The DOI matches its Crossref record; 115 of the 115 references it cites were found in a registry or an index.
Epigenetic Transgenerational Actions of Endocrine Disruptors
Abstract
Endocrine disruptors have recently been shown to promote an epigenetic transgenerational phenotype involving a number of disease states (e.g. male infertility). The anti-androgenic fungicide vinclozolin was found to act transiently at the time of embryonic sex determination to promote in the F1 generation a spermatogenic cell defect and subfertility in the male. When the animals were allowed to age up to 1 yr, a number of other disease states developed. This phenotype was transferred through the male germ line to all subsequent generations analyzed (F1-F4). The ability of an environmental factor (i.e. endocrine disruptor) to promote an epigenetic transgenerational phenotype impacts the potential hazards of environmental toxins, mechanisms of disease etiology, and evolutionary biology. The biological importance of the epigenetic actions of environmental agents is reviewed in the context of the primordial germ cell and development of epigenetic transgenerational phenotypes.
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“Environmental exposures have been linked to epigenetic mechanisms of transgenerational changes in gene expression and behavior.”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [143]
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Metadata
- Authors
- Anway, M. D., & Skinner, M. K.
- Affiliations
- Washington State University (US)
- Corresponding author
- Skinner, Michael K.
- ORCID
- Skinner, Michael K.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2006-06
- Volume
- 147
- Issue
- 6
- Pages
- s43-s49
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2054776840
- Cited by
- 455
- References
- 115
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 11 · 2023: 10 · 2022: 11 · 2021: 20 · 2020: 17 · 2019: 17 · 2018: 15 · 2017: 29 · 2016: 24 · 2015: 27 · 2014: 34 · 2013: 35 · 2012: 38
- FWCI
- 25.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Environmental Health Sciences (R01ES012974)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Keywords
- endocrine disruptors, transgenerational epigenetic inheritance, vinclozolin, male infertility, spermatogenic defects, subfertility, primordial germ cells, male germline, environmental toxins, epigenetic mechanisms
- MeSH terms
- Animals, Environmental Exposure, Environmental Pollutants, Biological Evolution, Humans, Mutation, Phenotype, Reproduction, Sex Differentiation, Epigenesis, Genetic, Endocrine Disruptors
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