Cited by 926Stress Responses and CortisolNeuropeptides and Animal PhysiologyAdrenal Hormones and Disorders

The DOI matches its Crossref record; 486 of the 486 references it cites were found in a registry or an index.

Stressor Specificity of Central Neuroendocrine Responses: Implications for Stress-Related Disorders

Pacák, Karel, Palkovits, Miklós·2001·Endocrine Reviews

Open this paper in CoChat — free account

Abstract

Despite the fact that many research articles have been written about stress and stress-related diseases, no scientifically accepted definition of stress exists. Selye introduced and popularized stress as a medical and scientific idea. He did not deny the existence of stressor-specific response patterns; however, he emphasized that such responses did not constitute stress, only the shared nonspecific component. In this review we focus mainly on the similarities and differences between the neuroendocrine responses (especially the sympathoadrenal and the sympathoneuronal systems and the hypothalamo-pituitary-adrenocortical axis) among various stressors and a strategy for testing Selye's doctrine of nonspecificity. In our experiments, we used five different stressors: immobilization, hemorrhage, cold exposure, pain, or hypoglycemia. With the exception of immobilization stress, these stressors also differed in their intensities. Our results showed marked heterogeneity of neuroendocrine responses to various stressors and that each stressor has a neurochemical "signature." By examining changes of Fos immunoreactivity in various brain regions upon exposure to different stressors, we also attempted to map central stressor-specific neuroendocrine pathways. We believe the existence of stressor-specific pathways and circuits is a clear step forward in the study of the pathogenesis of stress-related disorders and their proper treatment. Finally, we define stress as a state of threatened homeostasis (physical or perceived treat to homeostasis). During stress, an adaptive compensatory specific response of the organism is activated to sustain homeostasis. The adaptive response reflects the activation of specific central circuits and is genetically and constitutionally programmed and constantly modulated by environmental factors.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1210/edrv.22.4.0436

Cites

486 of 486 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Items 201–400 of 486

