Mucoadhesive nanoemulsion-based intranasal drug delivery system of olanzapine for brain targeting
Abstract
The objective of the present study was to optimize olanzapine nanoemulsion (ONE), for nose-to-brain delivery. The nanoemulsions and olanzapine mucoadhesive nanoemulsions (OMNEs) were prepared using water titration method and characterized for technical and electrokinetic properties. Biodistribution of nanoemulsions and olanzapine solution (OS) in the brain and blood of rats following intranasal (intranasal) and intravenous (intravenous) administrations were examined using optimized technetium-labeled ((99m)Tc-labeled) olanzapine formulations. The brain/blood uptake ratios of 0.45, 0.88, 0.80, and 0.04 of OS (intranasal), ONE (intranasal), OMNE (intranasal), ONE (intravenous), respectively, at 0.5 h are indicative of direct nose-to-brain transport (DTP). Higher % drug targeting efficiency (%DTE) and %DTP for mucoadhesive nanoemulsions indicated effective brain targeting of olanzapine among the prepared nanoemulsions. Gamma scintigraphy imaging of the rat brain conclusively demonstrated rapid and larger extent of transport of olanzapine by OMNE (intranasal), when compared with OS (intranasal), ONE (intranasal), and ONE (intravenous), into the rat brain.
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Analogous results to the risperidone nanoemulsion studies were obtained with olanzapine-loaded nanoemulsions.
“Analogous results were obtained by the same authors preparing drug-loaded NEs containing olanzapine, a second-generation antipsychotic agent with broad efficacy [49].”
From Nanoemulsions for “Nose-to-Brain” Drug Delivery (2019) · cites this paper as [49]
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- Authors
- Kumar, M., Misra, A., Mishra, A. K., Mishra, P., & Pathak, K.
- Affiliations
- Maharaja Sayajirao University of Baroda (IN)
- Government of India (IN)
- Corresponding author
- Pathak, Kamla
- Venue
- Journal of Drug Targeting
- Publisher
- Informa UK Limited
- Published
- 2008-01
- Volume
- 16
- Issue
- 10
- Pages
- 806-814
- ISSN
- 1026-7158 (ISSN-L)
- 1061-186X
- 1029-2330
- OpenAlex
- W2110084899
- Cited by
- 179
- References
- 30
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 17 · 2023: 8 · 2022: 11 · 2021: 12 · 2020: 21 · 2019: 15 · 2018: 13 · 2017: 10 · 2016: 16 · 2015: 11 · 2014: 5 · 2013: 10 · 2012: 5
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of drug targeting (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
- Keywords
- olanzapine, nanoemulsions, mucoadhesive formulation, intranasal drug delivery, nose-to-brain delivery, brain targeting, technetium-99m radiolabeling, tissue distribution, antipsychotic drug delivery
- MeSH terms
- Olanzapine, Administration, Intranasal, Animals, Benzodiazepines, Brain, Emulsions, Haloperidol, Injections, Intravenous, Male, Antipsychotic Agents, Drug Delivery Systems, Nanostructures, Rats
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