Cited by 1,102Hypothalamic control of reproductive hormonesNeuroendocrine regulation and behaviorEstrogen and related hormone effects

The DOI matches its Crossref record; 49 of the 50 references it cites were found in a registry or an index.

Regulation of Kiss1 Gene Expression in the Brain of the Female Mouse

Smith, Jeremy T., Cunningham, Matthew J., Rissman, Emilie F., Clifton, Donald K, Steiner, Robert A.·2005·Endocrinology

DOI 10.1210/en.2005-0488

Open this paper in CoChat — free account

Abstract

The Kiss1 gene encodes a family of neuropeptides called kisspeptins, which activate the receptor G protein-coupled receptor-54 and play a role in the neuroendocrine regulation of GnRH secretion. We examined whether estradiol (E2) regulates KiSS-1 in the forebrain of the female mouse by comparing KiSS-1 mRNA expression among groups of ovary-intact (diestrus), ovariectomized (OVX), and OVX plus E2-treated mice. In the arcuate nucleus (Arc), KiSS-1 expression increased after ovariectomy and decreased with E2 treatment. Conversely, in the anteroventral periventricular nucleus (AVPV), KiSS-1 expression was reduced after ovariectomy and increased with E2 treatment. To determine whether the effects of E2 on KiSS-1 are mediated through estrogen receptor (ER)alpha or ERbeta, we evaluated the effects of E2 in OVX mice that lacked functional ERalpha or ERbeta. In OVX mice that lacked functional ERalpha, KiSS-1 mRNA did not respond to E2 in either the Arc or AVPV, suggesting that ERalpha is essential for mediating the inhibitory and stimulatory effects of E2. In contrast, KiSS-1 mRNA in OVX mice that lacked functional ERbeta responded to E2 exactly as wild-type animals. Double-label in situ hybridization revealed that virtually all KiSS-1-expressing neurons in the Arc and AVPV coexpress ERalpha, suggesting that the effects of E2 are mediated directly through KiSS-1 neurons. We conclude that KiSS-1 neurons in the Arc, which are inhibited by E2, may play a role in the negative feedback regulation of GnRH secretion, whereas KiSS-1 neurons in the AVPV, which are stimulated by E2, may participate in the positive feedback regulation of GnRH secretion.

Integrity signals

Registry

Crossref · 10.1210/en.2005-0488

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The GPR54 Gene as a Regulator of Puberty
Seminara, S. B., Messager, S., Chatzidaki, E. E., Thresher, R. R., Acierno, J. S., Shagoury, J. K., Bo-Abbas, Y., Kuohung, W., Schwinof, K. M., Hendrick, A. G., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035322 · Cited by 2,557
Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54
de Roux, N., Genin, E., Carel, J.-C., Matsuda, F., Chaussain, J.-L., & Milgrom, E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834399100 · Cited by 2,431
Physiology of Reproduction
MAEDA, K., OHKURA, S., & Tsukamura, H. (2000) · Elsevier eBooks · doi:10.1016/b978-012426400-7/50048-0 · Cited by 2,136
Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: an in situ hybridization study
Simerly, R. B., Swanson, L. W., Chang, C., & Muramatsu, M. (1990) · Journal of Comparative Neurology · doi:10.1002/cne.902940107 · Cited by 2,118
Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.
Lubahn, D. B., Moyer, J. S., GOLDING, T. S., Couse, J. F., Korach, K. S., & Smithies, O. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11162 · Cited by 1,902
The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54
Kotani, M., Detheux, M., Vandenbogaerde, A., Communi, D., Vanderwinden, J.-M., Le Poul, E., Brézillon, S., Tyldesley, R., Suarez-Huerta, N., Vandeput, F., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104847200 · Cited by 1,546
Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor
Ohtaki, T., Shintani, Y., Honda, S., Matsumoto, H., Hori, A., Kanehashi, K., Terao, Y., Kumano, S., Takatsu, Y., Masuda, Y., et al. (2001) · Nature · doi:10.1038/35079135 · Cited by 1,447
A role for kisspeptins in the regulation of gonadotropin secretion in the mouse
Gottsch, M. L., Cunningham, M. J., Smith, J. T., Popa, S. M., Acohido, B. V., Crowley, W. F., Seminara, S., Clifton, D. K., & Steiner, R. A. (2004) · Endocrinology · doi:10.1210/en.2004-0431 · Cited by 1,161
Self-citation
Kisspeptin Activation of Gonadotropin Releasing Hormone Neurons and Regulation of KiSS-1 mRNA in the Male Rat
Irwig, M. S., Fraley, G. S., Smith, J. T., Acohido, B. V., Popa, S. M., Cunningham, M. J., Gottsch, M. L., Clifton, D. K., & Steiner, R. A. (2004) · Neuroendocrinology · doi:10.1159/000083140 · Cited by 930
Self-citation
Increased hypothalamic GPR54 signaling: A potential mechanism for initiation of puberty in primates
Shahab, M., Mastronardi, C. A., Seminara, S. B., Crowley, W. F., Ojeda, S. R., & Plant, T. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409822102 · Cited by 888