Intravenous angiotensin II induces Fos-immunoreactivity in circumventricular organs of the lamina terminalis
McKinley, M. J., Badoer, E., & Oldfield, B. J. (1992) · Brain Research · doi:10.1016/0006-8993(92)91138-5 · Cited by 165
Effects of Psychological Stress on Male Reproduction: A Review
McGrady, A. V. (1984) · Archives of Andrology · doi:10.3109/01485018408987495 · Cited by 163
Activation of brainstem catecholaminergic neurons by conditioned and unconditioned aversive stimuli as revealed by c-Fos immunoreactivity
Pezzone, M. A., Lee, W.-S., Hoffman, G. E., Pezzone, K. M., & Rabin, B. S. (1993) · Brain Research · doi:10.1016/0006-8993(93)91472-5 · Cited by 162
Anterior pituitary response to stress : time‐related changes and adaptation
Martı́, O., & Armario, A. (1998) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(98)00030-6 · Cited by 161
Interconnections between the Neuroendocrine Hypothalamus and the Central Autonomic System
Palkovits, M. (1999) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1999.0186 · Cited by 160
Self-citation
Spinal serotonin receptors mediate descending facilitation of a nociceptive reflex from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat
Zhuo, M., & Gebhart, G. F. (1991) · Brain Research · doi:10.1016/0006-8993(91)90402-h · Cited by 160
Antinociception following opioid stimulation of the basolateral amygdala is expressed through the periaqueductal gray and rostral ventromedial medulla
Helmstetter, F. J., Tershner, S. A., Poore, L. H., & Bellgowan, P. S. F. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01104-9 · Cited by 159
Organization of the efferent projections from the pontine parabrachial area to the bed nucleus of the stria terminalis and neighboring regions: A PHA‐L study in the rat
Alden, M., Besson, J., & Bernard, J. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903410302 · Cited by 159
Glucocorticoid Physiology, Pharmacology and Stress
Munck, A. U., & Guyre, P. M. (1986) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-5101-6_6 · Cited by 158
Spinal neurons reaching the lateral reticular nucleus as studied in the rat by retrograde transport of horseradish peroxidase
Menétrey, D., Roudier, F., & Besson, J. (1983) · The Journal of Comparative Neurology · doi:10.1002/cne.902200406 · Cited by 157
Expression of c-fos in regions of the basal limbic forebrain following intra-cerebroventricular corticotropin-releasing factor in unstressed or stressed male rats
Arnold, F. J. L., de Lucas Bueno, M., Shiers, H., Hancock, D. C., Evan, G. I., & Herbert, J. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90322-s · Cited by 155
The projection of noradrenergic neurons in the A7 catecholamine cell group to the spinal cord in the rat demonstrated by anterograde tracing combined with immunocytochemistry
Clark, F. M., & Proudfit, H. K. (1991) · Brain Research · doi:10.1016/0006-8993(91)90972-x · Cited by 155
Spinal afferents to functionally distinct periaqueductal gray columns in the rat: An anterograde and retrograde tracing study
Keay, K. A., Feil, K., Gordon, B. D., Herbert, H., & Bandler, R. J. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970825)385:2 · Cited by 154
Noradrenaline innervation of the spinal cord studied by the horseradish peroxidase method combined with monoamine oxidase staining
Satoh, K., Tohyama, M., Yamamoto, K., Sakumoto, T., & Shimizu, N. (1977) · Experimental Brain Research · doi:10.1007/bf00237249 · Cited by 149
Hypoglycemic ‘Stress’ and Gonadotropin-Releasing Hormone Pulse Generator Activity in the Rhesus Monkey: Role of the Ovary
Chen, M., O’Byrne, K. T., Chiappini, S. E., Hotchkiss, J., & Knobil, E. (2008) · Neuroendocrinology · doi:10.1159/000126291 · Cited by 148
Stress‐Specific Regulation of Corticotropin Releasing Hormone Receptor Expression in the Paraventricular and Supraoptic Nuclei of the Hypothalamus in the Rat
Luo, X., Kiss, A., Makara, G. B., Lolait, S. J., & Aguilera, G. (1994) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1994.tb00636.x · Cited by 148
Spinal cord and trigeminal projections to the pontine parabrachial region in the rat as demonstrated with Phaseolus vulgaris leucoagglutinin
Slugg, R. M., & Light, A. R. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903390106 · Cited by 145
Innervation of the nucleus of the solitary tract and the dorsal vagal nucleus by thyrotropin-releasing hormone-containing raphe neurons
Palkovits, M., Mezey, É., Eskay, R. L., & Brownstein, M. (1986) · Brain Research · doi:10.1016/0006-8993(86)90338-0 · Cited by 145
Self-citation
Effects of Various Stressors on In Vivo Norepinephrine Release in the Hypothalamic Paraventricular Nucleus and on the Pituitary‐Adrenocortical Axis
Pacák, K., Palkovits, M., Květňanský, R., Yadid, G., Kopin, I. J., & Goldstein, D. S. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb44675.x · Cited by 144
Self-citation
Chapter 4 Central control of the circulation by the rostral ventrolateral reticular nucleus: anatomical substrates
Ruggiero, D. A., Cravo, S. L. D., Arango, V., et al. (1989) · Progress in brain research · doi:10.1016/s0079-6123(08)61999-8 · Cited by 142
Chapter 5 Vagal efferent projections: viscerotopy, neurochemistry and effects of vagotomy
Hopkins, D. A., Bieger, D., de Vente, J., & Steinbusch, H. W. M. (1996) · Progress in brain research · doi:10.1016/s0079-6123(08)61859-2 · Cited by 141
Stress Selectively Activates the Vasopressin-Containing Subset of Corticotropin-Releasing Hormone Neurons
Whitnall, M. H. (2008) · Neuroendocrinology · doi:10.1159/000125302 · Cited by 140
Evidence for Multifactor Regulation of the Adrenocorticotropin Secretory Response to Hemodynamic Stimuli*
Plotsky, P. M., BRUHN, T. O., & Vale, W. (1985) · Endocrinology · doi:10.1210/endo-116-2-633 · Cited by 140
Noradrenergic activation in the paraventricular nucleus during acute and chronic immobilization stress in rats: an in vivo microdialysis study
Pacák, K., Armando, I., Fukuhara, K., Kvetnatsky, R., Palkovits, M., Kopin, I. J., & Goldstein, D. S. (1992) · Brain Research · doi:10.1016/0006-8993(92)91165-b · Cited by 139
Self-citation
Neuroendocrine and Autonomous Mechanisms Underlying Thermoregulation in Cold Environment
Arancibia, S., Rage, F., ASTIER, H. S., & Tapia‐Arancibia, L. (2008) · Neuroendocrinology · doi:10.1159/000127126 · Cited by 139
Rat central amygdaloid nucleus projections to the bed nucleus of the stria terminalis
Sun, N., Roberts, L. A., & Cassell, M. D. (1991) · Brain Research Bulletin · doi:10.1016/0361-9230(91)90041-h · Cited by 136
The relationship of efferent projections from the area postrema to vagal motor and brain stem catecholamine-containing cell groups: An axonal transport and immunohistochemical study in the rat
Cunningham, E. T., Miselis, R. R., & Sawchenko, P. E. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90087-6 · Cited by 133
Modulation of tyrosine hydroxylase gene expression in rat brain and adrenals by exposure to cold
Richard, F., Biguet, N. F., Labatut, R., Rollet, D., Mallet, J. J., & Buda, M. (1988) · Journal of Neuroscience Research · doi:10.1002/jnr.490200106 · Cited by 132
Repeated Immobilization Stress Alters Tyrosine Hydroxylase, Corticotropin‐Releasing Hormone and Corticosteroid Receptor Messenger Ribonucleic Acid Levels in Rat Brain
Mamalaki, E., Kvetnan̆ský, R., Brady, L., Gold, P., & Herkenham, M. (1992) · Journal of neuroendocrinology · doi:10.1111/j.1365-2826.1992.tb00220.x · Cited by 131
Immunocytochemical evidence for stimulatory control by the ventral noradrenergic bundle of parvocellular neurons of the paraventricular nucleus secreting corticotropin releasing hormone and vasopressin in rats
Alonso, G., SZAFARCZYK, A., Balmefrézol, M., & ASSENMACHER, I. (1986) · Brain Research · doi:10.1016/0006-8993(86)90631-1 · Cited by 130
In situ hybridization analysis of vasopressin gene transcription in the paraventricular and supraoptic nuclei of the rat: Regulation by stress and glucocorticoids
Herman, J. P. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903630103 · Cited by 129
