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Cited by 758Adrenal Hormones and DisordersImmunodeficiency and Autoimmune DisordersMyasthenia Gravis and Thymoma

The DOI matches its Crossref record; 341 of the 354 references it cites were found in a registry or an index.

Autoimmune Adrenal Insufficiency and Autoimmune Polyendocrine Syndromes: Autoantibodies, Autoantigens, and Their Applicability in Diagnosis and Disease Prediction

Betterle, Corrado, Dal Pra, Chiara, Mantero, Franco, Zanchetta, Renato·2002·Endocrine Reviews
DOI 10.1210/edrv.23.3.0466
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Abstract

Recent progress in the understanding of autoimmune adrenal disease, including a detailed analysis of a group of patients with Addison's disease (AD), has been reviewed. Criteria for defining an autoimmune disease and the main features of autoimmune AD (history, prevalence, etiology, histopathology, clinical and laboratory findings, cell-mediated andhumoral immunity, autoantigens and their autoepitopes, genetics, animal models, associated autoimmune diseases, pathogenesis, natural history, therapy) have been described. Furthermore, the autoimmune polyglandular syndromes (APS) associated with AD (revised classification, animal models, genetics, natural history) have been discussed. Of Italian patients with primary AD (n = 317), 83% had autoimmune AD. At the onset, all patients with autoimmune AD (100%) had detectable adrenal cortex and/or steroid 21-hydroxylase autoantibodies. In the course of natural history of autoimmune AD, the presence of adrenal cortex and/or steroid 21-hydroxylase autoantibodies identified patients at risk to develop AD. Different risks of progression to clinical AD were found in children and adults, and three stages of subclinical hypoadrenalism have been defined. Normal or atrophic adrenal glands have been demonstrated by imaging in patients with clinical or subclinical AD. Autoimmune AD presented in four forms: as APS type 1 (13% of the patients), APS type 2 (41%), APS type 4 (5%), and isolated AD (41%). There were differences in genetics, age at onset…

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Research works printed but not linked: 21

  1. Addison, 1855, On the constitutional and local effects of disease of the suprarenal capsules. In a collection of the published writing of the late Thomas Addison, M.D., physician to Guy’s Hospital. London: New Sydenham Society 1868. [, Reprinted in Medical Classics, 2, 244
  2. Trousseau, 1856, Bronze Addison’s disease., Arch Gen Med, 8, 478
  3. Guttman, 1930, Addison’s disease., Arch Pathol, 10, 742
  4. Betterle, 1989, Morbo di Addison: principali associazioni cliniche e descrizione della storia naturale della malattia., Ann Ital Med Int, 4, 195
  5. Asherson, 1988, A “primary” antiphospholipid syndrome?, J Rheumatol, 15, 1742
  6. Bottazzo, 1996, Adrenalitis, oophoritis and autoimmune polyglandular disease. In: Rich RR, Fleisher TA, Schwartz DB, Shearer WT, Strober W, eds. Clinical immunology. Principles and practice. St., Louis: Mosby; chap, 100, 1523
  7. Verghese, 1980, Decreased suppressor cell activity in patients with polyglandular failure., Clin Res, 28, 270
  8. Schmidt, 1926, Eine biglandulare Erkrankung (Nebennieren und Schilddrüse) bei Morbus Addisonii., Verh Dtsch Ges Pathol, 21, 212
  9. Claude, 1908, Insuffisance pluriglandulaire endocrinienne., J Physiol Pathol Gen, 10, 469
  10. Von Mayenburg, 1940, Uber “insulitis” bei diabetes., Schweiz Med Wochenschr, 71, 554
  11. Adams, 1956, Abnormal responses in the assay of thyrotropin., Proc Univ Otago Med School, 34, 11
  12. Betterle, 1991, Melanin-producing cell autoantibodies: predictive marker of autoimmune vitiligo., Arch Dermatol, 128, 123, 10.1001/archderm.1992.01680110137027 · DOI
  13. Pitkänen, 2000, The autoimmune regulator protein has transcriptional transactivating properties and interereacts with the common coactivator CREB-binding protein., Am Soc Biochem Mol Biol, 275, 16802
  14. Ludwig, 1975, HLA antigens in idiopathic Addison’s disease., Z Immunitatsforschung, 149, 423
  15. Bigazzi, 1970, Anticorpi anti-surrene nel morbo di Addison., Folia Allergol Immunol Clin, 17, 46
  16. Andrada, 1968, Serological investigation on Addison’s disease., Clin Sci, 206, 1535
  17. Pousset, 1970, Anticorps antisurrénaliens et maladie d’Addison., Ann Endocrinol (Paris), 31, 995
  18. Tanaka, 1997, Autoimmune adrenal diseases—a new sensitive assay for measurement of steroid 21-hydroxylase autoantibodies., J Clin Endocrinol Metab, 82, 1440
  19. Del Prete, 1976, Autoanticorpi nella menopausa precoce., Folia Allergol Immunol Clin, 23, 367
  20. Yu, 1999, DRB1*04 and DQ alleles: expressions of 21-hydroxylase autoantibodies and risk of progressions to Addison’s disease., J Clin Endocrinol Metab, 84, 328
  21. Auchus, 2001, The principles, pathways, and enzymes of human steroidogenesis, In De Groot LJ, Jameson JL, eds. Endocrinology, 4th ed. Philadelphia: WB Saunders Co.; chap, 115, 1616

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Metadata

Authors
Betterle, C., Dal Pra, C., Mantero, F., & Zanchetta, R.
Affiliations
  • University of Padua (IT)
  • Chair of Clinical Immunology and Allergy (C.B., C.D.P., R.Z.), Department of Medical and Surgical Sciences, University of Padova, I-35128, Padova, Italy
ORCID
Venue
Endocrine Reviews
Publisher
The Endocrine Society
Published
2002-06-01
Volume
23
Issue
3
Pages
327-364
ISSN
  • 0163-769X (ISSN-L)
  • 1945-7189
DOI
10.1210/edrv.23.3.0466
OpenAlex
W2125286421
Cited by
758
References
354
Citations by year
2026: 26 · 2025: 16 · 2024: 28 · 2023: 23 · 2022: 24 · 2021: 32 · 2020: 30 · 2019: 39 · 2018: 30 · 2017: 36 · 2016: 28 · 2015: 35 · 2014: 47 · 2013: 36 · 2012: 36
FWCI
4.26
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrine Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
  • Health Sciences › Medicine › Clinical Neurology › Myasthenia Gravis and Thymoma
Keywords
autoimmune adrenal insufficiency, Addison's disease, autoimmune polyglandular syndrome, autoantibodies, autoantigens, 21-hydroxylase, hypergonadotropic hypogonadism, adrenal imaging
MeSH terms
Adrenal Insufficiency, Autoantibodies, Autoantigens, Autoimmune Diseases, Humans, Prognosis, Polyendocrinopathies, Autoimmune

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