Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 159

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Diagnosis and Management of Central Diabetes Insipidus in Adults

Tomkins, Maria, Lawless, Sarah, Martin-Grace, Julie, Sherlock, Mark, Thompson, Chris J·2022·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/clinem/dgac381
Open this paper in CoChat — free account

Abstract

Central diabetes insipidus (CDI) is a clinical syndrome which results from loss or impaired function of vasopressinergic neurons in the hypothalamus/posterior pituitary, resulting in impaired synthesis and/or secretion of arginine vasopressin (AVP). AVP deficiency leads to the inability to concentrate urine and excessive renal water losses, resulting in a clinical syndrome of hypotonic polyuria with compensatory thirst. CDI is caused by diverse etiologies, although it typically develops due to neoplastic, traumatic, or autoimmune destruction of AVP-synthesizing/secreting neurons. This review focuses on the diagnosis and management of CDI, providing insights into the physiological disturbances underpinning the syndrome. Recent developments in diagnostic techniques, particularly the development of the copeptin assay, have improved accuracy and acceptability of the diagnostic approach to the hypotonic polyuria syndrome. We discuss the management of CDI with particular emphasis on management of fluid intake and pharmacological replacement of AVP. Specific clinical syndromes such as adipsic diabetes insipidus and diabetes insipidus in pregnancy as well as management of the perioperative patient with diabetes insipidus are also discussed.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1210/clinem/dgac381