Inhibin β, somatostatin, and enkephalin immunoreactivities coexist in caudal medullary neurons that project to the paraventricular nucleus of the hypothalamus
Sawchenko, P. E., Arias, C. M., & Bittencourt, J. C. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902910209 · Cited by 128
Increased transcription of the astrocyte gene GFAP during middle-age is attenuated by food restriction: Implications for the role of oxidative stress
Morgan, T. E., Rozovsky, I., Goldsmith, S. K., Stone, D. J., Yoshida, T., & Finch, C. E. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00120-2 · Cited by 126
Catecholamines in Individual Hypothalamic Nuclei of Acutely and Repeatedly Stressed Rats
Květňanský, R., Palkovits, M., Mitro, A., Torda, T., & MIKULAJ, L. (2008) · Neuroendocrinology · doi:10.1159/000122673 · Cited by 125
Self-citation
Vasopressin release within the supraoptic and paraventricular nuclei of the rat brain: osmotic stimulation via microdialysis
Landgraf, R., & Ludwig, M. (1991) · Brain Research · doi:10.1016/0006-8993(91)90768-q · Cited by 125
The preoptic area and bed nucleus of the stria terminalis are involved in the effects of the amygdala on adrenocortical secretion
Feldman, S., Conforti, N., & Saphier, D. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90107-f · Cited by 125
The spino-latero-reticular system of the rat: Projections from the superficial dorsal horn and structural characterization of marginal neurons involved
Lima, D., Mendes-Ribeiro, J. A., & Coimbra, A. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90110-a · Cited by 124
Corticotropin-Releasing Hormone-Mediated Neuroprotection against Oxidative Stress Is Associated with the Increased Release of Non-amyloidogenic Amyloid Precursor Protein and with the Suppression of Nuclear Factor- B
Lezoualc’h, F., Engert, S., Berning, B., & Behl, C. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.1.0403 · Cited by 124
Behavioral thermoregulation in rats with anterior hypothalamic lesions.
Satinoff, E., & Rutstein, J. E. (1970) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0028959 · Cited by 122
Noradrenaline release in the rat amygdala is increased by stress: studies with intracerebral microdialysis
Tanaka, T., Yokoo, H., Mizoguchi, K., Yoshida, M., Tsuda, A., & Tanaka, M. (1991) · Brain Research · doi:10.1016/0006-8993(91)90902-8 · Cited by 121
Activation of the Locus Ceruleus Brain Noradrenergic System during Stress: Circuitry, Consequences, and Regulation
Valentino, R. J., Curtis, A. L., Page, M. E., Pavcovich, L. A., & Florin-Lechner, S. M. (1997) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60863-7 · Cited by 120
Metabolic interfaces between growth and reproduction. V. Pulsatile luteinizing hormone secretion is dependent on glucose availability
Bucholtz, D. C., Vidwans, N. M., Herbosa, C. G., Schillo, K. K., & Foster, D. L. (1996) · Endocrinology · doi:10.1210/endo.137.2.8593808 · Cited by 120
HYPOTHALAMIC REGULATION OF BODY TEMPERATURE
Clark, G. A., Magoun, H. W., & Ranson, S. W. (1939) · Journal of Neurophysiology · doi:10.1152/jn.1939.2.1.61 · Cited by 120
Chapter 9 Biochemical switching in hypothalamic circuits mediating responses to stress
Swanson, L. W. (1991) · Progress in brain research · doi:10.1016/s0079-6123(08)63052-6 · Cited by 119
Endocrine and neurophysiologic responses of the pituitary to insulin-induced hypoglycemia: A review
Fish, H. R., Chernow, B., & O'Brian, J. T. (1986) · Metabolism · doi:10.1016/0026-0495(86)90245-3 · Cited by 117
Diurnal-stimulated and stress-induced ACTH release in rats is mediated by ventral noradrenergic bundle
SZAFARCZYK, A., Alonso, G., IXART, G., Malaval, F., & ASSENMACHER, I. (1985) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1985.249.2.e219 · Cited by 117
Gehirn und Sympathicus
Karplus, J. P., & Kreidl, A. (1927) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf01731342 · Cited by 117
Cold exposure elevates cellular levels of messenger ribonucleic acid encoding thyrotropin-releasing hormone in paraventricular nucleus despite elevated levels of thyroid hormones
ZOELLER, R. T., KABEER, N., & ALBERS, H. E. (1990) · Endocrinology · doi:10.1210/endo-127-6-2955 · Cited by 116 · cited 3×
“The effects of cold stress appear to be specific for TRH expression in the PVN, since cold stress does not affect cellular levels of TRH mRNA in other brain regions (233).”
Background
Morphological types of spinomesencephalic neurons in the marginal zone (Lamina I) of the rat spinal cord, as shown after retrograde labelling with cholera toxin subunit B
Lima, D., & Coimbra, A. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902790212 · Cited by 114
The involvement of noradrenergic ascending pathways in the stress-induced activation of ACTH and corticosterone secretions is dependent on the nature of stressors
Gaillet, S., Lachuer, J., Malaval, F., ASSENMACHER, I., & SZAFARCZYK, A. (1991) · Experimental Brain Research · doi:10.1007/bf00228518 · Cited by 112
Ascending noradrenergic projections from the brainstem: Evidence for a major role in the regulation of blood pressure and vasopressin secretion
Lightman, S. L., Todd, K., & Everitt, B. J. (1984) · Experimental Brain Research · doi:10.1007/bf00240508 · Cited by 110
A comparison of hypotensive and non-hypotensive hemorrhage on Fos expression in spinally projecting neurons of the paraventricular nucleus and rostral ventrolateral medulla
Badoer, E., McKinley, M. J., Oldfield, B. J., & McAllen, R. M. (1993) · Brain Research · doi:10.1016/0006-8993(93)91403-f · Cited by 109
Bodily Changes in Pain, Hunger, Fear, and Rage
P, J. H., & Cannon, W. B. (1930) · The American Journal of Psychology · doi:10.2307/1415295 · Cited by 107
Nucleus tractus solitarius efferent terminals synapse on neurons in the caudal ventrolateral medulla that project to the rostral ventrolateral medulla
Aicher, S. A., Kurucz, O. S., REIS, D. J., & Milner, T. A. (1995) · Brain Research · doi:10.1016/0006-8993(95)00660-i · Cited by 106
Effects of immobilization on in vivo release of norepinephrine in the bed nucleus of the stria terminalis in conscious rats
Pacák, K., McCarty, R. C., Palkovits, M., Kopin, I. J., & Goldstein, D. S. (1995) · Brain Research · doi:10.1016/0006-8993(95)00566-9 · Cited by 106
Self-citation
Über den Einfluß des Gehirns auf die Wärmeregulation
Isenschmid, R., & Krehl, L. (1912) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf01873889 · Cited by 106
Thermosensitivity of medulla oblongata in control of body temperature
Lipton, J. (1973) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1973.224.4.890 · Cited by 105
The organization of preoptic–medullary circuits in the male rat: evidence for interconnectivity of neural structures involved in reproductive behavior, antinociception and cardiovascular regulation
Murphy, A. Z., Rizvi, T. A., Ennis, M. J., & Shipley, M. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00677-0 · Cited by 104
Regional characteristics of stress-induced increases in brain noradrenaline release in rats
Tanaka, M., Kohno, Y., Nakagawa, R., et al. (1983) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(83)90132-6 · Cited by 104
CNS cell groups projecting to pancreatic parasympathetic preganglionic neurons
Loewy, A. D., & Haxhiu, M. A. (1993) · Brain Research · doi:10.1016/0006-8993(93)90174-l · Cited by 102
Electron microscopic analysis of tyrosine hydroxylase, dopamine-?-hydroxylase and phenylethanolamine-N-methyltransferase immunoreactive innervation of the hypothalamic paraventricular nucleus in the rat
Liposits, Z., Phelix, C. F., & Paull, W. K. (1986) · Histochemistry and Cell Biology · doi:10.1007/bf00499821 · Cited by 102
Periaqueductal gray matter projection to vagal preganglionic neurons and the nucleus tractus solitarius
Farkas, E., Jansen, A. S. P., & Loewy, A. D. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00592-1 · Cited by 101
Inhibiting the rabbit caudal ventrolateral medulla prevents baroreceptor‐initiated secretion of vasopressin.
Blessing, W. W., & Willoughby, J. O. (1985) · The Journal of Physiology · doi:10.1113/jphysiol.1985.sp015823 · Cited by 100
