Comparative Study of Antidiabetic Activity and Oxidative Stress Induced by Zinc Oxide Nanoparticles and Zinc Sulfate in Diabetic Rats
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In the current study, antidiabetic activity and toxic effects of zinc oxide nanoparticles (ZnO) were investigated in diabetic rats compared to zinc sulfate (ZnSO4) with particular emphasis on oxidative stress parameters. One hundred and twenty male Wistar rats were divided into two healthy and diabetic groups, randomly. Each major group was further subdivided into five subgroups and then orally supplemented with various doses of ZnO (1, 3, and 10 mg/kg) and ZnSO4 (30 mg/kg) for 56 consecutive days. ZnO showed greater antidiabetic activity compared to ZnSO4 evidenced by improved glucose disposal, insulin levels, and zinc status. The altered activities of erythrocyte antioxidant enzymes as well as raised levels of lipid peroxidation and a marked reduction of total antioxidant capacity were observed in rats receiving ZnO. ZnO nanoparticles acted as a potent antidiabetic agent, however, severely elicited oxidative stress particularly at higher doses.
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- Authors
- Nazarizadeh, A., & Asri-Rezaie, S.
- Affiliations
- Urmia University (IR)
- Corresponding author
- Nazarizadeh, Ali
- ORCID
- Nazarizadeh, Ali
- Venue
- AAPS PharmSciTech
- Published
- 2015-09-08
- Volume
- 17
- Issue
- 4
- Pages
- 834-843
- ISSN
- 1530-9932 (ISSN-L)
- OpenAlex
- W1692084832
- Cited by
- 135
- References
- 66
- Citations by year
- 2026: 6 · 2025: 17 · 2024: 14 · 2023: 17 · 2022: 22 · 2021: 22 · 2020: 11 · 2019: 11 · 2018: 6 · 2017: 6 · 2016: 3
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- AAPS PharmSciTech (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Keywords
- zinc oxide nanoparticles, zinc sulfate, antidiabetic activity, oxidative stress, diabetes mellitus, lipid peroxidation, antioxidant enzymes, erythrocytes, total antioxidant capacity, insulin, zinc status, oral supplementation, nanoparticle toxicity
- MeSH terms
- Animals, Antioxidants, Diabetes Mellitus, Experimental, Hypoglycemic Agents, Male, Streptozocin, Zinc Oxide, Lipid Peroxidation, Rats, Wistar, Oxidative Stress, Zinc Sulfate, Rats, Nanoparticles
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