Molecular mechanisms of glucocorticoid-induced osteoporosis.

Patschan, D.; Loddenkemper, K.; Buttgereit, F.

doi:10.1016/s8756-3282(01)00610-x

Cited by 201Bone health and osteoporosis researchBone Metabolism and DiseasesEstrogen and related hormone effects

Molecular mechanisms of glucocorticoid-induced osteoporosis.

Patschan, D., Loddenkemper, K., Buttgereit, F.·2001·Bone

DOI 10.1016/s8756-3282(01)00610-x

Open this paper in CoChat — free account

Abstract

Bone loss resulting from long-term glucocorticoid therapy is common and clinically relevant. A number of different glucocorticoid-mediated effects are responsible for the reduction in bone density: (i) glucocorticoid-induced direct impairment of osteoblast, osteocyte, and osteoclast function leads to reduced bone remodeling and diminished repair of microdamage in bone; (ii) the effects of parathyroid hormone (PTH) might be more pronounced in the presence of glucocorticoids, whereas vitamin D plays a lesser role in the pathogenesis of steroid-induced osteoporosis; (iii) glucocorticoids antagonize gonadal function and inhibit the osteoanabolic action of sex steroids; and (iv) increased renal elimination and reduced intestinal absorption of calcium lead to a negative calcium balance that has been suggested to promote secondary hyperparathyroidism. From a mechanistic point of view, all of the aforementioned effects have long been considered to be mediated at the molecular level exclusively by genomic actions. However, there is now increasing evidence for the existence of rapid glucocorticoid effects that are incompatible with this classical mode of action. These rapid effects, termed nongenomic effects, are mediated by glucocorticoid interactions with biological membranes, either through binding to membrane receptors or by physicochemical interactions. It is possible, but has yet to be shown, that these effects play a role in the pathogenesis of glucocorticoid-induced osteoporosis.

Integrity signals

Registry

Crossref · 10.1016/s8756-3282(01)00610-x

Cites

81 of 81 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Glucocorticoids have complex effects on bone, virtually all detrimental.
“Glucocorticoids also have remarkably complex effects on bone, virtually all of which are detrimental, and these influences have been summarized in recent reviews (241,242).”
From Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease (2008) · cites this paper as [242]