Flagged first, then by citations

Show all 50 references

1 of the 50 references couldn’t be matched to a known paper.

Sorted by citations

Items 401–500 of 994

The usefulness of melatonin in the field of obstetrics and gynecology
Genário, R., Morello, E., Bueno, A. A., & Santos, H. O. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104337 · Cited by 45
Clinical Potential of Kisspeptin in Reproductive Health
Abbara, A., Clarke, S. A., & Dhillo, W. S. (2021) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2021.05.008 · Cited by 47
Kisspeptin expression in guinea pig hypothalamus: Effects of 17β‐estradiol
Bosch, M. A., Xue, C., & Rønnekleiv, O. K. (2011) · The Journal of Comparative Neurology · doi:10.1002/cne.23032 · Cited by 44
Cross-talk between reproduction and energy homeostasis: central impact of estrogens, leptin and kisspeptin signaling
Nestor, C. C., Kelly, M. J., & Rønnekleiv, O. K. (2013) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2013-0050 · Cited by 49
Gonadotropin-releasing hormone, kisspeptin, and gonadal steroids directly modulate nucleobindin-2/nesfatin-1 in murine hypothalamic gonadotropin-releasing hormone neurons and gonadotropes†
Hatef, A., & Unniappan, S. (2017) · Biology of Reproduction · doi:10.1095/biolreprod.116.146621 · Cited by 44
Effect of a postnatal high-fat diet exposure on puberty onset, estrous cycle regularity, and kisspeptin expression in female rats
Lie, M. E. K., Overgaard, A., & Mikkelsen, J. D. (2013) · Reproductive Biology · doi:10.1016/j.repbio.2013.08.001 · Cited by 44
Kisspeptin and the Preovulatory Gonadotrophin‐Releasing Hormone/Luteinising Hormone Surge in the Ewe: Basic Aspects and Potential Applications in the Control of Ovulation
Caraty, A., Franceschini, I., & Hoffman, G. E. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02022.x · Cited by 43
Distribution and Seasonal Variation in Hypothalamic RF‐amide Peptides in a Semi‐Desert Rodent, the Jerboa
Janati, A., Talbi, R., Klosen, P., Mikkelsen, J. D., Magoul, R., Simonneaux, V., & Ouezzani, S. E. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12015 · Cited by 43
Actions of sex steroids on kisspeptin expression and other reproduction-related genes in the brain of the teleost fish european sea bass
Alvarado, M. V., Servili, A., Molés, G., Guéguen, M., Carrillo, M., Kah, O., & Felip, A. (2016) · Journal of Experimental Biology · doi:10.1242/jeb.137364 · Cited by 43
Estradiol Enables Chronic Corticosterone to Inhibit Pulsatile Luteinizing Hormone Secretion and Suppress Kiss1 Neuronal Activation in Female Mice
Kreisman, M. J., McCosh, R. B., Tian, K., Song, C. I., & Breen, K. M. (2020) · Neuroendocrinology · doi:10.1159/000502978 · Cited by 42
Galanin Activates G Protein Gated Inwardly Rectifying Potassium Channels and Suppresses Kisspeptin-10 Activation of GnRH Neurons
Constantin, S., & Wray, S. (2016) · Endocrinology · doi:10.1210/en.2016-1064 · Cited by 42
Evolutionary Insights into the Steroid Sensitive kiss1 and kiss2 Neurons in the Vertebrate Brain
Kanda, S., & Oka, Y. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00028 · Cited by 42
The kisspeptin signaling pathway and its role in human isolated GnRH deficiency
Wahab, F., Quinton, R., & Seminara, S. B. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.05.043 · Cited by 43
Kisspeptins and the control of gonadotrophin secretion
Dedes, I. (2012) · Systems Biology in Reproductive Medicine · doi:10.3109/19396368.2011.651555 · Cited by 43
Kisspeptin innervation of the hypothalamic paraventricular nucleus: sexual dimorphism and effect of estrous cycle in female mice
Marraudino, M., Miceli, D., Farinetti, A., Ponti, G., Panzica, G., & Gotti, S. (2017) · Journal of Anatomy · doi:10.1111/joa.12603 · Cited by 42
The roles of kisspeptin in the mechanism underlying reproductive functions in mammals
Uenoyama, Y., Inoue, N., Maeda, K., & Tsukamura, H. (2018) · Journal of Reproduction and Development · doi:10.1262/jrd.2018-110 · Cited by 44
Neurokinin B signalling in the human reproductive axis
Topaloglu, A. K., & Semple, R. K. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.07.014 · Cited by 41
