The DOI matches its Crossref record; 119 of the 120 references it cites were found in a registry or an index.
Transcriptional Characterizations of Differences between Eutopic and Ectopic Endometrium
Abstract
Endometriosis, defined as the presence of endometrial glandular and stromal cells outside the uterine cavity, is a common gynecological disease with poorly understood pathogenesis. Using laser capture microdissection and a cDNA microarray with 9600 genes/expressed sequence tags (ESTs), we have conducted a comprehensive profiling of gene expression differences between the ectopic and eutopic endometrium taken from 12 women with endometriosis adjusted for menstrual phase and the location of the lesions. With dye-swapping and replicated arrays, we found 904 genes/ESTs that are differentially expressed. We validated the gene expression using real-time RT-PCR. We found that the expression patterns of these genes/ESTs correctly classified the 12 patients into ovarian and nonovarian endometriosis. We identified gene clusters that are location-specific. In addition, we identified several biological themes using Expression Analysis Systematic Explorer. Finally, we identified 79 pathways with over 100 genes with known functions, which include oxidative stress, focal adhesion, Wnt signaling, and MAPK signaling. The identification of these genes and their associated pathways provides new insight. Our findings will stimulate future investigations on molecular genetic mechanisms underlying the pathogenesis of endometriosis.
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“Yet normal endometrial stromal cells are very different in behavior from endometriotic or even adenomyotic stromal cells.”
From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [66]
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“In fact, over 1000 genes are documented to be differentially expressed between adenomyotic lesions and eutopic endometrium [65] and close to 1000 genes are differentially expressed between ectopic and eutopic endometrium [66].”
From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [66]
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Cites
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- Institute, 1992, SAS technical report P-229.
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Sorted by citations
Bulun, S. E. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804690 · Cited by 1,772
Bulun, S. E., Yilmaz, B. D., Sison, C., Miyazaki, K., Bernardi, L., Liu, S., Kohlmeier, A., Yin, P., Milad, M., & Wei, J. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00242 · Cited by 844
Recurrence of endometriosis and its control
Guo, S.-W. (2009) · Human Reproduction Update · doi:10.1093/humupd/dmp007 · Cited by 719
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“…inside of the cyst involves very numerous studies and their description is beyond the scope of this review (Cox et al., 2001; Arimoto et al., 2003; Wu et al., 2006; Eyster et al., 2007; Hever et al., 2007; Mettler et al., 2007; Borghese et al., 2008; Zafrakas et al., 2008; Di Carlo et al., 2009;…”
Background
Metadata
- Authors
- Wu, Y., Kajdacsy-Balla, A., Strawn, E., Basir, Z., Halverson, G., Jailwala, P., Wang, Y., Wang, X., Ghosh, S., & Guo, S.-W.
- Affiliations
- Medical College of Wisconsin (US)
- Department of Pathology (A.K.-B.), University of Illinois, Chicago, Illinois 60612
- University of California, Santa Barbara (US)
- Corresponding author
- Guo, Sun-Wei
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2006-01-01
- Volume
- 147
- Issue
- 1
- Pages
- 232-246
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2032547793
- Cited by
- 208
- References
- 120
- Citations by year
- 2025: 4 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 12 · 2018: 14 · 2017: 11 · 2016: 8 · 2015: 11 · 2014: 13 · 2013: 11 · 2012: 12
- FWCI
- 13.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical College of Wisconsin
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Keywords
- endometriosis, ectopic endometrium, eutopic endometrium, gene expression profiling, differentially expressed genes, endometrioma, gene clusters, oxidative stress, focal adhesions, Wnt signaling, MAPK signaling, endometriosis pathogenesis
- MeSH terms
- Base Sequence, Endometrium, Female, Humans, Menstrual Cycle, Ovarian Diseases, Pregnancy, Pregnancy, Ectopic, Reference Values, Transcription, Genetic, DNA Primers, Reverse Transcriptase Polymerase Chain Reaction, Expressed Sequence Tags, Oligonucleotide Array Sequence Analysis
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