Bone Resorption by Osteoclasts
Teitelbaum, S. L. (2000) · Science · doi:10.1126/science.289.5484.1504 · Cited by 3,962 · see citing works
Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone.
Weinstein, R. S., Jilka, R. L., Parfitt, A. M., & Manolagas, S. C. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2799 · Cited by 1,753 · see citing works
Increased Osteoclast Development After Estrogen Loss: Mediation by Interleukin-6
Jilka, R. L., Hangoc, G., Girasole, G., Passeri, G., Williams, D. C., Abrams, J. S., Boyce, B. F., Broxmeyer, H. E., & Manolagas, S. C. (1992) · Science · doi:10.1126/science.1621100 · Cited by 1,440 · see citing works
Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors
Bertolini, D. R., Nedwin, G. E., Bringman, T. S., Smith, D. D., & Mundy, G. R. (1986) · Nature · doi:10.1038/319516a0 · Cited by 1,425 · see citing works
The Osteoblast: A Sophisticated Fibroblast under Central Surveillance
Ducy, P. F., Schinke, T., & Karsenty, G. (2000) · Science · doi:10.1126/science.289.5484.1501 · Cited by 1,121 · see citing works
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Management
Lukert, B. P., & Raisz, L. G. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-112-5-352 · Cited by 1,063 · see citing works
Stimulation of Osteoprotegerin Ligand and Inhibition of Osteoprotegerin Production by Glucocorticoids in Human Osteoblastic Lineage Cells: Potential Paracrine Mechanisms of Glucocorticoid-Induced Osteoporosis1
Hofbauer, L. C., Gori, F., Riggs, B. L., Lacey, D. L., Dunstan, C. R., Spelsberg, T. C., & Khosla, S. (1999) · Endocrinology · doi:10.1210/endo.140.10.7034 · Cited by 794 · see citing works
Mechanisms of Glucocorticoid Action in Bone
CANALIS, E., & DELANY, A. M. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04204.x · Cited by 406 · see citing works
Inhibition of Osf2/Cbfa1 expression and terminal osteoblast differentiation by PPAR?2
Lecka‐Czernik, B., Gubrij, I. B., Moerman, E. J., Kajkenova, O., Lipschitz, D. A., Manolagas, S. C., & Jilka, R. L. (1999) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19990901)74:3 · Cited by 403 · see citing works
Glucocorticoid-Induced Osteoporosis
Baylink, D. J. (1983) · New England Journal of Medicine · doi:10.1056/nejm198308043090509 · Cited by 398 · see citing works
New Developments in the Pathogenesis and Treatment of Steroid-Induced Osteoporosis
Manolagas, S. C., & Weinstein, R. S. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.7.1061 · Cited by 385 · see citing works
Testosterone Therapy in Glucocorticoid-Treated Men
Reid, I. R. (1996) · Archives of Internal Medicine · doi:10.1001/archinte.1996.00440100065008 · Cited by 369 · see citing works
Effects of Interleukin-1 on Bone Turnover in Normal Mice*
Boyce, B. F., Aufdemorte, T. B., Garrett, I. R., Yates, A. J. P., & Mundy, G. R. (1989) · Endocrinology · doi:10.1210/endo-125-3-1142 · Cited by 363 · see citing works
Intestinal Calcium Absorption in Exogenous Hypercortisonism
Klein, R. G., Arnaud, S. B., Gallagher, J. C., DeLuca, H. F., & Riggs, B. L. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108762 · Cited by 362 · see citing works
Human osteoblast-derived insulin-like growth factor (IGF) binding protein-5 stimulates osteoblast mitogenesis and potentiates IGF action.
Andress, D. L., & Birnbaum, R. S. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41695-x · Cited by 343 · see citing works
Effects of Short Term Glucocorticoid Administration on Intestinal Calcium Absorption and Circulating Vitamin D Metabolite Concentrations in Man*
Hahn, T. J., Halstead, L. R., & Baran, D. T. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-52-1-111 · Cited by 309 · see citing works
Bioenergetics of immune functions: fundamental and therapeutic aspects
Buttgereit, F., Burmester, G. R., & Brand, M. D. (2000) · Immunology Today · doi:10.1016/s0167-5699(00)01593-0 · Cited by 284 · see citing works
Self-citation
Glucocorticoid osteoporosis--mechanisms and management
Reid, I. R. (1997) · European Journal of Endocrinology · doi:10.1530/eje.0.1370209 · Cited by 281 · see citing works
Effect of cortisone treatment on the active transport of calcium by the small intestine
Kimberg, D. V., Baerg, R. D., Gershon, E., & Graudusius, R. T. (1971) · Journal of Clinical Investigation · doi:10.1172/jci106610 · Cited by 266 · see citing works
REDUCTION OF SERUM-1,25-DIHYDROXYVITAMIN-D3 IN CHILDREN RECEIVING GLUCOCORTICOIDS
Chesney, R. W., Hamstra, A., Mazess, R. B., Deluca, H., & O'Reagan, S. (1978) · The Lancet · doi:10.1016/s0140-6736(78)92277-8 · Cited by 192 · see citing works
Stimulation of Osteoprotegerin Ligand and Inhibition of Osteoprotegerin Production by Glucocorticoids in Human Osteoblastic Lineage Cells: Potential Paracrine Mechanisms of Glucocorticoid-Induced Osteoporosis
Hofbauer, L. C. (1999) · Endocrinology · doi:10.1210/en.140.10.4382 · Cited by 187 · see citing works
Rapid, Nongenomic Steroid Actions: A New Age?
Schmidt, B. M. W., Gerdes, D., Feuring, M., Falkenstein, E., Christ, M., & Wehling, M. (2000) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1999.0189 · Cited by 168 · see citing works
Glucocorticoid regulation of transforming growth factor beta 1 activity and binding in osteoblast-enriched cultures from fetal rat bone.
Centrella, M., McCarthy, T. L., & CANALIS, E. M. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.9.4490 · Cited by 164 · see citing works
Reduction in Transforming Growth Factor β Receptor I Expression and Transcription Factor CBFa1 on Bone Cells by Glucocorticoid
Chang, D. J., Ji, C., Kim, K. K., Casinghino, S. R., & McCarthy, T. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.9.4892 · Cited by 157 · see citing works
Osteoblasts mediate insulin-like growth factor-I and -II stimulation of osteoclast formation and function.
Hill, P. A., Reynolds, J. J., & Meikle, M. C. (1995) · Endocrinology · doi:10.1210/endo.136.1.7828521 · Cited by 157 · see citing works
11 beta-Hydroxysteroid dehydrogenase alleviates glucocorticoid-mediated inhibition of steroidogenesis in rat Leydig cells
Monder, C., Miroff, Y., Marandici, A., & Hardy, M. P. (1994) · Endocrinology · doi:10.1210/endo.134.3.8119160 · Cited by 154 · see citing works
Species-specific glucocorticoid and 1,25-dihydroxyvitamin D responsiveness in mouse MC3T3–E1 osteoblasts: dexamethasone inhibits osteoblast differentiation and vitamin D down-regulates osteocalcin gene expression.
Lian, J. B., Shalhoub, V., Aslam, F., Frenkel, B., Green, J., Hamrah, M., Stein, G. S., & Stein, J. L. (1997) · Endocrinology · doi:10.1210/endo.138.5.5117 · Cited by 154 · see citing works
Equivalent doses and relative drug potencies for non-genomic glucocorticoid effects: a novel glucocorticoid hierarchy
Buttgereit, F., Brand, M. D., & Burmester, G. R. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00090-8 · Cited by 146 · see citing works
Self-citation
Effects of prednisone and deflazacort on mineral metabolism and parathyroid hormone activity in humans
Gennari, C., Imbimbo, B. P., Montagnani, M., Bernini, M., Nardi, P., & Avioli, L. V. (1984) · Calcified Tissue International · doi:10.1007/bf02405325 · Cited by 133 · see citing works
Mechanisms of glucocorticoid action in bone cells
Delany, A. M., Dong, Y., & CANALIS, E. M. (1994) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240560304 · Cited by 133 · see citing works
Extracellular matrix is required for skeletal muscle differentiation but not myogenin expression
Melo, F., Carey, D. J., & Brandan, E. (1996) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(199608)62:2 · Cited by 118 · see citing works
Basal activities and hormone responsiveness of osteoclast-like and osteoblast-like bone cells are regulated by glucocorticoids.
Wong, G. L. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)50368-9 · Cited by 111 · see citing works
Direct inhibition of ovarian steroidogenesis by Cortisol and the modulatory role of 11β‐hydroxysteroid dehydrogenase
Michael, A. E., Pester, L. A., Curtis, P., Shaw, R. W., Edwards, C. R. W., & COOKE, B. A. (1993) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1993.tb02147.x · Cited by 110 · see citing works
Transcriptional repression of insulin-like growth factor I by glucocorticoids in rat bone cells.
Delany, A. M., & CANALIS, E. M. (1995) · Endocrinology · doi:10.1210/endo.136.11.7588206 · Cited by 108 · see citing works
Evidence for Decreased Tubular Reabsorption of Calcium in Glucocorticoid-Treated Asthmatics
Reid, I. R., & Ibbertson, H. K. (2008) · Hormone Research · doi:10.1159/000180820 · Cited by 105 · see citing works
Therapeutic implications of non-genomic glucocorticoid activity
Lipworth, B. J. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02463-6 · Cited by 101 · see citing works
Intestinal Calcium-Binding Protein and Calcium Absorption in Cortisol-Treated Chicks: Effects of Vitamin D3and 1,25-Dihydroxyvitamin D3*
Feher, J., & Wasserman, R. H. (1979) · Endocrinology · doi:10.1210/endo-104-2-547 · Cited by 99 · see citing works
Glucocorticoid regulation of alkaline phosphatase, osteocalcin, and proto‐oncogenes in normal human osteoblast‐like cells
Subramaniam, M., Colvard, D. S., Keeting, P. E., Rasmussen, K., Riggs, B. L., & Spelsberg, T. C. (1992) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240500410 · Cited by 99 · see citing works
Regulation of vitamin D-1alpha-hydroxylase and -24-hydroxylase expression by dexamethasone in mouse kidney
Akeno, N., Matsunuma, A., Maeda, T., Kawane, T., & Horiuchi, N. (2000) · Journal of Endocrinology · doi:10.1677/joe.0.1640339 · Cited by 97 · see citing works
Changes in (markers of) bone metabolism during high dose corticosteroid pulse treatment in patients with rheumatoid arthritis.
Lems, W. F., Gerrits, M. I., Jacobs, J. W. G., van Vugt, R. M., van Rijn, H. J. M., & Bijlsma, J. W. J. (1996) · Annals of the Rheumatic Diseases · doi:10.1136/ard.55.5.288 · Cited by 88 · see citing works
Cortisol Stimulation of Parathyroid Hormone Secretion by Rat Parathyroid Glands in Organ Culture
Au, W. Y. W. (1976) · Science · doi:10.1126/science.948759 · Cited by 86 · see citing works
Dexamethasone Stimulates Osteoclast-like Cell Formation by Directly Acting on Hemopoietic Blast Cells and Enhances Osteoclast-like Cell Formation Stimulated by Parathyroid Hormone and Prostaglandin E2