Cites

10 of 10 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 10 references

Research works printed but not linked: 134

  1. Garrahy, 2019, Diagnosis and management of central diabetes insipidus in adults, Clinical Endocrinology, 90, 23, 10.1111/cen.13866 · DOI
  2. Spiess, 2020, Genetic forms of neurohypophyseal diabetes insipidus, Best Pract Res Clin Endocrinol Metab., 34, 101432, 10.1016/j.beem.2020.101432 · DOI
  3. Verbalis, 2020, Acquired forms of central diabetes insipidus: mechanisms of disease, Best Pract Res Clin Endocrinol Metab., 34, 101449, 10.1016/j.beem.2020.101449 · doi:10.1016/j.beem.2020.101449
  4. Bellastella, 2012, Subclinical diabetes insipidus, Best Pract Res Clin Endocrinol Metab., 26, 471, 10.1016/j.beem.2011.11.008 · DOI
  5. Szinnai, 2007, Changes in plasma copeptin, the C-terminal portion of arginine vasopressin during water deprivation and excess in healthy subjects, J Clin Endocrinol Metab, 92, 3973, 10.1210/jc.2007-0232 · DOI
  6. Christ-Crain, 2016, Copeptin in the diagnosis of vasopressin-dependent disorders of fluid homeostasis, Nat Rev Endocrinol., 12, 168, 10.1038/nrendo.2015.224 · DOI
  7. Ito, 1991, A single base substitution in the coding region for neurophysin II associated with familial central diabetes insipidus, J Clin Invest., 87, 725, 10.1172/JCI115052 · DOI
  8. Alvelos, 2021, Familial neurohypophyseal diabetes insipidus: clinical, genetic and functional studies of novel mutations in the arginine vasopressin gene, Pituitary, 24, 400, 10.1007/s11102-020-01119-y · DOI
  9. Coggins, 1967, Diabetes insipidus, Am J Med., 42, 807, 10.1016/0002-9343(67)90097-6 · doi:10.1016/0002-9343(67)90097-6
  10. Czernichow, Diabetes Insipidus in Man Volume 13, International Symposium,
  11. Maghnie, 2000, Central diabetes insipidus in children and young adults, N Engl J Med., 343, 998, 10.1056/NEJM200010053431403 · DOI · Paper page
  12. Scherbaum, 1983, Autoantibodies to vasopressin cells in idiopathic diabetes insipidus: evidence for an autoimmune variant, Lancet, 1, 897, 10.1016/S0140-6736(83)91328-4 · DOI
  13. Pivonello, 2003, Central diabetes insipidus and autoimmunity: relationship between the occurrence of antibodies to arginine vasopressin-secreting cells and clinical, immunological, and radiological features in a large cohort of patients with central diabetes insipidus of known and unknown etiology, J Clin Endocrinol Metab, 88, 1629, 10.1210/jc.2002-020791 · DOI
  14. Scherbaum, 1986, Autoimmune cranial diabetes insipidus: its association with other endocrine diseases and with histiocytosis X, Clin Endocrinol., 25, 411, 10.1111/j.1365-2265.1986.tb01707.x · DOI
  15. Hannon, 2012, Anterior hypopituitarism is rare and autoimmune disease is common in adults with idiopathic central diabetes insipidus, Clin Endocrinol (Oxf), 76, 725, 10.1111/j.1365-2265.2011.04270.x · DOI
  16. Behan, 2015, Abnormal plasma sodium concentrations in patients treated with desmopressin for cranial diabetes insipidus: results of a long-term retrospective study, Eur J Endocrinol., 172, 243, 10.1530/EJE-14-0719 · DOI · Paper page
  17. Langlois, 2022, Hypophysitis, the Growing Spectrum of a Rare Pituitary Disease, J Clin Endocrinol Metab., 107, 10, 10.1210/clinem/dgab672 · DOI
  18. Agha, 2004, Neuroendocrine dysfunction in the acute phase of traumatic brain injury, Clin Endocrinol (Oxf), 60, 584, 10.1111/j.1365-2265.2004.02023.x · DOI · Paper page
  19. Qureshi, 2002, Prognostic significance of hypernatremia and hyponatremia among patients with aneurysmal subarachnoid hemorrhage, Neurosurgery, 50, 749, 10.1097/00006123-200204000-00012 · DOI
  20. Agha, 2005, The natural history of post-traumatic neurohypophysial dysfunction, Eur J Endocrinol, 152, 371, 10.1530/eje.1.01861 · DOI · Paper page
  21. Thompson, 1987, Thirst in diabetes insipidus: clinical relevance of quantitative assessment, Quarterly J Med., 65, 853
