CoChat
Sign Up
Cited by 353Growth Hormone and Insulin-like Growth FactorsDiabetes, Cardiovascular Risks, and LipoproteinsPancreatic function and diabetes

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Longitudinal Study of Physiologic Insulin Resistance and Metabolic Changes of Puberty

Hannon, Tamara S, Janosky, Janine, Arslanian, Silva A·2006·Pediatric Research
DOI 10.1203/01.pdr.0000246097.73031.27
Open this paper in CoChat — free account

Abstract

Cross-sectional studies have shown that 1) adolescents are insulin resistant compared with prepubertal children and adults, 2) pubertal insulin resistance is likely mediated by growth hormone (GH), and 3) pubertal insulin resistance is associated with increased fat oxidation and decreased glucose oxidation. The aim of this study was to assess the validity of these cross-sectional observations by performing a longitudinal study in normal children during the prepubertal and pubertal periods. Nine healthy, normal weight, prepubertal children underwent hyperinsulinemic-euglycemic and hyperglycemic clamp studies for evaluation of insulin sensitivity and insulin secretion. Children had repeat evaluations during puberty. Consistent with cross-sectional observations, this longitudinal study demonstrated that during puberty: 1) insulin sensitivity decreased by approximately 50%, 2) the decrease in insulin sensitivity was compensated by a doubling in insulin secretion, and 3) the decrease in insulin sensitivity was independent of changes in percentage of body fat. Puberty was associated with increased total body lipolysis and decreased glucose oxidation. A novel observation is the demonstration of approximately 50% decrease in adiponectin levels at the pubertal time point. These metabolic changes are proposed to be partially mediated by increased GH secretion and are consistent with the Randle cycle of competition between glucose and fat oxidation.

Overview

Integrity signals

Registry

Crossref · 10.1203/01.pdr.0000246097.73031.27

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 40 references

Research works printed but not linked: 6

  1. Caprio S, 1994, Am J Physiol, 266, E885
  2. Saad RJ, 2001, J Clin Endocrinol Metab, 86, 4881, 10.1210/jc.86.10.4881 · DOI
  3. Arslanian S, 1997, Am J Physiol, 272, E523
  4. DeFronzo RA, 1979, Am J Physiol, 237, E214
  5. Robinson C, 1998, Am J Physiol, 274, E737
  6. Cook JS, 1993, J Clin Endocrinol Metab, 77, 725, 10.1210/jc.77.3.725 · DOI

Cited by

Sorted by citations

Items 201–300 of 353

Related

See all

Metadata

Authors
Hannon, T. S., Janosky, J., & Arslanian, S. A.
Affiliations
  • Children's Hospital of Pittsburgh (US)
  • University of Pittsburgh (US)
Corresponding author
Hannon, Tamara S
ORCID
Venue
Pediatric Research
Publisher
Springer Science and Business Media LLC
Published
2006-12
Volume
60
Issue
6
Pages
759-763
ISSN
  • 0031-3998 (ISSN-L)
  • 1530-0447
DOI
10.1203/01.pdr.0000246097.73031.27
OpenAlex
W2091595618
Cited by
353
References
40
Citations by year
2026: 19 · 2025: 20 · 2024: 17 · 2023: 19 · 2022: 17 · 2021: 30 · 2020: 23 · 2019: 17 · 2018: 13 · 2017: 19 · 2016: 18 · 2015: 18 · 2014: 19 · 2013: 18 · 2012: 23
FWCI
10.23
Type
journal article
Language
en
Open access
closed
Locations
  • Pediatric Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Public Health Service
  • National Center for Research Resources (K23 RR17250-01, M01-RR-00084, K23RR017250, M01RR000084)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01‐HD27503, R01HD027503, K24HD001357, K24 HD 01357)
  • Children's Hospital of Pittsburgh (M01-RR00084)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Keywords
insulin resistance, puberty, insulin sensitivity, insulin secretion, growth hormone, hyperinsulinemic-euglycemic clamp, hyperglycemic clamp, lipolysis, glucose oxidation, fat oxidation, adiponectin, Randle cycle, prepubertal children, fat mass
MeSH terms
Body Composition, Child, Child, Preschool, Female, Glucose, Homeostasis, Humans, Insulin Resistance, Insulin-Like Growth Factor I, Longitudinal Studies, Male, Oxidation-Reduction, Puberty, Growth Hormone, Glucose Clamp Technique, Leptin, Lipid Metabolism, Adiponectin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review