Cited by 71Graphene and Nanomaterials ApplicationsNanoparticle-Based Drug DeliveryCarbon Nanotubes in Composites

Functionalized carbon nanotubes for anticancer drug delivery

Lay, Chee Leng, Liu, Jing, Liu, Ye·2011·Expert Review of Medical Devices

Abstract

In vitro and in vivo results reflect that functionalized carbon nanotubes (f-CNTs) are promising for the development of unique delivery systems of anticancer drugs. Functionalization of CNTs and drug loading are realized by covalent attachment and/or physical approaches. Poly(ethylene glycol) is the most adopted species for functionalization, which can increase the dispersity in aqueous solution and biocompatibility of CNTs. Several types of anticancer drugs, such as paclitaxel and doxorubicin, are loaded onto f-CNTs and their treatment efficacy has been demonstrated in vitro and in vivo. However, f-CNTs of well-controlled structures, such as uniform length and well-defined chemistry, which are not available so far, are important to solve the current controversy over the mechanisms of cell uptake of f-CNTs, and are a prerequisite to investigate whether f-CNTs can be platform materials for anticancer drug delivery with improved efficacy.

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Registry

Crossref · 10.1586/erd.11.34

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62 of 62 references verified0 citation errors · 0 not checkable

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  • PEGylation is a crucial step to boost solubility, circumvent the reticuloendothelial system, and reduce toxicity of CNTs.

    “To boost solubility, circumvent the reticuloendothelial system, and reduce toxicity, PEGylation is a crucial step.111”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [111]

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Authors
Lay, C. L., Liu, J., & Liu, Y.
Affiliations
Agency for Science, Technology and Research (SG)
Venue
Expert Review of Medical Devices
Published
2011-09
Volume
8
Issue
5
Pages
561-566
ISSN
  • 1743-4440 (ISSN-L)
  • 1745-2422
OpenAlex
W2139353605
Cited by
71
References
62
Citations by year
2026: 2 · 2025: 2 · 2024: 5 · 2023: 10 · 2022: 5 · 2021: 6 · 2020: 2 · 2019: 5 · 2018: 10 · 2017: 3 · 2016: 6 · 2015: 5 · 2014: 3 · 2013: 6 · 2012: 1
FWCI
0.26
Type
journal article
Language
en
Open access
closed
Locations
  • Expert Review of Medical Devices (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Graphene and Nanomaterials Applications
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Materials Science › Materials Chemistry › Carbon Nanotubes in Composites
Keywords
functionalized carbon nanotubes, anticancer drug delivery, polyethylene glycol functionalization, drug loading, paclitaxel, doxorubicin, biocompatibility
MeSH terms
Animals, Antineoplastic Agents, Biocompatible Materials, Cell Line, Doxorubicin, Humans, Polyethylene Glycols, Drug Delivery Systems, Paclitaxel, RNA, Small Interfering, Nanotechnology, Nanotubes, Carbon, Cell Line, Tumor

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