Anatomical distribution of sex steroid hormone receptors in the brain of female medaka
Zempo, B., Kanda, S., Okubo, K., Akazome, Y., & Oka, Y. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23255 · Cited by 41
Developmental Profile and Sexually Dimorphic Expression of Kiss1 and Kiss1r in the Fetal Mouse Brain
Knoll, J. G., Clay, C. M., Bouma, G. J., Henion, T. R., Schwarting, G. A., Millar, R. P., & Tobet, S. A. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00140 · Cited by 41
Kisspeptins and the neuroendocrine control of reproduction
Navarro, V. M. (2010) · Frontiers in Bioscience-Scholar · doi:10.2741/s150 · Cited by 42
Does Dynorphin Play a Role in the Onset of Puberty in Female Sheep?
Lopez, J. A., Bedenbaugh, M. N., McCosh, R. B., Weems, P. W., Meadows, L. J., Wisman, B. A., Coolen, L. M., Goodman, R. L., & Hileman, S. M. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12445 · Cited by 41
Estrogen and Progesterone Integration in an in vitro Model of RP3V Kisspeptin Neurons
Mittelman‐Smith, M. A., Wong, A., & Micevych, P. E. (2017) · Neuroendocrinology · doi:10.1159/000471878 · Cited by 41
The Development of Kisspeptin Circuits in the Mammalian Brain
Semaan, S. J., Tolson, K. P., & Kauffman, A. S. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-6199-9_11 · Cited by 42
Classical and Membrane-Initiated Estrogen Signaling in an In Vitro Model of Anterior Hypothalamic Kisspeptin Neurons
Mittelman-Smith, M. A., Wong, A., Kathiresan, A. S. Q., & Micevych, P. E. (2015) · Endocrinology · doi:10.1210/en.2014-1803 · Cited by 39
Kisspeptin/Metastin: A Key Molecule Controlling Two Modes of Gonadotrophin‐Releasing Hormone/Luteinising Hormone Release in Female Rats
Uenoyama, Y., Tsukamura, H., & Maeda, K. (2009) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2009.01853.x · Cited by 40
Estradiol Membrane‐Initiated Signaling and Female Reproduction
Micevych, P. E., Wong, A., & Mittelman-Smith, M. A. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140056 · Cited by 46
Endocrine disrupting chemicals (EDCs) and the neuroendocrine system: Beyond estrogen, androgen, and thyroid
Patisaul, H. B. (2021) · Advances in pharmacology · doi:10.1016/bs.apha.2021.03.007 · Cited by 44
Hypothalamic Kisspeptin Neurons: Integral Elements of the GnRH System
Prashar, V., Arora, T., Singh, R., Sharma, A., & Parkash, J. (2022) · Reproductive Sciences · doi:10.1007/s43032-022-01027-5 · Cited by 46
Immunofluorescent histochemical and ultrastructural studies on the innervation of kisspeptin/neurokinin B neurons to tuberoinfundibular dopaminergic neurons in the arcuate nucleus of rats
Sawai, N., Iijima, N., Takumi, K., Matsumoto, K. T., & Ozawa, H. (2012) · Neuroscience Research · doi:10.1016/j.neures.2012.05.011 · Cited by 41
DNA Methylation Patterns in the Hypothalamus of Female Pubertal Goats
Chen, Y., Ye, J., Li, X., Gao, X., Zhang, K., Luo, L., Ding, J., Zhang, Y., Li, Y., Cao, H., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0165327 · Cited by 40
Involvement of gonadotropin-inhibitory hormone in pubertal disorders induced by thyroid status
Kiyohara, M., Son, Y. L., & Tsutsui, K. (2017) · Scientific Reports · doi:10.1038/s41598-017-01183-8 · Cited by 42
High-Fat, High-Sugar Diet Disrupts the Preovulatory Hormone Surge and Induces Cystic Ovaries in Cycling Female Rats
Volk, K. M., Pogrebna, V. V., Roberts, J. A., Zachry, J. E., Blythe, S. G., & Toporikova, N. (2017) · Journal of the Endocrine Society · doi:10.1210/js.2017-00305 · Cited by 42
Gonadotropin-Releasing Hormone (GnRH) Neuron Excitability Is Regulated by Estradiol Feedback and Kisspeptin
Adams, C. E., Stroberg, W., DeFazio, R. A., Schnell, S. D., & Moenter, S. M. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2988-17.2017 · Cited by 42
Mutual interaction of kisspeptin, estrogen and bone morphogenetic protein-4 activity in GnRH regulation by GT1-7 cells
Terasaka, T., Otsuka, F., Tsukamoto, N., Nakamura, E., Inagaki, K., Toma, K., Ogura-Ochi, K., Glidewell-Kenney, C., Lawson, M. A., & Makino, H. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.07.009 · Cited by 41