Chapter 4 Neuronal networks controlling thermoregulatory effectors
Kanosue, K., Hosono, T., Zhang, Y.-H., & Chen, X.-M. (1998) · Progress in brain research · doi:10.1016/s0079-6123(08)62029-4 · Cited by 99
Differential distribution of fos-like immunoreactivity in the spinal trigeminal nucleus after noxious and innocuous thermal and chemical stimulation of rat cornea
Meng, I. D., & Bereiter, D. A. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00541-2 · Cited by 99
Protection Against Oxidative Stress‐induced Neuronal Cell Death‐A Novel Role for RU486
Behl, C., Trapp, T., Skutella, T., & Holsboer, F. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01442.x · Cited by 98
Beitrag zur Lokalisation des der Wärmeregulation vorstehenden Zentralapparates im Zwischenhirn
Isenschmid, R., & Schnitzler, W. (1914) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf01864729 · Cited by 96
The amygdalo-brainstem pathway: Selective innervation of dopaminergic, noradrenergic and adrenergic cells in the rat
Wallace, D. M., Magnuson, D. J., & Gray, T. S. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90606-x · Cited by 96
Hyperthermia induces c-fos expression in the preoptic area
Scammell, T. E., Price, K., & Sagar, S. M. (1993) · Brain Research · doi:10.1016/0006-8993(93)91280-6 · Cited by 94
Gender specificity in the neural regulation of the response to stress
Patchev, V. K., & Almeida, O. F. X. (1998) · Molecular Neurobiology · doi:10.1007/bf02740603 · Cited by 94
Differences in Fos expression in the rat brains between cold and warm ambient exposures
Kiyohara, T., Miyata, S., Nakamura, T. J., Shido, O., Nakashima, T., & Shibata, M. (1995) · Brain Research Bulletin · doi:10.1016/0361-9230(95)00093-t · Cited by 92
Direct Evidence of Short-Term Cold-Induced TRH Release in the Median Eminence of Unanesthetized Rats
Arancibia, S., Tapia‐Arancibia, L., ASSENMACHER, I., & ASTIER, H. S. (2008) · Neuroendocrinology · doi:10.1159/000123547 · Cited by 91
Distribution of hypothalamic, medullary and lamina terminalis neurons expressing Fos after hemorrhage in conscious rats
Badoer, E., McKinley, M. J., Oldfield, B. J., & McAllen, R. M. (1992) · Brain Research · doi:10.1016/0006-8993(92)90150-8 · Cited by 91
Specificity of spinal projections from hypothalamic and brainstem areas which innervate sympathetic preganglionic neurons
Tucker, D. C., & Saper, C. B. (1985) · Brain Research · doi:10.1016/0006-8993(85)91231-4 · Cited by 90
Fos-like immunoreactivity in the rat hypothalamic-pituitary axis after immobilization stress
Kononen, J., Honkaniemi, J., Alho, H., Koıstınaho, J., Iadarola, M. J., & Pelto‐Huikko, M. (1992) · Endocrinology · doi:10.1210/endo.130.5.1315265 · Cited by 90
Neurotransmitters in Temperature Control
Lipton, J. M., & Clark, W. G. (1986) · Annual Review of Physiology · doi:10.1146/annurev.ph.48.030186.003145 · Cited by 90
Pituitary-Adrenocortical Responses to Persistent Noxious Stimuli in the Awake Rat: Endogenous Corticosterone Does Not Reduce Nociception in the Formalin Test
Taylor, B. K. (1998) · Endocrinology · doi:10.1210/en.139.5.2407 · Cited by 89
Major role of 3',5'-cyclic adenosine monophosphate-dependent protein kinase A pathway in corticotropin-releasing factor gene expression in the rat hypothalamus in vivo
Itoi, K., HORIBA, N., Tozawa, F., Sakai, Y., Sakai, K., Abe, K., Demura, H., & Suda, T. (1996) · Endocrinology · doi:10.1210/endo.137.6.8641191 · Cited by 89
Awareness of Hypertension Increases Blood Pressure and Sympathetic Responses to Cold Pressor Test
Rostrup, M., Kjeldsen, S. E., & Eide, I. K. (1990) · American Journal of Hypertension · doi:10.1093/ajh/3.12.912 · Cited by 89
c-fos Expression in Vasopressin and Oxytocin Neurons Reveals Functional Heterogeneity within Magnocellular Neurons
Roberts, M. M., ROBINSON, A. G., Fitzsimmons, M. D., Grant, F., Lee, W.-S., & Hoffman, G. E. (2008) · Neuroendocrinology · doi:10.1159/000126384 · Cited by 88
Anorexigenic cocaine- and amphetamine-regulated transcript peptide intensifies fear reactions in rats
Kask, A., Schiöth, H. B., Mutulis, F., Wikberg, J. E. S., & Rägo, L. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02383-5 · Cited by 86
Adrenaline, noradrenaline and dopamine levels in specific brain stem areas of acutely immobilized rats
Saavedra, J. M., Květňanský, R., & Kopin, I. J. (1979) · Brain Research · doi:10.1016/0006-8993(79)90424-4 · Cited by 84
The insulin hypoglycemia-induced inhibition of gonadotropin-releasing hormone pulse generator activity in the rhesus monkey: roles of vasopressin and corticotropin-releasing factor
Chen, M. D., Ördög, T., O'Byrne, K. T., Goldsmith, J. R., Connaughton, M. A., & Knobil, E. (1996) · Endocrinology · doi:10.1210/endo.137.5.8612542 · Cited by 83
The Role of Ascending Neuronal Pathways in Stress‐Induced Release of Noradrenaline in the Hypothalamic Paraventricular Nucleus of Rats
Palkovits, M., Baffi, & Pacak (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00365.x · Cited by 83
Self-citation
Insulin-Induced Hypoglycemia Increases Corticotropin- Releasing Factor Messenger Ribonucleic Acid Levels in Rat Hypothalamus*
Suda, T., TOZAWA, F., YAMADA, M., USHIYAMA, T., Tomori, N., Sumitomo, T., NAKAGAMI, Y., Demura, H., & SHIZUME, K. (1988) · Endocrinology · doi:10.1210/endo-123-3-1371 · Cited by 82
Differential Early Time Course Activation of the Brainstem Catecholaminergic Groups in Response to Various Stresses
Lachuer, J., Gaillet, S., Barbagli, B., Buda, M., & Tappaz, M. (2008) · Neuroendocrinology · doi:10.1159/000125778 · Cited by 81
Hemorrhage induces Fos immunoreactivity in rat medullary catecholaminergic neurons
Dun, N. J., Dun, S. L., & Chiaia, N. L. (1993) · Brain Research · doi:10.1016/0006-8993(93)91462-2 · Cited by 80
Interrelations between Sympathoadrenal System andHypothalamo‐Pituitary‐Adrenocortical/Thyroid Systemsin Rats Exposed to Cold Stress
Fukuhara, K., Květňanský, R., Cizza, G., et al. (1996) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1996.04877.x · Cited by 80
Insulin-Induced Hypoglycemia Activates the Release of Adrenocorticotropin Predominantly via Central and Propranolol Insensitive Mechanisms
Ježová, D., Květňanský, R., Kovács, K., Opršalová, Z., Vigas, M., & Makara, G. B. (1987) · Endocrinology · doi:10.1210/endo-120-1-409 · Cited by 79
Hemodynamic regulation of tyrosine hydroxylase messenger RNA in medullary catecholamine neurons: a c- fos-guided hybridization histochemical study
Chan, R. K. W., & Sawchenko, P. E. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00600-a · Cited by 78
Neurons in the superficial dorsal horn of the rat spinal cord projecting to the medullary ventrolateral reticular formation express c-fos after noxious stimulation of the skin
Tavares, I., Lima, D., & Coimbra, A. (1993) · Brain Research · doi:10.1016/0006-8993(93)91438-x · Cited by 77
Loss of behavioral thermoregulation after lateral hypothalamic lesions in rats.
Satinoff, E., & Shan, S. Y. (1971) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0031652 · Cited by 76
Glucocorticoids, Stress, and Behavior: Shifting the Timeframe1
Orchinik, M. (1998) · Hormones and Behavior · doi:10.1006/hbeh.1998.1488 · Cited by 76
Hypothalamic network for thermoregulatory vasomotor control
Kanosue, K., Yanase‐Fujiwara, M., & Hosono, T. (1994) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1994.267.1.r283 · Cited by 76
Stress: Neurochemical and Humoral Mechanisms
Loon, G. R. V. (1989) · Cited by 76
Hormonal Responses to Insulin-Induced Hypoglycemia in Man*
Watabe, T., TANAKA, K., Kumagae, M., Itoh, S., Takeda, F., Morio, K., HASEGAWA, M., HORIUCHI, T., Miyabe, S., & Shimizu, N. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-65-6-1187 · Cited by 75
α1-Adrenergic receptor activation releases vasopressin and oxytocin from perfused rat hypothalamic explants
Randle, J. C. R., Mazurek, M. F., Kneifel, D., Dufresne, J., & Renaud, L. P. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90308-3 · Cited by 74
Spinothalamic cells in the rat lumbar cord with collaterals to the medullary reticular formation
