The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Transport of Protein-Bound Hormones into Tissues in Vivo*
Abstract
THE STEROID and thyroid hormones circulate in the plasma tightly bound by albumin and by specific plasma globulins (1, 2). Consequently, hormones exist in two states at equilibrium in vitro, i.e. free (dialyzable) and protein-bound. A widely held hypothesis in endocrinology is that the fraction of hormone that is free in vitro is equivalent to the fraction of hormone that is free and available for transport into tissues in vivo. Therefore, in vitro measurements of free hormones may be commonly used as reliable indices of the free hormone in vivo for a variety of clinical states. The purpose of this review is to advance the concept that the large protein-bound moiety of plasma hormone is available for transport into tissues. Consequently, the fraction of plasma hormone that is available for transport in vivo may deviate greatly from the free fraction in vitro. Under some conditions, changes in the free hormone fraction in vitro and in the fraction of plasma hormone that is available for transport in vivo will be proportional.
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Citations
Cites
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Blood-Brain Barrier in Physiology and Medicine
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Westphal, U. F. (1963) · doi:10.21236/ad0423987 · Cited by 674
Measurement of brain uptake of radiolabeled substances using a tritiated water internal standard
Oldendorf, W. H. (1970) · Brain Research · doi:10.1016/0006-8993(70)90123-x · Cited by 548
Transport of Steroid Hormones through the Rat Blood-Brain Barrier
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Self-citationNEUTRAL AMINO ACIDS IN THE BRAIN: CHANGES IN RESPONSE TO FOOD INGESTION1
Fernstrom, J. D., & Faller, D. V. (1978) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1978.tb10489.x · Cited by 423
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KINETICS OF COMPETITIVE INHIBITION OF NEUTRAL AMINO ACID TRANSPORT ACROSS THE BLOOD‐BRAIN BARRIER
Pardridge, W. M. (1977) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1977.tb07714.x · Cited by 367
Self-citationKinetic analysis of blood-brain barrier transport of amino acids
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Nuclear Receptors, RXR, and the Big Bang
Evans, R. M., & Mangelsdorf, D. J. (2014) · Cell · doi:10.1016/j.cell.2014.03.012 · Cited by 1,200
High throughput artificial membrane permeability assay for blood–brain barrier
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The serum transport of steroid hormones
SIITERI, P. K., MURAI, J. T., RAYMOURE, W. J., KUHN, R. W., HAMMOND, G. L., & NISKER, J. A. (1982) · Proceedings of the 1981 Laurentian Hormone Conference · doi:10.1016/b978-0-12-571138-8.50016-0 · Cited by 770
Role of Pharmacokinetics and Metabolism in Drug Discovery and Development
Lin, J. H., & Lu, A. Y. H. (1997) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01340-1 · Cited by 708
A Reappraisal of Testosterone’s Binding in Circulation: Physiological and Clinical Implications
Goldman, A. L., Bhasin, S., Wu, F. C. W., Krishna, M., Matsumoto, A. M., & Jasuja, R. (2017) · Endocrine Reviews · doi:10.1210/er.2017-00025 · Cited by 414
Metadata
- Authors
- PARDRIDGE, W. M.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 1981-01
- Volume
- 2
- Issue
- 1
- Pages
- 103-123
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W1995993817
- Cited by
- 440
- References
- 54
- FWCI
- 8.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- PARDRIDGE, W. M. (1981). Transport of Protein-Bound Hormones into Tissues in Vivo*. Endocrine Reviews. https://doi.org/10.1210/edrv-2-1-103
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