  22. McIver, 1991, Adipsic hypothalamic diabetes insipidus after clipping of anterior communicating artery aneurysm, BMJ, 303, 1465, 10.1136/bmj.303.6815.1465 · DOI
  23. Crowley, 2007, Clinical insights into adipsic diabetes insipidus: a large case series, Clin Endocrinol., 66, 475, 10.1111/j.1365-2265.2007.02754.x · DOI · Paper page
  24. Smith, 2004, Abnormal regulation of thirst and vasopressin secretion following surgery for craniopharyngioma, Clin Endocrinol., 61, 273, 10.1111/j.1365-2265.2004.02086.x · DOI
  25. Cuesta, 2015, Heterogenous patterns of recovery of thirst in adult patients with adipsic diabetes insipidus, QJM., 109, 303, 10.1093/qjmed/hcv175 · DOI
  26. Christ-Crain, 2019, Diabetes insipidus, Nat Rev Dis Primers., 5, 54, 10.1038/s41572-019-0103-2 · DOI · Paper page
  27. Baylis, 1988, Osmoregulation of vasopressin secretion and thirst in health and disease, Clin Endocrinol., 29, 549, 10.1111/j.1365-2265.1988.tb03704.x · DOI
  28. Refardt, 2020, Diagnosis and differential diagnosis of diabetes insipidus: Update, Best Pract Res Clin Endocrinol Metab., 34, 101398, 10.1016/j.beem.2020.101398 · DOI
  29. Christ-Crain, 2021, Diagnosis and management of diabetes insipidus for the internist: an update, J Intern Med., 290, 73, 10.1111/joim.13261 · DOI
  30. Refardt, 2020, Diabetes Insipidus: An Update, Endocrinol Metab Clin North Am., 49, 517, 10.1016/j.ecl.2020.05.012 · DOI
  31. McKenna, 1998, Osmoregulation in clinical disorders of thirst appreciation, Clin Endocrinol., 49, 139, 10.1046/j.1365-2265.1998.00572.x · DOI
  32. Mercier-Guidez, 2000, Polydipsia and water intoxication in 353 psychiatric inpatients: an epidemiological and psychopathological study, Eur Psychiatry., 15, 306, 10.1016/S0924-9338(00)00399-0 · DOI
  33. Sands, 2006, Nephrogenic diabetes insipidus, Ann Intern Med., 144, 186, 10.7326/0003-4819-144-3-200602070-00007 · DOI
  34. Thompson, 1986, The osmotic thresholds for thirst and vasopressin release are similar in healthy man, Clin Sci (Lond), 71, 651, 10.1042/cs0710651 · DOI
  35. Refardt, 2020, Copeptin-based diagnosis of diabetes insipidus, Swiss Med Wkly., 150, w20237, 10.4414/smw.2020.20237 · DOI
  36. Miller, 1970, Recognition of partial defects in antidiuretic hormone secretion, Ann Intern Med., 73, 721, 10.7326/0003-4819-73-5-721 · DOI · Paper page
  37. De Wardener, 1957, The effect of a high water intake on the kidney’s ability to concentrate the urine in man, J Physiol., 139, 42, 10.1113/jphysiol.1957.sp005873 · DOI
  38. Thompson, 1989, 9 Polyuric states in man, Baillière’s Clin Endocrinol Metab., 3, 473, 10.1016/S0950-351X(89)80012-6 · DOI
  39. Moses, 1984, Marked hypotonic polyuria resulting from nephrogenic diabetes insipidus with partial sensitivity to vasopressin, J Clin Endocrinol Metab., 59, 1044, 10.1210/jcem-59-6-1044 · doi:10.1210/jcem-59-6-1044
  40. Fenske, 2011, Copeptin in the differential diagnosis of the polydipsia-polyuria syndrome—revisiting the direct and indirect water deprivation tests, J Clin Endocrinol Metab., 96, 1506, 10.1210/jc.2010-2345 · DOI
  41. Rooke, 1982, A new sensitive radioimmunoassay for plasma arginine vasopressin, J Immunoassay, 3, 115, 10.1080/15321818208056990 · DOI
  42. Zerbe, 1981, A comparison of plasma vasopressin measurements with a standard indirect test in the differential diagnosis of polyuria, N Engl J Med., 305, 1539, 10.1056/NEJM198112243052601 · DOI · Paper page
  43. Milles, 1983, A comparison of diagnostic methods to differentiate diabetes insipidus from primary polyuria: a review of 21 patients, Acta Endocrinol (Copenh), 104, 410, 10.1530/acta.0.1040410 · DOI
  44. Baylis, 1998, Diabetes insipidus, Arch Dis Child., 79, 84, 10.1136/adc.79.1.84 · doi:10.1136/adc.79.1.84
  45. Sailer, 2021, Validity of different copeptin assays in the differential diagnosis of the polyuria-polydipsia syndrome, Sci Rep., 11, 10104, 10.1038/s41598-021-89505-9 · DOI
  46. Katan, 2007, Anterior and posterior pituitary function testing with simultaneous insulin tolerance test and a novel copeptin assay, J Clin Endocrinol Metab., 92, 2640, 10.1210/jc.2006-2046 · DOI · Paper page
