Cited by 1,102Hypothalamic control of reproductive hormonesNeuroendocrine regulation and behaviorEstrogen and related hormone effects

The DOI matches its Crossref record; 49 of the 50 references it cites were found in a registry or an index.

Regulation of Kiss1 Gene Expression in the Brain of the Female Mouse

Smith, Jeremy T., Cunningham, Matthew J., Rissman, Emilie F., Clifton, Donald K, Steiner, Robert A.·2005·Endocrinology

DOI 10.1210/en.2005-0488

Open this paper in CoChat — free account

Abstract

The Kiss1 gene encodes a family of neuropeptides called kisspeptins, which activate the receptor G protein-coupled receptor-54 and play a role in the neuroendocrine regulation of GnRH secretion. We examined whether estradiol (E2) regulates KiSS-1 in the forebrain of the female mouse by comparing KiSS-1 mRNA expression among groups of ovary-intact (diestrus), ovariectomized (OVX), and OVX plus E2-treated mice. In the arcuate nucleus (Arc), KiSS-1 expression increased after ovariectomy and decreased with E2 treatment. Conversely, in the anteroventral periventricular nucleus (AVPV), KiSS-1 expression was reduced after ovariectomy and increased with E2 treatment. To determine whether the effects of E2 on KiSS-1 are mediated through estrogen receptor (ER)alpha or ERbeta, we evaluated the effects of E2 in OVX mice that lacked functional ERalpha or ERbeta. In OVX mice that lacked functional ERalpha, KiSS-1 mRNA did not respond to E2 in either the Arc or AVPV, suggesting that ERalpha is essential for mediating the inhibitory and stimulatory effects of E2. In contrast, KiSS-1 mRNA in OVX mice that lacked functional ERbeta responded to E2 exactly as wild-type animals. Double-label in situ hybridization revealed that virtually all KiSS-1-expressing neurons in the Arc and AVPV coexpress ERalpha, suggesting that the effects of E2 are mediated directly through KiSS-1 neurons. We conclude that KiSS-1 neurons in the Arc, which are inhibited by E2, may play a role in the negative feedback regulation of GnRH secretion, whereas KiSS-1 neurons in the AVPV, which are stimulated by E2, may participate in the positive feedback regulation of GnRH secretion.

Integrity signals

Registry

Crossref · 10.1210/en.2005-0488

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The GPR54 Gene as a Regulator of Puberty
Seminara, S. B., Messager, S., Chatzidaki, E. E., Thresher, R. R., Acierno, J. S., Shagoury, J. K., Bo-Abbas, Y., Kuohung, W., Schwinof, K. M., Hendrick, A. G., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035322 · Cited by 2,557
Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54
de Roux, N., Genin, E., Carel, J.-C., Matsuda, F., Chaussain, J.-L., & Milgrom, E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834399100 · Cited by 2,431
Physiology of Reproduction
MAEDA, K., OHKURA, S., & Tsukamura, H. (2000) · Elsevier eBooks · doi:10.1016/b978-012426400-7/50048-0 · Cited by 2,136
Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: an in situ hybridization study
Simerly, R. B., Swanson, L. W., Chang, C., & Muramatsu, M. (1990) · Journal of Comparative Neurology · doi:10.1002/cne.902940107 · Cited by 2,118
Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.
Lubahn, D. B., Moyer, J. S., GOLDING, T. S., Couse, J. F., Korach, K. S., & Smithies, O. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11162 · Cited by 1,902
The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54
Kotani, M., Detheux, M., Vandenbogaerde, A., Communi, D., Vanderwinden, J.-M., Le Poul, E., Brézillon, S., Tyldesley, R., Suarez-Huerta, N., Vandeput, F., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104847200 · Cited by 1,546
Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor
Ohtaki, T., Shintani, Y., Honda, S., Matsumoto, H., Hori, A., Kanehashi, K., Terao, Y., Kumano, S., Takatsu, Y., Masuda, Y., et al. (2001) · Nature · doi:10.1038/35079135 · Cited by 1,447
A role for kisspeptins in the regulation of gonadotropin secretion in the mouse
Gottsch, M. L., Cunningham, M. J., Smith, J. T., Popa, S. M., Acohido, B. V., Crowley, W. F., Seminara, S., Clifton, D. K., & Steiner, R. A. (2004) · Endocrinology · doi:10.1210/en.2004-0431 · Cited by 1,161
Self-citation
Kisspeptin Activation of Gonadotropin Releasing Hormone Neurons and Regulation of KiSS-1 mRNA in the Male Rat
Irwig, M. S., Fraley, G. S., Smith, J. T., Acohido, B. V., Popa, S. M., Cunningham, M. J., Gottsch, M. L., Clifton, D. K., & Steiner, R. A. (2004) · Neuroendocrinology · doi:10.1159/000083140 · Cited by 930
Self-citation
Increased hypothalamic GPR54 signaling: A potential mechanism for initiation of puberty in primates
Shahab, M., Mastronardi, C. A., Seminara, S. B., Crowley, W. F., Ojeda, S. R., & Plant, T. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409822102 · Cited by 888

