Functionalized carbon nanotubes for anticancer drug delivery
Abstract
In vitro and in vivo results reflect that functionalized carbon nanotubes (f-CNTs) are promising for the development of unique delivery systems of anticancer drugs. Functionalization of CNTs and drug loading are realized by covalent attachment and/or physical approaches. Poly(ethylene glycol) is the most adopted species for functionalization, which can increase the dispersity in aqueous solution and biocompatibility of CNTs. Several types of anticancer drugs, such as paclitaxel and doxorubicin, are loaded onto f-CNTs and their treatment efficacy has been demonstrated in vitro and in vivo. However, f-CNTs of well-controlled structures, such as uniform length and well-defined chemistry, which are not available so far, are important to solve the current controversy over the mechanisms of cell uptake of f-CNTs, and are a prerequisite to investigate whether f-CNTs can be platform materials for anticancer drug delivery with improved efficacy.
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PEGylation is a crucial step to boost solubility, circumvent the reticuloendothelial system, and reduce toxicity of CNTs.
“To boost solubility, circumvent the reticuloendothelial system, and reduce toxicity, PEGylation is a crucial step.111”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [111]
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- Authors
- Lay, C. L., Liu, J., & Liu, Y.
- Affiliations
- Agency for Science, Technology and Research (SG)
- Venue
- Expert Review of Medical Devices
- Publisher
- Informa UK Limited
- Published
- 2011-09
- Volume
- 8
- Issue
- 5
- Pages
- 561-566
- ISSN
- 1743-4440 (ISSN-L)
- 1745-2422
- OpenAlex
- W2139353605
- Cited by
- 71
- References
- 62
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 10 · 2022: 5 · 2021: 6 · 2020: 2 · 2019: 5 · 2018: 10 · 2017: 3 · 2016: 6 · 2015: 5 · 2014: 3 · 2013: 6 · 2012: 1
- FWCI
- 0.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Expert Review of Medical Devices (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Graphene and Nanomaterials Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Materials Chemistry › Carbon Nanotubes in Composites
- Keywords
- functionalized carbon nanotubes, anticancer drug delivery, polyethylene glycol functionalization, drug loading, paclitaxel, doxorubicin, biocompatibility
- MeSH terms
- Animals, Antineoplastic Agents, Biocompatible Materials, Cell Line, Doxorubicin, Humans, Polyethylene Glycols, Drug Delivery Systems, Paclitaxel, RNA, Small Interfering, Nanotechnology, Nanotubes, Carbon, Cell Line, Tumor
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