The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Differential effects of glucocorticoid on recruitment and activity of osteoclasts induced by normal and osteocalcin-deficient bone implanted in rats.
Abstract
Prolonged glucocorticoid excess is associated with bone loss. Among the contributory factors are glucocorticoids' suppression of bone formation and stimulation of bone resorption. In this study, the effects of glucocorticoids on bone resorption were evaluated in a rodent model. Subcutaneous implants of devitalized mineralized bone particles (BPs) elicit the recruitment of progenitor cells and their differentiation to osteoclasts which resorb the BPs. The effects of glucocorticoids on both the recruitment and the activity of cells induced by normal BPs were distinguished based upon when treatment was initiated. When treatment with hydrocortisone or dexamethasone was initiated at the time of BP implantation, the recruitment of bone-resorbing cells was impaired and a subsequent decrease in BP resorption was found. On the other hand, when treatment was initiated on day 7, glucocorticoids increased osteoclastic resorption and tartrate-resistant acid phosphatase activity. We also tested hydrocortisone's effect to stimulate the activity of cells associated with osteocalcin-deficient BPs. As previously reported, BPs deficient in osteocalcin were poorly resorbed as a result of decreased formation and activity of osteoclasts. Hydrocortisone had an even more pronounced effect in stimulating the low level resorption of the osteocalcin-deficient BP implants than of the normal BP implants. These findings show differential effects of glucocorticoids on two aspects of bone resorption: they inhibit the recruitment and/or differentiation of bone-resorbing cells, but they stimulate the activity of existing osteoclastic cells. The ability of glucocorticoids to increase resorption of normal bone and to overcome resistance to resorption of osteocalcin-deficient bone suggests an important regulatory effect of glucocorticoids in the activation of osteoclasts to increase bone resorption.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A bone xenograft model showed that glucocorticoids inhibited osteoclast recruitment and bone resorption, whereas delayed treatment with glucocorticoids resulted in stimulation of osteoclast activity and bone resorption (256).”
From Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease (2008) · cites this paper as [256]
Citations
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 317,331
Jonat, C., Rahmsdorf, H. J., Park, K.-K., Cato, A. C. B., Gebel, S., Ponta, H., & Herrlich, P. (1990) · Cell · doi:10.1016/0092-8674(90)90395-u · Cited by 1,566
Corticosteroid‐Mediated Immunoregulation in Man
Cupps, T. R., & Fauci, A. S. (1982) · Immunological Reviews · doi:10.1111/j.1600-065x.1982.tb00431.x · Cited by 887
Osteopontin--a possible anchor of osteoclasts to bone.
Reinholt, F. P., Hultenby, K., Oldberg, A., & Heinegård, D. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.12.4473 · Cited by 824
Gillis, S. A., Crabtree, R. H., & Smith, K. A. (1979) · PubMed · Cited by 561
Hahn, T. J., Halstead, L. R., Teitelbaum, S. L., & Hahn, B. H. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109506 · Cited by 399
Price, P. A., Urist, M. R., & Otawara, Y. (1983) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(83)91663-7 · Cited by 357
A Radioimmunoassay for Cortisol in Plasma and Urine
RUDER, H. J., GUY, R. L., & LIPSETT, M. B. (1972) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-35-2-219 · Cited by 329
Alternate-Day Prednisone: Leukocyte Kinetics and Susceptibility to Infections
Dale, D. C., Fauci, A. S., & Wolff, S. M. (1974) · New England Journal of Medicine · doi:10.1056/nejm197411282912203 · Cited by 294
Recruitment of osteoclast precursors by purified bone matrix constituents.
Malone, J. D., Teitelbaum, S. L., Griffin, G. L., Senior, R. M., & Kahn, A. J. (1982) · The Journal of cell biology · doi:10.1083/jcb.92.1.227 · Cited by 266
Cited by
Kearns, A. E., Khosla, S., & Kostenuik, P. J. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0014 · Cited by 824
Molecular mechanisms of glucocorticoid-induced osteoporosis.
Patschan, D., Loddenkemper, K., & Buttgereit, F. (2001) · Bone · doi:10.1016/s8756-3282(01)00610-x · Cited by 201
Lian, J. B., Shalhoub, V., Aslam, F., Frenkel, B., Green, J., Hamrah, M., Stein, G. S., & Stein, J. L. (1997) · Endocrinology · doi:10.1210/endo.138.5.5117 · Cited by 154
Self-citationOsteoporosis and Fractures After Solid Organ Transplantation
Yu, T.-M., Lin, C.-L., Chang, S.-N., Sung, F.-C., Huang, S.-T., & Kao, C.-H. (2014) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2014.02.017 · Cited by 58
Metadata
- Authors
- Defranco, D. J., Lian, J. B., & Glowacki, J.
- Affiliations
- Harvard University (US)
- ORCID
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1992-07
- Volume
- 131
- Issue
- 1
- Pages
- 114-121
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2107571929
- Cited by
- 50
- References
- 45
- Citations by year
- 2023: 1 · 2019: 1 · 2017: 1 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- glucocorticoids, osteoclasts, bone resorption, cortisol, dexamethasone, bone implants, tartrate-resistant acid phosphatase, osteoclast recruitment, osteoclastogenesis, glucocorticoid resistance, bone loss
- MeSH terms
- Acid Phosphatase, Animals, Bone and Bones, Bone Resorption, Cell Differentiation, Dexamethasone, Glucocorticoids, Hydrocortisone, Osteoclasts, Tartrates, Osteocalcin, Bone Transplantation, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Differential effects of glucocorticoid on recruitment and activity of osteoclasts induced by normal and osteocalcin-deficient bone implanted in rats. https://app.cochat.ai/papers/10.1210/endo.131.1.1611989
- The paper
- Defranco, D. J., Lian, J. B., & Glowacki, J. (1992). Differential effects of glucocorticoid on recruitment and activity of osteoclasts induced by normal and osteocalcin-deficient bone implanted in rats. Endocrinology. https://doi.org/10.1210/endo.131.1.1611989
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