Flagged first, then by citations

Show all 50 references

1 of the 50 references couldn’t be matched to a known paper.

Sorted by citations

Items 301–400 of 994

Tachykinins and the hypothalamo–pituitary–gonadal axis: An update
Lasaga, M., & Debéljuk, L. (2011) · Peptides · doi:10.1016/j.peptides.2011.07.009 · Cited by 65
The roles of kisspeptin revisited: inside and outside the hypothalamus
Uenoyama, Y., Pheng, V., Tsukamura, H., & Maeda, K. (2016) · Journal of Reproduction and Development · doi:10.1262/jrd.2016-083 · Cited by 67
Seasonal regulation of structural plasticity and neurogenesis in the adult mammalian brain: Focus on the sheep hypothalamus
Migaud, M., Butrille, L., & Batailler, M. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.11.004 · Cited by 65
Steroid Sensitive kiss2 Neurones in the Goldfish: Evolutionary Insights into the Duplicate Kisspeptin Gene‐Expressing Neurones
Kanda, S., Karigo, T., & Oka, Y. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02296.x · Cited by 64
Assessment of Epigenetic Contributions to Sexually-Dimorphic Kiss1 Expression in the Anteroventral Periventricular Nucleus of Mice
Semaan, S. J., Dhamija, S., Kim, J., Ku, E., & Kauffman, A. S. (2012) · Endocrinology · doi:10.1210/en.2011-1975 · Cited by 65
Specialized Subpopulations of Kisspeptin Neurons Communicate With GnRH Neurons in Female Mice
Kumar, D., Candlish, M., Periasamy, V., Avcu, N., Mayer, C., & Boehm, U. (2014) · Endocrinology · doi:10.1210/en.2014-1671 · Cited by 64
Acute suppression of LH secretion by prolactin in female mice is mediated by kisspeptin neurons in the arcuate nucleus
Brown, R. S. E., Khant Aung, Z., Phillipps, H. R., Barad, Z., Lein, H.-J., Boehm, U., Szawka, R. E., & Grattan, D. R. (2019) · Endocrinology · doi:10.1210/en.2019-00038 · Cited by 62
Physiological Roles of the Kisspeptin/GPR54 System in the Neuroendocrine Control of Reproduction
Pineda, R., Aguilar, E., Pinilla, L., & Tena‐Sempere, M. (2010) · Progress in brain research · doi:10.1016/s0079-6123(08)81005-9 · Cited by 65
Developmental Changes in Hypothalamic Kiss1 Expression during Activation of the Pulsatile Release of Luteinising Hormone in Maturing Ewe Lambs
Redmond, J. S., Báez-Sandoval, G. M., Spell, K. M., Spencer, T. E., Lents, C. A., Williams, G. L., & Amstalden, M. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02177.x · Cited by 62
Differential Roles of Hypothalamic AVPV and Arcuate Kisspeptin Neurons in Estradiol Feedback Regulation of Female Reproduction
Wang, L., & Moenter, S. M. (2020) · Neuroendocrinology · doi:10.1159/000503006 · Cited by 63
GPR54 and Kisspeptins
Colledge, W. H. (2008) · Springer eBooks · doi:10.1007/400_2007_050 · Cited by 64
Photic and Nonphotic Seasonal Cues Differentially Engage Hypothalamic Kisspeptin and RFamide‐Related Peptide mRNA Expression in Siberian Hamsters
Paul, M. J., Pyter, L. M., Freeman, D. A., Galang, J., & Prendergast, B. J. (2009) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2009.01924.x · Cited by 62
Normal Physiology of Hypothalamic Pituitary Regulation
Sam, S., & Frohman, L. A. (2008) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2007.10.007 · Cited by 63
A Multi-Oscillatory Circadian System Times Female Reproduction
Simonneaux, V., & Bahougne, T. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00157 · Cited by 68
GPR54 and KiSS-1: Role in the regulation of puberty and reproduction
Kuohung, W., & Kaiser, U. B. (2006) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-006-9020-2 · Cited by 64
Direct and Indirect Effects of Sex Steroids on Gonadotrope Cell Plasticity in the Teleost Fish Pituitary
Fontaine, R., Royan, M. R., von Krogh, K., Weltzien, F., & Baker, D. M. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.605068 · Cited by 68
Photoperiod and Testosterone Interact to Drive Seasonal Changes in Kisspeptin Expression in Siberian Hamsters (Phodopus sungorus)
Greives, T. J., Humber, S. A., Goldstein, A. N., Scotti, M. L., Demas, G. E., & Kriegsfeld, L. J. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01790.x · Cited by 61
Impact of stress on male fertility: role of gonadotropin inhibitory hormone
