Cited by 179Advanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryInhalation and Respiratory Drug Delivery

Mucoadhesive nanoemulsion-based intranasal drug delivery system of olanzapine for brain targeting

Kumar, Mukesh, Misra, Ambikanandan, Mishra, A. K., Mishra, Pushpa, Pathak, Kamla·2008·Journal of Drug Targeting

Abstract

The objective of the present study was to optimize olanzapine nanoemulsion (ONE), for nose-to-brain delivery. The nanoemulsions and olanzapine mucoadhesive nanoemulsions (OMNEs) were prepared using water titration method and characterized for technical and electrokinetic properties. Biodistribution of nanoemulsions and olanzapine solution (OS) in the brain and blood of rats following intranasal (intranasal) and intravenous (intravenous) administrations were examined using optimized technetium-labeled ((99m)Tc-labeled) olanzapine formulations. The brain/blood uptake ratios of 0.45, 0.88, 0.80, and 0.04 of OS (intranasal), ONE (intranasal), OMNE (intranasal), ONE (intravenous), respectively, at 0.5 h are indicative of direct nose-to-brain transport (DTP). Higher % drug targeting efficiency (%DTE) and %DTP for mucoadhesive nanoemulsions indicated effective brain targeting of olanzapine among the prepared nanoemulsions. Gamma scintigraphy imaging of the rat brain conclusively demonstrated rapid and larger extent of transport of olanzapine by OMNE (intranasal), when compared with OS (intranasal), ONE (intranasal), and ONE (intravenous), into the rat brain.

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Crossref · 10.1080/10611860802476504

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  • Analogous results to the risperidone nanoemulsion studies were obtained with olanzapine-loaded nanoemulsions.

    “Analogous results were obtained by the same authors preparing drug-loaded NEs containing olanzapine, a second-generation antipsychotic agent with broad efficacy [49].”

    From Nanoemulsions for “Nose-to-Brain” Drug Delivery (2019) · cites this paper as [49]

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Authors
Kumar, M., Misra, A., Mishra, A. K., Mishra, P., & Pathak, K.
Affiliations
  • Maharaja Sayajirao University of Baroda (IN)
  • Government of India (IN)
Corresponding author
Pathak, Kamla
Venue
Journal of Drug Targeting
Published
2008-01
Volume
16
Issue
10
Pages
806-814
ISSN
  • 1026-7158 (ISSN-L)
  • 1061-186X
  • 1029-2330
OpenAlex
W2110084899
Cited by
179
References
30
Citations by year
2026: 5 · 2025: 7 · 2024: 17 · 2023: 8 · 2022: 11 · 2021: 12 · 2020: 21 · 2019: 15 · 2018: 13 · 2017: 10 · 2016: 16 · 2015: 11 · 2014: 5 · 2013: 10 · 2012: 5
FWCI
3.02
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of drug targeting (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
Keywords
olanzapine, nanoemulsions, mucoadhesive formulation, intranasal drug delivery, nose-to-brain delivery, brain targeting, technetium-99m radiolabeling, tissue distribution, antipsychotic drug delivery
MeSH terms
Olanzapine, Administration, Intranasal, Animals, Benzodiazepines, Brain, Emulsions, Haloperidol, Injections, Intravenous, Male, Antipsychotic Agents, Drug Delivery Systems, Nanostructures, Rats

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