Kevetter, G. A., & Willis, W. D. (1982) · Brain Research · doi:10.1016/0006-8993(82)90780-6 · Cited by 74
Thermoregulatory noradrenergic and serotonergic pathways to hypothalamic units
Brück, K., & Hinckel, P. (1980) · The Journal of Physiology · doi:10.1113/jphysiol.1980.sp013319 · Cited by 74
Hypothalamic neuronal responses to peripheral and deep-body temperatures
Boulant, J., & Bignall, K. (1973) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1973.225.6.1371 · Cited by 74
Up-Regulation of Vasopressin mRNA in Paraventricular Hypophysiotrophic Neurons after Acute Immobilization Stress
Bartanusz, V., Aubry, J.-M., Ježová, D., Baffi, J., & Kiss, J. Z. (2008) · Neuroendocrinology · doi:10.1159/000126602 · Cited by 73
Chronic stress enhances vasopressin but not corticotropin-releasing factor secretion during hypoglycemia
de Goeij, D. C. E., Binnekade, R., & Tilders, F. J. H. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.263.2.e394 · Cited by 73
The effects of restraint or hypertonic saline stress on corticotrophin-releasing factor, arginine vasopressin, and proenkephalin A mRNAs in the CFY, Sprague-Dawley and Wistar strains of rat
Harbuz, M. S., Jessop, D. S., Lightman, S. L., & Chowdrey, H. S. (1994) · Brain Research · doi:10.1016/0006-8993(94)91707-8 · Cited by 72
Differential recruitment of hypothalamic neuroendocrine and ventrolateral medulla catecholamine cells by non-hypotensive and hypotensive hemorrhages
Buller, K. M., Smith, D. W., & Day, T. A. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01539-5 · Cited by 71
Effects of Intrathecal NMDA and Non-NMDA Antagonists on Acute Thermal Nociception and Their Interaction with Morphine
Nishiyama, T., Yaksh, T. L., & Weber, E. (1998) · Anesthesiology · doi:10.1097/00000542-199809000-00023 · Cited by 70
Differential stimulation of c-fos expression in hypothalamic nuclei of the rat brain during short-term heat acclimation and mild dehydration
Patronas, P., Horowitz, M., Simon, E., & Gerstberger, R. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00405-3 · Cited by 69
Reduced Activity of Hypothalamic Corticotropin-Releasing Hormone Neurons in Transgenic Mice with Impaired Glucocorticoid Receptor Function
Dijkstra, I., Tilders, F. J. H., Aguilera, G., Kiss, A., Rabadan‐Diehl, C., Barden, N., Karanth, S., Holsboer, F., & Reul, J. M. H. M. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-10-03909.1998 · Cited by 69
Afferents to the midline thalamus issue collaterals to the nucleus tractus solitarii: an anatomical basis for thalamic and visceral reflex integration
Otake, K., Dj, R., & Ruggiero, D. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-09-05694.1994 · Cited by 67
Effects of Catecholamine-Depleting Medullary Knife Cuts on Corticotropin-Releasing Factor and Vasopressin Immunoreactivity in the Hypothalamus of Normal and Steroid-Manipulated Rats
Sawchenko, P. E. (2008) · Neuroendocrinology · doi:10.1159/000125050 · Cited by 67
Fine Topography of Brain Areas Activated by Cold Stress
Baffi, J., & Palkovits, M. (2000) · Neuroendocrinology · doi:10.1159/000054577 · Cited by 67
Self-citation
Stress-induced activation of CRF and c-fos mRNAs in the paraventricular nucleus are not affected by serotonin depletion
Harbuz, M. S., Chalmers, J., Souza, L. H. D., & Lightman, S. L. (1993) · Brain Research · doi:10.1016/0006-8993(93)90870-s · Cited by 66
Effects of Single or Repeated Immobilization on Release of Norepinephrine and Its Metabolites in the Central Nucleus of the Amygdala in Conscious Rats
Pacák, K., Palkovits, M., Květňanský, R., Fukuhara, K., Armando, I., Kopin, I. J., & Goldstein, D. S. (2008) · Neuroendocrinology · doi:10.1159/000126417 · Cited by 64
Self-citation
Serotonergic Innervation of the Rat Pituitary Intermediate Lobe: Decrease after Stalk Section*
FRIEDMAN, E., Krieger, D. T., MEZEY, E., Léránth, C., Brownstein, M., & Palkovits, M. (1983) · Endocrinology · doi:10.1210/endo-112-6-1943 · Cited by 63
Self-citation
Cold exposure elevates thyrotropin-releasing hormone gene expression in medullary raphe nuclei: Relationship with vagally mediated gastric erosions
Yang, H., Wu, S. V., Ishikawa, T., et al. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90442-1 · Cited by 63
Glucocorticoid receptor‐immunoreactivity in C1, C2, and C3 adrenergic neurons that project to the hypothalamus or to the spinal cord in the rat
Sawchenko, P. E., & Bohn, M. C. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902850109 · Cited by 63
Effect of immobilization stress on neuropeptides and their receptors in rat central nervous system
Takayama, H., Ota, Z., & Ogawa, N. (1986) · Regulatory Peptides · doi:10.1016/0167-0115(86)90065-0 · Cited by 63
An indirect projection from the nucleus of the solitary tract to the central nucleus of the amygdala via the parabrachial nucleus in the rat: a light and electron microscopic study
Jia, H.-G., Rao, Z., & Shi, J.-W. (1994) · Brain Research · doi:10.1016/0006-8993(94)91262-9 · Cited by 63
Coexistence of c-Fos and glucocorticoid receptor immunoreactivities in the CRF immunoreactive neurons of the paraventricular hypothalamic nucleus of the rat after acute immobilization stress
Coveñas, R., de León, M., Cintra, A., Bjelke, B., Gustafsson, J.-Α., & Fuxé, K. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90758-d · Cited by 62
Thermoregulatory, metabolic and sympathoadrenal responses to repeated brief exposure to cold
Marino, F. E., Sockler, J., & Fry, J. M. (1998) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365519850186157 · Cited by 62
Evidence for direct projections from the nucleus of the solitary tract onto medullary adrenaline cells
Hancock, M. B. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902760310 · Cited by 62
Effects of brainstem lesions on temperature regulation in hot and cold environments
Lipton, J., Dwyer, P., & Fossler, D. (1974) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1974.226.6.1356 · Cited by 62
Induction of Fos protein in the rat hypothalamus elicited by insulin-induced hypoglycemia
Niimi, M., Sato, M., Tamaki, M., Wada, Y., Takahara, J., & Kawanishi, K. (1995) · Neuroscience Research · doi:10.1016/0168-0102(95)00965-v · Cited by 61
Changes in blood volume and pressure induce c-fos expression in brainstem neurons that project to the paraventricular nucleus of the hypothalamus
Krukoff, T. L., MacTavish, D., Harris, K. H., & Jhamandas, J. H. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(95)00142-f · Cited by 61
Spinal trigeminal neurons excited by noxious and thermal stimuli
Mosso, J. A., & Kruger, L. (1972) · Brain Research · doi:10.1016/0006-8993(72)90605-1 · Cited by 61
Hypoglycemia Enhances Turnover of Corticotropin-Releasing Factor and of Vasopressin in the Zona Externa of the Rat Median Eminence*
BERKENBOSCH, F., de Goeij, D. C. E., & Tilders, F. J. H. (1989) · Endocrinology · doi:10.1210/endo-125-1-28 · Cited by 61
Transection of subfornical organ neural connections diminishes the pressor response to intravenously infused angiotensin II
Lind, R. W., Ohman, L. E., Lansing, M. B., et al. (1983) · Brain Research · doi:10.1016/0006-8993(83)90998-8 · Cited by 60
Central mechanism of neural activation with cold acclimation of rats using Fos immunohistochemistry
Miyata, S., Ishiyama, M., Shido, O., Nakashima, T., Shibata, M., & Kiyohara, T. (1995) · Neuroscience Research · doi:10.1016/0168-0102(95)00900-x · Cited by 60
Extracellular oxytocin in the paraventricular nucleus: hyperosmotic stimulation by in vivo microdialysis
Hattori, T., Morris, M., Alexander, N., & Sundberg, D. K. (1990) · Brain Research · doi:10.1016/0006-8993(90)91216-4 · Cited by 60
Role of the Hypothalamic Paraventricular Nucleus in the Secretion of Thyrotropin under Adrenergic and Cold-Stimulated Conditions in the Rat
Ishikawa, K., Kakegawa, T., & Suzuki, M. (1984) · Endocrinology · doi:10.1210/endo-114-2-352 · Cited by 60
Responses of thermosensitive preoptic and septal neurons to hippocampal and brain stem stimulation
Boulant, J. A., & Demieville, H. N. (1977) · Journal of Neurophysiology · doi:10.1152/jn.1977.40.6.1356 · Cited by 59
