The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Longitudinal Study of Physiologic Insulin Resistance and Metabolic Changes of Puberty
Abstract
Cross-sectional studies have shown that 1) adolescents are insulin resistant compared with prepubertal children and adults, 2) pubertal insulin resistance is likely mediated by growth hormone (GH), and 3) pubertal insulin resistance is associated with increased fat oxidation and decreased glucose oxidation. The aim of this study was to assess the validity of these cross-sectional observations by performing a longitudinal study in normal children during the prepubertal and pubertal periods. Nine healthy, normal weight, prepubertal children underwent hyperinsulinemic-euglycemic and hyperglycemic clamp studies for evaluation of insulin sensitivity and insulin secretion. Children had repeat evaluations during puberty. Consistent with cross-sectional observations, this longitudinal study demonstrated that during puberty: 1) insulin sensitivity decreased by approximately 50%, 2) the decrease in insulin sensitivity was compensated by a doubling in insulin secretion, and 3) the decrease in insulin sensitivity was independent of changes in percentage of body fat. Puberty was associated with increased total body lipolysis and decreased glucose oxidation. A novel observation is the demonstration of approximately 50% decrease in adiponectin levels at the pubertal time point. These metabolic changes are proposed to be partially mediated by increased GH secretion and are consistent with the Randle cycle of competition between glucose and fat oxidation.
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“The transient IR and hyperinsulinemia typical of early puberty may kindle the factors associated with development of PCOS [74, 75].”
From Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls (2019) · cites this paper as [75]
Citations
Cites
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425
Randle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093
Kahn, S. E., Prigeon, R. L., McCulloch, D. K., Boyko, E. J., Bergman, R. N., Schwartz, M. W., Neifing, J. L., Ward, W. K., Beard, J. C., & Palmer, J. P. (1993) · Diabetes · doi:10.2337/diab.42.11.1663 · Cited by 1,405
Impaired Insulin Action in Puberty
Amiel, S. A., Sherwin, R. S., Simonson, D. C., Lauritano, A. A., & Tamborlane, W. V. (1986) · New England Journal of Medicine · doi:10.1056/nejm198607243150402 · Cited by 960
Insulin resistance during puberty: results from clamp studies in 357 children.
Moran, A., Jacobs, D. R., Steinberger, J., Hong, C. P., Prineas, R. J., Luepker, R. V., & Sinaiko, A. R. (1999) · Diabetes · doi:10.2337/diabetes.48.10.2039 · Cited by 869
Longitudinal Study on Pubertal Insulin Resistance
Goran, M. I., & Gower, B. A. (2001) · Diabetes · doi:10.2337/diabetes.50.11.2444 · Cited by 713
Kahn, S. E., Prigeon, R. L., McCulloch, D. K., Boyko, E. J., Bergman, R. N., Schwartz, M. W., Neifing, J. L., Ward, W. K., Beard, J. C., Palmer, J. P., et al. (1993) · Diabetes · doi:10.2337/diabetes.42.11.1663 · Cited by 328
Increased insulin secretion in puberty: A compensatory response to reductions in insulin sensitivity
Caprio, S., Plewe, G., Diamond, M. P., Simonson, D. C., Boulware, S. D., Sherwin, R. S., & Tamborlane, W. V. (1989) · The Journal of Pediatrics · doi:10.1016/s0022-3476(89)80438-x · Cited by 320
Early metabolic abnormalities in adolescent girls with polycystic ovarian syndrome
Lewy, V. D., Danadian, K., Witchel, S. F., & Arslanian, S. (2001) · The Journal of Pediatrics · doi:10.1067/mpd.2001.109603 · Cited by 298
