Cited by 455Effects and risks of endocrine disrupting chemicalsEpigenetics and DNA MethylationSexual Differentiation and Disorders

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Epigenetic Transgenerational Actions of Endocrine Disruptors

Anway, Matthew D., Skinner, Michael K.·2006·Endocrinology

DOI 10.1210/en.2005-1058

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Abstract

Endocrine disruptors have recently been shown to promote an epigenetic transgenerational phenotype involving a number of disease states (e.g. male infertility). The anti-androgenic fungicide vinclozolin was found to act transiently at the time of embryonic sex determination to promote in the F1 generation a spermatogenic cell defect and subfertility in the male. When the animals were allowed to age up to 1 yr, a number of other disease states developed. This phenotype was transferred through the male germ line to all subsequent generations analyzed (F1-F4). The ability of an environmental factor (i.e. endocrine disruptor) to promote an epigenetic transgenerational phenotype impacts the potential hazards of environmental toxins, mechanisms of disease etiology, and evolutionary biology. The biological importance of the epigenetic actions of environmental agents is reviewed in the context of the primordial germ cell and development of epigenetic transgenerational phenotypes.

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Authors: Anway, M. D., & Skinner, M. K.
Affiliations: Washington State University (US)
Corresponding author: Skinner, Michael K.
ORCID: Skinner, Michael K.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2006-06
Volume: 147
Issue: 6
Pages: s43-s49
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2005-1058
OpenAlex: W2054776840
Cited by: 455
References: 115
Citations by year: 2026: 3 · 2025: 7 · 2024: 11 · 2023: 10 · 2022: 11 · 2021: 20 · 2020: 17 · 2019: 17 · 2018: 15 · 2017: 29 · 2016: 24 · 2015: 27 · 2014: 34 · 2013: 35 · 2012: 38
FWCI: 25.12
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Environmental Health Sciences (R01ES012974)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Keywords: endocrine disruptors, transgenerational epigenetic inheritance, vinclozolin, male infertility, spermatogenic defects, subfertility, primordial germ cells, male germline, environmental toxins, epigenetic mechanisms
MeSH terms: Animals, Environmental Exposure, Environmental Pollutants, Biological Evolution, Humans, Mutation, Phenotype, Reproduction, Sex Differentiation, Epigenesis, Genetic, Endocrine Disruptors

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