β-Adrenergic Mechanism of Insulin-Induced Adrenocorticotropin Release from the Anterior Pituitary
Mezey, É., Reisine, T., Brownstein, M. J., Palkovits, M., & Axelrod, J. (1984) · Science · doi:10.1126/science.6093262 · Cited by 59
Self-citation
Neurons in the hypothalamic paraventricular nucleus that project to the rostral ventrolateral medulla are activated by haemorrhage
Badoer, E., & Merolli, J. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00140-1 · Cited by 59
Effects of chronic intermittent cold stress on pituitary adrenocortical and sympathetic adrenomedullary functioning
Bhatnagar, S., Mitchell, J. B., Betito, K., Boksa, P., & Meaney, M. J. (1995) · Physiology & Behavior · doi:10.1016/0031-9384(94)00161-8 · Cited by 59
Apparent Dissociation of Adrenocorticotropin and Corticosteroid Responses to 15 ml/kg Hemorrhage in Conscious Dogs*
Wood, C. E., Shinsako, J., KEIL, L. C., et al. (1982) · Endocrinology · doi:10.1210/endo-110-4-1416 · Cited by 59
Effect of different types of stressors on peptide messenger ribonucleic acids in the hypothalamic paraventricular nucleus
Ceccatelli, S., & Orazzo, C. (1993) · European Journal of Endocrinology · doi:10.1530/acta.0.1280485 · Cited by 59
Stress-Induced Norepinephrine Release in the Paraventricular Nucleus of Rats with Brainstem Hemisections: A Microdialysis Study
Pacák, K., Palkovits, M., Květňanský, R., et al. (2008) · Neuroendocrinology · doi:10.1159/000126533 · Cited by 59
Self-citation
Vasopressin: An essential pressor factor for blood pressure recovery following hemorrhage
Zerbe, R. L., Bayorh, M. A., & Feuerstein, G. (1982) · Peptides · doi:10.1016/0196-9781(82)90117-6 · Cited by 59
Paraventricular norepinephrine release mediates glucoprivic suppression of pulsatile luteinizing hormone secretion
Nagatani, S., Tsukamura, H., Murahashi, K., Bucholtz, D. C., Foster, D. L., & Maeda, K. (1996) · Endocrinology · doi:10.1210/endo.137.8.8754737 · Cited by 59
Sensitization of sympathetic-adrenal medullary responses to a novel stressor in chronically stressed laboratory rats
Konarska, M., Stewart, R. E., & McCarty, R. C. (1989) · Physiology & Behavior · doi:10.1016/0031-9384(89)90245-x · Cited by 58
PET radiopharmaceuticals: state-of-the-art and future prospects
Tewson, T. J., & Krohn, K. A. (1998) · Seminars in Nuclear Medicine · doi:10.1016/s0001-2998(98)80028-7 · Cited by 57
Decreases in arterial pressure activate oxytocin neurons in conscious rats
Schiltz, J. C., Hoffman, G. E., Stricker, E. M., et al. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.273.4.r1474 · Cited by 57
Central catecholaminergic system stimulates secretion of CRH at different sites
SZAFARCZYK, A., Guillaume, V., Conte‐Devolx, B., Alonso, G., Malaval, F., Parés-Herbute, N., Oliver, C., & ASSENMACHER, I. (1988) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1988.255.4.e463 · Cited by 57
Modes of action of local hypothalamic and skin thermal stimulation on salivary secretion in rats.
Kanosue, K., Nakayama, T., Tanaka, H., Yanase, M., & Yasuda, H. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018077 · Cited by 56
Structural Types of Spinal Cord Marginal (Lamina I) Neurons Projecting to the Nucleus of the Tractus Solitarius in the Rat
Esteves, F., Lima, D., & Coimbra, A. (1993) · Somatosensory & Motor Research · doi:10.3109/08990229309028832 · Cited by 56
THE ROLE OF THE ANTERIOR HYPOTHALAMUS IN TEMPERATURE REGULATION
Teague, R. S., & Ranson, S. W. (1936) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1936.117.3.562 · Cited by 56
Descending projections from the hypothalamic paraventricular nucleus to the A5 area, including the superior salivatory nucleus, in the rat
Hosoya, Y., Sugiura, Y., Ito, R., & Kohno, K. (1990) · Experimental Brain Research · doi:10.1007/bf00228793 · Cited by 55
Regulation of the Adrenocortical Response to Insulin-Induced Hypoglycemia*
Kárteszi, M., Dallman, M. F., Makara, G. B., & Stark, E. (1982) · Endocrinology · doi:10.1210/endo-111-2-535 · Cited by 55
Steroid Hormone Resistance
Chrousos, G. P., Loriaux, D. L., & Lipsett, M. B. (1986) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-5101-6 · Cited by 55
Differential glucocorticoid effects on catecholamine responses to stress
Komesaroff, P. A., & Funder, J. W. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.266.1.e118 · Cited by 54
The Effect of Acute, Chronic and Chronic Intermittent Stress on the Central Noradrenergic System
Hellriegel, E. T., & D’mello, A. P. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00341-3 · Cited by 54
Predictability of chronic intermittent stress: effects on sympathetic-adrenal medullary responses of laboratory rats
Konarska, M., Stewart, R. E., & McCarty, R. (1990) · Behavioral and Neural Biology · doi:10.1016/0163-1047(90)90458-i · Cited by 53
Fos-like immunoreactivity in the rat superficial dorsal horn induced by formalin injection in the forepaw: effects of dorsal rhizotomies
Abbadie, C., Lombard, M., Morain, F., et al. (1992) · Brain Research · doi:10.1016/0006-8993(92)90224-w · Cited by 53
Rat vasopressin cell responses to simulated hemorrhage: stimulus-dependent role for A1 noradrenergic neurons
Smith, D. W., Sibbald, J. R., Khanna, S., & Day, T. A. (1995) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1995.268.5.r1336 · Cited by 53
Lacrimal preganglionic neurons form a subdivision of the superior salivatory nucleus of rat: transneuronal labelling by pseudorabies virus
Tóth, I. E., Boldogkői, Z., Medveczky, I., et al. (1999) · Journal of the Autonomic Nervous System · doi:10.1016/s0165-1838(99)00032-6 · Cited by 52
Stress. Molecular Genetic and Neurobiological Advances.
Aguilera, G., Sabban, E. L., & Květňanský, R. (1996) · University of Groningen research database (University of Groningen / Centre for Information Technology) · Cited by 52
Glucocorticoid receptor-immunoreactivity in corticotrophin-releasing factor afferents to the locus coeruleus
Lechner, S. M., & Valentino, R. J. (1999) · Brain Research · doi:10.1016/s0006-8993(98)00900-7 · Cited by 51
Effects of descending inhibitory systems on the c-Fos expression in the rat spinal cord during formalin-induced noxious stimulation
Zhang, R.-X., Wang, R., Chen, J.-Y., et al. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90036-1 · Cited by 51
Mechanisms by which stressful stimuli activate the pituitary-adrenal system.
Makara, G. B. (1985) · PubMed · Cited by 50
Neural Regulation of Corticotropin Releasing Hormone (CRH) and CRH Receptor mRNA in the Hypothalamic Paraventricular Nucleus in the Rat
Kiss, A., Palkovits, M., & Aguilera, G. (1996) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1996.tb00830.x · Cited by 49
Self-citation
Adrenergic projections from the lower brainstem to the hypothalamic paraventricular nucleus, the lateral hypothalamic area and the central nucleus of the amygdala in rats
Palkovits, M., Mezey, É., Skirboll, L. R., et al. (1992) · Journal of Chemical Neuroanatomy · doi:10.1016/0891-0618(92)90057-w · Cited by 49
Self-citation
ROLE OF THE HYPOTHALAMIC PARAVENTRICULAR NUCLEUS IN CARDIOVASCULAR REGULATION
Blair, M. L., Piekut, D. T., Want, A., & Olschowka, J. A. (1996) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1996.tb02590.x · Cited by 48
Thirst and sodium appetite
Fitzsimons, J. T. (1980) · Endeavour · doi:10.1016/0160-9327(80)90055-1 · Cited by 48
A1 catecholamine cell group: Fine structure and synaptic input from the nucleus of the solitary tract
Chan, R. K. W., Peto, C. A., & Sawchenko, P. E. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903510107 · Cited by 48
THE EFFECT OF EXPERIMENTAL HYPOTHALAMIC LESIONS UPON BLOOD SUGAR
Barris, R. W., & Ingram, W. R. (1936) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1936.114.3.555 · Cited by 48
Neurons (presumably A1-cells) projecting from the caudal ventrolateral medulla to the region of the supraoptic nucleus respond to baroreceptor inputs in the rabbit
McAllen, R. M., & Blessing, W. W. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90253-9 · Cited by 47
PLASMA OXYTOCIN, ARGININE VASOPRESSIN AND ATRIAL NATRIURETIC PEPTIDE RESPONSES TO INSULIN‐INDUCED HYPOGLYCAEMIA IN MAN
