PEGylated Single-Walled Carbon Nanotubes as Nanocarriers for Cyclosporin A Delivery
Open accessAbstract
Single-walled carbon nanotubes (SWCNTs) have attracted the attention of many researchers due to their remarkable physicochemical features and have been found to be a new family of nanovectors for the delivery of therapeutic molecules. The ability of these nanostructures to load large amounts of drug molecules on their outer surface has been considered as the main advantage by many investigators. Here, we report the development of a PEGylated SWCNT-mediated delivery system for cyclosporin A (CsA) as a potent immunosuppressive agent. The available OH group in the CsA structure was first linked to a bi-functional linker (i.e., succinic anhydride) in order to provide a COOH terminal group. CsA succinylation process was optimized by using the modified simplex method. The resulting compound, CsA-CO-(CH(2))(2)-COOH, was then grafted onto the exterior surface of SWCNTs, previously PEGylated with phospholipid-PEG(5000)-NH(2) conjugates, through the formation of an amide bond with the free amine group of PEGylated SWCNTs. Drug loading, stability of the PEGylated SWCNT-CsA complex, and in vitro release of the drug were evaluated. Loading efficiencies of almost 72% and 68% were achieved by UV spectrophotometry and elemental analysis methods, respectively. It was observed that 57.3% of cyclosporine was released from CsA-Pl-PEG(5000)-SWCNTs after 3 days. In this investigation, we conjugated CsA to an amine-terminated phospholipid-polyethylene glycol chain attached on SWCNTs via a cleavable ester bond and demonstrated the possible potential of PEGylated SWCNT-based systems for CsA delivery.
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CsA conjugated to an amine-terminated phospholipid-PEG chain attached on SWCNTs via a cleavable ester bond demonstrated the potential of PEGylated SWCNT-based systems for CsA delivery.
“For instance, the cyclosporin A (CsA) was conjugated to an amine-terminated phospholipid–PEG chain attached on SWCNTs via a cleavable ester bond and demonstrated the possible potential of PEGylated SWCNT-based systems for CsA delivery.112”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [112]
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- Authors
- Hadidi, N., Kobarfard, F., Nafissi-Varcheh, N., & Aboofazeli, R.
- Affiliations
- Shahid Beheshti University (IR)
- Corresponding author
- Aboofazeli, Reza
- Venue
- AAPS PharmSciTech
- Published
- 2013-03-12
- Volume
- 14
- Issue
- 2
- Pages
- 593-600
- ISSN
- 1530-9932 (ISSN-L)
- PMC
- PMC3666015
- OpenAlex
- W1996658501
- Cited by
- 39
- References
- 73
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 5 · 2015: 4 · 2014: 2 · 2013: 1
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- AAPS PharmSciTech (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Iran National Science Foundation
- Shahid Beheshti University of Medical Sciences
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Graphene and Nanomaterials Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Materials Chemistry › Carbon Nanotubes in Composites
- Keywords
- single-walled carbon nanotubes, PEGylation, cyclosporine, drug delivery, nanocarriers, succinylation, succinic anhydride, amide conjugation, drug loading, drug release, immunosuppressants, modified simplex method
- MeSH terms
- Chemistry, Pharmaceutical, Drug Carriers, Immunosuppressive Agents, Kinetics, Phospholipids, Polyethylene Glycols, Solubility, Spectrophotometry, Ultraviolet, Succinic Anhydrides, Surface Properties, Technology, Pharmaceutical, Cyclosporine, Nanotechnology, Nanotubes, Carbon
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