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Cited by 171Advanced Drug Delivery SystemsDrug Solubulity and Delivery SystemsAntibiotics Pharmacokinetics and Efficacy

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Once-daily tablet formulation and in vitro release evaluation of cefpodoxime using hydroxypropyl methylcellulose: A technical note

Open access
Merchant, Hamid A., Shoaib, Harris M., Tazeen, Jaweria, Yousuf, Rabia I.·2006·AAPS PharmSciTech
DOI 10.1208/pt070378PMC PMC2750520
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Abstract

Decreasing the dose frequency of cefpodoxime proxetil increases patient compliance; patients prefer to take the drug once daily. It also improves the rate of bacterial killing and hastens the cure from the indications, and therefore increases compliance. The hydrophilic matrix of HPMC controlled the cefpodoxime proxetil release effectively for 24 hours; hence, the formulation can be considered as a once-daily sustained-release tablet of cefpodoxime proxetil. The formulation showed acceptable pharmacotechnical properties and assay requirements. In vitro dissolution studies indicated a sustained-release pattern throughout 24 hours of the study that was comparable to the theoretical release profile. Drug release kinetics indicated that drug release was best explained by Higuchi's equation, as these plots showed the highest linearity (r 2=0.9734), but a close relationship was also noted with zero-order kinetics (r 2=0.9708). Korsmeyer's plots indicated ann value of 0.57, which was indicative of an anomalous diffusion mechanism or diffusion coupled with erosion; hence, the drug release was controlled by more than one process. Hixson-Crowell plots indicated a change in surface area and diameter of the tablets with the progressive dissolution of the matrix as a function of time.

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Crossref · 10.1208/pt070378

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16 of 16 references verified0 citation errors · 0 not checkable

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Research works printed but not linked: 4

  1. Alderman DA. A review of cellulose ethers in hydrophillic matrices for oral controlled-release dosage forms.Int J Pharm Tech Prod Mfr. 1984;5:1–9.
  2. Dollery C.Therapeutic Drugs. Edinburgh, Scotland: Churchill Livingstone; 1999:C113-C117.
  3. United States Pharmacopeia-27. Rockville, MD: US Pharmacopeial Convention; 2004:377–379. Also pp778–780.
  4. Bourne DW. Pharmacokinetics. In: Banker GS, Rhodes CT, eds.Modern Pharmaceutics. 4th ed. New York, NY: Marcel Dekker Inc; 2002:67–92.

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Metadata

Authors
Merchant, H. A., Shoaib, H. M., Tazeen, J., & Yousuf, R. I.
Affiliations
University of Karachi (PK)
ORCID
Venue
AAPS PharmSciTech
Publisher
Springer Science and Business Media LLC
Published
2006-09
Volume
7
Issue
3
Pages
E178-E183
ISSN
1530-9932 (ISSN-L)
DOI
10.1208/pt070378
PMC
PMC2750520
OpenAlex
W2115770965
Cited by
171
References
16
Citations by year
2026: 10 · 2025: 11 · 2024: 13 · 2023: 5 · 2022: 5 · 2021: 10 · 2020: 5 · 2019: 10 · 2018: 7 · 2017: 8 · 2016: 10 · 2015: 7 · 2014: 10 · 2013: 9 · 2012: 12
FWCI
2.79
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • AAPS PharmSciTech (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • University of Huddersfield Repository (University of Huddersfield) (submittedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
  • Health Sciences › Medicine › Pharmacology (medical) › Antibiotics Pharmacokinetics and Efficacy
Keywords
cefpodoxime proxetil, hydroxypropyl methylcellulose, sustained-release tablets, once-daily dosing, in vitro drug release, Higuchi model, zero-order kinetics, anomalous diffusion, medication adherence, cephalosporins
MeSH terms
Cefpodoxime, Chemistry, Pharmaceutical, Delayed-Action Preparations, Methylcellulose, Tablets, Enteric-Coated, Ceftizoxime, Hypromellose Derivatives

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