Self-citationInsulin Resistance of Puberty: a Defect Restricted to Peripheral Glucose Metabolism*
Amiel, S. A., Caprio, S., Sherwin, R. S., Plewe, G., Haymond, M. W., & Tamborlane, W. V. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-72-2-277 · Cited by 296
Research works printed but not linked: 6
- Caprio S, 1994, Am J Physiol, 266, E885
- Saad RJ, 2001, J Clin Endocrinol Metab, 86, 4881, 10.1210/jc.86.10.4881 · DOI
- Arslanian S, 1997, Am J Physiol, 272, E523
- DeFronzo RA, 1979, Am J Physiol, 237, E214
- Robinson C, 1998, Am J Physiol, 274, E737
- Cook JS, 1993, J Clin Endocrinol Metab, 77, 725, 10.1210/jc.77.3.725 · DOI
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The Diagnosis of Polycystic Ovary Syndrome during Adolescence
Witchel, S. F., Oberfield, S., Rosenfield, R. L., Codner, E., Bonny, A., Ibáñez, L., Pena, A., Horikawa, R., Gomez-Lobo, V., Joel, D., et al. (2015) · Hormone Research in Paediatrics · doi:10.1159/000375530 · Cited by 3,113
Self-citationHampl, S. E., Hassink, S. G., Skinner, A. C., Armstrong, S. C., Barlow, S. E., Bolling, C. F., Avila Edwards, K. C., Eneli, I., Hamre, R., Joseph, M. M., et al. (2023) · Pediatrics · doi:10.1542/peds.2022-060640 · Cited by 1,389
Styne, D. M., Arslanian, S. A., Connor, E. L., Farooqi, I. S., Murad, M. H., Silverstein, J. H., & Yanovski, J. A. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2573 · Cited by 1,375
Self-citationWitchel, S. F., Oberfield, S. E., & Peña, A. S. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2019-00078 · Cited by 653
Youth-Onset Type 2 Diabetes Consensus Report: Current Status, Challenges, and Priorities
Nadeau, K. J., Anderson, B. J., Berg, E. G., Chiang, J. L., Chou, H., Copeland, K. C., Hannon, T. S., Huang, T. T.-K., Lynch, J. L., Powell, J., et al. (2016) · Diabetes Care · doi:10.2337/dc16-1066 · Cited by 381
Self-citation
Metadata
- Authors
- Hannon, T. S., Janosky, J., & Arslanian, S. A.
- Affiliations
- Children's Hospital of Pittsburgh (US)
- University of Pittsburgh (US)
- Corresponding author
- Hannon, Tamara S
- Venue
- Pediatric Research
- Published
- 2006-12
- Volume
- 60
- Issue
- 6
- Pages
- 759-763
- ISSN
- 0031-3998 (ISSN-L)
- 1530-0447
- OpenAlex
- W2091595618
- Cited by
- 353
- References
- 40
- Citations by year
- 2026: 19 · 2025: 20 · 2024: 17 · 2023: 19 · 2022: 17 · 2021: 30 · 2020: 23 · 2019: 17 · 2018: 13 · 2017: 19 · 2016: 18 · 2015: 18 · 2014: 19 · 2013: 18 · 2012: 23
- FWCI
- 10.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pediatric Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service
- National Center for Research Resources (K23 RR17250-01, M01-RR-00084, K23RR017250, M01RR000084)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01‐HD27503, R01HD027503, K24HD001357, K24 HD 01357)
- Children's Hospital of Pittsburgh (M01-RR00084)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Keywords
- insulin resistance, puberty, insulin sensitivity, insulin secretion, growth hormone, hyperinsulinemic-euglycemic clamp, hyperglycemic clamp, lipolysis, glucose oxidation, fat oxidation, adiponectin, Randle cycle, prepubertal children, fat mass
- MeSH terms
- Body Composition, Child, Child, Preschool, Female, Glucose, Homeostasis, Humans, Insulin Resistance, Insulin-Like Growth Factor I, Longitudinal Studies, Male, Oxidation-Reduction, Puberty, Growth Hormone, Glucose Clamp Technique, Leptin, Lipid Metabolism, Adiponectin
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