The DOI matches its Crossref record; 159 of the 159 references it cites were found in a registry or an index.
Ovarian Follicle Atresia: A Hormonally Controlled Apoptotic Process*
Open accessAbstract
GREATER THAN 99% of ovarian follicles undergo a degenerative process called atresia during reproductive life. Extending earlier morphological analysis, recent studies have demonstrated that apoptotic cell death is the molecular mechanism underlying follicle atresia. The use of DNA 3′-end-labeling methods allows quantitation and identification of internucleosomal degradation of DNA after gel fractionation as well as in situ analysis of specific cell types undergoing DNA fragmentation in histological sections. Using rats as the experimental model, gonadotropins, epidermal growth factor (EGF)/transforming growth factor-α (TGFα), basic fibroblast growth factor (bFGF), insulin-like growth factor-I (IGF-I), and estrogens have been identified as follicle survival factors capable of suppressing apoptotic DNA fragmentation, whereas androgens, interleukin-6 (IL-6), and GnRH are potential atretogenic factors. This review summarizes the historical background of studies on follicle atresia and selection as well as recent advances in the intraovarian hormonal mechanisms that control follicle apoptosis. It is suggested that during the penultimate stage of follicle development, exposure to a survival factor (probably FSH) is responsible for follicle selection.
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Cites
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Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
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The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis
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Cited by
Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?
Couse, J. F., & Korach, K. S. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0370 · Cited by 2,045
Initial and cyclic recruitment of ovarian follicles
McGee, E. A., & Hsueh, A. J. W. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.2.0394 · Cited by 1,771
Self-citationThe variability of female reproductive ageing
te Velde, E. R. (2002) · Human Reproduction Update · doi:10.1093/humupd/8.2.141 · Cited by 1,214
Manipulation of Human Ovarian Function: Physiological Concepts and Clinical Consequences*
Fauser, B. C. J. M., & van Heusden, A. M. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.1.0290 · Cited by 509
REGULATION OF OVARIAN FOLLICLE ATRESIA
Kaipia, A., & Hsueh, A. J. W. (1997) · Annual Review of Physiology · doi:10.1146/annurev.physiol.59.1.349 · Cited by 455
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Metadata
- Authors
- HSUEH, A. J. W., BILLIG, H., & TSAFRIRI, A.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 1994-12
- Volume
- 15
- Issue
- 6
- Pages
- 707-724
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W2121852257
- Cited by
- 787
- References
- 159
- FWCI
- 38.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
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