Nitric oxide-heat shock protein axis in menopausal hot flushes: neglected metabolic issues of chronic inflammatory diseases associated with deranged heat shock response
Miragem, A. A., & de Bittencourt, P. I. H. (2017) · Human Reproduction Update · doi:10.1093/humupd/dmx020 · Cited by 39
Central aspects of systemic oestradiol negative‐ and positive‐feedback on the reproductive neuroendocrine system
Moenter, S. M., Silveira, M. A., Wang, L., & Adams, C. E. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12724 · Cited by 37
Arcuate and Preoptic Kisspeptin Neurons Exhibit Differential Projections to Hypothalamic Nuclei and Exert Opposite Postsynaptic Effects on Hypothalamic Paraventricular and Dorsomedial Nuclei in the Female Mouse
Stincic, T. L., Qiu, J., Connors, A. M., Kelly, M. J., & Rønnekleiv, O. K. (2021) · eNeuro · doi:10.1523/eneuro.0093-21.2021 · Cited by 40
Advances in clinical applications of kisspeptin-GnRH pathway in female reproduction
Hu, K.-L., Chen, Z., Li, X., Cai, E., Yang, H., Chen, Y., Wang, C., Ju, L., Deng, W., & Mu, L. (2022) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-022-00953-y · Cited by 47
Progesterone Receptors in AVPV Kisspeptin Neurons Are Sufficient for Positive Feedback Induction of the LH Surge
Mohr, M. A., Esparza, L. A., Steffen, P., Micevych, P. E., & Kauffman, A. S. (2021) · Endocrinology · doi:10.1210/endocr/bqab161 · Cited by 38
Estrogen differentially regulates transcriptional landscapes of preoptic and arcuate kisspeptin neuron populations
Göcz, B., Takács, S., Skrapits, K., Rumpler, É., Solymosi, N., Póliska, S., Colledge, W. H., Hrabovszky, E., & Sárvári, M. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.960769 · Cited by 36
Aging-related changes in RP3V kisspeptin neurons predate the reduced activation of GnRH neurons during the early reproductive decline in female mice
Zhang, J., Yang, L., Lin, N., Pan, X., Zhu, Y., & Chen, X. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.08.038 · Cited by 40
Kisspeptin expression in mouse Leydig cells correlates with age
Wang, J.-Y., Hsu, M.-C., Tseng, T.-H., Wu, L., Yang, K., & Chiu, C. (2015) · Journal of the Chinese Medical Association · doi:10.1016/j.jcma.2015.01.004 · Cited by 39
Disparate Changes in Kisspeptin and Neurokinin B Expression in the Arcuate Nucleus After Sex Steroid Manipulation Reveal Differential Regulation of the Two KNDy Peptides in Rats
Overgaard, A., Ruíz-Pino, F., Castellano, J. M., Tena‐Sempere, M., & Mikkelsen, J. D. (2014) · Endocrinology · doi:10.1210/en.2014-1200 · Cited by 38
Peripheral and Central Mechanisms Involved in the Hormonal Control of Male and Female Reproduction
Rudolph, L. M., Bentley, G. E., Calandra, R. S., Paredes, A. H., Tesone, M., Wu, T. J., & Micevych, P. E. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12405 · Cited by 38
Rodent Models of Non-classical Progesterone Action Regulating Ovulation
Mittelman-Smith, M. A., Rudolph, L. M., Mohr, M. A., & Micevych, P. E. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00165 · Cited by 40
ESR2 Is Essential for Gonadotropin-Induced Kiss1 Expression in Granulosa Cells
Chakravarthi, V. P., Khristi, V., Ghosh, S., Yerrathota, S., Dai, E., Roby, K. F., Wolfe, M. W., & Rumi, M. A. K. (2018) · Endocrinology · doi:10.1210/en.2018-00608 · Cited by 38
Social and neuromolecular phenotypes are programmed by prenatal exposures to endocrine-disrupting chemicals
Topper, V. Y., Reilly, M. P., Wagner, L. M., Thompson, L. M., Gillette, R., Crews, D. P., & Gore, A. C. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.09.010 · Cited by 39
Inhibiting Kiss1 Neurons With Kappa Opioid Receptor Agonists to Treat Polycystic Ovary Syndrome and Vasomotor Symptoms
McCarthy, E. A., Dischino, D., Maguire, C., León, S., Talbi, R., Cheung, E., Schteingart, C. D., Rivière, P. J.-M., Reed, S. D., Steiner, R. A., et al. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab602 · Cited by 41
Self-citation
The dendron and episodic neuropeptide release
Herbison, A. E. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.13024 · Cited by 35