Odetayo, A. F., Akhigbe, R. E., Bassey, G. E., Hamed, M. A., & Olayaki, L. A. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1329564 · Cited by 66
Effects of Environmental Endocrine Disruptors and Phytoestrogens on the Kisspeptin System
Patisaul, H. B. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-6199-9_21 · Cited by 62
Human kisspeptins activate neuropeptide FF2 receptor
Lyubimov, Y. E., Engström, M., Wurster, S., Savola, J., Korpi, E. R., & Panula, P. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.058 · Cited by 63
GABAergic Transmission to Kisspeptin Neurons Is Differentially Regulated by Time of Day and Estradiol in Female Mice
DeFazio, R. A., Elias, C. F., & Moenter, S. M. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3057-14.2014 · Cited by 59
Estrous Cycle Plasticity in the Hyperpolarization-Activated Current Ih Is Mediated by Circulating 17 -Estradiol in Preoptic Area Kisspeptin Neurons
Piet, R., Boehm, U., & Herbison, A. E. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1021-13.2013 · Cited by 59
Male mice ultrasonic vocalizations enhance female sexual approach and hypothalamic kisspeptin neuron activity
Asaba, A., Osakada, T., Touhara, K., Kato, M., Mogi, K., & Kikusui, T. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.06.006 · Cited by 56
Functional Implications of RFRP-3 in the Central Control of Daily and Seasonal Rhythms in Reproduction
Angelopoulou, E., Quignon, C., Kriegsfeld, L. J., & Simonneaux, V. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00183 · Cited by 58
Kisspeptin as a master player in the central control of reproduction in mammals: An overview of kisspeptin research in domestic animals
Okamura, H., Yamamura, T., & Wakabayashi, Y. (2013) · Animal Science Journal · doi:10.1111/asj.12056 · Cited by 60
Effects of Photoperiod on Kisspeptin Neuronal Populations of the Ewe Diencephalon in Connection with Reproductive Function
Chalivoix, S., Bagnolini, A., Caraty, A., Cognié, J., Malpaux, B., & Dufourny, L. (2009) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2009.01939.x · Cited by 67
Immunohistochemical characterization of the arcuate kisspeptin/neurokinin B/dynorphin (KNDy) and preoptic kisspeptin neuronal populations in the hypothalamus during the estrous cycle in heifers
Hassaneen, A. S. A., Naniwa, Y., Suetomi, Y., Matsuyama, S., Kimura, K., Ieda, N., Inoue, N., Uenoyama, Y., Tsukamura, H., Maeda, K.-I., et al. (2016) · Journal of Reproduction and Development · doi:10.1262/jrd.2016-075 · Cited by 60
Kobayashi Award 2019: The neuroendocrine regulation of the mammalian reproduction
Tsukamura, H. (2021) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2021.113755 · Cited by 59
KNDy Neurons of the Hypothalamus and Their Role in GnRH Pulse Generation: an Update
Moore, A. M., Novak, A. G., & Lehman, M. N. (2023) · Endocrinology · doi:10.1210/endocr/bqad194 · Cited by 62
Comparative analysis of kisspeptin-immunoreactivity reveals genuine differences in the hypothalamic Kiss1 systems between rats and mice
Overgaard, A., Tena‐Sempere, M., Franceschini, I., Desroziers, E., Simonneaux, V., & Mikkelsen, J. D. (2013) · Peptides · doi:10.1016/j.peptides.2013.04.013 · Cited by 57
Impaired GABAB Receptor Signaling Dramatically Up-Regulates Kiss1 Expression Selectively in Nonhypothalamic Brain Regions of Adult but Not Prepubertal Mice
Giorgio, N. P. D., Semaan, S. J., Kim, J., López, P. V., Bettler, B., Libertun, C., Lux-Lantos, V. A., & Kauffman, A. S. (2014) · Endocrinology · doi:10.1210/en.2013-1573 · Cited by 56
Gonadal and Nongonadal Regulation of Sex Differences in Hypothalamic Kiss1 Neurones
Kauffman, A. S. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02030.x · Cited by 57
The Two Kisspeptin Neuronal Populations Are Differentially Organized and Activated by Estradiol in Mice
Brock, O., & Bakker, J. (2013) · Endocrinology · doi:10.1210/en.2013-1120 · Cited by 57
Divergent Regulation of ER and Kiss Genes by 17β-Estradiol in Hypothalamic ARC Versus AVPV Models
Treen, A. K., Luo, V., Chalmers, J. A., Dalvi, P. S., Tran, D. Q., Ye, W., Kim, G. L., Friedman, Z., & Belsham, D. D. (2016) · Molecular Endocrinology · doi:10.1210/me.2015-1189 · Cited by 60
Loss of Fertility in the Absence of Progesterone Receptor Expression in Kisspeptin Neurons of Female Mice
Gal, A., Lin, P.-C. P., Cacioppo, J. A., Hannon, P. R., Mahoney, M. M., Wolfe, A., Fernandez‐Valdivia, R., Lydon, J. P., Elias, C. F., & Ko, C. J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159534 · Cited by 57
Impact of Perfluorooctane Sulfonate on Reproductive Ability of Female Mice through Suppression of Estrogen Receptor α-Activated Kisspeptin Neurons
Wang, X., Bai, Y., Tang, C., Cao, X., Chang, F., & Chen, L. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy167 · Cited by 57
Estrogen Regulation of the Molecular Phenotype and Active Translatome of AVPV Kisspeptin Neurons
Stephens, S. B. Z., & Kauffman, A. S. (2021) · Endocrinology · doi:10.1210/endocr/bqab080 · Cited by 52
The Physiological Role of Arcuate Kisspeptin Neurons in the Control of Reproductive Function in Female Rats
Beale, K., Kinsey‐Jones, J. S., Gardiner, J., Harrison, E., Thompson, E. L., Hu, M., Sleeth, M., Sam, A. H., Greenwood, H. C., McGavigan, A. K., et al. (2013) · Endocrinology · doi:10.1210/en.2013-1544 · Cited by 55
Bisphenol A enhances kisspeptin neurons in anteroventral periventricular nucleus of female mice
Wang, X., Chang, F., Bai, Y., Chen, F., Zhang, J., & Chen, L. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0475 · Cited by 58
Environmentally Relevant Perinatal Exposures to Bisphenol A Disrupt Postnatal Kiss1/NKB Neuronal Maturation and Puberty Onset in Female Mice
Ruíz-Pino, F., Miceli, D., Franssen, D., Vazquez, M. J., Farinetti, A., Castellano, J. M., Panzica, G., & Tena‐Sempere, M. (2019) · Environmental Health Perspectives · doi:10.1289/ehp5570 · Cited by 59
Mechanisms of Disease: the first kiss—a crucial role for kisspeptin-1 and its receptor, G-protein-coupled receptor 54, in puberty and reproduction
Seminara, S. B. (2006) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0139 · Cited by 57
The role of kisspeptin and gonadotropin inhibitory hormone in the seasonal regulation of reproduction in sheep
Smith, J. T. (2012) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2011.11.003 · Cited by 55
Self-citation
Kisspeptin antagonists: Unraveling the role of kisspeptin in reproductive physiology
Millar, R. P., Roseweir, A. K., Tello, J. A., Anderson, R. A., George, J. T., Morgan, K., & Pawson, A. J. (2010) · Brain Research · doi:10.1016/j.brainres.2010.09.044 · Cited by 69
17-Beta-Estradiol Directly Regulates the Expression of Adrenergic Receptors and Kisspeptin/GPR54 System in GT1-7 GnRH Neurons
Jacobi, J. S., Martin, C., Nava, G., Jeziorski, M. C., Clapp, C., & de la Escalera, G. M. (2007) · Neuroendocrinology · doi:10.1159/000107770 · Cited by 55
Kisspeptin across the human lifespan:evidence from animal studies and beyond
Clarke, S. A., & Dhillo, W. S. (2016) · Journal of Endocrinology · doi:10.1530/joe-15-0538 · Cited by 56
The Role of Central Androgen Receptor Actions in Regulating the Hypothalamic-Pituitary-Ovarian Axis
Walters, K. A., Edwards, M. C., Tesic, D., Caldwell, A. S. L., Jimenez, M., Smith, J. T., & Handelsman, D. J. (2018) · Neuroendocrinology · doi:10.1159/000487762 · Cited by 58
Self-citation
Kisspeptin Excitation of GnRH Neurons
Rønnekleiv, O. K., & Kelly, M. J. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-6199-9_6 · Cited by 57
Lesions of the ventral premammillary nucleus disrupt the dynamic changes in Kiss1 and GnRH expression characteristic of the proestrus–estrus transition
Donato, J., Lee, C., Ratra, D. V., Franci, C. R., Canteras, N. S., & Elias, C. F. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.03.013 · Cited by 54
REPRODUCTION SYMPOSIUM: Hypothalamic neuropeptides and the nutritional programming of puberty in heifers1,2
Amstalden, M., Cardoso, R. C., Alves, B. R. C., & Williams, G. L. (2014) · Journal of Animal Science · doi:10.2527/jas.2014-7808 · Cited by 55
Both Estrogen and Androgen Modify the Response to Activation of Neurokinin-3 and κ-Opioid Receptors in Arcuate Kisspeptin Neurons From Male Mice
Ruka, K. A., Burger, L. L., & Moenter, S. M. (2015) · Endocrinology · doi:10.1210/en.2015-1688 · Cited by 52
Kisspeptin and the regulation of the reproductive axis in domestic animals
Scott, C., Rose, J., Gunn, A. J., & McGrath, B. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0485 · Cited by 56
The role of kisspeptin and GPR54 in the hippocampus
Arai, A. (2008) · Peptides · doi:10.1016/j.peptides.2008.07.023 · Cited by 55
A potential mechanism for the sexual dimorphism in the onset of puberty and incidence of idiopathic central precocious puberty in children: sex-specific kisspeptin as an integrator of puberty signals
Bianco, S. D. C. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00149 · Cited by 57
IGF-1 Influences Gonadotropin-Releasing Hormone Regulation of Puberty
Dees, W. L., Hiney, J. K., & Srivastava, V. K. (2021) · Neuroendocrinology · doi:10.1159/000514217 · Cited by 55
Kisspeptin/KISS1R System in Breast Cancer
Cvetković, D., Babwah, A. V., & Bhattacharya, M. M. (2013) · Journal of Cancer · doi:10.7150/jca.7626 · Cited by 55
Negative Fetal FSH/LH Regulation in Late Pregnancy Is Associated with Declined Kisspeptin/KISS1R Expression in the Tuberal Hypothalamus
Guimiot, F., Chevrier, L., Dreux, S., Chevenne, D., Caraty, A., Delezoide, A., & de Roux, N. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2078 · Cited by 57
Involvement of Neurokinin Receptors in the Control of Pulsatile Luteinizing Hormone Secretion in Rats
Noritake, K., Matsuoka, T., Ohsawa, T., SHIMOMURA, K., Sanbuissho, A., Uenoyama, Y., Maeda, K., & Tsukamura, H. (2011) · Journal of Reproduction and Development · doi:10.1262/jrd.11-002s · Cited by 53
Kisspeptin as a link between metabolism and reproduction: Evidences from rodent and primate studies
Wahab, F., Atika, B., & Shahab, M. (2013) · Metabolism · doi:10.1016/j.metabol.2013.01.015 · Cited by 54
Organizational and activational effects of sex steroids on kisspeptin neuron development
Poling, M. C., & Kauffman, A. S. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.06.001 · Cited by 54
KISS1/KISS1R in Cancer: Friend or Foe?
Guzman, S., Brackstone, M., Radovick, S., Babwah, A. V., & Bhattacharya, M. M. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00437 · Cited by 53
Advances in the Regulation of Mammalian Follicle-Stimulating Hormone Secretion
Wang, H., Zhang, W.-D., Yuan, B., & Zhang, J. (2021) · Animals · doi:10.3390/ani11041134 · Cited by 57
Role of kisspeptins in the control of the hypothalamic-pituitary-ovarian axis: old dogmas and new challenges
Ruohonen, S. T., POUTANEN, M. H., & Tena‐Sempere, M. (2020) · Fertility and Sterility · doi:10.1016/j.fertnstert.2020.06.038 · Cited by 52
The Kiss1 system and polycystic ovary syndrome: lessons from physiology and putative pathophysiologic implications
Witchel, S. F., & Tena‐Sempere, M. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.05.024 · Cited by 52
Kisspeptin Regulates Tuberoinfundibular Dopaminergic Neurones and Prolactin Secretion in an Oestradiol‐Dependent Manner in Male and Female Rats
Ribeiro, A. B., Leite, C. M., Kalil, B., Franci, C. R., Anselmo-Franci, J. A., & Szawka, R. E. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12242 · Cited by 52
Peripheral kisspeptin reverses short photoperiod-induced gonadal regression in Syrian hamsters by promoting GNRH release
Ansel-Bollepalli, L., Bentsen, A. H., Ancel, C., Bolborea, M., Klosen, P., Mikkelsen, J. D., & Simonneaux, V. (2011) · Reproduction · doi:10.1530/rep-10-0313 · Cited by 58
Evidence for a Putative Circadian Kiss-Clock in the Hypothalamic AVPV in Female Mice
Chassard, D., Bur, I. M., Poirel, V., Mendoza, J., & Simonneaux, V. (2015) · Endocrinology · doi:10.1210/en.2014-1769 · Cited by 51
Crocetin attenuates DHT-induced polycystic ovary syndrome in mice via revising kisspeptin neurons
Hu, Q., Jin, J., Zhou, H., Yu, D., Qian, W., Zhong, Y., Zhang, J., Tang, C., Liu, P., Zhou, Y., et al. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.08.135 · Cited by 52
Clinical Manifestations of Impaired GnRH Neuron Development and Function
Kim, H., Bhagavath, B., & Layman, L. C. (2008) · Neurosignals · doi:10.1159/000111561 · Cited by 52
The roles of kisspeptins and G protein-coupled receptor-54 in pubertal development
Tena‐Sempere, M. (2006) · Current Opinion in Pediatrics · doi:10.1097/01.mop.0000236396.79580.cc · Cited by 52
Metabolic actions of kisspeptin signaling: Effects on body weight, energy expenditure, and feeding
Hudson, A. D., & Kauffman, A. S. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107974 · Cited by 51
The Genetic Basis for the Timing of Human Puberty
Banerjee, I., & Clayton, P. (2007) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2007.01598.x · Cited by 51
Immunoelectron microscopic observation of the subcellular localization of kisspeptin, neurokinin B and dynorphin A in KNDy neurons in the arcuate nucleus of the female rat
Murakawa, H., Iwata, K., Takeshita, T., & Ozawa, H. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.12.008 · Cited by 50
Delayed pubertal onset and prepubertalKiss1expression in female mice lacking centraloestrogen receptor beta
Naulé, L., Robert, V., Parmentier, C., Martini, M., Keller, M., Cohen-Solal, M. E., Hardin‐Pouzet, H., Grange‐Messent, V., Franceschini, I., & Mhaouty‐Kodja, S. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv430 · Cited by 51
Kisspeptin mRNA expression is increased in the posterior hypothalamus in the rat model of polycystic ovary syndrome
Matsuzaki, T., Tungalagsuvd, A., Iwasa, T., Munkhzaya, M., Yanagihara, R., Tokui, T., Yano, K., Mayila, Y., Kato, T., Kuwahara, A., et al. (2016) · Endocrine Journal · doi:10.1507/endocrj.ej16-0282 · Cited by 52
Electrical and manual acupuncture stimulation affect oestrous cyclicity and neuroendocrine function in an 5α‐dihydrotestosterone‐induced rat polycystic ovary syndrome model
Feng, Y., Johansson, J., Shao, R., Mannerås-Holm, L., Billig, H., & Stener‐Victorin, E. (2012) · Experimental Physiology · doi:10.1113/expphysiol.2011.063131 · Cited by 50
KISS1R Induces Invasiveness of Estrogen Receptor-Negative Human Mammary Epithelial and Breast Cancer Cells
Cvetković, D., Dragan, M., Leith, S. J., Mir, Z. M., Leong, H. S., Pampillo, M., Lewis, J. D., Babwah, A. V., & Bhattacharya, M. M. (2013) · Endocrinology · doi:10.1210/en.2012-2164 · Cited by 56
Immunocytochemical localization of kisspeptin neurons in the rat forebrain with special reference to sexual dimorphism and interaction with GnRH neurons
Xu, Z., Kaga, S., Mochiduki, A., Tsubomizu, J., Adachi, S., Sakai, T., Inoue, K., & Adachi, A. A. (2012) · Endocrine Journal · doi:10.1507/endocrj.ej11-0193 · Cited by 52
Kisspeptin and KISS1R: a critical pathway in the reproductive system
Gianetti, E., & Seminara, S. B. (2008) · Reproduction · doi:10.1530/rep-08-0091 · Cited by 53
Interactions Between Neurokinin B and Kisspeptin in Mediating Estrogen Feedback in Healthy Women
Skorupskaite, K., George, J. T., Veldhuis, J. D., Millar, R. P., & Anderson, R. A. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2132 · Cited by 50
Sex Differences in Steroid Receptor Coexpression and Circadian-Timed Activation of Kisspeptin and RFRP-3 Neurons May Contribute to the Sexually Dimorphic Basis of the LH Surge
Poling, M. C., Luo, E., & Kauffman, A. S. (2017) · Endocrinology · doi:10.1210/en.2017-00405 · Cited by 49
GnRH and the photoperiodic control of seasonal reproduction: Delegating the task to kisspeptin and RFRP ‐3
Dardente, H., & Simonneaux, V. (2022) · Journal of Neuroendocrinology · doi:10.1111/jne.13124 · Cited by 49
Male Effect Pheromone Tickles the Gonadotrophin‐Releasing Hormone Pulse Generator
Okamura, H., Murata, K., Sakamoto, K., Wakabayashi, Y., Ohkura, S., Takeuchi, Y., & Mori, Y. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02037.x · Cited by 49
The neurobiological mechanism underlying hypothalamic GnRH pulse generation: the role of kisspeptin neurons in the arcuate nucleus
Plant, T. M. (2019) · F1000Research · doi:10.12688/f1000research.18356.2 · Cited by 69
Hypothalamic Kisspeptin Neurons and the Control of Homeostasis
Rønnekleiv, O. K., Qiu, J., & Kelly, M. J. (2021) · Endocrinology · doi:10.1210/endocr/bqab253 · Cited by 48
Role of GnRH Neurons and Their Neuronal Afferents as Key Integrators between Food Intake Regulatory Signals and the Control of Reproduction
Roa, J. (2013) · International Journal of Endocrinology · doi:10.1155/2013/518046 · Cited by 48
Estrogen Stimulation of Kiss1 Expression in the Medial Amygdala Involves Estrogen Receptor-α But Not Estrogen Receptor-β
Stephens, S. B. Z., Chahal, N., Munaganuru, N., Parra, R. A., & Kauffman, A. S. (2016) · Endocrinology · doi:10.1210/en.2016-1431 · Cited by 50
Kisspeptin-10 inhibits proliferation and regulates lipolysis and lipogenesis processes in 3T3-L1 cells and isolated rat adipocytes
Pruszyńska‐Oszmałek, E., Kolodziejski, P. A., Sassek, M., & Sliwowska, J. H. (2017) · Endocrine · doi:10.1007/s12020-017-1248-y · Cited by 48
G protein-coupled KISS1 receptor is overexpressed in triple negative breast cancer and promotes drug resistance
Blake, A., Dragan, M., Tirona, R. G., Hardy, D. B., Brackstone, M., Tuck, A. B., Babwah, A. V., & Bhattacharya, M. M. (2017) · Scientific Reports · doi:10.1038/srep46525 · Cited by 52
ERα in Tac2 Neurons Regulates Puberty Onset in Female Mice
Greenwald-Yarnell, M. L., Marsh, C. A., Allison, M. B., Patterson, C. M., Faber, C. L., MacKenzie, A., Cravo, R. M., Elias, C. F., Moenter, S. M., & Myers, M. G. (2016) · Endocrinology · doi:10.1210/en.2015-1928 · Cited by 47
Characterisation of Kiss1r (Gpr54)‐Expressing Neurones in the Arcuate Nucleus of the Female Rat Hypothalamus
Higo, S., Iijima, N., & Ozawa, H. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12452 · Cited by 47
The roles of kisspeptin and gonadotropin inhibitory hormone in stress-induced reproductive disorders
Iwasa, T., Matsuzaki, T., Yano, K., Mayila, Y., & Irahara, M. (2018) · Endocrine Journal · doi:10.1507/endocrj.ej18-0026 · Cited by 50
Diverse actions of estradiol on anorexigenic and orexigenic hypothalamic arcuate neurons
Stincic, T. L., Rønnekleiv, O. K., & Kelly, M. J. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.04.001 · Cited by 49
Insulin-like growth factor-1 stimulation of hypothalamic KiSS-1 gene expression is mediated by Akt: effect of alcohol
Hiney, J. K., Srivastava, V. K., & Dees, W. L. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.12.030 · Cited by 47
Morphological Evidence for Enhanced Kisspeptin and Neurokinin B Signaling in the Infundibular Nucleus of the Aging Man
Molnár, C. S., Vida, B., Sipos, M. T., Ciofi, P., Borsay, B. Á., Racz, K., Herczeg, L., Bloom, S. R., Ghatei, M. A., Dhillo, W. S., et al. (2012) · Endocrinology · doi:10.1210/en.2012-1739 · Cited by 46
The Luteinising Hormone Surge‐Generating System is Functional in Male Goats as in Females: Involvement of Kisspeptin Neurones in the Medial Preoptic Area
Matsuda, F., NAKATSUKASA, K., Suetomi, Y., Naniwa, Y., Ito, D., Inoue, N., Wakabayashi, Y., Okamura, H., Maeda, K., Uenoyama, Y., et al. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12235 · Cited by 46
Role of kisspeptin neurons as a GnRH surge generator: Comparative aspects in rodents and non‐rodent mammals
Matsuda, F., Ohkura, S., Magata, F., Munetomo, A., Chen, J., Sato, M., Inoue, N., Uenoyama, Y., & Tsukamura, H. (2019) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.14124 · Cited by 48
Photoperiodic Signalling Through the Melatonin Receptor Turns Full Circle
Morgan, P. J., & Hazlerigg, D. G. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01724.x · Cited by 46
Seasonal breeding as a neuroendocrine model for puberty in sheep
Smith, J. T., & Clarke, I. J. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.03.007 · Cited by 46
Self-citation
Follicle-Stimulating Hormone Responses to Kisspeptin in the Female Rat at the Preovulatory Period: Modulation by Estrogen and Progesterone Receptors
Roa, J., Vigo, E., Castellano, J. M., Gaytán, F., García-Galiano, D., Navarro, V. M., Aguilar, E., Dijcks, F. A., EDERVEEN, A. G. H., Pinilla, L., et al. (2008) · Endocrinology · doi:10.1210/en.2008-0604 · Cited by 47
Kisspeptin‐Immunoreactivity Changes in a Sex‐ and Hypothalamic‐Region‐Specific Manner Across Rat Postnatal Development
Desroziers, E., Mikkelsen, J. D., Duittoz, A. H., & Franceschini, I. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02317.x · Cited by 44