  47. Winzeler, 2015, Postoperative copeptin concentration predicts diabetes insipidus after pituitary surgery, J Clin Endocrinol Metab., 100, 2275, 10.1210/jc.2014-4527 · DOI
  48. Teelucksingh, 1991, Hypothalamic syndrome and central sleep apnoea associated with toluene exposure, . QJM., 78, 185
  49. Engell, 1987, Thirst and fluid intake following graded hypohydration levels in humans, Physiol Behav., 40, 229, 10.1016/0031-9384(87)90212-5 · DOI
  50. Phillips, 1984, Reduced thirst after water deprivation in healthy elderly men, N Engl J Med., 311, 753, 10.1056/NEJM198409203111202 · DOI · Paper page
  51. Thompson, 1987, Acute suppression of plasma vasopressin and thirst after drinking in hypernatremic humans, Am J Physiol, 252, R1138
  52. Phillips, 1993, Effects of drinking on thirst and vasopressin in dehydrated elderly men, Am J Physiol, 264, R877
  53. Thompson, 1991, Reproducibility of osmotic and nonosmotic tests of vasopressin secretion in men, Am J Physiol., 260, R533
  54. Cuesta, 2017, Adipsic diabetes insipidus in adult patients, Pituitary, 20, 372, 10.1007/s11102-016-0784-4 · DOI
  55. Thompson, 1987, Hypernatraemia due to a reset osmostat for vasopressin release and thirst, complicated by nephrogenic diabetes insipidus, Postgrad Med J., 63, 979, 10.1136/pgmj.63.745.979 · DOI
  56. Thompson, 1991, Osmotic and non-osmotic regulation of thirst and vasopressin secretion in patients with compulsive water drinking, Clin Endocrinol., 35, 221, 10.1111/j.1365-2265.1991.tb03526.x · DOI
  57. Woods, 2008, Risk of diabetes insipidus after pituitary surgery, Expert Rev Endocrinol Metab, 3, 23, 10.1586/17446651.3.1.23 · DOI
  58. Schreckinger, 2013, Diabetes insipidus following resection of pituitary tumors, Clin Neurol Neurosurg., 115, 121, 10.1016/j.clineuro.2012.08.009 · DOI
  59. Lobatto, 2020, Feasibility, safety, and outcomes of a stratified fast-track care trajectory in pituitary surgery, Endocrine, 69, 175, 10.1007/s12020-020-02308-2 · DOI
  60. Kinoshita, 2022, Predictive factors of postoperative diabetes insipidus in 333 patients undergoing transsphenoidal surgery for non-functioning pituitary adenoma, Pituitary, 25, 100, 10.1007/s11102-021-01175-y · DOI
  61. Seckl, 1989, Postoperative diabetes insipidus, BMJ, 298, 2, 10.1136/bmj.298.6665.2 · DOI
  62. Hannon, 2012, Clinical review: Disorders of water homeostasis in neurosurgical patients, J Clin Endocrinol Metab., 97, 1423, 10.1210/jc.2011-3201 · DOI
  63. Loh, 2008, Disorders of water and salt metabolism associated with pituitary disease, Endocrinol Metab Clin North Am, 37, 213, 10.1016/j.ecl.2007.10.008 · DOI
  64. de Vries, 2021, Postoperative diabetes insipidus: how to define and grade this complication?, Pituitary, 24, 284, 10.1007/s11102-020-01083-7 · DOI
  65. Berton, 2020, Early copeptin determination allows prompt diagnosis of post-neurosurgical central diabetes insipidus, Neuroendocrinology, 110, 525, 10.1159/000503145 · DOI
  66. Kim, 2021, Changes in copeptin levels before and 3 months after transsphenoidal surgery according to the presence of postoperative central diabetes insipidus, Sci Rep., 11, 17240, 10.1038/s41598-021-95500-x · DOI
  67. Arslan, 1999, High intensity signal of the posterior pituitary. A study with horizontal direction of frequency-encoding and fat suppression MR techniques, Acta Radiol, 40, 142, 10.3109/02841859909177729 · doi:10.3109/02841859909177729
  68. Maghnie, 1998, Lymphocytic hypophysitis and central diabetes insipidus during adolescence: what are the criteria for diagnosis?, Eur J Pediatr., 157, A693, 10.1007/PL00008292 · doi:10.1007/pl00008292
  69. Fujisawa, 1987, Posterior lobe of the pituitary in diabetes insipidus: MR findings, J Comput Assist Tomogr., 11, 221, 10.1097/00004728-198703000-00004 · DOI
  70. Côté, 2014, Normal dimensions of the posterior pituitary bright spot on magnetic resonance imaging, J Neurosurg., 120, 357, 10.3171/2013.11.JNS131320 · DOI