Fisher, B. M., Baylis, P. H., & Frier, B. M. (1987) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1987.tb00775.x · Cited by 47
Responses of ACTH, epinephrine, norepinephrine, and cardiovascular system to hemorrhage
Darlington, D. N., Shinsako, J., & Dallman, M. F. (1986) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1986.251.3.h612 · Cited by 47
Role of catecholamines in mediating messenger RNA and hormonal responses to stress
Harbuz, M. S., Chowdrey, H. S., Jessop, D. S., et al. (1991) · Brain Research · doi:10.1016/0006-8993(91)90912-f · Cited by 46
Responses of pontine units to skin‐temperature changes in the guinea‐pig
Hinckel, P., & Schröder-Rosenstock, K. (1981) · The Journal of Physiology · doi:10.1113/jphysiol.1981.sp013700 · Cited by 46
Hypotensive hemorrhage elevates corticotropin-releasing hormone messenger ribonucleic acid (mRNA) but not vasopressin mRNA in the rat hypothalamus
Darlington, D. N., Barraclough, C. A., & Gann, D. S. (1992) · Endocrinology · doi:10.1210/endo.130.3.1311234 · Cited by 46
Genomic Effects of Cold and Isolation Stress on Magnocellular Vasopressin mRNA‐Containing Cells in the Hypothalamus of the Rat
Angulo, J. A., Ledoux, M., & McEwen, B. S. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb03463.x · Cited by 46
Spinal projections to the lateral reticular nucleus in the rat: A retrograde labelling study using horseradish peroxidase
Shokunbi, M. T., Hrycyshyn, A. W., & Flumerfelt, B. A. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902390208 · Cited by 46
Perception of sign language from an array of 27 moving spots
Tartter, V. C., & Knowlton, K. C. (1981) · Nature · doi:10.1038/289676a0 · Cited by 45
Effect of Cold Exposure on the Hypothalamic Release of Thyrotropin-Releasing Hormone and Catecholamines
Rondeel, J. M. M., GREEF, W. J. D., Hop, W. C. J., Rowland, D. L., & Visser, T. J. (2008) · Neuroendocrinology · doi:10.1159/000125940 · Cited by 44
Changes in gene expression in hippocampus in response to glucocorticoids and stress
Nichols, N. R., Masters, J. N., & Finch, C. E. (1990) · Brain Research Bulletin · doi:10.1016/0361-9230(90)90004-j · Cited by 43
Hypoglycemia-Induced Arginine Vasopressin and Oxytocin Release Is Mediated by Glucoreceptors Located Inside the Blood-Brain Barrier
Chiodera, P., Volpi, R., Capretti, L., et al. (2008) · Neuroendocrinology · doi:10.1159/000126185 · Cited by 42
Separate populations of neurons within the paraventricular hypothalamic nucleus of the rat project to vagal and thoracic autonomic preganglionic levels and express c-Fos protein induced by lithium chloride
Portillo, F., Carrasco, M., & Vallo, J. J. (1998) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(97)10022-9 · Cited by 42
Evidence for inhibition of leptin secretion by catecholamines in man
Fritsche, A., Wahl, H.-G., Metzinger, E., et al. (2009) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0029-1212008 · Cited by 42
Age and Gender Influence Basal and Stress-Modulated Hypothalamic-Pituitary-Thyroidal Function in Fischer 344/N Rats
Cizza, G., Brady, L. S., Esclapés, M., et al. (2008) · Neuroendocrinology · doi:10.1159/000127150 · Cited by 42
Spinal neuronal collaterals to the intralaminar thalamic nuclei and periaqueductal gray
Liu, R. P. C. (1986) · Brain Research · doi:10.1016/0006-8993(86)90731-6 · Cited by 42
The Hypothalamus and Heat Regulation
Keller, A. D., & Hare, W. K. (1932) · Experimental Biology and Medicine · doi:10.3181/00379727-29-6220 · Cited by 42
5‐Hydroxytryptamine‐Facilitated Release of Substance P from Rat Spinal Cord Slices Is Mediated by Nitric Oxide and Cyclic GMP
Inoue, A., Hashimoto, T., Hide, I., et al. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68010128.x · Cited by 41
Hypophysiotropic CRF Neurons Display a Sustained Immediate‐Early Gene Response to Chronic Stress but not to Adrenalectomy
Brown, E. R., & Sawchenko, P. E. (1997) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1997.00586.x · Cited by 41
Prolactin Response to Immobilization Stress and Hemorrhage: The Effect of Hypothalamic Deafferentations and Posterior Pituitary Denervation
Jur̀čovičová, J., Květňanský, R., Dobrakovová, M., et al. (1990) · Endocrinology · doi:10.1210/endo-126-5-2527 · Cited by 39
Paraventricular lesions: hormonal and cardiovascular responses to hemorrhage
Darlington, D. N., Shinsako, J., & Dallman, M. F. (1988) · Brain Research · doi:10.1016/0006-8993(88)91486-2 · Cited by 39
c-fos Expression as a Marker of Central Cardiovascular Neurons
Dun, N. J., Dun, S. L., Shen, E., Tang, H., Huang, R., & Chiu, T. H. (1995) · Neurosignals · doi:10.1159/000109431 · Cited by 39
Persisting sensitization of the behavioural response to formalin-induced injury in the rat through activation of serotonin2A receptors
Abbott, F. V., Hong, Y., & Blier, P. U. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00422-8 · Cited by 39
Hemorrhage-induced vasopressin release in the paraventricular nucleus measured by in vivo microdialysis
Ota, M., Crofton, J. T., & Share, L. (1994) · Brain Research · doi:10.1016/s0006-8993(09)90009-9 · Cited by 38
Insulin-induced hypoglycaemia increases colocalization of corticotrophin-releasing factor and arginine vasopressin mRNAs in the rat hypothalamic paraventricular nucleus
Paulmyer‐Lacroix, O., Anglade, G., & Grino, M. (1994) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0130313 · Cited by 38
Expression of Corticotropin Releasing Factor (CRF), Urocortin and CRF Type 1 Receptors in Hypothalamic‐Hypophyseal Systems Under Osmotic Stimulation
Imaki, T., Katsumata, H., Miyata, M., Naruse, M., Imaki, J., & Minami, S. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00629.x · Cited by 37
Absence of glucocorticoid negative feedback to moderate hemorrhage in conscious rats
Thrivikraman, K. V., & Plotsky, P. M. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.264.4.e497 · Cited by 37
Haemorrhage-induced release of noradrenaline, 5-hydroxytryptamine and uric acid in the supraoptic nucleus of the rat, measured by microdialysis
Kendrick, K. M., & Leng, G. (1988) · Brain Research · doi:10.1016/0006-8993(88)91016-5 · Cited by 35
Prior immobilization stress alters adrenal hormone responses to hemorrhage in rats
Graessler, J., Květňanský, R., Ježová, D., et al. (1989) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1989.257.3.r661 · Cited by 35
Lesions of A1 noradrenergic cells affect AVP release and heart rate during hemorrhage
Head, G. A., Quail, A., & Woods, R. L. (1987) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1987.253.5.h1012 · Cited by 35
Neuronal Organization of Stress Response
Palkovits, M., Baffi, J., & Dvori, S. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb44691.x · Cited by 34
Self-citation
Induction of Fos-immunoreactivity in prolactin-like containing neurons of the rat lateral hypothalamus after insulin treatment
Bouhaddi, M., FELLMANN, D., & Bugnon, C. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90404-9 · Cited by 34
Interaction between descending paraventricular neurons and vagal motor neurons
Lawrence, D., & Pittman, Q. J. (1985) · Brain Research · doi:10.1016/0006-8993(85)90399-3 · Cited by 34
Insulin and Glucose Administration Stimulates Fos Expression in Neurones of the Paraventricular Nucleus That Project to Autonomic Preganglionic Structures
Carrasco, M., Portillo, F., Larsen, P. J., et al. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00631.x · Cited by 33
Brainstem Hemisection Decreases Corticotropin‐Releasing Hormone mRNA in the Paraventricular Nucleus but not in the Central Amygdaloid Nucleus
Pacák, K., Palkovits, M., Makino, S., Kopin, I. J., & Goldstein, D. S. (1996) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1996.04888.x · Cited by 33
Self-citation
Different effects of insulin and 2-deoxy-D-glucose administration on tyrosine hydroxylase gene expression in the locus coeruleus and the adrenal medulla in rats.
Rusnák, M., Jeloková, J., Vietor, I., Sabban, E., & Kvetn̂anský, R. (1998) · Brain Research Bulletin · doi:10.1016/s0361-9230(98)00033-1 · Cited by 33