Gonadal Steroid Induction of Kisspeptin Peptide Expression in the Rostral Periventricular Area of the Third Ventricle During Postnatal Development in the Male Mouse
Clarkson, J., Shamas, S., Mallinson, S., & Herbison, A. E. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02294.x · Cited by 39
Membrane-initiated Actions of Estradiol that Regulate Reproduction, Energy Balance and Body Temperature
Kelly, M. J., & Rønnekleiv, O. (2012) · Frontiers in neuroendocrinology (Print) · doi:10.1016/j.yfrne.2012.07.002 · Cited by 40
Development of an excitatory kisspeptin projection to the oxytocin system in late pregnancy
Seymour, A. J., Scott, V., Augustine, R. A., Bouwer, G. T., Campbell, R. E., & Brown, C. H. (2016) · The Journal of Physiology · doi:10.1113/jp273051 · Cited by 36
Effects of Selective Deletion of Tyrosine Hydroxylase from Kisspeptin Cells on Puberty and Reproduction in Male and Female Mice
Stephens, S. B. Z., Rouse, M. L., Tolson, K. P., Liaw, R. B., Parra, R. A., Chahal, N., & Kauffman, A. S. (2017) · eNeuro · doi:10.1523/eneuro.0150-17.2017 · Cited by 41
Integrative neurohumoural regulation of oxytocin neurone activity in pregnancy and lactation
Augustine, R. A., Seymour, A. J., Campbell, R. E., Grattan, D. R., & Brown, C. H. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12569 · Cited by 38
Xenoestrogens Ethinyl Estradiol and Zearalenone Cause Precocious Puberty in Female Rats via Central Kisspeptin Signaling
Kriszt, R., Winkler, Z., Polyák, Á., Kuti, D., Molnár, C., Hrabovszky, E., Kalló, I., Szőke, Z., Ferenczi, S., & Kovács, K. (2015) · Endocrinology · doi:10.1210/en.2015-1330 · Cited by 38
Neural Connectivity in the Mediobasal Hypothalamus of the Sheep Brain
Qi, Y., Iqbal, J., Oldfield, B. J., & Clarke, I. J. (2007) · Neuroendocrinology · doi:10.1159/000109944 · Cited by 37
Age-related alterations in hypothalamic kisspeptin, neurokinin B, and dynorphin neurons and in pulsatile LH release in female and male rats
Kunimura, Y., Iwata, K., Ishigami, A., & Ozawa, H. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.10.018 · Cited by 37
Kisspeptin and Gonadotropin-Releasing Hormone Neuronal Excitability: Molecular Mechanisms Driven by 17β-Estradiol
Rønnekleiv, O. K., Zhang, C., Bosch, M. A., & Kelly, M. J. (2014) · Neuroendocrinology · doi:10.1159/000370311 · Cited by 38
The Changes They are A-Timed: Metabolism, Endogenous Clocks, and the Timing of Puberty
Tolson, K. P., & Chappell, P. E. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00045 · Cited by 37
Progress and Challenges in the Search for the Mechanisms of Pulsatile Gonadotropin-Releasing Hormone Secretion
Constantin, S. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00180 · Cited by 37
Long-Term Recordings of Arcuate Nucleus Kisspeptin Neurons Reveal Patterned Activity That Is Modulated by Gonadal Steroids in Male Mice
Vanacker, C., Moya, M. R., DeFazio, R. A., Johnson, M. L., & Moenter, S. M. (2017) · Endocrinology · doi:10.1210/en.2017-00382 · Cited by 36
Neurochemical Characterization of Neurons Expressing Estrogen Receptor β in the Hypothalamic Nuclei of Rats Using in Situ Hybridization and Immunofluorescence
Kanaya, M., Higo, S., & Ozawa, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010115 · Cited by 38
Dissecting the Molecular Mechanisms Surrounding Post-COVID-19 Syndrome and Neurological Features
Mohamed, M. S., Johansson, A., Jonsson, J., & Schiöth, H. B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084275 · Cited by 37
Sexual differentiation of kisspeptin neurons responsible for sex difference in gonadotropin release in rats
Tsukamura, H., Homma, T., Tomikawa, J., Uenoyama, Y., & Maeda, K. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05645.x · Cited by 37
Socially regulated reproductive development: Analysis of GnRH‐1 and kisspeptin neuronal systems in cooperatively breeding naked mole‐rats (Heterocephalus glaber)
Zhou, S., Holmes, M. M., Forger, N. G., Goldman, B. D., Lovern, M. B., Caraty, A., Kalló, I., Faulkes, C. G., & Coen, C. W. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23327 · Cited by 36
Effects of estradiol on kisspeptin neurons during puberty