  71. Brooks, 1989, Frequency and variation of the posterior pituitary bright signal on MR images, Am J Neuroradiol., 10, 943
  72. Ma, 1996, MR evaluation of the brain in central diabetes insipidus, Chin Med J (Engl)., 109, 724
  73. Moses, 1992, Use of T1-weighted MR imaging to differentiate between primary polydipsia and central diabetes insipidus, AJNR Am J Neuroradiol., 13, 1273
  74. Bonneville, 2005, Magnetic resonance imaging of pituitary adenomas, Eur Radiol., 15, 543, 10.1007/s00330-004-2531-x · doi:10.1007/s00330-004-2531-x
  75. Imura, 1993, Lymphocytic infundibuloneurohypophysitis as a cause of central diabetes insipidus, N Engl J Med., 329, 683, 10.1056/NEJM199309023291002 · DOI · Paper page
  76. Rao, 2008, Imaging characteristics of common suprasellar lesions with emphasis on MRI findings, Clin Radiol., 63, 939, 10.1016/j.crad.2007.10.003 · doi:10.1016/j.crad.2007.10.003
  77. Saeki, 1999, MRI detection of suprasellar germinoma causing central diabetes insipidus, Endocr J., 46, 263, 10.1507/endocrj.46.263 · doi:10.1507/endocrj.46.263
  78. Saleem, 2007, Lesions of the hypothalamus: MR imaging diagnostic features, Radiographics, 27, 1087, 10.1148/rg.274065123 · DOI · Paper page
  79. Leger, 1999, Thickened pituitary stalk on magnetic resonance imaging in children with central diabetes insipidus, J Clin Endocrinol Metab., 84, 1954
  80. Di Iorgi, 2014, Central diabetes insipidus in children and young adults: etiological diagnosis and long-term outcome of idiopathic cases, J Clin Endocrinol Metab., 99, 1264, 10.1210/jc.2013-3724 · DOI
  81. Allen, 2012, Diagnostic sensitivity of serum and lumbar CSF bHCG in newly diagnosed CNS germinoma, Pediatr Blood Cancer., 59, 1180, 10.1002/pbc.24097 · doi:10.1002/pbc.24097
  82. Bommakanti, 2010, Optic chiasmatic-hypothalamic gliomas: Is tissue diagnosis essential?, Neurol India, 58, 833, 10.4103/0028-3886.73738 · doi:10.4103/0028-3886.73738
  83. Winzeler, 2019, Arginine-stimulated copeptin measurements in the differential diagnosis of diabetes insipidus: a prospective diagnostic study, Lancet, 394, 587, 10.1016/S0140-6736(19)31255-3 · DOI
  84. Fushimi, 1993, Cloning and expression of apical membrane water channel of rat kidney collecting tubule, Nature, 361, 549, 10.1038/361549a0 · DOI · Paper page
  85. Agre, 2000, Aquaporin Water Channels in Kidney, J Am Soc Nephrol., 11, 764, 10.1681/ASN.V114764 · DOI
  86. Sawyer, 1974, Structural changes in the arginine vasopressin molecule that prolong its antidiuretic action, Endocrinology, 95, 140, 10.1210/endo-95-1-140 · DOI
  87. Manning, 1976, Synthesis and some pharmacological properties of deamino[4-threonine,8-D-arginine]vasopressin and deamino[8-D-arginine]vasopressin, highly potent and specific antidiuretic peptides, and [8-D-arginine]vasopressin and deamino-arginine-vasopressin, J Med Chem., 19, 842, 10.1021/jm00228a023 · DOI
  88. Williams, 1986, Antidiuretic effect and pharmacokinetics of oral 1-desamino-8-d-arginine vasopressin. 1. Studies in adults and children, J Clin Endocrinol Metab., 63, 129, 10.1210/jcem-63-1-129 · DOI
  89. Rittig, 1998, Effect of food intake on the pharmacokinetics and antidiuretic activity of oral desmopressin (DDAVP) in hydrated normal subjects, Clin Endocrinol., 48, 235, 10.1046/j.1365-2265.1998.00340.x · DOI
  90. Lam, 1996, Pharmacokinetics, pharmacodynamics, long-term efficacy and safety of oral 1-deamino-8-D-arginine vasopressin in adult patients with central diabetes insipidus, Br J Clin Pharmacol., 42, 379, 10.1046/j.1365-2125.1996.39914.x · DOI · Paper page
  91. Chanson, 2011, Treatment of neurogenic diabetes insipidus, Ann Endocrinol (Paris)., 72, 496, 10.1016/j.ando.2011.09.001 · DOI
  92. Arima, 2013, Efficacy and safety of desmopressin orally disintegrating tablet in patients with central diabetes insipidus: results of a multicenter open-label dose-titration study, Endocr J., 60, 1085, 10.1507/endocrj.EJ13-0165 · DOI · Paper page
  93. Vande Walle, 2007, Desmopressin 30 years in clinical use: a safety review, Curr Drug Saf, 2, 232, 10.2174/157488607781668891 · DOI
  94. Seif, 1978, DDAVP (1-desamino-8-D-arginine-vasopressin) treatment of central diabetes insipidus—mechanism of prolonged antidiuresis, J Clin Endocrinol Metab., 46, 381, 10.1210/jcem-46-3-381 · DOI
  95. Radó, 1976, Individual differences in the antidiuretic response induced by single doses of 1-deamino-8-D-arginine-vasopressin (DDAVP) in patients with pituitary diabetes insipidus, Int J Clin Pharmacol Biopharm, 14, 259
  96. Wales, 1975, Treatment of diabetes insipidus with carbamazepine, Lancet, 2, 948, 10.1016/S0140-6736(75)90361-X · doi:10.1016/s0140-6736(75)90361-x
  97. Durr, 2000, Chlorpropamide upregulates antidiuretic hormone receptors and unmasks constitutive receptor signaling, Am J Physiol Renal Physiol., 278, F799, 10.1152/ajprenal.2000.278.5.F799 · DOI
  98. Moses, 1973, Clofibrate-induced antidiuresis, J Clin Invest., 52, 535, 10.1172/JCI107213 · DOI
  99. Tudor, 2019, Posterior pituitary dysfunction following traumatic brain injury: review, Pituitary, 22, 296, 10.1007/s11102-018-0917-z · DOI · Paper page
  100. Tritos, 2022, Pituitary Society Delphi Survey: an international perspective on endocrine management of patients undergoing transsphenoidal surgery for pituitary adenomas, Pituitary, 25, 64, 10.1007/s11102-021-01170-3 · DOI
  101. Hannon, 2014, Hyponatremia following mild/moderate subarachnoid hemorrhage is due to SIAD and glucocorticoid deficiency and not cerebral salt wasting, J Clin Endocrinol Metab., 99, 291, 10.1210/jc.2013-3032 · DOI
  102. Martin, 1969, Coexisting anterior pituitary and neurohypophyseal insufficiency. A syndrome with diagnostic implication, Arch Intern Med., 123, 409, 10.1001/archinte.1969.00300140055013 · DOI
  103. Masri-Iraqi, 2017, Central Diabetes Insipidus: clinical characteristics and long-term course in a large cohort of adults, Endocr Pract., 23, 600, 10.4158/EP161555.OR · DOI
  104. Verbalis, 2013, Diagnosis, evaluation, and treatment of hyponatremia: expert panel recommendations, Am J Med., 126, S1, 10.1016/j.amjmed.2013.07.006 · DOI · Paper page
  105. Kataoka, 2015, Comparison of incidence of hyponatremia between intranasal and oral desmopressin in patients with central diabetes insipidus, Endocr J., 62, 195, 10.1507/endocrj.EJ14-0368 · DOI
  106. Achinger, 2014, Desmopressin acetate (DDAVP)-associated hyponatremia and brain damage: a case series, Nephrol Dial Transplant, 29, 2310, 10.1093/ndt/gfu263 · doi:10.1093/ndt/gfu263
  107. Achinger, 2019, Use of desmopressin in hyponatremia: foe and friend, Kidney Med, 1, 65, 10.1016/j.xkme.2019.02.002 · doi:10.1016/j.xkme.2019.02.002
  108. Gleeson, 2016, Concerns about the safety of patients with diabetes insipidus admitted to hospital, Clin Endocrinol (Oxf), 84, 950, 10.1111/cen.13028 · doi:10.1111/cen.13028
  109. Baldeweg, 2018, Society for Endocrinology clinical guidance: inpatient management of cranial diabetes insipidus, Endocr Connect, 7, G8, 10.1530/EC-18-0154 · DOI
  110. Levy, 2019, Diabetes insipidus, BMJ, 364, l321, 10.1136/bmj.l321 · DOI
  111. Sterns, 2019, Evidence for managing hypernatremia. Is it just hyponatremia in reverse?, Clin J Am Soc Nephrol., 14, 645, 10.2215/CJN.02950319 · doi:10.2215/cjn.02950319
  112. Miljic, 2014, Adipsic diabetes insipidus and venous thromboembolism (VTE): recommendations for addressing its hypercoagulability, Hormones (Athens), 13, 420
  113. Kung, 1991, Rhabdomyolysis associated with cranial diabetes insipidus, Postgrad Med J., 67, 912, 10.1136/pgmj.67.792.912 · doi:10.1136/pgmj.67.792.912
  114. Parrish, 2018, Electrolyte disturbances in chronic alcohol-use disorder, N Engl J Med., 378, 203
  115. Steiner, 1998, Physiology of beer or non-beer potomania, Am J Kidney Dis., 32, 1123, 10.1016/S0272-6386(98)70094-0 · doi:10.1016/s0272-6386(98)70094-0
  116. Yamamoto, 1976, Letter: Diabetes insipidus and drinking alcohol, N Engl J Med., 294, 55, 10.1056/NEJM197601012940129 · doi:10.1056/nejm197601012940129
  117. Sterns, 2006, Brain volume regulation in response to hypo-osmolality and its correction, Am J Med., 119, S12, 10.1016/j.amjmed.2006.05.003 · DOI
  118. Schrier, 2010, Systemic arterial vasodilation, vasopressin, and vasopressinase in pregnancy, J Am Soc Nephrol., 21, 570, 10.1681/ASN.2009060653 · DOI
  119. Chanson, 2019, Other pituitary conditions and pregnancy, Endocrinol Metab Clin North Am., 48, 583, 10.1016/j.ecl.2019.05.005 · DOI
  120. Davison, 1993, Metabolic clearance of vasopressin and an analogue resistant to vasopressinase in human pregnancy, Am J Physiol., 264, F348
  121. Chanson, 2016, Diabetes insipidus and pregnancy, Ann Endocrinol (Paris)., 77, 135, 10.1016/j.ando.2016.04.005 · DOI
  122. Robertson, 2016, Diabetes insipidus: differential diagnosis and management, Best Pract Res Clin Endocrinol Metab., 30, 205, 10.1016/j.beem.2016.02.007 · DOI
  123. Ananthakrishnan, 2016, Diabetes insipidus during pregnancy, Best Pract Res Clin Endocrinol Metab., 30, 305, 10.1016/j.beem.2016.02.005 · DOI
  124. Ray, 1998, DDAVP use during pregnancy: an analysis of its safety for mother and child, Obstet Gynecol Surv., 53, 450, 10.1097/00006254-199807000-00025 · DOI
  125. Karaca, 2011, Pregnancy and other pituitary disorders (including GH deficiency), Best Pract Res Clin Endocrinol Metab., 25, 897, 10.1016/j.beem.2011.07.006 · doi:10.1016/j.beem.2011.07.006
  126. Baylis, 1980, Plasma vasopressin response to hypertonic saline infusion to assess posterior pituitary function, J R Soc Med., 73, 255, 10.1177/014107688007300408 · DOI
  127. Sherlock, 2006, Adipsic diabetes insipidus following pituitary surgery for a macroprolactinoma, Pituitary, 9, 59, 10.1007/s11102-006-8280-x · doi:10.1007/s11102-006-8280-x
  128. Mavrakis, 2008, Diabetes insipidus with deficient thirst: report of a patient and review of the literature, Am J Kidney Dis., 51, 851, 10.1053/j.ajkd.2007.11.028 · DOI
  129. Nandi, 1978, Successful treatment of hypernatremic thirst deficiency with chlorpropamide, Clin Nephrol., 10, 90
  130. Johnston, 1991, Management of adipsia by a behavioural modification technique, J Neurol Neurosurg Psychiatry., 54, 272, 10.1136/jnnp.54.3.272 · doi:10.1136/jnnp.54.3.272
  131. Sinha, 2011, Objective assessment of thirst recovery in patients with adipsic diabetes insipidus, Pituitary, 14, 307, 10.1007/s11102-011-0294-3 · DOI
  132. O’Reilly, 2015, Radiological remission and recovery of thirst appreciation after infliximab therapy in adipsic diabetes insipidus secondary to neurosarcoidosis, QJM, 108, 657, 10.1093/qjmed/hct023 · doi:10.1093/qjmed/hct023
  133. Nozaki, 2016, Quality of life in the patients with central diabetes insipidus assessed by Nagasaki Diabetes Insipidus Questionnaire, Endocrine, 51, 140, 10.1007/s12020-015-0637-3 · DOI
  134. Aulinas, 2019, Low plasma oxytocin levels and increased psychopathology in hypopituitary men with diabetes insipidus, J Clin Endocrinol Metab., 104, 3181, 10.1210/jc.2018-02608 · DOI

Cited by

See all 159

Metadata

Authors
Tomkins, M., Lawless, S., Martin-Grace, J., Sherlock, M., & Thompson, C. J.
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2022-06-30
Volume
107
Issue
10
Pages
2701-2715
ISSN
  • 0021-972X
  • 1945-7197
DOI
10.1210/clinem/dgac381
Cited by
159
References
10
Language
en
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Funders
  • Wellcome Trust (203930/B/16/Z)
  • Irish Endocrine Society Clinical Science

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Diagnosis and Management of Central Diabetes Insipidus in Adults. https://app.cochat.ai/papers/10.1210/clinem/dgac381
The paper
Tomkins, M., Lawless, S., Martin-Grace, J., Sherlock, M., & Thompson, C. J. (2022). Diagnosis and Management of Central Diabetes Insipidus in Adults. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/clinem/dgac381

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.