycle of competition between glucose and fat oxidation.

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Authors: Hannon, T. S., Janosky, J., & Arslanian, S. A.
Affiliations: Children's Hospital of Pittsburgh (US)
University of Pittsburgh (US)
Corresponding author: Hannon, Tamara S
ORCID: Hannon, Tamara S
Arslanian, Silva A
Venue: Pediatric Research
Publisher: Springer Science and Business Media LLC
Published: 2006-12
Volume: 60
Issue: 6
Pages: 759-763
ISSN: 0031-3998 (ISSN-L)
1530-0447
DOI: 10.1203/01.pdr.0000246097.73031.27
OpenAlex: W2091595618
Cited by: 353
References: 40
Citations by year: 2026: 19 · 2025: 20 · 2024: 17 · 2023: 19 · 2022: 17 · 2021: 30 · 2020: 23 · 2019: 17 · 2018: 13 · 2017: 19 · 2016: 18 · 2015: 18 · 2014: 19 · 2013: 18 · 2012: 23
FWCI: 10.23
Type: journal article
Language: en
Open access: closed
Locations: Pediatric Research (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Public Health Service
National Center for Research Resources (K23 RR17250-01, M01-RR-00084, K23RR017250, M01RR000084)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01‐HD27503, R01HD027503, K24HD001357, K24 HD 01357)
Children's Hospital of Pittsburgh (M01-RR00084)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Keywords: insulin resistance, puberty, insulin sensitivity, insulin secretion, growth hormone, hyperinsulinemic-euglycemic clamp, hyperglycemic clamp, lipolysis, glucose oxidation, fat oxidation, adiponectin, Randle cycle, prepubertal children, fat mass
MeSH terms: Body Composition, Child, Child, Preschool, Female, Glucose, Homeostasis, Humans, Insulin Resistance, Insulin-Like Growth Factor I, Longitudinal Studies, Male, Oxidation-Reduction, Puberty, Growth Hormone, Glucose Clamp Technique, Leptin, Lipid Metabolism, Adiponectin

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Longitudinal Study of Physiologic Insulin Resistance and Metabolic Changes of Puberty

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