Clarkson, J. (2013) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.02.002 · Cited by 38
Voltage-Gated Potassium Currents Are Targets of Diurnal Changes in Estradiol Feedback Regulation and Kisspeptin Action on Gonadotropin-Releasing Hormone Neurons in Mice1
Pielecka-Fortuna, J., DeFazio, R. A., & Moenter, S. M. (2011) · Biology of Reproduction · doi:10.1095/biolreprod.111.093492 · Cited by 35
α-Estrogen and Progesterone Receptors Modulate Kisspeptin Effects on Prolactin: Role in Estradiol-Induced Prolactin Surge in Female Rats
Aquino, N. S. S., Araújo-Lopes, R., Henriques, P. C., Lopes, F. E. F., Gusmão, D. O., Coimbra, C. C., Franci, C. R., dos Reis, A. M., & Szawka, R. E. (2017) · Endocrinology · doi:10.1210/en.2016-1855 · Cited by 37
GnRH receptor and GPR54 inactivation in isolated gonadotropic deficiency
de Roux, N. (2006) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2006.10.005 · Cited by 35
Immunohistochemical Evidence for the Presence of Various Kisspeptin Isoforms in the Mammalian Brain
Franceschini, I., Yeo, S., Beltramo, M., Desroziers, E., Okamura, H., Herbison, A. E., & Caraty, A. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12069 · Cited by 37
Hypothalamic Expression of KiSS1 and RFamide-related Peptide-3 mRNAs during The Estrous Cycle of Rats.
Salehi, M. S., Shirazi, M. R. J., Zamiri, M. J., Pazhoohi, F., Namavar, M. R., Niazi‎, A., Ramezani, A., Tanideh, N., Tamadon, A., & Zarei, A. (2013) · Europe PMC (PubMed Central) · Cited by 35
Estradiol Upregulates Kisspeptin Expression in the Preoptic Area of both the Male and Female Rhesus Monkey (Macaca mulatta): Implications for the Hypothalamic Control of Ovulation in Highly Evolved Primates
Trujillo, M. V., Kalil, B., Ramaswamy, S., & Plant, T. M. (2016) · Neuroendocrinology · doi:10.1159/000448520 · Cited by 35
Regulation and Possible Functions of Kisspeptin in the Medial Amygdala
Stephens, S. B. Z., & Kauffman, A. S. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00191 · Cited by 33
Role of amygdala kisspeptin in pubertal timing in female rats
Adekunbi, D. A., Li, X. F., Li, S., Adegoke, O. A., Iranloye, B. O., Morakinyo, A., Lightman, S. L., Taylor, P. D., Poston, L., & O’Byrne, K. T. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183596 · Cited by 35
Daily rhythms count for female fertility
Simonneaux, V., Bahougne, T., & Angelopoulou, E. (2017) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2017.10.012 · Cited by 41
The KiNG of reproduction: Kisspeptin/ nNOS interactions shaping hypothalamic GnRH release
Delli, V., Silva, M. S. B., Prévot, V., & Chachlaki, K. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111302 · Cited by 38
Kisspeptin neurons as an integration center of reproductive regulation: Observation of reproductive function based on a new concept of reproductive regulatory nervous system
Ozawa, H. (2021) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12419 · Cited by 36
Basic Aspects of the Control of GnRH and LH Secretions by Kisspeptin: Potential Applications for Better Control of Fertility in Females
Caraty, A., & Franceschini, I. (2008) · Reproduction in Domestic Animals · doi:10.1111/j.1439-0531.2008.01158.x · Cited by 35
Cross-talk between metabolism and reproduction: the role of POMC and SF1 neurons
Xu, Y. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00098 · Cited by 36
Estradiol Increases Glutamate and GABA Neurotransmission into GnRH Neurons via Retrograde NO-Signaling in Proestrous Mice during the Positive Estradiol Feedback Period
Farkas, I., Bálint, F., Farkas, E., Vastagh, C., Fekete, C., & Liposits, Z. (2018) · eNeuro · doi:10.1523/eneuro.0057-18.2018 · Cited by 35
Feeding prepubescent gilts a high-fat diet induces molecular changes in the hypothalamus-pituitary-gonadal axis and predicts early timing of puberty
Zhuo, Y., Zhou, D., Che, L., Fang, Z., Lin, Y., & Wu, D. (2014) · Nutrition · doi:10.1016/j.nut.2013.12.019 · Cited by 33
Role for the membrane estrogen receptor alpha in the sexual differentiation of the brain
Khbouz, B., de Bournonville, C., Court, L., Taziaux, M., Corona, R., Arnal, J., Lenfant, F., & Cornil, C. A. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14646 · Cited by 36
