The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Gonadotropin-Releasing Hormone Analog Design. Structure-Function Studies Toward the Development of Agonists and Antagonists: Rationale and Perspective
Abstract
ON JUNE 24, 1971, Andrew V. Schally announced the determination of the primary structure of porcine GnRH at The Endocrine Society Meeting in San Francisco. This announcement was followed by publications by Matsuo et al. (1, 2) and Baba et al. (3) on the proposed amino acid sequence for porcine GnRH and its synthesis and by Burgus et al. (4) who characterized ovine GnRH and found the sequence to be identical with that of porcine GnRH. The physiological and therapeutic importance attributed to the discovery of the new substance was greatly increased by the prospect of the design of potent and long acting GnRH agonists and antagonists. Since that time more than 2000 analogs of GnRH have been synthesized. The impact of research of GnRH and its analogs on clinical medicine recently led Ziporyn (5) to note, “There's almost no subspecialty of medicine that will be left untouched by the [research] advances associated with LHRH or its analogs.” It is the intent of this article to provide a historical review of the major, and some minor, aspects of the chemical development of GnRH agonists and antagonists up to the present state of development (July 1, 1985). The synthetic chemical efforts have been devoted largely to increasing the affinity of the peptides to the GnRH receptor and their resistance to degradation or elimination in in vivo systems, characteristics which, for the GnRH analogs, are generally interrelated.
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Citations
Cites
Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide
Merrifield, R. B. (1963) · Journal of the American Chemical Society · doi:10.1021/ja00897a025 · Cited by 7,647
Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence
(1976) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(76)90821-8 · Cited by 1,033
Culture of Enzymatically Dispersed Anterior Pituitary Cells: Functional Validation of a Method
VALE, W., GRANT, G., AMOSS, M., BLACKWELL, R., & GUILLEMIN, R. (1972) · Endocrinology · doi:10.1210/endo-91-2-562 · Cited by 550
Primary Structure of the Ovine Hypothalamic Luteinizing Hormone-Releasing Factor (LRF)
Burgus, R., Butcher, M., Amoss, M., Ling, N., Monahan, M., Rivier, J., Fellows, R., Blackwell, R., Vale, W., & Guillemin, R. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.1.278 · Cited by 476
Self-citationMiyamoto, K., Hasegawa, Y., Nomura, M., Igarashi, M., Kangawa, K., & Matsuo, H. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.12.3874 · Cited by 457
Regulatory Peptides of the Hypothalamus
Vale, W., Rivier, C., & Brown, M. (1977) · Annual Review of Physiology · doi:10.1146/annurev.ph.39.030177.002353 · Cited by 392
Characterization of a teleost gonadotropin-releasing hormone.
Sherwood, N., Eiden, L., Brownstein, M., Spiess, J., Rivier, J., & Vale, W. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.9.2794 · Cited by 349
Self-citationFreidinger, R. M., Veber, D. F., Perlow, D. S., Brooks, J. R., & Saperstein, R. (1980) · Science · doi:10.1126/science.7001627 · Cited by 315
Baba, Y., Matsuo, H., & Schally, A. V. (1971) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(71)90623-1 · Cited by 247
Monahan, M. W., Amoss, M. S., Anderson, H., & Vale, W. (1973) · Biochemistry · doi:10.1021/bi00747a012 · Cited by 246
Cited by
10.1016/b978-1-4160-2911-3.50026-1
(2000) · CrossRef Listing of Deleted DOIs · doi:10.1016/b978-1-4160-2911-3.50026-1 · Cited by 554
Gonadotropin-releasing hormone and its analogues
Desforges, J. F., Conn, P. M., & Crowley, W. F. (1991) · New England Journal of Medicine · doi:10.1056/nejm199101103240205 · Cited by 470
Hypothalamic Hormones and Cancer
Schally, A. V., Comaru-Schally, A. M., Nagy, A., Kovacs, M., Szepeshazi, K., Plonowski, A., Varga, J. L., & Halmos, G. (2001) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2001.0217 · Cited by 254
Jimenez-Liñan, M., Rubin, B. S., & King, J. C. (1997) · Endocrinology · doi:10.1210/endo.138.10.5454 · Cited by 140
Lüking Jayes, F. C., Britt, J. H., & Esbenshade, K. L. (1997) · Biology of Reproduction · doi:10.1095/biolreprod56.4.1012 · Cited by 30
Metadata
- Authors
- KARTEN, M. J., & RIVIER, J. E.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 1986-02
- Volume
- 7
- Issue
- 1
- Pages
- 44-66
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W2042415727
- Cited by
- 560
- References
- 39
- FWCI
- 26.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Gonadotropin-Releasing Hormone Analog Design. Structure-Function Studies Toward the Development of Agonists and Antagonists: Rationale and Perspective. https://app.cochat.ai/papers/10.1210/edrv-7-1-44
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- KARTEN, M. J., & RIVIER, J. E. (1986). Gonadotropin-Releasing Hormone Analog Design. Structure-Function Studies Toward the Development of Agonists and Antagonists: Rationale and Perspective. Endocrine Reviews. https://doi.org/10.1210/edrv-7-1-44
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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