Flagged first, then by citations

Research works printed but not linked: 7

Delgado, 1972, Dialytrode for long-term intravertebral perfusion in awake monkeys., Arch Int Pharmacodyn Ther, 198, 9
Plotsky, 1985, Hypophysiotrophic regulation of adenohypophyseal adrenocorticotropin secretion., Fed Proc, 44, 207
Brizzee, 1991, Role of vasopressin release in acutely altered baroreflex sensitivity during hemorrhage in rats, Am J Physiol, 261, R667
Mezey, 1991, CRF-containing neurons in the hypothalamic paraventricular nucleus: Regulation, especially by catecholamines., Front Neuroendocrinol, 12, 23
Záborszky, 1979, Afferent brain stem connections of the central amygdaloid nucleus., Verh Anat Ges, 73, 1117
Chrousos, 1997, The neuroendocrinology of stress: its relation to the hormonal milieu, growth, and development., Growth Genet Horm, 13, 1
Hyman, 1998, Brain neurocircuitry of anxiety and fear: implications for clinical research and practice., Biol Psychiat, 44, 1201

Sorted by citations

The Timing of Normal Puberty and the Age Limits of Sexual Precocity: Variations around the World, Secular Trends, and Changes after Migration
Parent, A.-S., Teilmann, G., Juul, A., Skakkebaek, N. E., Toppari, J., & Bourguignon, J.-P. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0019 · Cited by 1,762
Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo–pituitary–adrenocortical responsiveness
Herman, J. P., Figueiredo, H., Mueller, N. K., Ulrich-Lai, Y., Ostrander, M. M., Choi, D. C., & Cullinan, W. E. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2003.07.001 · Cited by 1,586
Timing of pubertal maturation in girls: an integrated life history approach
Ellis, B. J. (2004) · Psychological Bulletin · doi:10.1037/0033-2909.130.6.920 · Cited by 1,014
Hair cortisol, stress exposure, and mental health in humans: A systematic review
Staufenbiel, S. M., Penninx, B. W. J. H., Spijker, A. T., Elzinga, B. M., & van Rossum, E. F. C. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.11.015 · Cited by 736
Estrogen actions in the brain and the basis for differential action in men and women: a case for sex-specific medicines
Gillies, G. E., & McArthur, S. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002071 · Cited by 733

See all 926

Authors: Pacák, K., & Palkovits, M.
Affiliations: Pediatric and Reproductive Endocrinology Branch (K.P.), National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland
Laboratory of Genetics (M.P.), National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-1583
Venue: Endocrine Reviews
Publisher: The Endocrine Society
Published: 2001-08-01
Volume: 22
Issue: 4
Pages: 502-548
ISSN: 0163-769X (ISSN-L)
1945-7189
DOI: 10.1210/edrv.22.4.0436
OpenAlex: W2066156347
Cited by: 926
References: 486
Citations by year: 2026: 15 · 2025: 18 · 2024: 21 · 2023: 24 · 2022: 23 · 2021: 26 · 2020: 28 · 2019: 24 · 2018: 38 · 2017: 27 · 2016: 36 · 2015: 47 · 2014: 45 · 2013: 39 · 2012: 56
FWCI: 4.07
Type: journal article
Language: en
Open access: closed
Locations: Endocrine Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Child Health and Human Development
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: stressor specificity, neuroendocrine response, stress-related disorders, sympathoadrenal system, hypothalamic-pituitary-adrenal axis, Fos-like immunoreactivity, restraint stress, hemorrhage, cold exposure, pain, hypoglycemia
MeSH terms: Adrenocorticotropic Hormone, Animals, Brain, Humans, Hypothalamo-Hypophyseal System, Neurosecretory Systems, Paraventricular Hypothalamic Nucleus, Stress, Physiological

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Stressor Specificity of Central Neuroendocrine Responses: Implications for Stress-Related Disorders

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks