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Cited by 135Thyroid Disorders and TreatmentsThyroid Cancer Diagnosis and TreatmentOphthalmology and Eye Disorders

Transient Painless Thyroiditis with Hyperthyroidism: A Variant of Lymphocytic Thyroiditis?*

WOOLF, PAUL D.·1980·Endocrine Reviews
DOI 10.1210/edrv-1-4-411
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Abstract

WITHIN the past decade and particularly within the past 5 years, an unusual form of hyperthyroidism has received increasing attention (1–22). The hyperthyroid manifestations are generally self limiting, although some cases relapse, are accompanied by chronic inflammatory changes within the thyroid parenchyma, and are marked by a very low 131I uptake. Despite the usually abrupt onset of symptoms and the diffuse lymphocytic infiltration, thyroidal pain and/or tenderness is completely absent. Because this syndrome overlaps many of the features of both lymphocytic thyroiditis and subacute thyroiditis, there has been much debate about how to categorize it or whether to consider it a new disease entity. Nomenclature used by the several groups describing it includes: painless thyroiditis (7, 11, 17, 20), silent thyroiditis (3, 9, 19, 22), occult subacute thyroiditis (1), painless subacute thyroiditis (10, 14), subacute nonsuppurative thyroiditis (2), atypical (“silent”) subacute thyroiditis (16), lymphocytic thyroiditis with spontaneously resolving hyperthyroidism (22), hyperthyroiditis (6), lymphocytic thyroiditis (4, 18) and autoimmune disease and thyroiditis (12). The current review was undertaken, therefore, because of this confusion and because of the newly emerging clinical importance of this syndrome. It will focus on the manifestations of this self-limited form of hyperthyroidism and will try to place it into perspective with the more conventional forms of thyrotoxicosis. Although far from clear cut, the data supporting a possible immunological basis will be discussed.

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Crossref · 10.1210/edrv-1-4-411

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  • Patients with painless thyroiditis presenting within the first year after childbirth (postpartum thyroiditis) often have a personal or family history of autoimmune thyroid disease and typically have measurable serum concentrations of anti-thyroid peroxidase antibodies.

    “Patients with painless thyroiditis presenting within the first year after childbirth (postpartum thyroiditis) often have a personal or family history of autoimmune thyroid disease and typically have measurable serum concentrations of anti-thyroid peroxidase antibodies (52).”

    From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [52]

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Authors
WOOLF, P. D.
Affiliations
University of Rochester Medicine (US)
Corresponding author
WOOLF, PAUL D.
Venue
Endocrine Reviews
Publisher
The Endocrine Society
Published
1980-10
Volume
1
Issue
4
Pages
411-420
ISSN
  • 0163-769X (ISSN-L)
  • 1945-7189
DOI
10.1210/edrv-1-4-411
OpenAlex
W2140896713
Cited by
135
References
44
Citations by year
2026: 2 · 2025: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 5 · 2019: 4 · 2017: 2 · 2016: 4 · 2015: 4 · 2014: 2 · 2013: 3 · 2012: 3
FWCI
4.15
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrine Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Ophthalmology and Eye Disorders
Keywords
silent thyroiditis, lymphocytic thyroiditis, subacute thyroiditis, hyperthyroidism, thyrotoxicosis, thyroid pain, 131I uptake, lymphocyte infiltration, autoimmune thyroid disease, disease nomenclature
MeSH terms
Adolescent, Adult, Aged, Autoantibodies, Child, Child, Preschool, Female, Humans, Hyperthyroidism, Iodine, Lymphocytes, Male, Middle Aged, Pain, Pregnancy, Protein Binding, Thyroglobulin, Thyroid Gland, Thyroiditis, Thyroiditis, Autoimmune, Thyrotropin, Thyroxine, Triiodothyronine, Postpartum Period

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