The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Relationships between Circulating and Intracellular Thyroid Hormones: Physiological and Clinical Implications*
Abstract
THYROXINE (T4), measured as protein-bound iodine, was the first hormone to be quantitated in human serum. As a consequence, it was possible to demonstrate clear relationships between circulating T4 concentrations and many of the physiological manifestations of thyroid hormone excess or deficiency. In 1952, 3,5,3′-triiodothyronine (T3) was identified in human plasma and metabolic studies in man soon led to the realization that this hormone was 3–4 times as potent metabolically as T4 (1–4). At that time, the question was first raised as to whether T4 or T3 was the “active” thyroid hormone (3). This question became even more pertinent when it was suggested first in 1955 (5) and shown conclusively in 1970 that T4 could be converted to T3 by peripheral human tissues (6, 7). These studies were made possible by the development of methods for quantitating T3 in human serum, initially by competitive protein binding techniques, followed soon thereafter by specific and sensitive RIAs.
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Cites
Propylthiouracil inhibits the conversion of l-thyroxine to l-triiodothyronine
Oppenheimer, J. H., Schwartz, H. L., & Surks, M. I. (1972) · Journal of Clinical Investigation · doi:10.1172/jci107063 · Cited by 258
Geffner, D. L., Azukizawa, M., & Hershman, J. M. (1975) · Journal of Clinical Investigation · doi:10.1172/jci107925 · Cited by 192
SILVA, J. E., DICK, T. E., & LARSEN, P. R. (1978) · Endocrinology · doi:10.1210/endo-103-4-1196 · Cited by 189
Self-citationReduction in extrathyroidal triiodothyronine production by propylthiouracil in man.
Saberi, M., Sterling, F. H., & Utiger, R. D. (1975) · Journal of Clinical Investigation · doi:10.1172/jci107924 · Cited by 138
Serum Thyroid Hormone and Thyrotropin Levels in Subjects from Endemic Goiter Regions of New Guinea
CHOPRA, I. J., HERSHMAN, J. M., & HORNABROOK, R. W. (1975) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-40-2-326 · Cited by 106
Cited by
Jonklaas, J., Bianco, A. C., Bauer, A. J., Burman, K. D., Cappola, A. R., Celi, F. S., Cooper, D. S., Kim, B. W., Peeters, R. P., Rosenthal, M. S., et al. (2014) · Thyroid® · doi:10.1089/thy.2014.0028 · Cited by 1,928
“The consequences of differential deiodinase expression are striking: rodent studies indicate that the TRs in brain cells are almost fully occupied under normal conditions, whereas in the liver cells the receptors are only about half occupied (360).”
Bianco, A. C., Salvatore, D., Gereben, B., Berry, M. J., & Larsen, P. R. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.1.0455 · Cited by 1,853
State-of-the-science of endocrine disrupting chemicals, 2012
Bergman, Å., Heindel, J., Jobling, S., Kidd, K., & Zoeller, R. T. (2012) · Toxicology Letters · doi:10.1016/j.toxlet.2012.03.020 · Cited by 1,388
Glinoer, D. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.3.0300 · Cited by 1,364
Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling1
Gereben, B., Zavacki, A. M., Ribich, S., Kim, B. W., Huang, S. A., Simonides, W. S., Zeöld, A., & Bianco, A. C. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0019 · Cited by 891
Metadata
- Authors
- LARSEN, P. R., SILVA, J. E., & KAPLAN, M. M.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 1981-01
- Volume
- 2
- Issue
- 1
- Pages
- 87-102
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W2077564553
- Cited by
- 546
- References
- 5
- FWCI
- 27.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- LARSEN, P. R., SILVA, J. E., & KAPLAN, M. M. (1981). Relationships between Circulating and Intracellular Thyroid Hormones: Physiological and Clinical Implications*. Endocrine Reviews. https://doi.org/10.1210/edrv-2-1-87
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