Hypothalamic Astrocyte Development and Physiology for Neuroprogesterone Induction of the Luteinizing Hormone Surge
Sinchak, K., Mohr, M. A., & Micevych, P. E. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00420 · Cited by 35
Androgen Suppresses In Vivo and In Vitro LH Pulse Secretion and Neural Kiss1 and Tac2 Gene Expression in Female Mice
Esparza, L. A., Terasaka, T., Lawson, M. A., & Kauffman, A. S. (2020) · Endocrinology · doi:10.1210/endocr/bqaa191 · Cited by 33
Emerging concepts on the epigenetic and transcriptional regulation of the Kiss1 gene
Semaan, S. J., & Kauffman, A. S. (2013) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2013.03.006 · Cited by 33
The Interplay between Circadian System, Cholesterol Synthesis, and Steroidogenesis Affects Various Aspects of Female Reproduction
Urlep, Ž., & Rozman, D. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00111 · Cited by 33
Circulating Estradiol Regulates Brain-Derived Estradiol via Actions at GnRH Receptors to Impact Memory in Ovariectomized Rats
Nelson, B. S., Black, K. L., & Daniel, J. M. (2016) · eNeuro · doi:10.1523/eneuro.0321-16.2016 · Cited by 32
Effect of the Camelid’s Seminal Plasma Ovulation-Inducing Factor/β-NGF: A Kisspeptin Target Hypothesis
Allali, K. E., Bousmaki, N. E., Ainani, H., & Simonneaux, V. (2017) · Frontiers in Veterinary Science · doi:10.3389/fvets.2017.00099 · Cited by 32
Does the KNDy Model for the Control of Gonadotropin-Releasing Hormone Pulses Apply to Monkeys and Humans?
Lehman, M. N., He, W., Coolen, L. M., Levine, J. E., & Goodman, R. L. (2019) · Seminars in Reproductive Medicine · doi:10.1055/s-0039-3400254 · Cited by 35
Environmental disruption of reproductive rhythms
Moralia, M.-A., Quignon, C., Simonneaux, M., & Simonneaux, V. (2022) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2022.100990 · Cited by 35
Identification of a Novel Kisspeptin with High Gonadotrophin Stimulatory Activity in the Dog
Albers-Wolthers, K. H. J., de Gier, J., Kooistra, H. S., Rutten, V. P. M. G., van Kooten, P. J. S., de Graaf, J. J., Leegwater, P. A. J., Millar, R. P., & Okkens, A. C. (2014) · Neuroendocrinology · doi:10.1159/000364877 · Cited by 33
Kisspeptin Antagonists
Roseweir, A. K., & Millar, R. P. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-6199-9_8 · Cited by 32
Hypothalamic kisspeptin neurons as potential mediators of estradiol negative and positive feedback
Starrett, J. R., & Moenter, S. M. (2023) · Peptides · doi:10.1016/j.peptides.2023.170963 · Cited by 29
KNDy neurones and GnRH / LH pulse generation: Current understanding and future aspects
Uenoyama, Y., & Tsukamura, H. (2023) · Journal of Neuroendocrinology · doi:10.1111/jne.13285 · Cited by 32
Effects of menopause on temperature regulation
Gombert, M., Vesterdorf, K., Fuller, A., Maloney, S. K., & Baker, F. C. (2025) · Temperature · doi:10.1080/23328940.2025.2484499 · Cited by 45
Effects and Therapeutic Potentials of Kisspeptin Analogs: Regulation of the Hypothalamic-Pituitary-Gonadal Axis
Matsui, H., & Asami, T. (2014) · Neuroendocrinology · doi:10.1159/000357809 · Cited by 32
Rola sygnalizacji kisspeptyny w osi podwzgórze–przysadka–nadnercza — aktualna perspektywa
Javed, Z., Qamar, U., & Sathyapalan, T. (2015) · Endokrynologia Polska · doi:10.5603/ep.2015.0066 · Cited by 30
Role of Agouti-Related Protein-Expressing Neurons in Lactation
Phillips, C. T., & Palmiter, R. D. (2007) · Endocrinology · doi:10.1210/en.2007-1153 · Cited by 29
Aromatase Knockout Mice Show Normal Steroid‐Induced Activation of Gonadotrophin‐Releasing Hormone Neurones and Luteinising Hormone Surges With a Reduced Population of Kisspeptin Neurones in the Rostral Hypothalamus
Szymanski, L. A., & Bakker, J. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02334.x · Cited by 31
KiSS‐1: A Likely Candidate for the Photoperiodic Control of Reproduction in Seasonal Breeders
Revel, F. G., Saboureau, M., Masson‐Pévet, M., Pévet, P., Mikkelsen, J. D., & Simonneaux, V. (2006) · Chronobiology International · doi:10.1080/07420520500521939 · Cited by 31

