The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Wine Antioxidant Polyphenols Inhibit the Proliferation of Human Prostate Cancer Cell Lines
Abstract
The effect of different wine antioxidant polyphenols (catechin, epicatechin, quercetin, and resveratrol) on the growth of three prostate cancer cell lines (LNCaP, PC3, and DU145) was investigated. A dose- and time-dependent inhibition of cell growth by polyphenols was found at nanomolar concentrations. The proliferation of LNCaP and PC3 cells was preferentially inhibited by flavonoids (catechin, epicatechin, and quercetin), whereas resveratrol was the most potent inhibitor of DU145 cell growth. Possible mechanisms of action were investigated: 1) The competition of polyphenols for androgen binding in LNCaP cells revealed significant interaction only in the case of high concentrations of quercetin, at least at five orders of magnitude higher than the concentrations needed for cell growth inhibition. All other phenols showed low interactions. 2) Oxygen species production after mitogen stimulation and H2O2 sensitivity of these cell lines did not correlate with the observed antiproliferative effects, ruling out such a mode of action. 3) NO production revealed two different patterns: LNCaP and DU145 cells produced high concentrations of NO, whereas PC3 cells produced low concentrations. Phorbol ester stimulation of cells did not reveal any additional effect in LNCaP and DU145 cells, whereas it enhanced the secretion of NO in PC3 cells. Polyphenols decreased NO secretion. This effect correlates with their antiproliferative action and the inhibition of inducible NO synthase. It is therefore proposed that the antiproliferative effect of polyphenols is mediated through the modulation of NO production. In conclusion, our data show a direct inhibitory effect of low concentrations of antioxidant wine phenols on the proliferation of human prostate cancer cell lines mediated by the production of NO, further suggesting potential beneficial effects of wine and other phenol-containing foods or drinks for the control of prostate cancer cell growth.
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The L-Arginine-Nitric Oxide Pathway
Epstein, F. H., Moncada, S., & Higgs, A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292706 · Cited by 6,678
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997) · Science · doi:10.1126/science.275.5297.218 · Cited by 4,935
Berthois, Y., Katzenellenbogen, J. A., & Katzenellenbogen, B. S. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.8.2496 · Cited by 1,307
The multifaceted roles of nitric oxide in cancer
Wink, D. (1998) · Carcinogenesis · doi:10.1093/carcin/19.5.711 · Cited by 682
Cited by
Middleton, E., Kandaswami, C., & Theoharides, T. C. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01472-8 · Cited by 4,882
Plant Phenolics: Extraction, Analysis and Their Antioxidant and Anticancer Properties
Dai, J., & Mumper, R. J. (2010) · Molecules · doi:10.3390/molecules15107313 · Cited by 4,506
Resveratrol: A review of preclinical studies for human cancer prevention
ATHAR, M., BACK, J., TANG, X., KIM, K., KOPELOVICH, L., BICKERS, D., & KIM, A. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2006.12.025 · Cited by 731
Potential Impact of Strawberries on Human Health: A Review of the Science
HANNUM, S. M. (2004) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690490263756 · Cited by 485
Cancer Chemopreventive Activity of Resveratrol
BHAT, K. P. L., & PEZZUTO, J. M. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02918.x · Cited by 398
Metadata
- Authors
- Kampa, M., Hatzoglou, A., Notas, G., Damianaki, A., Bakogeorgou, E., Gemetzi, C., Kouroumalis, E., Martin, P.-M., & Castanas, E.
- Venue
- Nutrition and Cancer
- Publisher
- Informa UK Limited
- Published
- 2000-07
- Volume
- 37
- Issue
- 2
- Pages
- 223-233
- ISSN
- 0163-5581 (ISSN-L)
- 1532-7914
- OpenAlex
- W2047565676
- Cited by
- 248
- References
- 4
- FWCI
- 7.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kampa, M., Hatzoglou, A., Notas, G., Damianaki, A., Bakogeorgou, E., Gemetzi, C., Kouroumalis, E., Martin, P.-M., & Castanas, E. (2000). Wine Antioxidant Polyphenols Inhibit the Proliferation of Human Prostate Cancer Cell Lines. Nutrition and Cancer. https://doi.org/10.1207/s15327914nc372_16
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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