Authors: Smith, J. T., Cunningham, M. J., Rissman, E. F., Clifton, D. K., & Steiner, R. A.
Affiliations: University of Washington (US)
University of Virginia (US)
Corresponding author: Steiner, Robert A.
ORCID: Cunningham, Matthew J.
Rissman, Emilie F.
Steiner, Robert A.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2005-09-01
Volume: 146
Issue: 9
Pages: 3686-3692
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2005-0488
OpenAlex: W1975890243
Cited by: 1,102
References: 50
Citations by year: 2026: 19 · 2025: 30 · 2024: 49 · 2023: 42 · 2022: 58 · 2021: 75 · 2020: 42 · 2019: 61 · 2018: 62 · 2017: 66 · 2016: 65 · 2015: 49 · 2014: 63 · 2013: 73 · 2012: 65
FWCI: 41.36
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
ResearchWorks at the University of Washington (University of Washington) (submittedVersion)
Funders: National Institutes of Health (5u54hd012629-31)
National Institute of Mental Health (R01 MH 57759, K02 MH-01349, K02MH001349, R01MH057759)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK061517, R01 DK61517)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD 27142, U54-HD-12629, R01HD027142)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords: KISS1, kisspeptin, kisspeptin neurons, estradiol, estrogen receptor alpha, estrogen receptor beta, arcuate nucleus, anteroventral periventricular nucleus, GnRH secretion, negative feedback, positive feedback, ovariectomy, forebrain
MeSH terms: Animals, Arcuate Nucleus of Hypothalamus, Body Weight, Estrogens, Female, Mice, Inbred C57BL, Mice, Mutant Strains, Ovariectomy, Paraventricular Hypothalamic Nucleus, Proteins, RNA, Messenger, Estrogen Receptor alpha, Estrogen Receptor beta, Mice, Kisspeptins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Regulation of Kiss1 Gene Expression in the Brain of the Female Mouse

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks