Regulation of Kiss1 Gene Expression in the Brain of the Female Mouse

The GPR54 Gene as a Regulator of Puberty

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Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54

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Physiology of Reproduction

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Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.

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The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54

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Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor

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A role for kisspeptins in the regulation of gonadotropin secretion in the mouse

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Kisspeptin Activation of Gonadotropin Releasing Hormone Neurons and Regulation of KiSS-1 mRNA in the Male Rat

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Increased hypothalamic GPR54 signaling: A potential mechanism for initiation of puberty in primates

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Vasoactive Intestinal Peptide Modulation of the Steroid-Induced LH Surge Involves Kisspeptin Signaling in Young but Not in Middle-Aged Female Rats

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Hypothalamic Effects of Tamoxifen on Oestrogen Regulation of Luteinising Hormone and Prolactin Secretion in Female Rats

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The role of kisspeptin and RFRP in the circadian control of female reproduction

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Distinct dynorphin expression patterns with low- and high-dose estrogen treatment in the arcuate nucleus of female rats†,‡

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Co‐expression of the calcitonin receptor gene in the hypothalamic kisspeptin neurons in female rats

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Role of Kisspeptin/GPR54 System in Human Reproductive Axis

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Male animal sterilization: history, current practices, and potential methods for replacing castration

Hess, R. A., Park, C., Soto‐Heras, S., Reinacher, L., Oh, J., Bunnell, M., & Ko, C. J. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1409386 · Cited by 28

Kisspeptin neurons as a key player bridging the endocrine system and sexual behavior in mammals

Nakamura, S., Watanabe, Y., Goto, T., Ikegami, K., Inoue, N., Uenoyama, Y., & Tsukamura, H. (2021) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2021.100952 · Cited by 20

Beyond Leptin: Emerging Candidates for the Integration of Metabolic and Reproductive Function during Negative Energy Balance

True, C. A., Grove, K. L., & Smith, M. S. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00053 · Cited by 21

Neuroendocrine Control of Reproduction

Clarke, I. J., Campbell, R. E., Smith, J. T., Prévot, V., & Wray, S. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-375097-6.10009-5 · Cited by 22

Neuroendocrine regulation of pubertal suppression in the naked mole-rat: What we know and what comes next

Faykoo-Martinez, M., Kalinowski, L., & Holmes, M. M. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111360 · Cited by 20

Hypothalamic neurokinin signalling and its application in reproductive medicine

Skorupskaite, K., & Anderson, R. A. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107960 · Cited by 19

The human hypothalamic kisspeptin system: Functional neuroanatomy and clinical perspectives

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Sex-specific pubertal and metabolic regulation of Kiss1 neurons via Nhlh2

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17β‐Oestradiol Regulation of Gonadotrophin‐Releasing Hormone Neuronal Excitability

Rønnekleiv, O. K., Bosch, M. A., & Zhang, C. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02160.x · Cited by 19

Regulation of endogenous conductances in GnRH neurons by estrogens

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Microarray Analysis of Perinatal-Estrogen-Induced Changes in Gene Expression Related to Brain Sexual Differentiation in Mice

SAKAKIBARA, M., Uenoyama, Y., Minabe, S., Watanabe, Y., Deura, C., Nakamura, S., Suzuki, G., Maeda, K., & Tsukamura, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079437 · Cited by 19

Timeline: the role of kisspeptins in reproductive biology

Tena‐Sempere, M. (2008) · Nature Medicine · doi:10.1038/nm1108-1196 · Cited by 20

Overview of the impact of kisspeptin on reproductive function

Sonigo, C., & Binart, N. (2012) · Annales d Endocrinologie · doi:10.1016/j.ando.2012.07.680 · Cited by 21

Endogenous Kisspeptin Tone Is a Critical Excitatory Component of Spontaneous GnRH Activity and the GnRH Response to NPY and CART

Verma, S., Kirigiti, M. A., Millar, R. P., Grove, K. L., & Smith, M. S. (2014) · Neuroendocrinology · doi:10.1159/000365419 · Cited by 19

Long-Term Neonatal Estrogen Exposure Causes Irreversible Inhibition of LH Pulses by Suppressing Arcuate Kisspeptin Expression via Estrogen Receptors α and β in Female Rodents

Minabe, S., Ieda, N., Watanabe, Y., Inoue, N., Uenoyama, Y., Maeda, K., & Tsukamura, H. (2017) · Endocrinology · doi:10.1210/en.2016-1144 · Cited by 20

Male Hypogonadism: A Review

Marcelli, M., & Mediwala, S. N. (2020) · Journal of Investigative Medicine · doi:10.1136/jim-2019-001233 · Cited by 23

Expression of genes for Kisspeptin ( KISS1 ), Neurokinin B ( TAC3 ), Prodynorphin ( PDYN ), and gonadotropin inhibitory hormone ( RFRP ) across natural puberty in ewes

Li, Q., Smith, J. T., Henry, B. A., Rao, A., Pereira, A., & Clarke, I. J. (2020) · Physiological Reports · doi:10.14814/phy2.14399 · Cited by 19

Identification of kisspeptin2 cDNA in the catfish Heteropneustes fossilis: Expression profile, in situ localization and steroid modulation

Chaube, R., Sharma, S., Senthilkumaran, B., Bhat, S. G., & Joy, K. P. (2020) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2020.113472 · Cited by 19

Effects of Obesity and Diabetes on Sperm Cell Proteomics in Rats

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The KiSS‐1/GPR54 system: putative target for endocrine disruption of reproduction at hypothalamic–pituitary unit?

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Kiss of the Mutant Mouse: How Genetically Altered Mice Advanced Our Understanding of Kisspeptin's Role in Reproductive Physiology

Lemko, H. M. D., & Elias, C. F. (2012) · Endocrinology · doi:10.1210/en.2012-1494 · Cited by 17

Estrogen upregulates the firing activity of hypothalamic gonadotropin‐releasing hormone (GnRH1) neurons in the evening in female medaka

Ikegami, K., Kajihara, S., Umatani, C., Nakajo, M., Kanda, S., & Oka, Y. (2022) · Journal of Neuroendocrinology · doi:10.1111/jne.13101 · Cited by 18

The effect of maternal consumption of high-fat diet on ovarian development in offspring

Wei, W., Qin, F., Gao, J., Chang, J., Pan, X., Jiang, X., Che, L., Zhuo, Y., Wu, D., & Xu, S. (2023) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2023.107294 · Cited by 18

Comparative aspects of kisspeptin gene regulation

Kitahashi, T., & Parhar, I. S. (2012) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2012.10.003 · Cited by 18

Endogenously elevated androgens alter the developmental programming of the hypothalamic–pituitary axis in male mice

González, B., Ratner, L. D., Giorgio, N. P. D., POUTANEN, M. H., Huhtaniemi, I. T., Calandra, R. S., Lux-Lantos, V. A., & Rulli, S. B. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.09.016 · Cited by 18

Minireview: Metabolic Control of the Reproductive Physiology: insights from genetic mouse models

Bellefontaine, N., & Elias, C. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.04.007 · Cited by 15

Reproductive status‐dependent kisspeptin and RF amide‐related peptide (Rfrp) gene expression in female Damaraland mole‐rats

Voigt, C., & Bennett, N. C. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12571 · Cited by 18

Three-dimensional imaging of KNDy neurons in the mammalian brain using optical tissue clearing and multiple-label immunocytochemistry

Moore, A. M., Lucas, K. A., Goodman, R. L., Coolen, L. M., & Lehman, M. N. (2018) · Scientific Reports · doi:10.1038/s41598-018-20563-2 · Cited by 20

Neuroanatomical Relationship of Neuronal Nitric Oxide Synthase to Gonadotropin-Releasing Hormone and Kisspeptin Neurons in Adult Female Sheep and Primates

Bedenbaugh, M. N., McCosh, R. B., Lopez, J. A., Connors, J. M., Goodman, R. L., & Hileman, S. M. (2018) · Neuroendocrinology · doi:10.1159/000491393 · Cited by 18

Action of neurotensin, corticotropin-releasing hormone, and RFamide-related peptide-3 in E2-induced negative feedback control: studies using a mouse arcuate nucleus hypothalamic cell model†

Tumurbaatar, T., Kanasaki, H., Oride, A., Hara, T., Okada, H., Tsutsui, K., & Kyo, S. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy145 · Cited by 18

KISS1/KISS1R and Breast Cancer: Metastasis Promoter

Guzman, S., Brackstone, M., Wondisford, F. E., Babwah, A. V., & Bhattacharya, M. M. (2019) · Seminars in Reproductive Medicine · doi:10.1055/s-0039-3400968 · Cited by 23

Conserved functions of hypothalamic kisspeptin in vertebrates

Sivalingam, M., Ogawa, S., Trudeau, V. L., & Parhar, I. S. (2021) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2021.113973 · Cited by 17

Estrogenic regulation of reproduction and energy homeostasis by a triumvirate of hypothalamic arcuate neurons

Stincic, T. L., & Kelly, M. J. (2022) · Journal of Neuroendocrinology · doi:10.1111/jne.13145 · Cited by 18

Leptina: aspectos sobre o balanço energético, exercício físico e amenorréia do esforço

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Characterisation of kisspeptin system genes in an ovoviviparous teleost: Sebastes schlegeli

Song, H., He, Y., Ma, L., Zhou, X., Liu, X., Qi, J., & Zhang, Q. (2014) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2014.06.010 · Cited by 17

Expression of RFamide-Related Peptide-3 (RFRP-3) mRNA in Dorsomedial Hypothalamic Nucleus and KiSS-1 mRNA in Arcuate Nucleus of Rat during Pregnancy.

Sarvestani, F. S., Tamadon, A., Koohi‐Hosseinabadi, O., Mohammadi Nezhad, S., Rahmanifar, F., Shirazi, M. R. J., Tanideh, N., Moghadam, A. A., & Niazi‎, A. (2014) · PubMed Central · Cited by 16

miR-29a/b1 Regulates the Luteinizing Hormone Secretion and Affects Mouse Ovulation

Guo, Y., Wu, Y., Shi, J., Zhuang, H., Ci, L., Huang, Q., Wan, Z., Yang, H., Zhang, M., Tan, Y., et al. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.636220 · Cited by 18

Kisspeptin cell-specific PI3K signaling regulates hypothalamic kisspeptin expression and participates in the regulation of female fertility

Beymer, M., Negrón, A. L., Yu, G., Wu, S., Mayer, C., Lin, R. Z., Boehm, U., & Acosta‐Martínez, M. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00385.2014 · Cited by 17

Absence of GPR54 and TACR3 Mutations in Sporadic Cases of Idiopathic Central Precocious Puberty

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Progesterone-induced amplification and advancement of GnRH/LH surges are associated with changes in kisspeptin system in preoptic area of estradiol-primed female rats

Leite, C. M., Kalil, B., Uchôa, E. T., Antunes‐Rodrigues, J., Elias, L. L. K., Levine, J. E., & Anselmo-Franci, J. A. (2016) · Brain Research · doi:10.1016/j.brainres.2016.08.021 · Cited by 17

Impact of Proestrus on Gene Expression in the Medial Preoptic Area of Mice

Vastagh, C., & Liposits, Z. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00183 · Cited by 18

Gonadotropin Hormones

Kaiser, U. B. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-380926-1.10007-0 · Cited by 19

Human genetics of GPR54

Cerrato, F. E., & Seminara, S. B. (2007) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-007-9027-3 · Cited by 17

Neuroendocrinology of Reproduction

Clifton, D. K., & Steiner, R. A. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-4907-4.00001-2 · Cited by 17

Ovarian Endocrinology

Takae, S., & Suzuki, N. (2017) · Springer eBooks · doi:10.1007/978-3-319-53454-1_1 · Cited by 17

Morphological Analysis of the Axonal Projections of EGFP-Labeled Esr1-Expressing Neurons in Transgenic Female Medaka

Zempo, B., Karigo, T., Kanda, S., Akazome, Y., & Oka, Y. (2017) · Endocrinology · doi:10.1210/en.2017-00873 · Cited by 16

Response to exogenous kisspeptin varies according to sex and reproductive condition in Siberian hamsters (Phodopus sungorus)

Greives, T. J., Long, K. L. P., Burns, C. M. B., & Demas, G. E. (2010) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2010.10.001 · Cited by 16

Delayed Puberty in Spontaneously Hypertensive Rats Involves a Primary Ovarian Failure Independent of the Hypothalamic KiSS-1/GPR54/GnRH System

Pinilla, L., Castellano, J. M., Romero, M., Tena‐Sempere, M., Gaytán, F., & Aguilar, E. (2009) · Endocrinology · doi:10.1210/en.2008-1381 · Cited by 16

Developmental GnRH Signaling Is Not Required for Sexual Differentiation of Kisspeptin Neurons but Is Needed for Maximal Kiss1 Gene Expression in Adult Females

Kim, J. P., Tolson, K. P., Dhamija, S., & Kauffman, A. S. (2013) · Endocrinology · doi:10.1210/en.2013-1271 · Cited by 15

Reproductive responses of male Brandt’s voles (Lasiopodomys brandtii) to 6-methoxybenzoxazolinone (6-MBOA) under short photoperiod

Dai, X., Jiang, L. Y., Han, M., Ye, M. H., Wang, A. Q., Wei, W. H., & Yang, S. M. (2016) · Die Naturwissenschaften · doi:10.1007/s00114-016-1347-2 · Cited by 16

Influence of HFD-induced precocious puberty on neurodevelopment in mice

Bo, T., Wen, J., Gao, W., Tang, L., Liu, M., & Wang, D. (2021) · Nutrition & Metabolism · doi:10.1186/s12986-021-00604-w · Cited by 15

Vasoactive intestinal peptide exerts an excitatory effect on hypothalamic kisspeptin neurons during estrogen negative feedback

Mansano, N. D. S., Paradela, R. S., Bohlen, T. M., Zanardi, I. M., Chaves, F. M., Silveira, M. A., Tavares, M. R., Donato, J., & Frazão, R. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111532 · Cited by 16

The role of kisspeptin/GPR54 in the reproductive system.

Papaoiconomou, E., Msaouel, P., Makri, A., Diamanti‐Kandarakis, E., & Koutsilieris, M. (2011) · PubMed · Cited by 16

Effect of pituitary adenylate cyclase-activating polypeptide (PACAP) in the regulation of hypothalamic kisspeptin expression

Tumurbaatar, T., Kanasaki, H., Oride, A., Okada, H., Hara, T., Tumurgan, Z., & Kyo, S. (2018) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2018.10.006 · Cited by 16

Role of RFRP-3 in the Regulation of Kiss-1 Gene Expression in the AVPV Hypothalamic Cell Model mHypoA-50

Kanasaki, H., Tumurbaatar, T., Oride, A., Tumurgan, Z., Okada, H., Hara, T., Tsutsui, K., & Kyo, S. (2018) · Reproductive Sciences · doi:10.1177/1933719118813456 · Cited by 16

Kisspeptin and Prolactin

Grattan, D. R., & Szawka, R. E. (2019) · Seminars in Reproductive Medicine · doi:10.1055/s-0039-3400956 · Cited by 17

Mating-induced increase in Kiss1 mRNA expression in the anteroventral periventricular nucleus prior to an increase in LH and testosterone release in male rats

Watanabe, Y., Ikegami, K., Nakamura, S., Uenoyama, Y., Ozawa, H., Maeda, K., Tsukamura, H., & Inoue, N. (2020) · Journal of Reproduction and Development · doi:10.1262/jrd.2020-067 · Cited by 16

Hypothalamic Expression of Estrogen Receptor Isoforms Underlies Estradiol Control of Luteinizing Hormone in Female Rats

Henriques, P. C., Aquino, N. S. S., Campideli-Santana, A. C., Silva, J. F., Araújo-Lopes, R., Franci, C. R., Coimbra, C. C., & Szawka, R. E. (2022) · Endocrinology · doi:10.1210/endocr/bqac101 · Cited by 15

Targeting KNDy neurons to control GnRH pulses

Constantin, S. (2022) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2022.102316 · Cited by 15

Sex and interspecies differences in ESR2-expressing cell distributions in mouse and rat brains

Morishita, M., Higo, S., Iwata, K., & Ishii, H. (2023) · Biology of Sex Differences · doi:10.1186/s13293-023-00574-z · Cited by 15

Estradiol action in the female hypothalamo–pituitary–gonadal axis

Moenter, S. M., & Starrett, J. R. (2024) · Journal of Neuroendocrinology · doi:10.1111/jne.13390 · Cited by 15

Central estrogen action sites involved in prepubertal restraint of pulsatile luteinizing hormone release in female rats

Uenoyama, Y., Tanaka, A., Takase, K., Yamada, S., Pheng, V., Inoue, N., Maeda, K., & Tsukamura, H. (2015) · Journal of Reproduction and Development · doi:10.1262/jrd.2014-143 · Cited by 16

Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus?

Arslan, E., Görkem, Ü., & Toğrul, C. (2019) · Gynecology Obstetrics and Reproductive Medicine · doi:10.21613/gorm.2019.946 · Cited by 15

Estradiol Enhances the Depolarizing Response to GABA and AMPA Synaptic Conductances in Arcuate Kisspeptin Neurons by Diminishing Voltage-Gated Potassium Currents

DeFazio, R. A., Navarro, M. A., Adams, C. E., Milescu, L. S., & Moenter, S. M. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.0378-19.2019 · Cited by 17

Neuropeptidergic and Neuroendocrine Systems Underlying Eusociality and the Concomitant Social Regulation of Reproduction in Naked Mole-Rats: A Comparative Approach

Coen, C. W., Bennett, N. C., Holmes, M. M., & Faulkes, C. G. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-65943-1_3 · Cited by 16

Heterogeneity in GnRH and kisspeptin neurons and their significance in vertebrate reproductive biology

Ogawa, S., & Parhar, I. S. (2021) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2021.100963 · Cited by 15

Fibroblast Growth Factor Signaling Deficiencies Impact Female Reproduction and Kisspeptin Neurons in Mice1

Tata, B. K., Chung, W. C. J., Brooks, L. R., Kavanaugh, S. I., & Tsai, P. (2012) · Biology of Reproduction · doi:10.1095/biolreprod.111.095992 · Cited by 18

The effects of kisspeptin agonist canine KP-10 and kisspeptin antagonist p271 on plasma LH concentrations during different stages of the estrous cycle and anestrus in the bitch

Albers-Wolthers, C. H. J., de Gier, J., Rutten, V. P. M. G., van Kooten, P. J. S., Leegwater, P. A. J., Okkens, A. C., & Kooistra, H. S. (2016) · Theriogenology · doi:10.1016/j.theriogenology.2016.02.009 · Cited by 15

Molecular identification of Kiss/GPR54 and function analysis with mRNA expression profiles exposure to 17α-ethinylestradiol in rare minnow Gobiocypris rarus

Yang, Y., Gao, J., Yuan, C., Zhang, Y., Guan, Y., & Wang, Z. (2016) · Molecular Biology Reports · doi:10.1007/s11033-016-4014-y · Cited by 15

Prenatal Alcohol Exposure and Pair Feeding Differentially Impact Puberty and Reproductive Development in Female Rats: Role of the Kisspeptin System

Sliwowska, J. H., Comeau, W. L., Bodnar, T. S., Ellis, L. A., & Weinberg, J. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13233 · Cited by 15

Feedback regulation of 17β-estradiol on two kisspeptin genes in the Dabry's sturgeon (Acipenser dabryanus)

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The fifty years following the discovery of gonadotropin‐releasing hormone

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