Authors: Smith, J. T., Cunningham, M. J., Rissman, E. F., Clifton, D. K., & Steiner, R. A.
Affiliations: University of Washington (US)
University of Virginia (US)
Corresponding author: Steiner, Robert A.
ORCID: Cunningham, Matthew J.
Rissman, Emilie F.
Steiner, Robert A.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2005-09-01
Volume: 146
Issue: 9
Pages: 3686-3692
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2005-0488
OpenAlex: W1975890243
Cited by: 1,102
References: 50
Citations by year: 2026: 19 · 2025: 30 · 2024: 49 · 2023: 42 · 2022: 58 · 2021: 75 · 2020: 42 · 2019: 61 · 2018: 62 · 2017: 66 · 2016: 65 · 2015: 49 · 2014: 63 · 2013: 73 · 2012: 65
FWCI: 41.36
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
ResearchWorks at the University of Washington (University of Washington) (submittedVersion)
Funders: National Institutes of Health (5u54hd012629-31)
National Institute of Mental Health (R01 MH 57759, K02 MH-01349, K02MH001349, R01MH057759)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK061517, R01 DK61517)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD 27142, U54-HD-12629, R01HD027142)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords: KISS1, kisspeptin, kisspeptin neurons, estradiol, estrogen receptor alpha, estrogen receptor beta, arcuate nucleus, anteroventral periventricular nucleus, GnRH secretion, negative feedback, positive feedback, ovariectomy, forebrain
MeSH terms: Animals, Arcuate Nucleus of Hypothalamus, Body Weight, Estrogens, Female, Mice, Inbred C57BL, Mice, Mutant Strains, Ovariectomy, Paraventricular Hypothalamic Nucleus, Proteins, RNA, Messenger, Estrogen Receptor alpha, Estrogen Receptor beta, Mice, Kisspeptins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Regulation of Kiss1 Gene Expression in the Brain of the Female Mouse

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks