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Cited by 106Adrenal Hormones and DisordersHormonal Regulation and HypertensionStress Responses and Cortisol

Remission of subclinical adrenocortical failure in subjects with adrenal autoantibodies.

De Bellis, A, Bizzarro, A, Rossi, R, Paglionico, V A, Criscuolo, T, Lombardi, G, Bellastella, A·1993·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.76.4.8473373
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Abstract

Idiopathic Addison's disease is a chronic organ-specific autoimmune disorder with a long subclinical period characterized only by the presence of adrenal autoantibodies (AA) with or without adrenal function failure. The aim of this longitudinal study was to evaluate the behavior of AA using, an indirect fluorescence method, and adrenal function in 20 AA-positive and 50 AA-negative patients screened by an investigation of a large population of organ-specific autoimmune disease patients without clinical Addison's disease. As controls, 100 normal age-matched subjects were tested only once. In the 20 AA-positive and 50 negative patients, AA and adrenal functional tests were evaluated every 4 months for 5 yr. The AA-positive patients were grouped into 5 adrenal functional stages, specifically: stage 0, normal adrenal function; stage 1, high PRA and low (or normal) aldosterone levels alone; stage 2, along with impaired cortisol response to ACTH, stage 3, along with increased ACTH levels; and stage 4, clinically overt Addison's disease. On the basis of the behavior of AA, the 20 positive patients were grouped as follows: group A, 11 patients with AA titer of 1:8 or higher at the first observation and persistently AA positive in subsequent observations, with titers ranging from 1:8 to 1:64; group B, 6 patients with initial AA titers of 1:8 or lower and AA disappearance in subsequent observations; and group C, 3 patients with AA titer of 1:32 or higher, undergoing corticosteroid thera…

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Authors
De Bellis, A., Bizzarro, A., Rossi, R., Paglionico, V. A., Criscuolo, T., Lombardi, G., & Bellastella, A.
Affiliations
University of Naples Federico II (IT)
ORCID
Bellastella, A
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1993-04
Volume
76
Issue
4
Pages
1002-1007
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.76.4.8473373
OpenAlex
W2148524987
Cited by
106
References
17
Citations by year
2022: 1 · 2019: 5 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 5
FWCI
2.41
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
Addison's disease, adrenal autoantibodies, remission, autoimmune adrenal insufficiency, adrenal function recovery, corticosteroid therapy, ACTH stimulation test, antibody titer decline, disease progression, organ-specific autoimmunity, indirect immunofluorescence
MeSH terms
Addison Disease, Adolescent, Adrenal Cortex, Adrenal Cortex Function Tests, Adrenal Cortex Hormones, Adrenal Insufficiency, Adrenal Glands, Adult, Autoantibodies, Child, Female, Humans, Longitudinal Studies, Male, Time Factors

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