Kaji, H., Sugimoto, T., Kanatani, M., Nishiyama, K., & Chihara, K. (1997) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1997.12.5.734 · Cited by 85 · see citing works
Developmental Changes in Glucocorticoid Receptor and 11β-Hydroxysteroid Dehydrogenase Oxidative and Reductive Activities in Rat Leydig Cells1
Ge, R.-S., Hardy, D. O., Catterall, J. F., & Hardy, M. P. (1997) · Endocrinology · doi:10.1210/endo.138.12.5614 · Cited by 81 · see citing works
Intact parathyroid hormone levels are not elevated in glucocorticoid-treated subjects
Paz-Pacheco, E. T., Fuleihan, G. E., & LeBoff, M. S. (1995) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650101114 · Cited by 79 · see citing works
Cortisol Inhibits the Synthesis of Insulin-like Growth Factor-binding Protein-5 in Bone Cell Cultures by Transcriptional Mechanisms
Gabbitas, B., Pash, J. M., Delany, A. M., & CANALIS, E. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.15.9033 · Cited by 75 · see citing works
A working hypothesis for the regulation of steroidogenesis and germ cell development in the gonads by glucocorticoids and 11β-hydroxysteroid dehydrogenase (11βHSD)
Michael, A. E., & COOKE, B. A. (1994) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(94)90279-8 · Cited by 73 · see citing works
Cortisol decreases IGF-I mRNA levels in human osteoblast-like cells
Swolin‐Eide, D., Brantsing, C., Matejka, G., & Ohlsson, C. (1996) · Journal of Endocrinology · doi:10.1677/joe.0.1490397 · Cited by 72 · see citing works
Glucocorticoid-induced Osteoporosis: Prevention and Treatment
Ziegler, R., & Kasperk, C. H. (1998) · Steroids · doi:10.1016/s0039-128x(98)00022-1 · Cited by 72 · see citing works
Insulin-like growth factor-binding protein-1 expression in cultured human bone cells: regulation by insulin and glucocorticoid
Conover, C. A., Lee, P., Riggs, B. L., & Powell, D. R. (1996) · Endocrinology · doi:10.1210/endo.137.8.8754754 · Cited by 72 · see citing works
Comparative aspects of 11β-hydroxysteroid dehydrogenase. Testicular 11β-hydroxysteroid dehydrogenase: Development of a model for the mediation of Leydig cell function by corticosteroids
Monder, C., Hardy, M. P., Blanchard, R. J., & Blanchard, D. C. (1994) · Steroids · doi:10.1016/0039-128x(94)90078-7 · Cited by 69 · see citing works
PARATHYROID HORMONE AND 25‐HYDROXYVITAMIN D LEVELS IN GLUCOCORTICOID‐TREATED PATIENTS
Slovik, D. M., Neer, R. M., Ohman, J. L., Lowell, F. C., Clark, M. B., Segre, G. V., & Potts, J. T. J. (1980) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1980.tb02706.x · Cited by 67 · see citing works
Evidence for a role for insulin-like growth factor binding proteins in glucocorticoid inhibition of normal human osteoblast-like cell proliferation
Chevalley, T., Strong, D. D., Mohan, S., Baylink, D. J., & Linkhart, T. A. (1996) · European Journal of Endocrinology · doi:10.1530/eje.0.1340591 · Cited by 65 · see citing works
Elevated 1,25-dihydroxyvitamin D levels in patients with chronic obstructive pulmonary disease treated with prednisone
Bikle, D. D., Halloran, B. P., Fong, L. G., Steinbach, L. S., & Shellito, J. E. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.76.2.8432789 · Cited by 59 · see citing works
Decreased intestinal calcium absorption in vivo and normal brush border membrane vesicle calcium uptake in cortisol-treated chickens: evidence for dissociation of calcium absorption from brush border vesicle uptake.
Shultz, T. D., Bollman, S., & Kumar, R. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.11.3542 · Cited by 57 · see citing works
The effect of long-and short-term corticosteroids on plasma calcitonin and parathyroid hormone levels
Hattersley, A. T., Meeran, K. M., Burrin, J. M., Hill, P. A., Shiner, R. J., & Ibbertson, H. K. (1994) · Calcified Tissue International · doi:10.1007/bf00301678 · Cited by 56 · see citing works
Testosterone therapy in glucocorticoid-treated men
Reid, I. R. (1996) · Archives of Internal Medicine · doi:10.1001/archinte.156.11.1173 · Cited by 56 · see citing works
The effects of methylprednisolone on oxidative phosphorylation in Concanavalin‐A‐stimulated thymocytes
Buttgereit, F., GRANT, A., Müller, M. R., & Brand, M. D. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.tb19020.x · Cited by 53 · see citing works
Self-citation
Methylprednisolone inhibits uptake of Ca2+ and Na+ ions into concanavalin A-stimulated thymocytes
Buttgereit, F., Krauss, S. J. K., & Brand, M. D. (1997) · Biochemical Journal · doi:10.1042/bj3260329 · Cited by 52 · see citing works
Self-citation
Glucocorticoid dose dependent downregulation of glucocorticoid receptors in patients with rheumatic diseases.
Sanden, S., Tripmacher, R., Weltrich, R., Rohde, W., Hiepe, F., Gr, B., & Buttgereit, F. (2000) · PubMed · Cited by 51 · see citing works
Self-citation
Differential effects of glucocorticoid on recruitment and activity of osteoclasts induced by normal and osteocalcin-deficient bone implanted in rats.
Defranco, D. J., Lian, J. B., & Glowacki, J. (1992) · Endocrinology · doi:10.1210/endo.131.1.1611989 · Cited by 50 · see citing works
11β-Hydroxysteroid dehydrogenase in the rat ovary: high expression in the oocyte
Benediktsson, R., Yau, J. L. W., Low, S., Brett, L. P., Cooke, B. E., Edwards, C. R. W., & Seckl, J. R. (1992) · Journal of Endocrinology · doi:10.1677/joe.0.1350053 · Cited by 45 · see citing works
Osteoblasts mediate insulin-like growth factor-I and -II stimulation of osteoclast formation and function
Hill, P. (1995) · Endocrinology · doi:10.1210/en.136.1.124 · Cited by 44 · see citing works
SHORT‐TERM EFFECT OF PREDNISONE ON SERUM 1,25‐DIHYDROXYVITAMIN D IN NORMAL INDIVIDUALS AND IN HYPER‐AND HYPOPARATHYROIDISM
Braun, J. J., Juttmann, J. R., Visser, T. J., & Birkenhäger, J. C. (1982) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1982.tb02630.x · Cited by 42 · see citing works
Autocrine down-regulation of collagenase-3 in rat bone cell cultures by insulin-like growth factors
Delany, A. M., Rydziel, S., & CANALIS, E. M. (1996) · Endocrinology · doi:10.1210/endo.137.11.8895331 · Cited by 41 · see citing works
Effect of hydrocortisone on osteoclasts generated in cat bone marrow cultures
Suda, T., Testa, N. G., Allen, T. D., Onions, D. E., & Jarrett, O. (1983) · Calcified Tissue International · doi:10.1007/bf02405011 · Cited by 40 · see citing works
Intestinal calcium absorption and parathyroid hormone secretion in asthmatic patients on prolonged oral or inhaled steroid treatment
Luengo, M., Picado, C., Piera, C., Guañabens, N., Montserrat, J. M., Rivera, J., & Setoaín, J. (1991) · European Respiratory Journal · doi:10.1183/09031936.93.04040441 · Cited by 38 · see citing works
Effects of cortisol on the expression of interleukin-6 and interleukin-1 beta in human osteoblast-like cells.
Swolin-Eide, D., & Ohlsson, C. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1560107 · Cited by 36 · see citing works
The Effects of Chronic Prednisone Administration on Intestinal Receptors for 1,25-Dihydroxyvitamin D3in the Dog*
Korkor, A. B., KUCHIBOTLA, J., ARRIEH, M., Gray, R. W., & Gleason, W. A. (1985) · Endocrinology · doi:10.1210/endo-117-6-2267 · Cited by 32 · see citing works
Developmental Changes in Glucocorticoid Receptor and 11 -Hydroxysteroid Dehydrogenase Oxidative and Reductive Activities in Rat Leydig Cells
Ge, R. (1997) · Endocrinology · doi:10.1210/en.138.12.5089 · Cited by 32 · see citing works
Transcriptional repression of insulin-like growth factor I by glucocorticoids in rat bone cells
Delany, A. M. (1995) · Endocrinology · doi:10.1210/en.136.11.4776 · Cited by 32 · see citing works
Calcium Absorption in Corticoid Treated Subjects Effects of a Single Oral Dose of Calcitriol
Colette, C., Monnier, L., Parés-Herbute, N., Blotman, F., & Mirouze, J. (1987) · Hormone and Metabolic Research · doi:10.1055/s-2007-1011815 · Cited by 30 · see citing works
Sex steroids and osteoporosis: Effects of deficiencies and substitutive treatments
Schot, L. P. C., & Schuurs, A. H. W. M. (1990) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(90)90325-f · Cited by 28 · see citing works
Combined Effects of Dexamethasone and 1,25-Dihydroxyvitamin D3on Parathyroid Hormone Secretion in Cultured Bovine Parathyroid Cells*
Sugimoto, T., Brown, A. J., Ritter, C. S., Morrissey, J. J., Slatopolsky, E., & Martin, K. J. (1989) · Endocrinology · doi:10.1210/endo-125-2-638 · Cited by 27 · see citing works
Dexamethasone increases preproparathyroid hormone messenger RNA in human hyperplastic parathyroid cells in vitro
Péraldi, M., Rondeau, É., Jousset, V., M'SELMI, A. E., Lacave, R., Delarue, F., Garel, J.-M., & Sraer, J. (1990) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1990.tb01875.x · Cited by 25 · see citing works
Effects of IGF-I combined with GH on glucocorticoid-induced changes of bone and connective tissue turnover in man
Berneis, K. K., Oehri, M., KRAENZLIN, M. E., & Keller, U. B. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1620259 · Cited by 21 · see citing works
In vitro motility assay of atrial and ventricular myosin from pig
Svensson, C., Morano, I. L., & Arner, A. (1997) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19971101)67:2 · Cited by 17 · see citing works
Cortisol Decreases Hepatocyte Growth Factor Levels in Human Osteoblast-Like Cells
Skrtic, S., & Ohlsson, C. (2000) · Calcified Tissue International · doi:10.1007/pl00005831 · Cited by 17 · see citing works
Cellular Regulatory Mechanisms that May Underlie the Effects of Corticosteroids on Bone
Russell, R. G. G. (1993) · Lara D. Veeken · doi:10.1093/rheumatology/32.suppl_2.6 · Cited by 15 · see citing works
Mechanism of the regulation of the 1α,25-dihydroxyvitamin D3 receptor in the rat jejunum by glucocorticoids
Chan, S. D. H., Chiu, D. K. H., & Atkins, D. (1984) · Journal of Endocrinology · doi:10.1677/joe.0.1030295 · Cited by 14 · see citing works
Prednisolone Induces an Increase in Serum Calcium Concentration: Possible Involvement of the Kidney, the Bone, and the Intestine
Yonemura, K., Hishida, A., Kimura, M., Watanabe, T., & Kumagai, H. (1999) · Calcified Tissue International · doi:10.1007/s002239900696 · Cited by 11 · see citing works
Untitled work
Lawrence (1998) · doi:10.1002/1529-0131(199805)41:5
Self-citation

