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The Arcuate Nucleus Is the Major Source for Neuropeptide Y-Innervation of Thyrotropin-Releasing Hormone Neurons in the Hypothalamic Paraventricular Nucleus 1
Abstract
Neuropeptide Y (NPY) immunoreactive (-ir) nerve fibers densely innervate hypophysiotropic TRH perikarya and dendrites in the hypothalamic paraventricular nucleus (PVN). To evaluate the contribution of the arcuate nucleus (Arc) to this innervation, the effect of Arc ablation by neonatal monosodium glutamate (MSG) treatment on the density of NPY-fibers contacting TRH neurons in the PVN was investigated. After the lesioned animals and vehicle-treated controls reached adulthood, the number of contacts between NPY-ir boutons and TRH-ir perikarya in the PVN was determined in double-immunostained sections. In controls, numerous contacts between NPY-ir terminals and TRH perikarya and dendrites were observed, confirming earlier findings. MSG treatment resulted in a marked reduction of the size of the Arc and also the number of NPY-perikarya with a concomitant reduction of 82.4 +/-2.1% in the relative number of NPY terminals contacting TRH perikarya and first order dendrites in the medial parvocellular and periventricular subdivisions of the PVN. In contrast, lesioning of the ascending adrenergic bundle in the brain stem caused no statistically significant change in the number of NPY-terminals in close apposition to hypophysiotropic TRH neurons in the PVN. These data confirm earlier findings that NPY-containing axon terminals innervate TRH neurons in the PVN and further demonstrate a potentially important anatomical relationship between NPY-producing neurons in the Arc and hypophysiotropic TRH neurons.
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“The arcuate nucleus neurons provide approximately 75% of the NPY innervation to TRH neurons in the PVN (64,65), whereas the adrenergic NPY neurons of the brainstem contribute the remaining 25% (64).”
From Central regulation of hypothalamic-pituitary-thyroid axis under physiological and pathophysiological conditions (2014) · cites this paper as [65]
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Cites
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Légrádi, G., Emerson, C. H., Ahima, R. S., Flier, J. S., & Lechan, R. M. (1997) · Endocrinology · doi:10.1210/en.138.6.2569 · Cited by 505
Self-citationNeuropeptide Y: Anatomical distribution and possible function in mammalian nervous system
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Leptin Regulation of Neuroendocrine Systems
Ahima, R. S., Saper, C. B., Flier, J. S., & Elmquist, J. K. (2000) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2000.0197 · Cited by 767
Harris, M., Aschkenasi, C., Elias, C. F., Chandrankunnel, A., Nillni, E. A., Bjørbæk, C., Elmquist, J. K., Flier, J. S., & Hollenberg, A. N. (2001) · Journal of Clinical Investigation · doi:10.1172/jci10741 · Cited by 341
Fekete, C., & Lechan, R. M. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1087 · Cited by 342
Self-citationThe TRH neuron: a hypothalamic integrator of energy metabolism
Lechan, R. M., & Fekete, C. (2006) · Progress in brain research · doi:10.1016/s0079-6123(06)53012-2 · Cited by 338
Self-citationDiet-Induced Obesity Causes Ghrelin Resistance in Arcuate NPY/AgRP Neurons
Briggs, D. I., Enriori, P. J., Lemus, M. B., Cowley, M. A., & Andrews, Z. B. (2010) · Endocrinology · doi:10.1210/en.2010-0556 · Cited by 320
Metadata
- Authors
- Légrádi, G., & Lechan, R. M.
- Affiliations
- Tufts Medical Center (US)
- Tufts University (US)
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1998-07
- Volume
- 139
- Issue
- 7
- Pages
- 3262-3270
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W1992841732
- Cited by
- 138
- References
- 39
- Citations by year
- 2026: 1 · 2024: 1 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 5 · 2013: 2 · 2012: 7
- FWCI
- 4.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK-37021, R01DK037021)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- neuropeptide Y, arcuate nucleus, paraventricular nucleus, hypothalamus, axon terminals, perikarya
- MeSH terms
- Adrenergic Fibers, Afferent Pathways, Animals, Arcuate Nucleus of Hypothalamus, Medulla Oblongata, Nerve Fibers, Neurons, Neuropeptide Y, Paraventricular Hypothalamic Nucleus, Sodium Glutamate, Thyrotropin-Releasing Hormone, Rats, Sprague-Dawley, Rats
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- CoChat. (2026). Citation check: The Arcuate Nucleus Is the Major Source for Neuropeptide Y-Innervation of Thyrotropin-Releasing Hormone Neurons in the Hypothalamic Paraventricular Nucleus 1. https://app.cochat.ai/papers/10.1210/endo.139.7.6113
- The paper
- Légrádi, G., & Lechan, R. M. (1998). The Arcuate Nucleus Is the Major Source for Neuropeptide Y-Innervation of Thyrotropin-Releasing Hormone Neurons in the Hypothalamic Paraventricular Nucleus 1. Endocrinology. https://doi.org/10.1210/endo.139.7.6113
