Antitumor Activity of Milk Kefir and Soy Milk Kefir in Tumor-Bearing Mice
Abstract
The effects of oral administration of milk and soy milk kefirs on tumor growth in tumor-bearing mice and the mucosal immunoglobulin A response in mice were studied. Oral administration of milk and soy milk kefirs to mice inoculated with sarcoma 180 tumor cells resulted in 64.8% and 70.9% inhibition of tumor growth, respectively, compared with controls. In addition, oral administration of the two kefir types induced apoptotic tumor cell lysis. Total immunoglobulin A levels for tissue extracts from the wall of the small intestine were also significantly higher for mice fed a milk kefir or a soy milk kefir regimen for 30 days. These results suggest that milk and soy milk kefirs may be considered among the more promising food components in terms of cancer prevention and enhancement of mucosal resistance to gastrointestinal infection.
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A concentration of kefir from 7 to 10% (w/w) was able to completely inhibit the sporulation of Aspergillus flavus, and consequently the production of aflatoxin B1.
“The concentration of kefir from 7 to 10 % (w/w) was able to completely inhibit the sporulation of Aspergillus flavus, and consequently the production of aflatoxin B1, which demonstrates the antifungal properties of kefir against filamentous fungi.”
From Milk <i>kefir</i> : nutritional, microbiological and health benefits (2017) · cites this paper as [59]
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- Authors
- Liu, J.-R., Wang, S.-Y., Lin, Y.-Y., & Lin, C.-W.
- Affiliations
- National Taiwan University (TW)
- Venue
- Nutrition and Cancer
- Publisher
- Informa UK Limited
- Published
- 2002-11
- Volume
- 44
- Issue
- 2
- Pages
- 183-187
- ISSN
- 0163-5581 (ISSN-L)
- 1532-7914
- OpenAlex
- W2087350807
- Cited by
- 114
- References
- 0
- Citations by year
- 2025: 1 · 2024: 6 · 2023: 6 · 2022: 5 · 2021: 18 · 2020: 7 · 2019: 6 · 2018: 7 · 2017: 7 · 2016: 5 · 2015: 5 · 2014: 4 · 2013: 4 · 2012: 4
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition and Cancer (publishedVersion)
- PubMed (publishedVersion)
- AH-Scopus to ORCID
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Cancer Research and Treatments
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- kefir, milk kefir, anticancer activity, sarcoma 180, tumor growth inhibition, apoptosis, immunoglobulin A, intestinal mucosa, cancer prevention, oral administration, functional foods
- MeSH terms
- Animals, Antineoplastic Agents, Body Weight, Disease Models, Animal, Drug Screening Assays, Antitumor, Female, Gastrointestinal Neoplasms, Immunoglobulin A, Mice, Inbred ICR, Mucous Membrane, Peyer's Patches, Sarcoma, Experimental, Glycine max, Cultured Milk Products, Mice
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