Flagged first, then by citations

Sorted by citations

Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease
Kearns, A. E., Khosla, S., & Kostenuik, P. J. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0014 · Cited by 824 · see citing works
Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects
Schäcke, H., Schottelius, A., Döcke, W.-D., Strehlke, P., Jaroch, S., Schmees, N., Rehwinkel, H., Hennekes, H., & Asadullah, K. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0300372101 · Cited by 466 · see citing works
The Pathogenesis, Epidemiology and Management of Glucocorticoid-Induced Osteoporosis
van Staa, T. P. (2006) · Calcified Tissue International · doi:10.1007/s00223-006-0019-1 · Cited by 257 · see citing works
“Moderate doses of oral GCs inhibit synthesis of bone collagen by pre-existing osteoblasts and conversion of precursor into functioning osteoblasts [5, 6].”
Background
Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis
Deng, C., Zhang, Q., He, P., Zhou, B., He, K., Sun, X., Lei, G., Gong, T., & Zhang, Z. (2021) · Nature Communications · doi:10.1038/s41467-021-22454-z · Cited by 252 · see citing works
“However, the application of glucocorticoids can result in severe side effects including bone loss and hyperglycemia 28,29 , while the frequent use of antibodies to block in ﬂ ammatory cytokines can cause systemic immune suppression, thereby leading to a high risk of infections 30,31 .”
Glucocorticoids Promote Chondrogenic Differentiation of Adult Human Mesenchymal Stem Cells by Enhancing Expression of Cartilage Extracellular Matrix Genes
Derfoul, A., Perkins, G. L., Hall, D. J., & Tuan, R. S. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0415 · Cited by 202 · see citing works
Vitamin D insufficiency in a large female SLE cohort
Toloza, S., Cole, D., Gladman, D., Ibañez, D., & Urowitz, M. B. (2009) · Lupus · doi:10.1177/0961203309345775 · Cited by 187 · see citing works
Selective regulation of bone cell apoptosis by translational isoforms of the glucocorticoid receptor
Lu, N. Z., Collins, J. B., Grissom, S. F., & Cidlowski, J. A. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00253-07 · Cited by 160 · see citing works
“Osteoporosis, for instance, is one of the side effects that can be life-threatening (22).”
Background
Osmoregulation in zebrafish: ion transport mechanisms and functional regulation
Guh, Y.-J., Lin, C.-H., & Hwang, P. (2015) · EXCLI journal · doi:10.17179/excli2015-246 · Cited by 159 · see citing works
“Unlike its role in mammals as a hypocalcemic hormone (Patschan et al., 2001), cortisol was found to act as a stimulator for Ca uptake in fish.”
Background
Glucocorticoid-induced osteoporosis: a systematic review and cost-utility analysis
Kanis, J. A., Stevenson, M., McCloskey, E. V., Davis, S., & Lloyd-Jones, M. (2007) · Health Technology Assessment · doi:10.3310/hta11070 · Cited by 151 · see citing works
Prevention of Glucocorticoid-Induced Apoptosis in Osteocytes and Osteoblasts by Calbindin-D28k
Liu, Y., Porta, A., Peng, X., Gengaro, K., Cunningham, E. B., Li, H., Dominguez, L. A., Bellido, T., & Christakos, S. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.0301242 · Cited by 148 · see citing works
“intestinal calcium absorption, increased renal clearance of calcium, and sex steroid deficiency.((1,3,5,6)) Studies in mice”
Background
Skeletal Health of Children and Adolescents With Inflammatory Bowel Disease
Pappa, H. M., Thayu, M., Sylvester, F. A., Leonard, M. B., Zemel, B. S., & Gordon, C. M. (2011) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31821988a3 · Cited by 135 · see citing works
Prevention and treatment of glucocorticoid-induced osteoporosis with active vitamin D3 analogues: a review with meta-analysis of randomized controlled trials including organ transplantation studies
de Nijs, R. N. J., Jacobs, J. W. G., Algra, A., Lems, W. F., & Bijlsma, J. W. J. (2004) · Osteoporosis International · doi:10.1007/s00198-004-1614-5 · Cited by 124 · see citing works
“GCs have inhibitory effects on the synthesis and secretion of sex steroids [9].”
Background
Acute Kidney Injury in Diabetes Mellitus
Patschan, D., & Muller, G. A. (2016) · International Journal of Nephrology · doi:10.1155/2016/6232909 · Cited by 122 · see citing works
“The ultimate consequence is aggravated fibrosis and an increased risk for CKD [33, 41, 42].”
BackgroundSelf-citation
Fas/CD95 is associated with glucocorticoid-induced osteocyte apoptosis
Kogianni, G., Mann, V., Ebetino, F. H., NUTTALL, M. E., Nijweide, P. J., Simpson, H., & Noble, B. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.04.048 · Cited by 110 · see citing works
Inhibition of growth and differentiation of osteoprogenitors in mouse bone marrow stromal cell cultures by increased donor age and glucocorticoid treatment
Chen, T. L. (2004) · Bone · doi:10.1016/j.bone.2004.03.019 · Cited by 108 · see citing works
Fracture risk associated with systemic and topical corticosteroids
Vestergaard, P., Rejnmark, L., & Mosekilde, L. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2005.01467.x · Cited by 107 · see citing works
Management of osteoporosis
Lewiecki, E. M. (2004) · Clinical and Molecular Allergy · doi:10.1186/1476-7961-2-9 · Cited by 106 · see citing works
“The pathophysiology of glucocorticoid-induced osteoporosis is multifactorial, and includes 1.) impairment of osteoblast, osteocyte, and osteoclast function, leading to decreased bone turnover and reduced microfracture repair; 2.) disordered calcium metabolism, with reduced intestinal absorption, increased renal excret…”
Background
Distal Convoluted Tubule
McCormick, J. A., & Ellison, D. H. (2014) · Comprehensive physiology · doi:10.1002/cphy.c140002 · Cited by 103 · see citing works
“calcium absorption by the duodenum (210) increased renal calcium excretion (486), and osteoporosis (56, 380, 398).”
Dexamethasone Enhances Osteoclast Formation Synergistically with Transforming Growth Factor-β by Stimulating the Priming of Osteoclast Progenitors for Differentiation into Osteoclasts
詫摩, 敦., Kaneda, T., Sato, T., Ninomiya, S., Kumegawa, M., & Hakeda, Y. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300213200 · Cited by 100 · see citing works
Recent advances in our understanding of 1,25-dihydroxyvitamin D3 regulation of intestinal calcium absorption
Christakos, S. (2012) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.12.020 · Cited by 92 · see citing works
Understanding and managing corticosteroid-induced osteoporosis
Kobza, A. O., Herman, D., Papaioannou, A., Lau, A. N., & Adachi, J. D. (2021) · Open Access Rheumatology Research and Reviews · doi:10.2147/oarrr.s282606 · Cited by 84 · see citing works
Reverse Effect of Mammalian Hypocalcemic Cortisol in Fish: Cortisol Stimulates Ca2+ Uptake via Glucocorticoid Receptor-Mediated Vitamin D3 Metabolism
Lin, C.-H., Tsai, I., Su, C.-H., Tseng, D.-Y., & Hwang, P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023689 · Cited by 80 · see citing works
“An imbalance of Ca handling is an important factor causing osteoporosis [3].”
Background
Corticosteroid use and risk of hip fracture: a population‐based case–control study in Denmark
Vestergaard, P., Olsen, M. L., Johnsen, S. P., Rejnmark, L., Sørensen, H. T., & Mosekilde, L. (2003) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2003.01219.x · Cited by 77 · see citing works
Action of Vitamin D and the Receptor, VDRa, in Calcium Handling in Zebrafish (Danio rerio)
Lin, C.-H., Su, C.-H., Tseng, D.-Y., Ding, F.-C., & Hwang, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045650 · Cited by 76 · see citing works
“Decrease of renal Ca reabsorption and intestinal Ca absorption is an important factor causing osteoporosis [1].”
Background
Glucocorticoid-induced osteoporosis: a review on pathophysiology and treatment options.
de Nijs, R. N. J. (2008) · PubMed · Cited by 74 · see citing works
Sclerostin antibody treatment enhances bone strength but does not prevent growth retardation in young mice treated with dexamethasone
Marenzana, M., Greenslade, K. J., Eddleston, A., Okoye, R., Marshall, D. R., Moore, A., & Robinson, M. K. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30385 · Cited by 73 · see citing works
Fracture Risk in Patients With Chronic Lung Diseases Treated With Bronchodilator Drugs and Inhaled and Oral Corticosteroids
Vestergaard, P., Rejnmark, L., & Mosekilde, L. (2007) · CHEST Journal · doi:10.1378/chest.07-1092 · Cited by 71 · see citing works
Icariin Protects Against Glucocorticoid-Induced Osteoporosis In Vitro and Prevents Glucocorticoid-Induced Osteocyte Apoptosis In Vivo
Feng, R., Li, F., Yuan, Z., Wang, D., Wang, F., Tan, B., Han, S., Li, T., Li, D., & Han, Y. (2013) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-013-9533-8 · Cited by 71 · see citing works
“However, long-term GC therapy has significant side effects, for instance, reduction in bone density [2].”
L-Arginine and L-Lysine stimulation on cultured human osteoblasts
Torricelli, P., Fini, M., Giavaresi, G., Giardino, R., Gnudi, S., Nicolini, A., & Carpi, A. (2002) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(02)00287-1 · Cited by 69 · see citing works
New and improved glucocorticoid receptor ligands
Miner, J. N., Hong, M. H., & Negro-Vilar, A. F. (2005) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.14.12.1527 · Cited by 68 · see citing works
“Increased PTH levels in response to lower serum calcium enhances bone resorption relative to formation, further shifting the balance towards bone [31].”
Background
Curculigo orchioides, a traditional Chinese medicinal plant, prevents bone loss in ovariectomized rats
Cao, D.-P., Zheng, Y. N., Qin, L., Han, T., Zhang, H., Rahman, K., & Zhang, Q.-Y. (2008) · Maturitas · doi:10.1016/j.maturitas.2008.03.010 · Cited by 62 · see citing works
Current use of glucocorticoids in patients with rheumatoid arthritis in Germany
Thiele, K., Buttgereit, F., Huscher, D., & Zink, A. (2005) · Arthritis Care & Research · doi:10.1002/art.21467 · Cited by 61 · see citing works
Self-citation
Effects of escin on acute inflammation and the immune system in mice
Wang, T., Fu, F.-H., Zhang, L., Han, B., Zhu, M. J., & Zhang, X. (2009) · Pharmacological Reports · doi:10.1016/s1734-1140(09)70122-7 · Cited by 60 · see citing works
“fective for treatment of a wide variety of inflammatory diseases, long-term therapy with glucocorticoids causes osteoporosis, resulting in severe bone loss, which has recently become a major clinical problem [14].”
Background
Genistein aglycone reverses glucocorticoid‐induced osteoporosis and increases bone breaking strength in rats: a comparative study with alendronate
Bitto, A., Burnett, B. P., Polito, F., Levy, R. M., Marini, H. R., Stefano, V. D., Irrera, N., Armbruster, M. A., Minutoli, L., Altavilla, D., et al. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00100.x · Cited by 59 · see citing works
“The manner in which glucocorticoids induce bone loss is complex and incompletely understood (Patschan et al., 2001; Canalis et al., 2007), in part because there are no animal models absolutely comparable to humans.”
Background
Glucocorticoid Treatment of Ovariectomized Sheep Affects Mineral Density, Structure, and Mechanical Properties of Cancellous Bone
Schorlemmer, S., Gohl, C., Iwabu, S., Ignatius, A. A., Claes, L., & Augat, P. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.11.2010 · Cited by 58 · see citing works
“Moreover, the initial phase of rapid bone loss in glucocorticoid-induced osteoporosis is caused by an extension of the osteoclastic lifespan.((28,29))”
Background
Inductive effects of dexamethasone on the mineralization and the osteoblastic gene expressions in mature osteoblast-like ROS17/2.8 cells
Mikami, Y., Omoteyama, K., Kato, S., & Takagi, M. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.07.192 · Cited by 57 · see citing works
Dental extractions and bisphosphonates: the assessment, consent and management, a proposed algorithm
Malden, N., Beltes, C., & Lopes, V. (2009) · BDJ · doi:10.1038/sj.bdj.2009.5 · Cited by 58 · see citing works
“The question therefore arises: are corticosteroids a risk factor for osteonecrosis of the jaws? A number of molecular mechanisms of corticosteroid-induced osteonecrosis have been described”
Enhanced osteogenic differentiation of stem cells via microfluidics synthesized nanoparticles
Hasani‐Sadrabadi, M. M., Hajrezaei, S. P., Emami, S. H., Bahlakeh, G., Daneshmandi, L., Dashtimoghadam, E., Seyedjafari, E., Jacob, K. I., & Tayebi, L. (2015) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2015.04.005 · Cited by 56 · see citing works
Stress and Alterations in Bones: An Interdisciplinary Perspective
Wippert, P., Rector, M., Kuhn, G. A., & Wuertz‐Kozak, K. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00096 · Cited by 59 · see citing works
Drug-Induced Musculoskeletal Disorders
Bannwarth, B. (2007) · Drug Safety · doi:10.2165/00002018-200730010-00004 · Cited by 54 · see citing works
New understanding of glucocorticoid action in bone cells
Kim, H. J. (2010) · BMB Reports · doi:10.5483/bmbrep.2010.43.8.524 · Cited by 54 · see citing works
“brane-bound GR or by direct interactions with biological membranes (55).”
Glucocorticoids differentially regulate expression of duodenal and renal calbindin-D9k through glucocorticoid receptor-mediated pathway in mouse model
Lee, G., Choi, K., & Jeung, E. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00232.2005 · Cited by 52 · see citing works
“Of these, potentially the most serious and debilitating disease is GC-induced osteoporosis (GIO) (40).”
BackgroundInfluential
Rheumatoid Arthritis Exacerbates the Severity of Osteonecrosis of the Jaws (ONJ) in Mice. A Randomized, Prospective, Controlled Animal Study
de Molon, R. S., Hsu, C., Bezouglaia, O., Dry, S., Pirih, F. Q. M., Soundia, A., Cunha, F. Q., Cirelli, J. A., Aghaloo, T. L., & Tetradis, S. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2827 · Cited by 50 · see citing works
“However, biologic agents increase the risk of opportunistic infections,((51)) corticosteroids have been shown to impair bone and wound healing,((52)) methotrexate may affect bone healing through inhibition of osteoblastic proliferation and bone turnover suppression,((53)) steroids reduce bone remodeling,((54)) suppres…”
Background
Incidence, Risk Factors and Evaluation of Osteoporosis in Patients With Inflammatory Bowel Disease: A Danish Population-Based Inception Cohort With 10 Years of Follow-Up
Lo, B. Z. S., Holm, J., Vester-Andersen, M. K., Bendtsen, F., Vind, I., & Burisch, J. M. (2020) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjaa019 · Cited by 49 · see citing works
Zoledronic Acid Enhances Lipopolysaccharide-Stimulated Proinflammatory Reactions through Controlled Expression of SOCS1 in Macrophages
Muratsu, D., Yoshiga, D., Taketomi, T., Onimura, T., Seki, Y., Matsumoto, A., & Nakamura, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067906 · Cited by 48 · see citing works
“A proposed hypothesis for the development of BRONJ is an alteration in bone turnover associated with the particular characteristics of the jaw bone [10,20], such as mucosal coating, frequent risk of infection, and constant potential for trauma [18,21].”
Background
Protective effect of genistein aglycone on the development of osteonecrosis of the femoral head and secondary osteoporosis induced by methylprednisolone in rats
Bitto, A., Polito, F., Burnett, B. P., Levy, R. M., Stefano, V. D., Armbruster, M. A., Marini, H. R., Minutoli, L., Altavilla, D., & Squadrito, F. (2009) · Journal of Endocrinology · doi:10.1677/joe-08-0552 · Cited by 47 · see citing works
“In fact, there is a decreased absorption from the intestine and an increased loss of calcium in the urine as a result of defective vitamin D3 metabolism (Cosman et al. 1994, Patschan et al. 2001).”
Background
Rheumatoid arthritis and incident fracture in women: a case–control study
Brennan-Olsen, S. L., Toomey, L., Kotowicz, M. A., Henry, M. J., Griffiths, H., & Pasco, J. A. (2014) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-15-13 · Cited by 47 · see citing works
“of glucocorticoids is that they disrupt bone metabolism, causing an increase in bone resorption and a decrease in formation via several different mechanisms [2].”
Background
Risks and benefits of corticosteroids in arthritic diseases in the clinic
Πέττα, Ι., Peene, I., Elewaut, D. S., Vereecke, L., & Bosscher, K. D. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.04.009 · Cited by 47 · see citing works
Glucocorticoid use in rheumatoid arthritis: benefits, mechanisms, and risks.
Townsend, H. B., & Saag, K. G. (2004) · PubMed · Cited by 47 · see citing works
Dexamethasone down-regulates cAMP-phosphodiesterase in human osteosarcoma cells
Ahlström, M., Pekkinen, M., Huttunen, M. M., & Lamberg-Allardt, C. J. E. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.09.012 · Cited by 47 · see citing works
“Glucocorticoids have been shown to decrease the formation of new osteoblasts, modulate type 1 collagen synthesis, and affect the transcription of osteopontin, fibronectin, bone sialoprotein and a number of local growth factors [ 4 ,5].”
Background
High-dose glucocorticoids increase serum levels of soluble IL-6 receptor α and its ratio to soluble gp130: an additional mechanism for early increased bone resorption
Dovio, A., Perazzolo, L., Saba, L., Termine, A., Capobianco, M. A. N., Bertolotto, A., & Angeli, A. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02147 · Cited by 46 · see citing works
“Nongenomic effects are conceivable, but have not been documented so far ( 6 ).”
Background
Distal Convoluted Tubule
McCormick, J. A., & Ellison, D. H. (2015) · Comprehensive physiology · doi:10.1002/j.2040-4603.2015.tb00597.x · Cited by 46 · see citing works
Glucocorticoid induced osteoporosis
Hu, K., & Adachi, J. D. (2019) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2019.1617131 · Cited by 43 · see citing works
Pubertal abnormalities in adolescents with chronic disease
Kao, K., Denker, M. W., Zacharin, M., & Wong, S. C. (2019) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2019.04.009 · Cited by 42 · see citing works
Glucocorticoid-Induced Osteoporosis
Lukert, B. P. (1992) · Southern Medical Journal · doi:10.1097/00007611-199208001-00009 · Cited by 42 · see citing works
Effects of glucocorticoids on growth and bone mineralization
Donatti, T. L., Koch, V. H. K., Takayama, L., & Pereira, R. M. R. (2011) · Jornal de Pediatria · doi:10.1590/s0021-75572011000100002 · Cited by 56 · see citing works
Glucocorticoid-induced osteoporosis: Insights for the clinician
Hayat, S., & Magrey, M. (2020) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.87a.19039 · Cited by 39 · see citing works
“14 By decreasing bone formation.”
Oral bisphosphonate-related osteonecrosis of the jaws in rheumatoid arthritis patients: a critical discussion and two case reports
Neto, N. C., Bastos, A. D. S., Spolidório, L. C., Marcantonio, R. A. C., & Marcantônio, É. (2011) · Head & Face Medicine · doi:10.1186/1746-160x-7-7 · Cited by 39 · see citing works
“Hypothetical factors linked with BRONJ include a possible excessive suppression of bone turnover and jaw angiogenesis resulting from the association between bisphosphonates and steroids, since these drugs also reduce bone remodeling [6] and angiogenesis [7].”
Background
The negative effect of dexamethasone on calcium-processing gene expressions is associated with a glucocorticoid-induced calcium-absorbing disorder
Kim, M., Lee, G., Jung, E., Choi, K., & Jeung, E. (2009) · Life Sciences · doi:10.1016/j.lfs.2009.05.013 · Cited by 39 · see citing works
Drugs Causing Bone Loss
Vestergaard, P. (2019) · Handbook of experimental pharmacology · doi:10.1007/164_2019_340 · Cited by 38 · see citing works
Effect of pamidronate on new vertebral fractures and bone mineral density in patients with malignant lymphoma receiving chemotherapy
Kim, S. H., Lim, S. K., & Hahn, J. S. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2003.12.019 · Cited by 36 · see citing works
Weight loss by calorie restriction versus bariatric surgery differentially regulates the hypothalamo-pituitary-adrenocortical axis in male rats
Grayson, B. E., Hakala-Finch, A. P., Kekulawala, M., Laub, H. N., Egan, A. E., Ressler, I. B., Woods, S. C., Herman, J. P., Seeley, R. J., Benoit, S. C., et al. (2014) · Stress · doi:10.3109/10253890.2014.967677 · Cited by 35 · see citing works
“…cognitive function (McEwen, 2001; Sapolsky et al., 1985), immune dysfunction (e.g. thymic atrophy) (Dimitrijevic et al., 2012; Elenkov & Chrousos, 2002), osteoporosis (Mitchell & Lyles, 1990; Patschan et al., 2001), and increased risk for mood and anxiety disorders (Tafet & Bernardini, 2003).”
Background
Pharmacogenomics of serious adverse drug reactions in pediatric oncology.
Ross, C. J., Visscher, H., Rassekh, S. R., Pastrana, L. I. C., Shereck, E. B., Carleton, B., & Hayden, M. R. (2011) · PubMed · Cited by 34 · see citing works
Vitamin D status and bone biomarkers in childhood cancer
Atkinson, S. A. (2007) · Pediatric Blood & Cancer · doi:10.1002/pbc.21406 · Cited by 34 · see citing works
“Osteocalcin is reduced in growing piglets receiving highdose steroids, [17] possibly through a direct action of the drug on the expression of osteocalcin mRNA in osteoblastic cells [20].”
Background
Glucocorticoids induce glutamine synthetase expression in human osteoblastic cells: a novel observation in bone
Olkku, A., Bodine, P. V. N., Linnala‐Kankkunen, A., & Mahonen, A. (2003) · Bone · doi:10.1016/j.bone.2003.09.010 · Cited by 34 · see citing works
“There is also increasing evidence for nongenomic actions of glucocorticoids that are mediated by membrane receptors or other physicochemical interactions [27,38].”
Background
Synergistic antiosteoporotic effect of Lepidium Sativum and alendronate in glucocorticoid-induced osteoporosis in wistar rats
Elshal, M. F., Almalki, A., Hussein, H., & Khan, J. A. (2013) · African Journal of Traditional Complementary and Alternative Medicines · doi:10.4314/ajtcam.v10i5.8 · Cited by 32 · see citing works
“Bone loss is one of the most devastating side effects of glucocorticoids because they inhibit calcium transport, cause secondary hyperparathyroidism, hypogonadism, and impairment of osteoblast function (Patschan et al., 2001, Rackoff and Rosen 1998).”
Background
Animal Models of Osteoporosis
Hayashi, K., & Fotovati, A. (2002) · CRC Press eBooks · doi:10.1201/b14228-7 · Cited by 32 · see citing works
Alendronate sodium in the management of osteoporosis
Prinsloo, P., & Hosking, D. J. (2006) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.2006.2.3.235 · Cited by 32 · see citing works
“…gut and increased renal losses, may lead to low-grade secondary hyperparathyroidism with further increased osteoclast activity (Cosman et al 1994; Patschan et al 2001; Weinstein 2001; Canalis et al 2004) Several studies investigated the efficiency of alendronate for the prevention and treatment…”
Effects of salvianolate on bone metabolism in glucocorticoid-treated lupus-prone B6.MRL-Faslpr/J mice
Liu, Y., Cui, Y., Zhang, X., Gao, X., Su, Y., Xu, B., Wu, T., Chen, W., & Cui, L. (2016) · Drug Design Development and Therapy · doi:10.2147/dddt.s110125 · Cited by 31 · see citing works
“22 These effects indirectly lead to osteoporosis.”
Tactile/kinesthetic stimulation (TKS) increases tibial speed of sound and urinary osteocalcin (U-MidOC and unOC) in premature infants (29–32weeks PMA)
Haley, S., BEACHY, J. C., Ivaska, K. K., Slater, H., Smith, S. L., & Moyer‐Mileur, L. J. (2012) · Bone · doi:10.1016/j.bone.2012.07.016 · Cited by 29 · see citing works
“suppression and development of insulin-like growth factor 1 (IGF1) resistance[57].”
Background
Impaired bone healing in rabbits with steroid-induced osteonecrosis
Xie, X., Wang, X., Zhang, G., Liu, Z., Yao, D., Hung, L. K., Hung, V. W.-Y., & Qin, L. (2011) · Journal of Bone and Joint Surgery - British Volume · doi:10.1302/0301-620x.93b4.25442 · Cited by 30 · see citing works
Full-mouth rehabilitation using dental implants in a patient with scleroderma.
Zigdon, H., Gutmacher, Z., Teich, S., & Levin, L. (2011) · PubMed · Cited by 30 · see citing works
Cannabinoid Receptors as Target for Treatment of Osteoporosis: A Tale of Two Therapies
Idris, A. I. (2010) · Current Neuropharmacology · doi:10.2174/157015910792246173 · Cited by 29 · see citing works
“Osteoclast formation and activity is controlled by the combined action of receptor activator of nuclear factor kappa-B ligand (RANKL) [40], osteoprotegerin (OPG) [41] and monocyte colony forming factor (M-CSF) [42] produced by cells of the osteoblastic lineage.”
BackgroundInfluential
Compared clinical efficacy and bone metabolic effects of low-dose deflazacort and methyl prednisolone in male inflammatory arthropathies: a 12-month open randomized pilot study
Saviola, G., Abdì-Alì, L., Eddin, S. S., Coppini, A., Cavalieri, F., Campostrini, L., Sacco, S., Bucci, M., Cirino, G., & Rossini, M. (2007) · Lara D. Veeken · doi:10.1093/rheumatology/kem030 · Cited by 29 · see citing works
Dexamethasone differentially regulates renal and duodenal calcium‐processing genes in calbindin‐D9k and ‐D28k knockout mice
Kim, M., Lee, G., Jung, E., Choi, K., Oh, G., & Jeung, E. (2008) · Experimental Physiology · doi:10.1113/expphysiol.2008.044339 · Cited by 29 · see citing works
“Finally, increased excretion of urinary calcium and reduced intestinal absorption of calcium lead to a negative calcium balance that has been suggested to promote secondary hyperparathyroidism (Reid, 1997; Patschan et al. 2001).”
Background
The treatment of glucocorticoid-induced osteoporosis
Cohen, D., & Adachi, J. D. (2004) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.01.003 · Cited by 29 · see citing works
The protective role of bone morphogenetic protein-8 in the glucocorticoid-induced apoptosis on bone cells
Kosa, J. P., Kis, A., Bácsi, K., Balla, B., Nagy, Z., Takács, I., Speer, G., & Lakatos, P. L. (2011) · Bone · doi:10.1016/j.bone.2011.01.017 · Cited by 28 · see citing works
“Besides the genomic actions of GCs, nongenomic mechanisms can also be found in GR positive bone cells [11].”
Background
A Study to Evaluate the Cause of Bone Demineralization in Gynecological Cancer Survivors
Stavraka, C., Maclaran, K., Gabra, H., Agarwal, R., Ghaem‐Maghami, S., Taylor, A., Dhillo, W. S., Panay, N., & Blagden, S. P. (2013) · The Oncologist · doi:10.1634/theoncologist.2012-0416 · Cited by 27 · see citing works
Duodenal calcium absorption in dexamethasone-treated mice: Functional and molecular aspects
Cromphaut, S. J. V., Stockmans, I., Torrekens, S., Herck, E. V., Carmeliet, G., & Bouillon, R. (2006) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2006.11.027 · Cited by 27 · see citing works
Effects of glucocorticoids on growth and bone mineralization
Donatti, T. L., Koch, V. H. K., Takayama, L., & Pereira, R. M. R. (2011) · Jornal de Pediatria · doi:10.2223/jped.2052 · Cited by 26 · see citing works
Immunocytochemical Evidence on the Effects of Glucocorticoids on Type I Collagen Synthesis in Human Osteoblastic Cells
Hernández, M. V., Guañabens, N., Álvarez, L., Monegal, A., Peris, P., Riba, J., Ercilla, G., de Osaba, M. J. M., & Muñoz-Gómez, J. (2003) · Calcified Tissue International · doi:10.1007/s00223-002-1095-5 · Cited by 25 · see citing works
“The effects of glucocorticoids on bone mineral metabolism have been extensively analyzed [1].”
Background
Design and development of glucocorticoid receptor modulators
Buttgereit, F., Elling, C., & Jakob, F. (2025) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2025.06.005 · Cited by 25 · see citing works
Self-citation
Therapeutic interactions between mesenchymal stem cells for healing medication-related osteonecrosis of the jaw
Matsuura, Y., Atsuta, I., Ayukawa, Y., Yamaza, T., Kondo, R., Takahashi, A., Ueda, N., Oshiro, W., Tsukiyama, Y., & Koyano, K. (2016) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0367-3 · Cited by 24 · see citing works
“Although MSCs have been shown to exert an inhibitory effect on cancer cells [29], some reports show that MSCs themselves promote the progression of disease symptoms in experimental mice [8, 30, 31], as shown in Fig.”
Result
Siglec-15-targeting therapy protects against glucocorticoid-induced osteoporosis of growing skeleton in juvenile rats
Sato, D., Takahata, M., Ota, M., Fukuda, C., Hasegawa, T., Yamamoto, T., Amizuka, N., Tsuda, E., Okada, A., Hiruma, Y., et al. (2020) · Bone · doi:10.1016/j.bone.2020.115331 · Cited by 24 · see citing works
Association of genetic variations of genes encoding thrombospondin, type 1, domain-containing 4 and 7A with low bone mineral density in Japanese women with osteoporosis
Mori, S., Kou, I., Sato, H., Emi, M., Ito, H., Hosoi, T., & Ikegawa, S. (2008) · Journal of Human Genetics · doi:10.1007/s10038-008-0300-4 · Cited by 23 · see citing works
“In addition to the sex steroids, attention must be paid to adrenal corticoids, as indicated by clinical knowledge of glucocorticoid-induced osteoporosis (Patschan et al. 2001).”
Background
Secondary Osteoporosis
Templeton, K. J. (2005) · Journal of the American Academy of Orthopaedic Surgeons · doi:10.5435/00124635-200511000-00007 · Cited by 23 · see citing works
Second generation sequencing of microRNA in Human Bone Cells treated with Parathyroid Hormone or Dexamethasone
Laxman, N., Rubin, C., Mallmin, H., Nilsson, O., Tellgren‐Roth, C., & Kindmark, A. (2015) · Bone · doi:10.1016/j.bone.2015.12.053 · Cited by 21 · see citing works
Bone response of broiler chickens (Gallus gallus domesticus) induced by corticosterone
Luo, J., Zhou, Z., Zhang, H., Ma, R., & Hou, J. F. (2012) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2012.12.001 · Cited by 21 · see citing works
“The results of the earlier studies indicated that elevated CORT concentration led to reduction in bone mass and disturbed longitudinal bone growth in human and rodents (Li et al., 1996; Patschan et al., 2001; Bianchi, 2002).”
Result
Role of Serum- and Glucocorticoid-Inducible Kinase SGK1 in Glucocorticoid Regulation of Renal Electrolyte Excretion and Blood Pressure
Boini, K. M., Nammi, S., Grahammer, F., Oßwald, H., Kuhl, D., & Lang, F. J. W. (2008) · Kidney & Blood Pressure Research · doi:10.1159/000151666 · Cited by 21 · see citing works
“plasma Ca 2+ concentration. The increase of plasma Ca 2+ concentration may result in part from demineralization of bone [”
Background
Effects of Alfacalcidol on Mechanical Properties and Collagen Cross-Links of the Femoral Diaphysis in Glucocorticoid-Treated Rats
Saito, M., Marumo, K., Ushiku, C., Kato, S., Sakai, S., Hayakawa, N., Mihara, M., & Shiraishi, A. (2011) · Calcified Tissue International · doi:10.1007/s00223-011-9472-6 · Cited by 20 · see citing works
“A number of GC-mediated effects are responsible for bone fragility: (1) GC-induced direct impairment of osteoblast, osteocyte, and osteoclast function leads to reduced bone remodeling; (2) reduced intestinal absorption of calcium and increased renal elimination lead to a negative calcium balance that has been suggeste…”
Background
Alpinumisoflavone rescues glucocorticoid-induced apoptosis of osteocytes via suppressing Nox2-dependent ROS generation
Yin, J., Han, L., & Cong, W. (2017) · Pharmacological Reports · doi:10.1016/j.pharep.2017.11.001 · Cited by 20 · see citing works
Retracted
The utility of human dedifferentiated fat cells in bone tissue engineering in vitro
Sakamoto, F., Hashimoto, Y., Kishimoto, N., Honda, Y., & Matsumoto, N. (2013) · Cytotechnology · doi:10.1007/s10616-013-9659-y · Cited by 19 · see citing works
Use of high-dose intermittent systemic glucocorticoids and the risk of fracture in patients with chronic obstructive pulmonary disease
Oshagbemi, O. A., Burden, A. M., Shudofsky, K. N., Driessen, J. H. M., Vestergaard, P., Krings, A., Franssen, F. M. E., van den Bergh, J. P., & de Vries, F. (2018) · Bone · doi:10.1016/j.bone.2018.02.007 · Cited by 18 · see citing works
Skeletal Effects of Systemic and Topical Corticosteroids
Vestergaard, P. (2008) · Current Drug Safety · doi:10.2174/157488608785699487 · Cited by 19 · see citing works
“Corticosteroids also interfere with collagen synthesis, leading to decreased synthesis and increased degradation, resulting in bone fragility [1, 2].”
BackgroundInfluential
The efficacy of core decompression for steroid‐associated osteonecrosis of the femoral head in rabbits
Maruyama, M., Lin, T., Kaminow, N. I., Thio, T., Storaci, H. W., Pan, C., Yao, Z., Takagi, M., Goodman, S. B., & Yang, Y. (2020) · Journal of Orthopaedic Research® · doi:10.1002/jor.24888 · Cited by 18 · see citing works
The inhibitory mechanisms of losartan and vitamin D on amiodarone‐induced lung inflammation in rats: Role of mitogen‐activated protein kinases/activator protein‐1
Alhassan, S. A., Attia, H., Alomar, H. A., Arafa, M., & Ali, R. (2021) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22923 · Cited by 17 · see citing works
Is the glucocorticoid receptor a key player in prostate cancer?: A literature review
Sakellakis, M., & Flores, L. J. (2022) · Medicine · doi:10.1097/md.0000000000029716 · Cited by 17 · see citing works
“Hence, they enhance osteoclastogenesis and result in osteoporosis, a common side effect of chronic glucocorticoid treatment.[70,71] This contrasts with the fact that prostate cancer bone metastases are mostly osteoblastic.”
Background
Glucocorticoid-induced osteoporosis—from molecular mechanism to clinical practice
Hsu, C. H., Hsu, C. L., Langley, A., Wojcik, C., Iraganje, E., & Grygiel‐Górniak, B. (2024) · Drugs & Therapy Perspectives · doi:10.1007/s40267-024-01079-4 · Cited by 17 · see citing works
“GCs are demonstrated to suppress the transcription of IGF-1 and the synthesis of IGF-binding proteins and, thus, decrease bone density [79, 82].”
Intraoperative detection of viable bone with fluorescence imaging using Visually Enhanced Lesion Scope in patients with bisphosphonate-related osteonecrosis of the jaw: clinical and pathological evaluation
Yoshiga, D., Sasaguri, M., Matsuo, K., Kokuryou, S., Habu, M., Oda, M., Kodama, M., Tsurushima, H., Sakaguchi, O., Sakurai, T., et al. (2015) · Osteoporosis International · doi:10.1007/s00198-015-3096-z · Cited by 16 · see citing works
Application of Large Language Models in Drug-Induced Osteotoxicity Prediction
Chen, Y.-Q., Yu, T., Song, Z.-Q., Wang, C., Luo, J.-T., Xiao, Y. L., Qiu, H., Wang, Q., & Jin, H. (2025) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.5c00275 · Cited by 15 · see citing works

Authors: Patschan, D., Loddenkemper, K., & Buttgereit, F.
Affiliations: Humboldt-Universität zu Berlin (DE)
Corresponding author: Buttgereit, F.
ORCID: Patschan, D.
Buttgereit, F.
Venue: Bone
Publisher: Elsevier BV
Published: 2001-12
Volume: 29
Issue: 6
Pages: 498-505
ISSN: 1873-2763 (ISSN-L)
8756-3282
DOI: 10.1016/s8756-3282(01)00610-x
OpenAlex: W2005326563
Cited by: 201
References: 80
Citations by year: 2026: 2 · 2025: 7 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 11 · 2020: 5 · 2019: 8 · 2018: 6 · 2017: 6 · 2016: 8 · 2015: 9 · 2014: 8 · 2013: 6 · 2012: 6
FWCI: 8.19
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Bone (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords: glucocorticoid-induced osteoporosis, bone loss, bone remodeling, osteoblast activity, osteoclast function, osteocyte function, parathyroid hormone, vitamin D, sex steroids, gonadal function, calcium balance, secondary hyperparathyroidism, glucocorticoid receptor signaling
MeSH terms: Calcium, Glucocorticoids, Humans, Intestinal Absorption, Kidney, Osteoblasts, Osteoclasts, Osteoporosis, Parathyroid Hormone, Gonadal Steroid Hormones, Vitamin D

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Molecular mechanisms of glucocorticoid-induced osteoporosis.

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks